Publication Information

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248], 'times': [93, 601], 'helping': [95], 'prevent': [96, 589, 1035], 'contain': [98], 'spread': [100], 'infection.3': [102], 'They': [103], 'are': [104, 114, 542, 568, 579, 604, 656, 753, 886, 1181, 1707, 2415, 2735, 2840], 'also': [105, 163, 488, 1047, 2082, 2469, 2517], 'convenient': [106], 'medical': [111, 2009, 2054], 'staff': [112], 'likely': [115, 438, 522], 'become': [117, 184, 198], 'part': [118, 681], 'future.': [124], 'reduction': [126, 1781], 'contacts': [129], 'means': [130], 'there': [131, 321, 939, 1803, 1930, 1939, 2541], 'is': [132, 149, 162, 239, 332, 383, 426, 437, 459, 521, 740, 782, 787, 857, 940, 988, 1001, 1062, 1111, 1197, 1241, 1245, 1334, 1424, 1916, 1931, 2127, 2134, 2194, 2325, 2440, 2475, 2542, 2761, 2861], 'a': [133, 257, 297, 342, 496, 625, 721, 929, 944, 1054, 1059, 1075, 1127, 1146, 1317, 1351, 1454, 1489, 1628, 1649, 1745, 1780, 1985, 2027, 2167, 2171, 2254, 2292, 2405, 2543, 2691, 2762], 'pressing': [134], 'need': [135, 1037, 1399, 1491, 2298], 'rethink': [137], 'how': [138, 1896], 'best': [139, 171], 'prepare': [141], 'surgery,': [145, 592, 738, 1734], 'ensuring': [146], 'comprehensive': [147, 2242], 'performed': [150, 675, 2005, 2103], 'within': [151, 1260], 'limitations': [153], 'imposed': [154], 'pandemic-related': [156], 'working': [159], 'practices.': [160], 'It': [161, 425, 560, 2318], 'opportunity': [165, 1935], 'review': [167, 267, 1360, 2002, 2243], 'evidence': [169, 2523, 2801], 'evaluate': [174], 'benefit': [176, 526, 1723], 'certain': [178], 'aspects': [179], 'what': [181], 'may': [182, 487, 557, 630, 644, 666, 672, 792, 861, 891, 1122, 1218, 1722, 2025, 2071, 2187, 2234, 2435, 2703], 'consideration': [188], 'risk': [190, 545, 1279, 1580, 1676, 1988, 2030, 2211, 2260, 2273, 2369, 2497], 'balance': [191], 'patient.': [194, 1295], 'Surgical': [195], 'PBM': [196, 281, 1958, 2466], 'standard': [199], 'over': [202], 'last': [204], 'decade': [205], 'involves': [207], 'preoperative,': [208], 'operative': [209, 2041], 'postoperative': [211, 371, 1512, 1811, 1835, 1849, 2329], 'phases,': [212], 'manage': [214], 'anaemia,': [215, 913], 'minimise': [216, 706, 2496], 'blood': [217, 232, 238, 250, 254, 263, 287, 397, 497, 555, 648, 712, 751, 811, 813, 932, 1040, 1081, 1157, 1401, 1493, 1787, 1947, 1975, 2095, 2388, 2391, 2432, 2438, 2509, 2574], 'loss': [218, 556, 2389, 2433], 'ensure': [220, 883], 'appropriate': [221, 1221], 'transfusion': [222, 319, 1231, 1494, 1679, 2515, 2558, 2565, 2575], 'practices,': [223], 'with': [224, 364, 368, 407, 432, 451, 468, 527, 636, 700, 846, 943, 1003, 1224, 1293, 1298, 1621, 1739, 1844, 2111, 2158, 2220, 2275, 2282, 2327, 2350, 2354, 2404, 2417, 2554], 'benefits': [225], 'both': [227], 'outcomes': [229, 367, 1405], 'supply': [233], 'chain.': [234], 'Appropriate': [235], 'use': [236, 313, 743, 896, 1363, 1626, 2428, 2450], 'critical': [240], 'mitigate': [242], 'negative': [244], 'impact': [245], 'on': [249, 833, 871, 1235, 1361, 1539, 1771, 2145, 2304, 2706, 2847], 'collection': [251], 'resulting': [253], 'stocks': [255], 'at': [256, 907, 963, 1031, 1187, 1438, 1524, 1552, 1685, 1876, 1891, 2367, 2589, 2868], 'time': [258, 771, 1190, 1314, 1879, 2591, 2870], 'great': [260], 'challenge': [261], 'services.4': [264], 'A': [265, 1886, 2001, 2014, 2241, 2259], 'systematic': [266], 'meta-analysis': [269, 299, 2407], '393': [271], 'randomised': [272, 302, 1378, 1430, 1736], 'controlled': [273, 303, 1379], 'trials': [274, 304, 1262, 1380, 1652], '(n': [275], '=': [276, 1502], '54': [277], '917)': [278], 'showed': [279, 1531], 'that': [280, 436, 731, 884, 1230, 1607, 1667, 1721, 2322, 2738, 2804], 'interventions': [282, 917, 1193, 1959], 'reduced': [283, 393, 404, 418, 471, 1490, 1674, 1834], 'exposure': [284, 1356, 1853, 1870], 'allogeneic': [286], 'components,': [288], 'length': [289, 1695, 1814], 'stay': [291, 1515, 1698, 1720], 'intensive': [293], 'usage.': [295], 'In': [296, 899, 921, 997, 1729], 'network': [298], 'most': [305, 378, 998], 'effects': [308], 'were': [309, 1386, 1406, 1505, 1658, 1690, 1702, 2598, 2654], 'explained': [310], 'tranexamic': [315, 2381, 2453], 'acid': [316, 1768, 2382, 2454], 'restrictive': [318, 2528], 'triggers;': [320], 'was': [322, 1391, 1464, 1470, 1571, 1683, 1804, 2251, 2334], 'less': [323, 1425, 1573], 'additive': [324], 'effect': [325], 'interventions.5': [329], 'Preoperative': [330], 'anaemia': [331, 363, 382, 430, 446, 494, 534, 585, 614, 781, 941, 969, 1013, 1056, 1107, 1244, 1369, 1419, 1638, 1740, 1836, 1895], 'common,': [333], 'affecting': [334], '10–15%': [335], 'before': [338, 697, 1206, 1466, 1774, 1949], 'orthopaedic': [340, 2399], 'surgery,8': [341], 'third': [343], 'those': [345, 352, 516, 547, 566, 778], 'undergoing': [346, 353, 548, 569, 736, 1434, 1641, 1825, 2398], 'abdominal': [347, 1436], 'surgery': [348, 510, 550, 603, 623, 693, 1207, 1238, 1437, 1537, 1556, 1570, 1643, 1827], 'half': [350], 'colorectal': [354], 'surgery.9': [355], 'Several': [356], 'large': [357], 'database': [358], 'analyses': [359], 'associated': [361, 431, 450, 942, 1355, 2274, 2281, 2326], 'worse': [365], 'regard': [369, 528], 'complications,': [372, 1513], 'morbidity': [373], 'mortality.10,': [375], '11': [376], 'common': [379], 'cause': [380, 1105, 1417], 'absolute,': [384], 'classical': [386], 'iron': [387, 394, 400, 413, 423, 434, 442, 453, 457, 464, 966, 976, 1299, 1321, 1333, 1343, 1365, 1389, 1445, 1469, 1545, 1590, 1615, 1634, 1673, 1742, 1821, 2742], 'deficiency': [388, 401, 454, 458, 967, 1061, 1300, 1616, 1743], 'due': [389, 1014, 1281], 'nutritional': [391], 'deficiency,': [392, 435], 'uptake': [395], 'loss.12': [398], 'Absolute': [399], 'results': [402, 716, 745, 885, 1528], 'ferritin': [405, 478], 'levels,': [406], 'low': [408, 462, 947], 'circulating': [409, 463], 'iron,': [410], 'raised': [411, 2208], 'total': [412, 2430], 'binding': [414], 'capacity': [415], '(TIBC)': [416], 'transferrin': [419], 'saturation': [420], '(TSAT': [421], 'saturation).': [424], 'necessary': [427, 1142], 'distinguish': [429], 'absolute': [433], 'respond': [440], 'replacement': [443], 'therapy,': [444], 'chronic': [448, 971, 2112], 'disease': [449, 972], 'functional': [452], '(FID).': [455], 'Functional': [456], 'characterised': [460], 'levels': [465, 1396, 1689], 'TSAT,': [467], 'normal': [469, 474, 945], 'TIBC': [472], 'increased': [476, 2328], 'serum': [477], 'levels.': [479], 'Systemic': [480], 'markers': [481], 'inflammation': [483], 'C-reactive': [484], 'protein': [485], '(CRP)': [486], 'be': [489, 513, 524, 536, 558, 563, 607, 631, 668, 757, 793, 820, 863, 905, 919, 961, 995, 1023, 1029, 1049, 1095, 1114, 1162, 1185, 1219, 1233, 1249, 1256, 1287, 1302, 1323, 1340, 1345, 1619, 1727, 1860, 1874, 1889, 1900, 1941, 1990, 1998, 2004, 2033, 2057, 2083, 2102, 2107, 2188, 2202, 2218, 2263, 2308, 2316, 2320, 2363, 2443, 2456, 2477, 2518, 2538, 2552, 2568, 2577, 2704, 2823, 2845, 2864], 'elevated.': [490], 'diagnosis': [492, 964, 1147, 1893], 'necessitates': [495, 1229], 'test,': [498], 'potential': [501, 1840, 1852, 1869], 'additional': [503, 867, 893, 957, 1868, 1937, 1946], 'exposure.': [505], 'Testing': [506], 'advance': [508], 'should': [511, 535, 561, 756, 818, 926, 960, 994, 1046, 1066, 1094, 1161, 1168, 1184, 1248, 1255, 1301, 1617, 1726, 1864, 1873, 1888, 2003, 2056, 2081, 2100, 2106, 2216, 2262, 2307, 2319, 2361, 2455, 2468, 2516, 2537, 2551, 2576], 'therefore': [512, 1048, 2362], 'limited': [514, 1659], 'whom': [519, 553, 584, 780, 1103, 1415], 'it': [520, 739, 1000, 1904, 2186, 2818, 2834], 'surgery.': [531, 598, 1120, 1912, 1953, 2050], 'Screening': [532], 'undertaken': [537, 564, 1030, 1875, 1999], 'all': [539, 815, 877], 'who': [541, 567, 578, 1610], 'themselves': [543], 'high': [544], 'major': [549, 1435], 'significant': [554, 1532], 'anticipated.13': [559], 'not': [562, 587, 667, 858, 1063, 1139, 1327, 1335, 1421, 1486, 1612, 1618, 1865, 2101, 2128], 'minor': [570], 'intermediate': [572], 'procedures,': [574], 'otherwise': [580, 733], 'well': [581, 2129, 2480, 2665, 2725], 'would': [586, 1940, 2628, 2805], 'normally': [588], 'delay': [591, 889], 'nor': [593, 2880], 'affect': [594, 1906], 'outcome': [596], 'Where': [599, 750, 825, 855, 938, 985, 1179, 1913], 'waiting': [600], 'anticipated': [605, 2441], 'prolonged,': [608], 'early': [609, 761], 'identification': [610], 'treatment': [612, 1713, 1921], 'will': [615, 705, 840, 882, 1022, 1138, 1349, 1899, 1905, 2567, 2791, 2822, 2844], 'allow': [616, 769], 'proceed': [620, 1910, 1919], 'directly': [621], 'when': [624, 1164, 1289, 1681, 2393, 2429], 'slot': [626], 'becomes': [627, 2802, 2835], 'available.': [628], 'achieved': [632], 'through': [633], 'close': [634], 'liaison': [635], 'primary-care': [637], 'teams': [638], 'enable': [640], 'timely': [641], 'investigations.': [642], 'Patients': [643, 1254], 'had': [646, 1547], 'recent': [647, 2406], 'tests': [649, 671, 752, 817, 845, 879, 903, 959, 1041, 2096], 'purposes': [652], 'where': [654, 1058, 1239, 1263], 'these': [655, 755, 1180, 2249, 2409, 2413, 2535], 'present,': [657], 'acceptable,': [658], 'clinically': [663], 'stable,': [664], 'repetition': [665], 'necessary.': [669, 1024], 'These': [670], 'general': [678], 'practitioner': [679], 'as': [680, 760, 766, 789, 928, 1132, 1134, 1191, 1194, 1196, 1308, 1880, 2253, 2479, 2481, 2664, 2666, 2724, 2726], 'instance': [687, 924], 'case': [690], 'cancer': [692], 'pathway': [696, 765], 'operation.': [698], 'Coordination': [699, 784], 'duplication.': [707], 'Studies': [708], 'healthy': [710, 734], 'volunteer': [711], 'donors': [713], 'suggest': [714, 1666], 'haemoglobin': [715, 836, 955, 1395, 1474, 1550, 1688], 'remain': [717], 'steady': [718], 'even': [719], 'after': [720, 1536], 'prolonged': [722], 'inter-test': [723], 'period': [724], 'up': [726], 'two': [728], 'years,': [729], 'suggesting': [730], 'reasonable': [741], 'historic': [744], 'assess': [747, 1711, 2098], 'anaemia.14': [749], 'required,': [754], 'carried': [758], 'out': [759, 1002, 1520], 'possible': [767], 'adequate': [770], 'interpretation': [773], 'effective': [775, 916, 1324], 'intervention': [776, 1883], 'identified.': [783], 'between': [785, 1508], 'departments': [786], 'critical,': [788], 'such': [790, 1149, 1291], 'opportunities': [791], 'diverse': [795], 'areas,': [796], 'example,': [798], 'radiological': [799], 'investigations': [800], 'unrelated': [804, 1115], 'problems.': [805], 'To': [806], 'avoid': [807, 852], 'multiple': [808, 1439], 'visits': [809], 'tests,': [812], 'diagnostic': [816, 844, 878, 958, 1462], 'preferably': [819], 'taken': [821, 864, 1171, 1186, 1234], 'one': [823], 'visit.': [824], 'laboratory': [826], 'systems': [827], 'allow,': [828], 'automatic': [829], 'reflex': [830], 'testing': [831, 868, 1026], 'based': [832], 'initial': [835, 2205], 'red-cell': [838, 1678, 2514], 'indices': [839], 'relevant': [843, 2286], 'minimum': [848, 930], 'delay,': [850], 'unnecessary': [853], 'tests.': [854], 'this': [856, 925, 1032, 1240, 1247, 1348, 1712, 1863, 1897, 2132, 2178, 2594, 2647, 2682, 2814, 2859, 2891], 'possible,': [859], 'samples': [860, 873, 1170, 1232], 'still': [862], 'together': [865], 'requested': [869], 'manually': [870], 'held.': [874], 'Alternatively,': [875], 'requesting': [876], "'up": [880], "front'": [881], 'available': [887, 2803], 'without': [888], 'but': [890, 1484, 1665, 1704, 2105, 2200], 'incur': [892, 1866], 'cost': [894], 'resources.': [898], 'setting,': [902], 'must': [904, 1286, 1859, 2315], 'directed': [906, 962], 'detection': [908], 'treatable': [910], 'causes': [911, 1017], 'which': [915, 1166, 1982, 1996, 2024, 2070, 2233, 2566, 2702], 'can': [918, 1027, 1322, 1344, 1989, 1997, 2031], 'delivered.': [920], 'first': [923, 1791], 'include': [927, 974, 1067], 'full': [931, 1055], 'count,': [933], 'renal': [934, 2077], 'liver': [936, 2079, 2113], 'profile.': [937], 'mean': [948, 953], 'corpuscular': [949, 954], 'volume': [950], '(MCV)': [951], 'and/or': [952], '(MCH),': [956], 'ferritin,': [975], 'studies': [977, 2414], '(serum': [978], 'Fe,': [979], 'TIBC,': [980], 'TSAT)': [981], 'inflammatory': [983], 'markers.': [984], 'MCV': [987], 'raised,': [989], 'B12': [990], 'folate': [992], 'assays': [993], 'requested.': [996], 'circumstances': [999], 'scope': [1005], 'investigate': [1010], 'treat': [1012, 1368, 1636, 2396], 'referral': [1019, 1125], 'management': [1021, 1410, 2015, 2247], 'Further': [1025], 'however': [1028], 'stage': [1033], 'further': [1039, 1705], 'infection': [1043, 1278], 'risk.': [1044, 1357], 'Consideration': [1045], 'given': [1050], 'completion': [1052], 'screen': [1057, 1077, 1175], 'simple': [1060], 'found.': [1064], 'addition': [1069], 'of:': [1070], 'thyroid': [1071], 'stimulating': [1072], 'hormone': [1073], '(TSH),': [1074], 'haemolysis': [1076], '(lactate': [1078], 'dehydrogenase,': [1079], 'reticulocytes,': [1080], 'film,': [1082], 'haptoglobin': [1083], 'direct': [1085], 'antiglobulin': [1086], 'test)': [1087], 'immunoglobulins.': [1089], 'Pathways': [1090], 'individual': [1092], 'responsibilities': [1093], 'agreed': [1096], 'follow-up,': [1098], 'particularly': [1099], 'undiagnosed': [1109], 'found': [1112, 1338], 'reason': [1118], 'require': [1123, 1328, 1350], 'onward': [1124], 'haematologist,': [1128], 'gastroenterologist': [1129], 'gynaecologist': [1131], 'indicated,': [1133], 'clinics': [1137], 'expertise': [1143], 'pursue': [1145], 'cases.': [1150], 'Existing': [1151], 'national': [1152, 2137], 'guidance': [1153, 2425, 2860], 'local': [1155, 1225], 'maximum': [1156], 'ordering': [1158], 'schedules': [1159], '(MSBOS)': [1160], 'followed': [1163], 'determining': [1165], 'group': [1173, 1546, 1591, 1597, 2775, 2790, 2795], 'cross': [1177], 'match.': [1178], 'necessary,': [1182], 'they': [1183], 'same': [1189, 1878], 'far': [1195], 'possible.': [1198, 1885], 'recommendation': [1200], 'isolation': [1202, 1217], '14': [1204], 'days': [1205, 1459, 1517, 1793], 'pandemic15': [1210], '(though': [1211], 'some': [1213], 'cases': [1214], 'shorter': [1215], 'deemed': [1220], 'accordance': [1223], 'public': [1226], 'guidance)': [1228], 'admission': [1236], 'required.': [1242], 'When': [1243, 1331, 1954], 'identified,': [1246], 'investigated': [1250], 'managed': [1252, 1259], 'accordingly.': [1253], 'enrolled': [1257], 'clinical': [1261], 'possible;': [1264], 'however,': [1265], 'trial': [1266], 'activity': [1267], 'significantly': [1270, 1548, 1572], 'curtailed': [1271], 'added': [1277, 1978], 'incurred': [1280, 2677], 'trial-related': [1283], 'hospital': [1284, 1329, 1352, 1514, 1523, 1568, 1697, 1816], 'attendances': [1285], 'considered': [1288, 2108, 2569], 'discussing': [1290], 'options': [1292], 'Those': [1296], 'treated,': [1303], 'setting': [1307, 1731, 2199], 'any': [1310, 2060, 2501, 2798, 2884], 'setting.': [1312], 'If': [1313, 2837], 'allows': [1315], 'then': [1316, 2032, 2217], 'course': [1318], 'oral': [1320, 1332, 1766], 'does': [1326], 'attendance.': [1330], 'tolerated,': [1336], 'ineffective,': [1341], 'intravenous': [1342, 1444, 1544, 1589, 1623, 1633, 1819], 'used': [1346, 2394, 2478], 'though': [1347, 2131], 'attendance': [1353, 2754], 'Cochrane': [1359], 'therapy': [1366, 1390, 2301, 2324, 2340, 2360], 'recently': [1371, 1654], 'updated.16': [1373], 'One': [1374], 'hundred': [1375], 'twelve': [1377], '(RCTs)': [1381], 'totalling': [1382], '22': [1383, 2141], '169': [1384], 'included.': [1387], 'Overall,': [1388], 'efficacious': [1392, 1471], 'increasing': [1394], 'reducing': [1398, 1851], 'transfusion.': [1402], 'However,': [1403, 1802], 'heterogeneously': [1407], 'reported.': [1408], 'determined': [1423], 'clear.': [1426], 'PREVENTT': [1428, 1530], 'trial17': [1429], '487': [1431], 'anaemic': [1432, 1608], 'UK': [1440], 'sites': [1441], 'receive': [1443], '(ferric': [1446], 'carboxymaltose,': [1447, 1751], '1': [1448, 1758], '000': [1449, 1753], 'mg)': [1450], 'placebo': [1452, 1596, 1770, 2333], '(saline)': [1453], 'median': [1455, 1784], '15': [1457], '(12–22)': [1458], 'preoperatively.': [1460], 'No': [1461, 1692], 'process': [1463], 'mandated': [1465], 'randomisation.': [1467], 'Intravenous': [1468], 'increase': [1473, 2026, 2072, 2235], '[mean': [1475], 'difference,': [1476, 1558], '4·7': [1477], 'g/l;': [1478, 1560], '95%': [1479, 1498, 1561, 1583, 1601], 'confidence': [1480], 'interval': [1481], '(CI),': [1482], '2·7–6·8]': [1483], 'did': [1485], 'result': [1487, 1832], '(risk': [1495], 'ratio,': [1496, 1581, 1599], '1·03;': [1497], 'CI,': [1499, 1562, 1584, 1602], '0·78–1·37;': [1500], 'P': [1501], '0·84).': [1503], 'There': [1504], 'no': [1506, 1805, 1934, 2777], 'differences': [1507, 1533, 1693], 'groups': [1510], 'alive': [1518], '30': [1525], 'days.': [1526], 'Secondary': [1527], 'discharge': [1540], 'hospital.': [1542], 'higher': [1549, 1686], 'concentrations': [1551], 'eight': [1553], 'weeks': [1554], 'following': [1555, 1569, 2458, 2770], '(mean': [1557], '10·7': [1559], '7·8–13·7),': [1563], 're-admission': [1565], 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1826, 2402], 'Spahn': [1735], '505': [1737], '20': [1748], 'mg/kg': [1749], 'ferric': [1750], '40': [1752], 'U': [1754], 'subcutaneous': [1755, 1760], 'alpha,': [1757], 'mg': [1759, 1765], 'vitamin': [1761], 'B12,': [1762], '5': [1764], 'folic': [1767], 'day': [1773, 1951], 'surgery.19': [1775], 'primary': [1777, 2044], 'end-point': [1778], 'demonstrated': [1779, 2385], 'transfusions': [1788, 2392], 'seven': [1792], '[odds': [1794], 'ratio': [1795], '(OR)': [1796], '0·70': [1798], '(95%': [1799], 'CI': [1800], '0·50–0·98)].': [1801], 'difference': [1806], 'patient-reported': [1808], 'end-points': [1809], 'complications': [1812], 'stay.': [1817], 'Perioperative': [1818], '(IV)': [1820], 'non-anaemic': [1823], 'shown': [1830], 'reduce': [1842, 2387, 2508], 'contact': [1843], 'settings': [1846], 'period,': [1850], 'events.20': [1854], 'Following': [1855], 'treatment,': [1856, 1928, 1938], 'response': [1857], 'undertaken.': [1861], 'Ideally': [1862], 'event,': [1871], 'another': [1881], 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