Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3157971991', 'doi': 'https://doi.org/10.3390/cells10051046', 'title': 'The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression', 'display_name': 'The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression', 'publication_year': 2021, 'publication_date': '2021-04-29', 'ids': {'openalex': 'https://openalex.org/W3157971991', 'doi': 'https://doi.org/10.3390/cells10051046', 'mag': '3157971991', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33946660', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8145942'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells10051046', 'pdf_url': 'https://www.mdpi.com/2073-4409/10/5/1046/pdf', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2073-4409/10/5/1046/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020288422', 'display_name': 'Jorge Martı́nez', 'orcid': 'https://orcid.org/0000-0002-2078-7918'}, 'institutions': [{'id': 'https://openalex.org/I69737025', 'display_name': 'University of Chile', 'ror': 'https://ror.org/047gc3g35', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I69737025']}], 'countries': ['CL'], 'is_corresponding': True, 'raw_author_name': 'Jorge Martinez', 'raw_affiliation_strings': ['Cell Biology Laboratory, INTA, University of Chile, Santiago 7810000, Chile'], 'affiliations': [{'raw_affiliation_string': 'Cell Biology Laboratory, INTA, University of Chile, Santiago 7810000, Chile', 'institution_ids': ['https://openalex.org/I69737025']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101473864', 'display_name': 'Patricio C. Smith', 'orcid': 'https://orcid.org/0000-0001-7314-621X'}, 'institutions': [{'id': 'https://openalex.org/I162148367', 'display_name': 'Pontificia Universidad Católica de Chile', 'ror': 'https://ror.org/04teye511', 'country_code': 'CL', 'type': 'education', 'lineage': ['https://openalex.org/I162148367']}], 'countries': ['CL'], 'is_corresponding': True, 'raw_author_name': 'Patricio C. Smith', 'raw_affiliation_strings': ['School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile'], 'affiliations': [{'raw_affiliation_string': 'School of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile', 'institution_ids': ['https://openalex.org/I162148367']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5020288422', 'https://openalex.org/A5101473864'], 'corresponding_institution_ids': ['https://openalex.org/I69737025', 'https://openalex.org/I162148367'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 0.673, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.999595, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '10', 'issue': '5', 'first_page': '1046', 'last_page': '1046'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12110', 'display_name': 'Bone and Dental Protein Studies', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/desmoplasia', 'display_name': 'Desmoplasia', 'score': 0.988255}], 'concepts': [{'id': 'https://openalex.org/C2781005279', 'wikidata': 'https://www.wikidata.org/wiki/Q5264825', 'display_name': 'Desmoplasia', 'level': 4, 'score': 0.988255}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.8750069}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.5695679}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5272949}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.50138116}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.46931624}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.44117945}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.4143864}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39778948}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34159666}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3038028}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.2008208}, {'id': 'https://openalex.org/C52124034', 'wikidata': 'https://www.wikidata.org/wiki/Q557179', 'display_name': 'Stroma', 'level': 3, 'score': 0.17513248}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.15885419}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.12243074}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.061704725}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008249', 'descriptor_name': 'Protein-Lysine 6-Oxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells10051046', 'pdf_url': 'https://www.mdpi.com/2073-4409/10/5/1046/pdf', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/fdac3bff00df4f6f9c48e9c9c11ba245', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/cells10051046', 'pdf_url': 'https://www.mdpi.com/2073-4409/10/5/1046/pdf?version=1619669934', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145942', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33946660', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells10051046', 'pdf_url': 'https://www.mdpi.com/2073-4409/10/5/1046/pdf', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320338073', 'funder_display_name': 'Fondo Nacional de Desarrollo Científico y Tecnológico', 'award_id': '1181168'}, {'funder': 'https://openalex.org/F4320338073', 'funder_display_name': 'Fondo Nacional de Desarrollo Científico y Tecnológico', 'award_id': '1170555'}], 'datasets': [], 'versions': [], 'referenced_works_count': 86, 'referenced_works': ['https://openalex.org/W157436130', 'https://openalex.org/W1747138696', 'https://openalex.org/W1844836761', 'https://openalex.org/W1871742131', 'https://openalex.org/W1893626655', 'https://openalex.org/W1965037168', 'https://openalex.org/W1968324755', 'https://openalex.org/W1979729004', 'https://openalex.org/W1982906893', 'https://openalex.org/W1988664472', 'https://openalex.org/W1989095124', 'https://openalex.org/W2005334224', 'https://openalex.org/W2007724842', 'https://openalex.org/W2016193552', 'https://openalex.org/W2024972965', 'https://openalex.org/W2029600778', 'https://openalex.org/W2039430052', 'https://openalex.org/W2039694476', 'https://openalex.org/W2040552143', 'https://openalex.org/W2044850629', 'https://openalex.org/W2047503754', 'https://openalex.org/W2048305477', 'https://openalex.org/W2060066380', 'https://openalex.org/W2067114310', 'https://openalex.org/W2068875289', 'https://openalex.org/W2086244192', 'https://openalex.org/W2086310075', 'https://openalex.org/W2088812649', 'https://openalex.org/W2093784914', 'https://openalex.org/W2099055911', 'https://openalex.org/W2099687396', 'https://openalex.org/W2100122781', 'https://openalex.org/W2100203276', 'https://openalex.org/W2100303404', 'https://openalex.org/W2100409677', 'https://openalex.org/W2102882750', 'https://openalex.org/W2105665055', 'https://openalex.org/W2108184788', 'https://openalex.org/W2111547416', 'https://openalex.org/W2116208747', 'https://openalex.org/W2121262075', 'https://openalex.org/W2140343175', 'https://openalex.org/W2141662760', 'https://openalex.org/W2142765712', 'https://openalex.org/W2145449209', 'https://openalex.org/W2146971577', 'https://openalex.org/W2147213735', 'https://openalex.org/W2159762598', 'https://openalex.org/W2160408484', 'https://openalex.org/W2161744213', 'https://openalex.org/W2164846110', 'https://openalex.org/W2167105902', 'https://openalex.org/W2203717837', 'https://openalex.org/W2242735364', 'https://openalex.org/W2302332254', 'https://openalex.org/W2304570313', 'https://openalex.org/W2338795774', 'https://openalex.org/W2419221324', 'https://openalex.org/W2476542314', 'https://openalex.org/W2530608816', 'https://openalex.org/W2755696550', 'https://openalex.org/W2770898760', 'https://openalex.org/W2794316390', 'https://openalex.org/W2804105851', 'https://openalex.org/W2811105465', 'https://openalex.org/W2890625366', 'https://openalex.org/W2902677664', 'https://openalex.org/W2904712055', 'https://openalex.org/W2920302920', 'https://openalex.org/W2922555728', 'https://openalex.org/W2952606886', 'https://openalex.org/W2953948952', 'https://openalex.org/W2954941941', 'https://openalex.org/W2981606633', 'https://openalex.org/W2991559983', 'https://openalex.org/W2996862224', 'https://openalex.org/W3012463633', 'https://openalex.org/W3014096200', 'https://openalex.org/W3021358866', 'https://openalex.org/W3094089230', 'https://openalex.org/W3103914930', 'https://openalex.org/W3126154645', 'https://openalex.org/W3128646645', 'https://openalex.org/W3132259578', 'https://openalex.org/W4230489839', 'https://openalex.org/W4252650885'], 'related_works': ['https://openalex.org/W4391445805', 'https://openalex.org/W4361273905', 'https://openalex.org/W4318920099', 'https://openalex.org/W4309862897', 'https://openalex.org/W3157376430', 'https://openalex.org/W3117894910', 'https://openalex.org/W3012628191', 'https://openalex.org/W2944211926', 'https://openalex.org/W2069518226', 'https://openalex.org/W2063672911'], 'abstract_inverted_index': {'Desmoplastic': [0], 'tumors': [1, 17], 'correspond': [2], 'to': [3, 53, 67, 185], 'a': [4, 19, 27, 41, 69, 114, 122], 'unique': [5], 'tissue': [6, 76, 97, 102, 165], 'structure': [7], 'characterized': [8], 'by': [9], 'the': [10, 62, 74, 92, 104, 119, 129, 134, 141, 144, 149, 154, 168, 176, 180, 196], 'abnormal': [11], 'deposition': [12], 'of': [13, 22, 25, 44, 73, 106, 121, 136, 143, 156, 164, 170, 179, 188, 198], 'extracellular': [14, 137, 181], 'matrix.': [15], 'Breast': [16], 'are': [18], 'typical': [20], 'example': [21], 'this': [23, 126], 'type': [24, 37], 'lesion,': [26], 'property': [28], 'that': [29, 111, 117], 'allows': [30], 'its': [31, 48], 'palpation': [32], 'and': [33, 47, 57, 71, 158], 'early': [34, 191], 'detection.': [35], 'Fibrillar': [36], 'I': [38], 'collagen': [39], 'is': [40, 50, 113], 'major': [42], 'component': [43], 'tumor': [45, 54, 78], 'desmoplasia': [46, 112], 'accumulation': [49], 'causally': [51], 'linked': [52], 'cell': [55, 159], 'survival': [56], 'metastasis.': [58], 'For': [59], 'many': [60], 'years,': [61], 'desmoplastic': [63, 96, 145], 'phenomenon': [64], 'was': [65, 98], 'considered': [66], 'be': [68], 'reaction': [70], 'response': [72], 'host': [75], 'against': [77], 'cells': [79], 'and,': [80], 'accordingly,': [81], 'designated': [82], 'as': [83, 161], '“desmoplastic': [84], 'reaction”.': [85], 'This': [86, 108], 'notion': [87], 'has': [88], 'been': [89], 'challenged': [90], 'in': [91, 100, 103, 128, 140, 195], 'last': [93], 'decades': [94], 'when': [95], 'detected': [99], 'breast': [101, 199], 'absence': [105], 'tumor.': [107], 'finding': [109], 'suggests': [110], 'preexisting': [115], 'condition': [116], 'stimulates': [118], 'development': [120, 142, 169], 'malignant': [123], 'phenotype.': [124], 'With': [125], 'perspective,': [127], 'present': [130], 'review,': [131], 'we': [132, 151], 'analyze': [133, 153], 'role': [135], 'matrix': [138, 182], 'remodeling': [139, 166, 178], 'response.': [146], 'Importantly,': [147], 'during': [148, 167], 'discussion,': [150], 'also': [152], 'impact': [155], 'obesity': [157], 'metabolism': [160], 'critical': [162], 'drivers': [163], 'desmoplasia.': [171], 'New': [172], 'knowledge': [173], 'derived': [174], 'from': [175], 'dynamic': [177], 'may': [183], 'lead': [184], 'novel': [186], 'targets': [187], 'interest': [189], 'for': [190], 'diagnosis': [192], 'or': [193], 'therapy': [194], 'context': [197], 'tumors.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3157971991', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-12-27T21:31:34.991338', 'created_date': '2021-05-10'}