Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays

Name: Work Video:
Duration: 3 min 30 s
Anna S. Young; Thomas Zoeller; Russ Hauser; Tamarra James‐Todd; Brent A. Coull; Peter Behnisch; Abraham Brouwer; Hongkai Zhu; Kurunthachalam Kannan; Joseph G. Allen
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'https://openalex.org/W2803934923', 'https://openalex.org/W2604832456', 'https://openalex.org/W2138535366', 'https://openalex.org/W2135503807', 'https://openalex.org/W2119275063', 'https://openalex.org/W2086939834', 'https://openalex.org/W1980223867', 'https://openalex.org/W1978086795'], 'abstract_inverted_index': {'Vol.': [0], '129,': [1], 'No.': [2], '4': [3, 2893], 'ResearchOpen': [4], 'AccessAssessing': [5], 'Indoor': [6], 'Dust': [7, 2523], 'Interference': [8], 'with': [9, 375, 389, 415, 445, 461, 622, 1024, 1209, 1505, 1616, 1657, 1769, 1802, 1809, 1841, 1941, 2019, 2040, 2538, 2604, 2618, 2714, 2765, 2823, 2832, 2909, 2918, 2955, 3023, 3176, 3223, 3368, 3478, 3790, 3804, 3834, 3879, 3913, 3919, 3943, 3959, 4115], 'Human': [10], 'Nuclear': [11], 'Hormone': [12], 'Receptors': [13], 'in': [14, 302, 407, 521, 566, 705, 710, 767, 781, 1077, 1218, 1236, 1251, 1279, 1344, 1371, 1385, 1410, 1432, 1471, 1507, 1575, 1694, 1714, 1775, 1821, 1825, 1861, 1968, 1988, 2077, 2083, 2089, 2107, 2158, 2259, 2343, 2401, 2486, 2575, 2597, 2677, 2688, 2701, 2759, 2801, 2842, 2849, 2887, 2965, 2968, 3004, 3008, 3031, 3049, 3117, 3131, 3187, 3203, 3309, 3476, 3569, 3578, 3992, 4007, 4066, 4086, 4110, 4132, 4200], 'Cell-Based': [15, 2520], 'Luciferase': [16, 1850, 2885], 'Reporter': [17, 467, 1851], 'Assays': [18, 2521], 'Anna': [19, 44, 50], 'S.': [20, 45, 51], 'Young,': [21, 52], 'Thomas': [22, 98], 'Zoeller,': [23], 'Russ': [24, 111], 'Hauser,': [25], 'Tamarra': [26, 128], 'James-Todd,': [27], 'Brent': [28, 145], 'A.': [29, 32, 146, 164], 'Coull,': [30], 'Peter': [31, 163], 'Behnisch,': [33], 'Abraham': [34, 171], 'Brouwer,': [35], 'Hongkai': [36, 178], 'Zhu,': [37], 'Kurunthachalam': [38, 200], 'Kannan,': [39], 'and': [40, 92, 183, 205, 222, 253, 260, 275, 287, 308, 316, 356, 372, 448, 464, 499, 501, 519, 544, 547, 561, 611, 644, 665, 673, 676, 740, 785, 807, 825, 882, 903, 929, 938, 960, 999, 1018, 1021, 1045, 1049, 1061, 1082, 1098, 1101, 1122, 1146, 1169, 1229, 1257, 1353, 1368, 1391, 1467, 1531, 1534, 1539, 1593, 1614, 1618, 1628, 1652, 1673, 1689, 1734, 1812, 1856, 1883, 1894, 1899, 1982, 2022, 2052, 2070, 2148, 2153, 2361, 2428, 2489, 2507, 2542, 2551, 2588, 2612, 2726, 2729, 2745, 2757, 2772, 2775, 2804, 2818, 2874, 2938, 2945, 2985, 3037, 3163, 3192, 3230, 3289, 3415, 3454, 3461, 3471, 3496, 3589, 3604, 3617, 3626, 3635, 3639, 3684, 3701, 3769, 3799, 3822, 3837, 3841, 3847, 3857, 3867, 3876, 3892, 3986, 4037, 4060, 4166, 4189], 'Joseph': [41, 223], 'G.': [42, 224], 'Allen': [43, 225], 'Young': [46], 'Address': [47], 'correspondence': [48], 'to': [49, 278, 606, 722, 735, 817, 920, 945, 1022, 1157, 1191, 1232, 1350, 1408, 1461, 1473, 1514, 1549, 1581, 1621, 1670, 1681, 1716, 1780, 1843, 1904, 2026, 2046, 2064, 2099, 2261, 2326, 2369, 2383, 2522, 2633, 2642, 2649, 2656, 2670, 2953, 2960, 2989, 2997, 3092, 3382, 3849, 3873, 3908, 4026, 4033, 4041, 4094], '401': [53], 'Park': [54], 'Dr.,': [55], '4W': [56], 'Suite': [57], '405,': [58], 'Boston,': [59, 79, 124, 141, 159, 237], 'MA': [60], '02215': [61], 'USA.': [62], 'Email:': [63], 'E-mail': [64], 'Address:': [65], '[email': [66], 'protected]': [67], 'Department': [68, 82, 100, 113, 130, 148, 180, 184, 202, 206, 226], 'of': [69, 76, 83, 90, 101, 104, 114, 121, 131, 138, 149, 156, 181, 185, 192, 203, 207, 214, 227, 234, 283, 299, 311, 346, 394, 419, 476, 479, 517, 571, 574, 591, 690, 701, 720, 827, 1047, 1198, 1205, 1224, 1238, 1247, 1282, 1298, 1414, 1420, 1446, 1481, 1493, 1510, 1519, 1537, 1559, 1603, 1624, 1644, 1675, 1711, 1878, 1891, 1897, 1901, 1953, 1980, 1991, 2015, 2029, 2044, 2060, 2073, 2109, 2126, 2132, 2141, 2180, 2198, 2209, 2217, 2245, 2254, 2306, 2313, 2323, 2354, 2375, 2396, 2443, 2452, 2461, 2468, 2477, 2519, 2558, 2577, 2590, 2606, 2623, 2627, 2667, 2685, 2690, 2782, 2825, 2836, 2853, 2855, 2881, 2926, 2957, 2980, 2993, 3018, 3020, 3025, 3034, 3041, 3047, 3120, 3170, 3200, 3227, 3233, 3244, 3305, 3311, 3324, 3335, 3339, 3427, 3483, 3523, 3543, 3613, 3794, 3855, 3864, 3881, 3974, 4012, 4052, 4062, 4073, 4079, 4082, 4136, 4138, 4198, 4220], 'Environmental': [70, 115, 132, 150, 186, 208, 228, 4143], 'Health,': [71, 78, 116, 123, 133, 140, 151, 158, 229, 236], 'Harvard': [72, 87, 117, 134, 152, 230], 'T.H.': [73, 118, 135, 153, 231], 'Chan': [74, 119, 136, 154, 232], 'School': [75, 89, 120, 137, 155, 191, 213, 233], 'Public': [77, 122, 139, 157, 235], 'Massachusetts,': [80, 95, 108, 125, 142, 160, 238], 'USA': [81, 96, 109, 126, 143, 161, 198, 220, 239], 'Population': [84], 'Health': [85], 'Sciences,': [86, 93], 'Graduate': [88], 'Arts': [91], 'Cambridge,': [94], ',': [97, 110, 127, 144, 162, 170, 177, 199, 221], 'Zoeller': [99], 'Biology,': [102], 'University': [103, 190, 212], 'Massachusetts': [105], 'Amherst,': [106, 107], 'Hauser': [112], 'James-Todd': [129], 'Coull': [147], 'Behnisch': [165], 'BioDetection': [166, 173, 1870, 3152, 3440], 'Systems,': [167, 174], 'Amsterdam,': [168, 175], 'Netherlands': [169, 176], 'Brouwer': [172], 'Zhu': [179], 'Pediatrics': [182, 204], 'Medicine,': [187, 193, 209, 215], 'New': [188, 194, 196, 210, 216, 218], 'York': [189, 211], 'York,': [195, 197, 217, 219], 'Kannan': [201, 548, 3627, 3640], 'Published:14': [240], 'April': [241], '2021CID:': [242], '047010https://doi.org/10.1289/EHP8054AboutSectionsPDF': [243], 'Supplemental': [244], 'Materials': [245], 'ToolsDownload': [246], 'CitationsTrack': [247], 'Citations': [248], 'ShareShare': [249], 'onFacebookTwitterLinked': [250], 'InRedditEmail': [251], 'AbstractBackground:Per-': [252], 'polyfluoroalkyl': [254, 502, 2508], 'substances': [255, 503], '(PFAS),': [256], 'organophosphate': [257, 798], 'esters': [258, 799], '(OPEs),': [259], 'polybrominated': [261, 757], 'diphenyl': [262, 758, 3723, 3727, 3737, 3741], 'ethers': [263, 759], '(PBDEs)': [264], 'are': [265, 471, 485, 588, 620, 718, 779, 801, 905, 1187, 1226, 1400, 1554, 1692, 3439, 3576, 4101, 4213], 'hormone-disrupting': [266, 493, 906, 1206, 1249], 'chemicals': [267, 289, 444, 513, 596, 1250, 1256, 1449, 1506, 1533, 1553, 1967, 1998, 2038, 4084, 4139, 4231], 'that': [268, 482, 540, 900, 1170, 1214, 1338, 1639, 1653, 1748, 1983, 2136, 2238, 2266, 2300, 2330, 2335, 2912, 2958, 3182, 3527, 3537, 4017, 4226], 'migrate': [269], 'from': [270, 1166, 1245, 1393, 1566, 1609, 1636, 1668, 1679, 2005, 2177, 2287, 2866, 3015, 3060, 3195, 3563, 3977, 4140], 'building': [271, 483, 741], 'materials': [272], 'into': [273, 789, 1174, 1761, 1799, 3423, 3824, 3859, 3904], 'air': [274], 'dust.Objectives:We': [276], 'aimed': [277], 'quantify': [279, 1192, 1516, 3236], 'the': [280, 291, 522, 567, 666, 691, 706, 711, 714, 768, 813, 1043, 1055, 1137, 1143, 1167, 1193, 1242, 1252, 1280, 1296, 1376, 1440, 1478, 1556, 1576, 1604, 1648, 1687, 1731, 1796, 1803, 1887, 1942, 1969, 1989, 2002, 2007, 2027, 2033, 2037, 2048, 2078, 2086, 2128, 2133, 2138, 2156, 2159, 2178, 2186, 2190, 2199, 2213, 2218, 2230, 2234, 2243, 2252, 2255, 2262, 2279, 2282, 2288, 2296, 2302, 2307, 2314, 2321, 2324, 2344, 2349, 2355, 2358, 2363, 2372, 2376, 2384, 2393, 2526, 2530, 2533, 2570, 2613, 2630, 2635, 2639, 2644, 2647, 2651, 2654, 2658, 2668, 2671, 2678, 2686, 2692, 2814, 2819, 2833, 2861, 2867, 2869, 2875, 2903, 2910, 2913, 2919, 2971, 2981, 2986, 2991, 3032, 3050, 3065, 3077, 3093, 3112, 3121, 3129, 3132, 3168, 3177, 3198, 3204, 3245, 3303, 3317, 3322, 3325, 3332, 3336, 3340, 3375, 3377, 3384, 3396, 3425, 3435, 3507, 3519, 3524, 3541, 3544, 3553, 3564, 3570, 3582, 3647, 3773, 3785, 3843, 3993, 4000, 4049, 4057, 4063, 4119, 4131, 4141, 4201, 4218, 4233], 'hormonal': [281, 297, 417, 456, 1517, 1535, 2394, 4080], 'activities': [282, 298, 418, 1235, 1297, 1518, 1536, 2179, 2192, 2395], '46': [284, 345, 347, 1520, 1567, 2397], 'dust': [285, 301, 309, 331, 420, 453, 523, 1225, 1239, 1299, 1346, 1373, 1522, 1560, 1564, 1706, 1719, 1760, 1797, 1854, 1970, 2200, 2210, 2226, 2399, 2527, 2559, 2837, 3465, 3615, 3774, 4008, 4014, 4087], 'samples': [286, 332, 454, 1483, 1565, 1605, 1632, 1651, 1855, 1910, 2157, 2400, 2528, 2534, 3130, 3351, 3367, 3545, 3616, 3775, 3786, 4015], 'identify': [288, 1474, 1525], 'driving': [290, 1477, 1555], 'observed': [292, 388, 1557], 'activities.Methods:We': [293], 'evaluated': [294, 3146], 'associations': [295, 1526], 'between': [296, 1363, 1527, 1612, 1815], 'extracted': [300, 395, 2543, 2561, 3800], 'five': [303, 3511], 'cell-based': [304, 469, 1222, 1305, 1732], 'luciferase': [305, 1864, 1928, 1944, 2402], 'reporter': [306, 1929, 1945, 2403, 4156], 'assays': [307, 470, 1186, 1223, 1237, 1262, 1306, 1868, 1931, 3397, 3512], 'concentrations': [310, 324, 412, 1407, 1466, 3991, 4006, 4207], '42': [312], 'measured': [313, 1295, 1340, 1378, 1528, 1552, 2018, 2087, 2154, 2268, 2274, 2331, 2891, 3175, 3648, 4005], 'PFAS,': [314, 462, 901, 1529, 2505, 3865, 3886, 4029], 'OPEs,': [315, 3866, 3891, 3981, 4036], 'PBDEs,': [317, 902, 3985], 'transformed': [318], 'as': [319, 390, 392, 600, 804, 808, 1052, 1054, 1269, 1439, 1546, 1647, 1660, 1662, 2119, 3106, 3210, 3302, 3321, 3486, 3567], 'either': [320, 3998], 'raw': [321], 'or': [322, 409, 569, 603, 829, 933, 940, 1196, 1277, 1342, 1365, 1875, 2151, 2161, 2839, 3515, 4002, 4122], 'potency-weighted': [323, 408, 1494, 1542], 'based': [325, 2682, 4106, 4162, 4216], 'on': [326, 365, 378, 627, 1464, 1846, 1873, 2683, 3068, 3251, 3359, 4107, 4130, 4163, 4217], 'Tox21': [327, 450, 1441, 4128, 4202], 'high-throughput': [328, 1434, 1498], 'screening': [329, 1435, 1499, 4135], 'data.Results:All': [330], 'were': [333, 387, 413, 459, 697, 761, 1347, 1380, 1513, 1607, 1634, 1807, 1819, 1859, 2146, 2202, 2341, 2351, 2367, 2535, 2573, 2594, 2616, 2699, 2735, 2755, 2799, 2821, 2847, 2864, 2877, 2951, 3006, 3079, 3101, 3144, 3189, 3193, 3249, 3257, 3300, 3319, 3363, 3398, 3474, 3503, 3620, 3650, 3706, 3776, 3788, 3817, 3845, 3871, 3877, 3898, 3911, 3936, 3954, 3963, 3996, 4022], 'hormonally': [334], 'active,': [335, 446], 'showing': [336, 3388], 'antagonistic': [337, 1997, 2901], 'activity': [338, 364, 1413, 2223, 2886, 4081, 4206], 'toward': [339, 1300], 'peroxisome': [340, 968, 2511], 'proliferator-activated': [341, 969, 2437, 2512], 'receptor': [342, 351, 358, 367, 948, 970, 981, 1002, 1412, 2030, 2438, 2446, 2456, 2464, 2680, 2695, 3136], '(PPARγ2)': [343], '(100%;': [344], 'samples),': [348, 355], 'thyroid': [349, 628, 819, 1000, 1025, 1138], 'hormone': [350, 910, 1001, 1026, 1139, 1199, 1302, 1956, 2455, 2471, 2679, 2694, 3135], '(TRβ)': [352, 1004], '(89%;': [353], '41': [354], 'androgen': [357, 980, 2493], '(AR)': [359, 982], '(87%;': [360], '40': [361], 'samples);': [362, 371], 'agonist': [363, 2004, 2928, 2959], 'estrogen': [366, 947, 2496], '(ERα)': [368, 950], '(96%;': [369], '44': [370], 'binding': [373, 1903, 2956, 2973, 3287, 3419, 3606], 'competition': [374, 2983], 'thyroxine': [376, 1140], '(T4)': [377, 1141], 'serum': [379, 1027, 2719], 'transporter': [380, 1130], 'transthyretin': [381, 1131], '(TTR)': [382, 1132], '(98%;': [383], '45': [384], 'samples).': [385], 'Effects': [386], 'little': [391], '4μg': [393], 'dust.': [396, 4053], 'In': [397, 558, 796, 2032], 'regression': [398], 'models': [399], 'for': [400, 443, 832, 1117, 1135, 1264, 1443, 1721, 1726, 1729, 1736, 1755, 1881, 1911, 2104, 2120, 2171, 2224, 2233, 2278, 2334, 2346, 2392, 2529, 2562, 2787, 2806, 2892, 2942, 3081, 3103, 3111, 3147, 3261, 3265, 3271, 3277, 3285, 3294, 3298, 3395, 3400, 3404, 3408, 3412, 3417, 3434, 3443, 3447, 3451, 3456, 3509, 3581, 3586, 3622, 3862, 3885, 3890, 3894, 3980, 3984, 3989, 4028, 4035, 4043, 4076, 4103, 4229, 4232], 'each': [401, 1216, 1423, 1709, 1712, 1740, 2105, 2172, 2225, 2563, 2591, 3252, 3793, 4104], 'chemical': [402, 411, 480, 1154, 1171, 1217, 1284, 1465, 1543, 1626, 4064, 4105, 4222], 'class,': [403], 'interquartile': [404], 'range': [405, 2374], 'increases': [406], 'unknown-potency': [410], 'associated': [414, 460, 621], 'higher': [416, 2387], 'extracts': [421, 2201, 2572, 3816, 3844, 3897], '(potency-weighted:': [422], 'ΣPFAS–TRβ,': [423], '↑28%,': [424], 'p<0.05;': [425, 431, 438], 'ΣOPEs–TRβ,': [426], '↑27%,': [427], 'p=0.08;': [428, 434], 'ΣPBDEs–TRβ,': [429], '↑20%,': [430], 'ΣPBDEs–ERα,': [432], '↑7.7%,': [433], 'unknown-potency:': [435], 'ΣOPEs–TTR,': [436], '↑34%,': [437], 'ΣOPEs–AR,': [439], '↑13%,': [440], 'p=0.06),': [441], 'adjusted': [442], 'inactive,': [447], 'unknown': [449, 1258], 'designations.Discussion:All': [451], 'indoor': [452, 1521, 2398], 'exhibited': [455], 'activities,': [457], 'which': [458, 1551, 1806, 3076, 3097, 3173, 3360, 4100], 'PBDE,': [463, 1530], 'OPE': [465, 1366, 1532, 3704], 'levels.': [466], 'gene': [468, 1865, 1930, 2404, 4157], 'relatively': [472], 'inexpensive,': [473, 1227], 'health-relevant': [474], 'evaluations': [475], 'toxic': [477, 695], 'loads': [478], 'mixtures': [481, 1204], 'occupants': [484], 'exposed': [486, 2856, 3102], 'to.': [487], 'https://doi.org/10.1289/EHP8054IntroductionMaterials': [488], 'inside': [489], 'buildings': [490, 1571], 'contain': [491, 2793], 'many': [492], 'chemicals,': [494, 1727], 'including': [495, 1254, 1752], 'flame': [496], 'retardants': [497], '(FRs)': [498], 'per-': [500, 2506], '(PFAS)': [504], '(Lucattini': [505], 'et': [506, 525, 529, 533, 537, 551, 555, 577, 581, 585, 616, 631, 635, 648, 652, 658, 662, 670, 680, 684, 726, 744, 748, 752, 772, 793, 836, 840, 844, 848, 852, 856, 860, 864, 872, 877, 886, 890, 894, 952, 956, 964, 977, 984, 988, 992, 996, 1006, 1010, 1014, 1030, 1034, 1038, 1065, 1069, 1085, 1089, 1107, 1111, 1126, 1149, 1179, 1183, 1286, 1290, 1308, 1312, 1316, 1320, 1324, 1328, 1334, 1357, 1454, 1485, 1699, 1792, 1961, 3125, 3215, 3593, 3599, 3609, 3632, 4069, 4150], 'al.': [507, 526, 530, 534, 538, 552, 556, 578, 582, 586, 617, 632, 636, 649, 653, 659, 663, 671, 681, 685, 727, 745, 749, 753, 773, 794, 837, 841, 845, 849, 853, 857, 861, 865, 873, 878, 887, 891, 895, 953, 957, 965, 978, 985, 989, 993, 997, 1007, 1011, 1015, 1031, 1035, 1039, 1066, 1070, 1086, 1090, 1108, 1112, 1127, 1150, 1180, 1184, 1287, 1291, 1309, 1313, 1317, 1321, 1325, 1329, 1335, 1358, 1455, 1486, 1700, 1793, 1962, 3126, 3216, 3594, 3600, 3610, 3633, 4070, 4151], '2018).': [508, 686], 'As': [509], 'unbound': [510], 'additives,': [511], 'these': [512], 'can': [514, 786, 918, 1102, 2116, 2483], 'leach': [515], 'out': [516, 700, 764], 'products': [518, 778, 791], 'accumulate': [520], '(Allen': [524, 835, 1791], '2008b;': [527], 'Mitro': [528], '2016;': [531, 746, 838, 990, 1012], 'Rauert': [532], '2014;': [535, 994], 'Tokranov': [536], '2019)': [539], 'we': [541, 1742, 1835, 1885, 1921, 2228, 2294, 2976, 3174, 4089, 4126, 4204], 'unintentionally': [542], 'ingest': [543], 'breathe': [545], '(Johnson-Restrepo': [546, 3638], '2009;': [549], 'Poothong': [550], '2020;': [553, 1318], 'Xu': [554], '2016).': [557, 1330, 4152], 'fact,': [559], 'FRs': [560, 731, 1379, 1627], 'PFAS': [562, 619, 696, 717, 937, 1406, 1882, 3624, 3649, 3953, 3962], 'have': [563, 732, 942, 1294, 1717, 2000, 3353], 'been': [564, 733, 943, 1503, 1655], 'detected': [565, 3521, 3533], 'urine': [568], 'blood': [570], 'over': [572, 592], '90%': [573], 'Americans': [575], '(Calafat': [576], '2007;': [579, 1326], 'Ospina': [580], '2018;': [583, 660, 875, 888, 1016, 1288], 'Sjödin': [584], '2008).PFAS': [587], 'a': [589, 1153, 1219, 1271, 1415, 1418, 1547, 1573, 1641, 1705, 1762, 1770, 1776, 1781, 1787, 1973, 2020, 2041, 2090, 2096, 2101, 2121, 2206, 2240, 2539, 2624, 2779, 2882, 2896, 2966, 2978, 3016, 3038, 3184, 3224, 3354, 3372, 3532, 3779, 3852, 3939, 3944, 4111, 4221, 4224], 'class': [590], '4,700': [593], 'extremely': [594], 'persistent': [595], '(OECD': [597], '2018)': [598, 866], 'applied': [599], 'stain-,': [601], 'grease-,': [602], 'water-resistant': [604], 'coatings': [605], 'carpet,': [607, 738], 'furniture,': [608, 737, 1754], 'clothing,': [609], 'cookware,': [610], 'disposable': [612], 'food': [613], 'packaging': [614], '(Sunderland': [615], '2019).': [618], 'adverse': [623, 814], 'human': [624, 723, 1879, 1933, 4173, 4186, 4192], 'health': [625, 724, 815], 'effects': [626, 816, 1105, 1244, 1390, 1558], 'function': [629, 1124, 1419], '(Rappazzo': [630, 669], '2017;': [633, 750, 892], 'Xiao': [634, 661], '2020),': [637, 664], 'metabolism': [638], '(including': [639], 'overweight/obesity,': [640], 'diabetes,': [641], 'insulin': [642, 1099], 'resistance,': [643], 'high': [645, 2743], 'cholesterol)': [646], '(Lin': [647], '2019;': [650, 846, 975, 1322, 1452], 'Sunderland': [651], '2019),': [654, 3634], 'fetal': [655, 927, 2717], 'development': [656, 831, 1044, 1080], '(Liew': [657], 'immune': [667], 'system': [668, 3206], '2017),': [672], 'possibly': [674], 'kidney': [675, 4175], 'testicular': [677], 'cancer': [678, 4194], '(Barry': [679], '2013;': [682, 850, 854, 954, 962, 1008, 1181], 'Stanifer': [683], 'Even': [687], 'though': [688, 1375], 'two': [689], 'most': [692], 'widely': [693], 'known': [694, 1874], 'voluntarily': [698], 'phased': [699, 763], 'production': [702], 'by': [703, 765, 1201, 1869, 1951, 2204, 2481, 2544, 3063, 3123, 3642, 3810, 3965], 'manufacturers': [704], 'United': [707, 769, 1577], 'States': [708, 770, 1578], 'starting': [709], 'early': [712], '2000s,': [713], 'numerous': [715], 'replacement': [716], 'also': [719, 1240, 1427], 'concern': [721], '(Wang': [725], '2013,': [728], '2015,': [729], '2017).Chemical': [730], 'added': [734, 1992, 2003, 3091], 'foam': [736], 'electronics,': [739], 'insulation': [742], '(Cooper': [743], 'Jinhui': [747], 'Kemmlein': [751], '2003).': [754], 'One': [755], 'type,': [756], '(PBDEs),': [760], 'largely': [762], '2013': [766], '(Dodson': [771], '2012).': [774], 'However,': [775], 'old': [776], 'PBDE-containing': [777], 'still': [780, 2062, 2995], 'use': [782], 'after': [783, 2999, 3075, 3096], 'decades': [784], 'be': [787, 1622, 2056, 2117, 2370, 2484, 3208], 'recycled': [788], 'new': [790, 3825], '(Abbasi': [792], '2015).': [795, 1071, 1091, 1113, 1128], 'addition,': [797], '(OPEs)': [800], 'often': [802], 'used': [803, 2229, 2277, 2295, 2342, 2977, 4090, 4205], 'PBDE': [805, 1364, 3690], 'replacements': [806], 'plasticizers.': [809], 'Research': [810], 'has': [811, 1457, 1501, 2407], 'found': [812, 1360, 2485], 'include': [818], 'dysfunction,': [820], 'poor': [821], 'pregnancy': [822], 'outcomes,': [823], 'infertility,': [824], 'impairment': [826], 'cognitive': [828], 'reproductive': [830, 921, 1059], 'both': [833], 'PBDEs': [834, 939, 1341, 3637, 3935], 'Boas': [839], '2012;': [842], 'Choi': [843], 'Czerska': [847], 'Johnson': [851], 'Linares': [855], '2015;': [858, 862, 1067, 1087, 1109, 1310, 1314], 'Mumford': [859], 'Vuong': [863], 'and,': [867], 'more': [868, 1163, 4238], 'recently,': [869], 'OPEs': [870, 904, 941, 1343, 3630], '(Carignan': [871], '2017,': [874], 'Doherty': [876], '2019a,': [879], '2019b;': [880], 'Meeker': [881], 'Stapleton': [883], '2010;': [884], 'Messerlian': [885], 'Preston': [889], 'Wang': [893], '2020).There': [896], 'is': [897, 1115, 1133, 1162, 1274, 1417, 3115, 4227], 'considerable': [898], 'evidence': [899], 'chemicals.': [907, 1207, 1395, 4117], 'Because': [908], 'nuclear': [909, 1301, 1955, 2693, 3134], 'receptors': [911, 1200, 1303, 1957], 'regulate': [912], 'critical': [913], 'genes,': [914], 'their': [915, 1468], 'signaling': [916], 'disruption': [917], 'lead': [919], '(e.g.,': [922, 925, 931], 'infertility),': [923], 'developmental': [924], 'abnormal': [926], 'growth),': [928], 'metabolic': [930], 'obesity': [932], 'diabetes)': [934], 'diseases.': [935], 'Certain': [936], 'shown': [944], 'activate': [946], 'α': [949, 2447], '(Du': [951, 1005], 'Hamers': [955, 1315], '2006;': [958, 986, 1032], 'Ren': [959, 1017], 'Guo': [961, 1019], 'Suzuki': [963, 995, 1323, 1333], '2013);': [966], 'suppress': [967], 'γ': [971], '(PPARγ)': [972], '(U.S.': [973, 1450], 'EPA': [974, 1451], 'Wen': [976], '2016),': [979, 1456], '(Hamers': [983, 1029], 'Klopčič': [987, 1009], 'Orton': [991], '2013),': [998], 'β': [1003, 2457], 'Kollitz': [1013, 1356], '2013)': [1020], 'interfere': [1023], 'transport': [1028, 2049, 2472, 2515], 'Rosenmai': [1033], '2021;': [1036], 'Weiss': [1037], '2009).': [1040], 'ERα': [1041, 1351, 3262, 3401, 3448, 3590], 'regulates': [1042, 1093], 'maintenance': [1046], 'breast': [1048, 4187], 'uterine': [1050], 'tissue,': [1051], 'well': [1053, 3517], 'cardiovascular': [1056], 'system,': [1057], 'female': [1058, 1934], 'cycle,': [1060], 'bone': [1062], 'density': [1063, 3226], '(Delfosse': [1064, 1084, 1106], 'Grimaldi': [1068, 1088, 1110], 'AR': [1072, 1354, 2946, 3266, 3405, 3444, 3587], 'plays': [1073], 'an': [1074, 1188, 2272, 2927, 3479], 'important': [1075, 1134, 1175], 'role': [1076], 'male': [1078], 'sexual': [1079], 'differentiation': [1081], 'spermatogenesis': [1083], 'PPARγ': [1092, 1912, 3272, 3413, 3452, 3596], 'fat': [1094], 'storage,': [1095], 'lipid': [1096], 'metabolism,': [1097, 1121], 'sensitivity': [1100], 'produce': [1103], 'anti-inflammatory': [1104], 'TRβ': [1114, 1369, 2074, 2079, 2788, 2987, 3098, 3278, 3409, 3457, 3536, 3602], 'crucial': [1116], 'normal': [1118], 'development,': [1119], 'growth,': [1120], 'brain': [1123], '(Grimaldi': [1125], 'Serum': [1129], 'delivering': [1136], 'across': [1142, 1569, 1597], 'blood–brain': [1144], 'barrier': [1145], 'placenta': [1147], '(Grimm': [1148, 1178], '2013).': [1151], 'When': [1152, 1964], 'competitively': [1155], 'binds': [1156], 'TTR': [1158, 2065, 2998, 3035], 'instead,': [1159], 'free': [1160, 1623, 3061], 'T4': [1161, 1902, 2045, 2054, 2061, 2994, 3042, 3057, 3062], 'readily': [1164], 'eliminated': [1165], 'body,': [1168], 'could': [1172, 3207, 3352], 'move': [1173], 'target': [1176], 'tissues': [1177], 'Ishihara': [1182], '2003).Cell-based': [1185], 'emerging': [1189], 'method': [1190, 1548, 3296], 'total': [1194, 1479], 'activation': [1195, 1352, 1952, 2072], 'suppression': [1197], 'complex': [1202], 'environmental': [1203], 'Compared': [1208], 'traditional': [1210, 4239], 'targeted': [1211, 2368], 'laboratory': [1212, 4058], 'approaches': [1213], 'measure': [1215], 'mixture': [1220, 1266, 1389, 1416, 3017, 3067, 3798], 'individually,': [1221], 'rapid,': [1228], 'statistically': [1230], 'simple': [1231], 'model.': [1233], 'Hormonal': [1234], 'reflect': [1241], 'combined': [1243, 3846], 'co-exposures': [1246], 'all': [1248, 1625, 1730, 1744, 3464, 3505, 3510, 3997, 4230], 'sample,': [1253, 1741], 'unmeasurable': [1255], 'regrettable': [1259], 'substitutes.': [1260], 'The': [1261, 1430, 1584, 1630, 1817, 2013, 2058, 2143, 2248, 2317, 2599, 2661, 3044, 3086, 3109, 3218, 3254, 3392, 3431, 3499, 3703, 3814, 3828, 3869, 3896], 'account': [1263, 3424, 4075], 'any': [1265, 1965, 3164], 'effects,': [1267], 'such': [1268, 1438], 'when': [1270, 1383], "chemical's": [1272, 1424], 'effect': [1273], 'triggered,': [1275], 'enhanced,': [1276], 'reduced': [1278, 3167], 'presence': [1281, 1990, 3033], 'another': [1283], '(Kollitz': [1285], 'Vandermarken': [1289, 1327], '2016).Few': [1292], 'studies': [1293, 1404, 1460, 3580], 'using': [1304, 1497, 2185, 2549, 2638, 2646, 2653, 2879, 2895, 3801, 3928, 3938, 3956], '(Chou': [1307], 'Fang': [1311], 'Kassotis': [1319], 'For': [1331, 1739, 1832, 2221, 2292, 3315, 3366, 4118], 'example,': [1332], '(2013)': [1336], 'reported': [1337], 'certain': [1339, 2207, 3428], 'household': [1345, 1372], 'probable': [1348], 'contributors': [1349], 'suppression.': [1355], '(2018)': [1359], 'significant': [1361], 'correlations': [1362], 'levels': [1367, 2340, 2366], 'antagonism': [1370, 1890, 2162, 2789, 3211, 3267, 3273, 3279, 3299, 3588, 3597, 4121], 'even': [1374], '12': [1377], 'not': [1381, 1421, 1502, 1923, 2792, 3387], 'active': [1382], 'tested': [1384, 1908, 2848], 'isolation,': [1386], 'demonstrating': [1387], 'possible': [1388], 'influence': [1392], 'unmeasured': [1394], 'To': [1396, 1488], 'our': [1397, 1489, 1695], 'knowledge,': [1398, 1490], 'there': [1399], 'currently': [1401], 'no': [1402, 1916, 3369], 'published': [1403, 1789, 3644, 4092], 'relating': [1405], 'bioactivities': [1409, 1480], 'dust.Hormone': [1411], 'only': [1422, 1801], 'concentration,': [1425, 2281], 'but': [1426, 1915], 'its': [1428, 2071, 2961, 3312, 3491, 4108], 'potency.': [1429], 'increase': [1431], 'available': [1433], 'assay': [1436, 2092, 2760, 2829, 2984, 2988, 3094, 3114, 3220, 3436, 3584, 4113, 4158], 'data,': [1437], 'database': [1442], 'individual': [1444, 4083], 'potencies': [1445, 1470], 'almost': [1447, 3504], '10,000': [1448, 3228], 'Huang': [1453], 'recently': [1458, 1661], 'enabled': [1459], 'integrate': [1462], 'information': [1463, 4093], 'respective': [1469, 2962], 'order': [1472, 1715], 'key': [1475], 'contaminants': [1476], 'water': [1482, 1811], '(Blackwell': [1484], '2017).': [1487], 'this': [1491, 1511, 3157], 'type': [1492], 'exposure': [1495, 2666, 2826, 2870, 2914], 'evaluation': [1496], 'data': [1500, 2231, 4129], 'done': [1504], 'dust.The': [1508], 'objectives': [1509], 'study': [1512, 1959], 'a)': [1515], 'samples;': [1523], 'b)': [1524], 'dust;': [1538], 'c)': [1540], 'evaluate': [1541], 'concentration': [1544, 2043, 2208, 2237, 2258, 2264, 2284, 2299, 2328, 2664, 2781, 2924, 3040, 3046, 3304], 'calculations': [1545, 2345], 'determine': [1550, 2990], 'mixtures.MethodsStudy': [1561], 'DesignWe': [1562], 'collected': [1563, 1608, 1635, 1704], 'rooms': [1568, 1585, 1610, 1638, 1688], '21': [1570], 'at': [1572, 1828, 2265, 2329, 2737, 2778, 3029, 3084, 4208, 4223], 'university': [1574], 'during': [1579, 2665], 'January': [1580], 'March': [1582], '2019.': [1583], 'included': [1586, 3250, 3692], '22': [1587, 1650], 'common': [1588], 'spaces,': [1589], '6': [1590], 'office': [1591], 'suites,': [1592], '18': [1594], 'classrooms': [1595], 'distributed': [1596], 'different': [1598, 1723, 2338, 2347, 3350, 3356, 3882, 4077], 'renovation': [1599, 1677], 'statuses.': [1600], 'Approximately': [1601], 'half': [1602, 2921, 3540], '(n=22)': [1606], 'renovated': [1611, 1656], '2017': [1613], '2019,': [1615], 'furniture': [1617, 1659], 'carpet': [1619], 'specified': [1620], 'PFAS.': [1629], 'remaining': [1631], '(n=24)': [1633], 'carpeted': [1637], 'constituted': [1640], 'similar': [1642], 'distribution': [1643], 'room': [1645, 1713], 'types': [1646], 'other': [1649, 1737, 3155, 3548, 4116], 'had': [1654, 3345, 3531, 3550], 'conventional': [1658], 'possible.': [1663], 'Building': [1664], 'construction': [1665], 'years': [1666, 1674], 'ranged': [1667, 1678, 3976], '1863': [1669], '2018': [1671], '(median=1966)': [1672], 'last': [1676], '2001': [1680], '2019': [1682], '(median=2017).': [1683], 'Further': [1684], 'details': [1685, 3575], 'about': [1686, 3539], 'sample': [1690, 1707, 2106, 2236, 2263, 2280, 2298, 2327, 2482, 3002, 3429, 3466, 3565], 'collection': [1691], 'provided': [1693], 'previous': [1696, 3579], 'manuscript': [1697, 3122], '(Young': [1698, 4068], '2021).Dust': [1701], 'Sample': [1702, 3179], 'CollectionWe': [1703], 'within': [1708, 1747, 2371], 'third': [1710], 'sufficient': [1718], 'mass': [1720, 2123, 2129, 3925, 3945], 'three': [1722, 3547, 3860], 'laboratories': [1724], '(one': [1725], 'one': [1728, 1735, 3528, 4155], 'assays,': [1733, 2163, 2532, 2681, 2696, 2947, 3137, 3156], 'research).': [1738], 'vacuumed': [1743, 1759], 'floor': [1745], 'surfaces': [1746], 'one-third': [1749], 'sampling': [1750, 1848], 'area,': [1751], 'underneath': [1753], '10': [1756, 1909, 3330, 3820], 'min.': [1757], 'We': [1758, 1906, 3557, 4153], 'cellulose': [1763], 'extraction': [1764, 2547, 3829], 'thimble': [1765], '(Whatman': [1766], 'International)': [1767], 'secured': [1768], 'nitrile': [1771], 'rubber': [1772], 'O-ring': [1773], '(McMaster-Carr)': [1774], 'crevice': [1777, 1804], 'tool': [1778], 'attached': [1779], 'vacuum': [1782], 'cleaner': [1783], '(Dyson': [1784], 'CY18),': [1785], 'following': [1786, 1888, 3643], 'previously': [1788, 4091], 'protocol': [1790], '2008a).': [1794], 'Thus,': [1795], 'came': [1798], 'contact': [1800], 'tools,': [1805], 'cleaned': [1808], 'hot': [1810], 'isopropyl': [1813], 'alcohol': [1814], 'samples.': [1816, 4009], 'thimbles': [1818, 1842], 'stored': [1820], 'polypropylene': [1822, 3826], 'centrifuge': [1823, 1839], 'tubes': [1824, 1840], 'polyethylene': [1826], 'bags': [1827], '−13°C': [1829], 'until': [1830], 'analysis.': [1831], 'field': [1833, 1844, 1857, 3501, 3529, 3560, 3618, 3994], 'blanks,': [1834, 3348], 'carried': [1836], 'four': [1837, 3500, 4120], 'unopened': [1838], 'sites': [1845], 'various': [1847], 'days.Cell-Based': [1849], 'Gene': [1852], 'AssaysThe': [1853], 'blanks': [1858, 3473, 3502, 3549, 3619, 3995], 'analyzed': [1860, 3364, 3475, 3621, 3912, 3937, 3955], 'chemically': [1862], 'activated': [1863, 1972], 'expression': [1866, 1948, 1979], '(CALUX)': [1867], 'Systems.': [1871], 'Based': [1872], 'suspected': [1876], 'mechanisms': [1877], 'toxicity': [1880, 4134], 'FRs,': [1884], 'chose': [1886, 4154], 'assays:': [1889], 'TRβ,': [1892, 2943], 'AR,': [1893, 2492], 'PPARγ2;': [1895], 'agonism': [1896, 1913, 1917, 2080, 2160, 3591, 4123], 'ERα;': [1898], 'interference': [1900, 2035, 2974, 3607], 'transthyretin.': [1905], 'initially': [1907], 'too,': [1914], 'was': [1918, 1949, 2017, 2023, 2066, 2075, 2093, 2175, 2250, 2276, 2285, 2319, 2560, 2602, 2675, 2816, 2872, 2890, 2907, 2916, 3052, 3058, 3090, 3221, 3379, 3538, 3831], 'detected,': [1919, 2418, 2427], 'so': [1920, 3349], 'did': [1922, 2791], 'proceed': [1924], 'further': [1925, 2382], '(Figure': [1926], 'S2bi,bj).These': [1927], 'employed': [1932], 'osteosarcoma': [1935], 'cell': [1936, 2531, 3158, 3165, 3201, 3225, 3437, 4167], 'lines': [1937, 3438], '(U2OS)': [1938], 'stably': [1939], 'transfected': [1940], 'firefly': [1943], 'gene,': [1946], 'whose': [1947], 'controlled': [1950], 'specific': [1954, 1974], 'under': [1958, 2568, 2809, 2858, 3851, 3948, 3970], '(Sonneveld': [1960, 3592], '2005).': [1963], 'agonistic': [1966, 2222, 2750], 'extract': [1971, 2211, 2593, 2838, 3180], 'receptor,': [1975, 2008, 2963], 'it': [1976], 'would': [1977, 1999, 2055], 'trigger': [1978], 'luciferase,': [1981, 3162], 'enzyme': [1984], 'produced': [1985, 2239, 2301], 'light': [1986, 2011, 2016, 2969, 3171, 3188], '(luminescence)': [1987], 'luciferin': [1993], 'substrate.': [1994], 'By': [1995, 4236], 'contrast,': [1996, 4237], 'inhibited': [2001], 'activating': [2006], 'thereby': [2009], 'reducing': [2010], 'induction.': [2012], 'intensity': [2014], 'luminometer': [2021, 2897], 'directly': [2024], 'proportional': [2025], 'degree': [2028], 'activation.': [2031], 'TTR-T4': [2034, 2972, 2982, 3113, 3286, 3418, 3605], 'assay,': [2036], 'competed': [2039], 'fixed': [2042, 3039], 'bind': [2047], 'protein': [2050], 'TTR,': [2051], 'some': [2053], 'replaced.': [2057], 'amount': [2059, 2992, 3169], 'bound': [2063, 2996], 'then': [2067, 2251, 2320, 2595, 3842], 'separated': [2068, 3059], 'out,': [2069], 'quantified': [2076], 'assay.As': [2081], 'demonstrated': [2082], 'Figure': [2084, 2490, 3118], 'S1,': [2085], 'luminescence': [2088], 'particular': [2091], 'benchmarked': [2094, 2191], 'against': [2095, 3535], 'reference': [2097, 2134, 2144, 2173, 2219, 2256, 2283, 2315, 2325, 2359, 2377, 2840, 3247, 3255, 3306, 3468, 3493], 'compound': [2098, 2135, 2174, 2257, 2841, 3307, 3469, 3494], 'calculate': [2100, 4095], 'final': [2102, 2592, 2662, 2780, 3045], 'result': [2103, 2249, 2318], 'units': [2108], 'microgram': [2110, 2194], 'equivalents': [2111, 2195], 'per': [2112, 2196, 4159], 'gram.': [2113], 'This': [2114, 4045], 'unit': [2115], 'interpreted': [2118], 'given': [2122, 4112, 4234], '(in': [2124, 2130, 2193], 'grams)': [2125], 'dust,': [2127], 'micrograms)': [2131], 'produces': [2137], 'same': [2139, 2267], 'level': [2140, 2333, 2626], 'activity.': [2142], 'compounds': [2145, 2950, 3248, 3256], 'potent': [2147], 'selective': [2149], 'agonists': [2150], 'antagonists': [2152], 'alongside': [2155], 'respectively': [2164], '(Table': [2165, 3555], '1).': [2166], 'A': [2167, 3752], 'full': [2168, 3240], 'dose–response': [2169, 2290, 3241], 'curve': [2170, 2216, 2360], 'fitted': [2176], 'eight': [2181, 2408], 'separate': [2182, 3346], 'serial': [2183, 2582, 2673, 3139], 'dilutions': [2184, 2583, 2615, 2674, 2846, 3003, 3140, 3181, 3370], 'Hill': [2187], 'equation.': [2188], 'Then,': [2189, 3784], 'gram)': [2197], 'calculated': [2203, 2214, 2289, 3320], 'interpolating': [2205], 'onto': [2212, 2357], 'calibration': [2215], 'compound.': [2220, 2316], 'extract,': [2227], 'point': [2232, 2275, 4161], 'lowest': [2235, 2297], 'response': [2241, 2269, 2304, 2309, 2332, 2339, 2365, 3373, 3522, 3534], 'above': [2242, 2906, 3374], 'limit': [2244], 'quantification': [2246], '(LOQ).': [2247], 'ratio': [2253, 2322], 'medium': [2260, 2761, 2763, 2786, 2815, 2827, 2830, 2871, 2915], 'level.': [2270], 'Whereas': [2271], 'actual': [2273], 'interpolated': [2286], 'curve.': [2291, 2378], 'antagonism,': [2293, 3406, 3410, 3414, 3445, 3453, 3603], 'highest': [2303], '<80%': [2305], 'maximal': [2308, 2922, 3313], '(i.e.,': [2310], '>20%': [2311], 'inhibition)': [2312], 'sample.': [2336, 2564], 'Although': [2337], 'samples,': [2348, 3525], 'results': [2350, 4061], 'comparable': [2352], 'because': [2353, 2362, 3197, 4211], 'interpolation': [2356], 'chosen': [2364], 'linear': [2373], 'Dose–response': [2379], 'curves': [2380], 'shifted': [2381], 'left': [2385], 'indicated': [2386], 'potency.Table': [2388], '1': [2389, 2406, 3082], 'Summary': [2390], 'statistics': [2391], 'assays.Table': [2405], 'columns,': [2409], 'namely,': [2410], 'Assay': [2411, 2785], 'end': [2412, 2430, 4124, 4160], 'point,': [2413], 'Abbreviation,': [2414], 'Reference': [2415], 'compound,': [2416], 'Percentage': [2417], 'Geometric': [2419], 'mean': [2420], '(geometric': [2421], 'standard': [2422, 2503, 3333, 3797], 'deviation),': [2423], 'Median,': [2424], 'Range': [2425], 'among': [2426, 2435], 'Units.Assay': [2429], 'pointAbbreviationReference': [2431], 'compoundPercentage': [2432], 'detectedGM': [2433], '(GSD)MedianRange': [2434], 'detectedUnitsPeroxisome': [2436], 'γ2': [2439], 'antagonismPPARγGW9662': [2440], '(chemical)100%': [2441], '(46': [2442], '46)0.554': [2444], '(1.92)0.5800.150–2.90μg-eq/gEstrogen': [2445], 'agonismER17β-estradiol': [2448], '(natural': [2449], 'hormone)96%': [2450], '(44': [2451], '46)2.21': [2453], '(2.38)1.760.287–22.0ng-eq/gThyroid': [2454], 'antagonismTRDeoxynivalenol': [2458], '(mycotoxin)89%': [2459], '(41': [2460], '46)68.7': [2462], '(2.30)80.812.8–370μg-eq/gAndrogen': [2463], 'antagonismARFlutamide': [2465], '(medication)87%': [2466], '(40': [2467], '46)105': [2469], '(2.26)10427.5–434μg-eq/gThyroid': [2470], 'interferenceTTR-T4Perfluorooctanoate': [2473], '(PFAS': [2474], 'chemical)98%': [2475], '(45': [2476], '46)104': [2478], '(2.90)14115.2–626μg-eq/gNote:': [2479], 'Activities': [2480], 'Table': [2487], 'S2': [2488], 'S2.': [2491], 'receptor;': [2494, 2497, 2513], 'ER,': [2495], 'GM,': [2498], 'geometric': [2499, 2502], 'mean;': [2500], 'GSD,': [2501], 'deviation;': [2504], 'substances;': [2509], 'PPARγ2,': [2510], 'TR,': [2514], 'protein;': [2516], 'TTR-T4,': [2517], 'transthyretin–thyroxine.Exposure': [2518], 'ExtractsTo': [2524], 'prepare': [2525], 'first': [2536, 3145, 3385], 'sieved': [2537, 3777], '1-mm': [2540], 'mesh': [2541], 'accelerated': [2545], 'solvent': [2546, 3327, 3341, 3347, 3472, 3497], '(ASE)': [2548], 'hexane': [2550, 3893], 'acetone': [2552], '(1:1,': [2553], 'vol/vol).': [2554], 'An': [2555], 'average': [2556, 3323, 3393, 3559], '0.43g': [2557], 'After': [2565], 'gentle': [2566, 3853], 'evaporation': [2567], 'nitrogen,': [2569], 'hexane/acetone': [2571], 'dissolved': [2574], '100μL': [2576], 'dimethyl': [2578], 'sulfoxide': [2579], '(DMSO).': [2580], 'Five-point': [2581], '(1×,': [2584], '3×,': [2585], '10×,': [2586], '30×,': [2587, 2645], '100×)': [2589], 'prepared': [2596, 2672, 3138], 'DMSO.': [2598, 2844], '3×': [2600, 2640], 'dilution': [2601, 2608, 2628, 2632, 2641, 2687, 2834, 3242, 3386], 'made': [2603, 2617], '8μL': [2605], '1×': [2607, 2631], 'plus': [2609, 2621, 3329], '16μL': [2610], 'DMSO,': [2611], 'subsequent': [2614], '36μL': [2619], 'DMSO': [2620, 2663, 3005, 3048, 3326], '4μL': [2622], 'prior': [2625, 3907], '(using': [2629], 'make': [2634, 2643, 2650, 2657], '10×': [2636, 2648], 'dilution,': [2637], '100×,': [2652], '30×': [2655], '300×,': [2659], 'etc.).': [2660], 'cells': [2669, 2698, 2754, 2798, 2820, 2857, 2876, 3100], '0.1%': [2676, 2843], '1μL': [2684], '1mL': [2689], 'medium.For': [2691], 'CALUX': [2697, 2753, 3099, 3133, 3237, 3583], 'cultured': [2700, 2752], "Dulbecco's": [2702], 'Modified': [2703], 'Eagle': [2704], 'Medium/Nutrient': [2705], 'Mixture': [2706], 'F12': [2707], '(DMEM/F12)': [2708], 'without': [2709, 3421], 'phenol-red': [2710], '(#31331-028;': [2711], 'Gibco)': [2712, 2725], 'supplemented': [2713, 2764, 2831, 2917], '7.5%': [2715], 'charcoal-stripped': [2716, 2767, 2795], 'calf': [2718], '(FCS),': [2720], 'nonessential': [2721, 2769], 'amino': [2722, 2770], 'acids': [2723], '(#11140-03;': [2724], '10U/mL': [2727, 2773], 'penicillin': [2728, 2774], '10μg/mL': [2730, 2776], 'streptomycin': [2731], '(culture': [2732], 'medium).': [2733], 'Cells': [2734], 'maintained': [2736], 'standardized': [2738, 2810, 2859], 'conditions': [2739], '(37°C,': [2740], '5%': [2741, 2766], 'CO2,': [2742], 'humidity)': [2744], 'subcultured': [2746], 'every': [2747], '3–4': [2748], 'd.For': [2749], 'analysis,': [2751, 2902, 2975], 'trypsinized': [2756], 'resuspended': [2758], '(DMEM/F12': [2762], 'FCS,': [2768], 'acids,': [2771], 'streptomycin)': [2777], '1×105': [2783], 'cells/mL.': [2784], 'analyses': [2790, 4059, 4065], 'dextran-coated': [2794], 'FCS.': [2796], 'Resuspended': [2797], 'seeded': [2800], '96-well': [2802], 'plates': [2803, 2863], 'incubated': [2805, 2822, 3007], '16–24': [2807], 'h': [2808], 'conditions.': [2811], 'Following': [2812, 2851, 3054], 'incubation,': [2813, 3055], 'removed,': [2817, 2873], '200μL': [2824, 3013, 3880], 'containing': [2828], 'series': [2835, 3243, 3495], 'All': [2845], 'triplicate.': [2850], '24±2h': [2852], 'incubation': [2854, 2862, 3066], 'conditions,': [2860], 'removed': [2865], 'incubator,': [2868], 'lysed': [2878], '30μL/well': [2880], 'Triton-lysis': [2883], 'buffer.': [2884], 'cellular': [2888], 'lysates': [2889], 's': [2894], '(TriStar': [2898], 'LB941;': [2899], 'Berthold).For': [2900], 'procedure': [2904, 3110, 3830], 'described': [2905, 3107, 3568, 3577], 'followed': [2908, 3809], 'exception': [2911], 'nonsaturating,': [2920], 'effective': [2923], '(EC50)': [2925], '[triiodothyronine': [2929], '(T3)': [2930], '(#T2877;': [2931], 'Sigma-Aldrich),': [2932, 3269, 3281], 'rosiglitazone': [2933], '(#71740;': [2934], 'Cayman': [2935], 'Chemical': [2936], 'Company),': [2937], 'dihydrotestosterone': [2939], '(#S4757;': [2940], 'Selleckchem)': [2941], 'PPARγ,': [2944], 'respectively].': [2948], 'Antagonistic': [2949], 'expected': [2952], 'compete': [2954], 'resulting': [2964, 3308], 'reduction': [2967, 3186], 'emission.For': [2970], 'combination': [2979], 'exposure.': [3000], 'Serial': [3001], 'Tris': [3009, 3021], 'buffer': [3010, 3022], '(pH': [3011], '8.0;': [3012], 'transferred': [3014, 3823], '140μL': [3019], '500μL': [3024], 'serum-free': [3026], 'medium)': [3027], 'overnight': [3028], '4°C': [3030], '(0.058μM)': [3036], '(0.052μM).': [3043], 'incubations': [3051], '3.2%.': [3053], 'TTR-bound': [3056], 'placing': [3064], 'cooled': [3069], 'Bio-Gel': [3070], 'P-6DG': [3071], 'columns': [3072, 3078], '(#150-0739;': [3073], 'Bio-Rad)': [3074], 'centrifuged': [3080, 3818], 'min': [3083], '120×g.': [3085], 'eluate': [3087], '(TTR-bound': [3088], 'T4)': [3089], 'medium,': [3095], '24': [3104, 3234], 'h,': [3105], 'above.': [3108], 'presented': [3116], '2': [3119], 'Collet': [3124], '(2019).Before': [3127], 'evaluating': [3128], '(with': [3141], '1%': [3142], 'DMSO)': [3143], 'cytotoxicity': [3148, 3219, 3389, 3426], '(cell': [3149], 'line': [3150, 3159, 4168], '#83;': [3151], 'Systems).': [3153], 'Unlike': [3154], 'continuously': [3160], 'expressed': [3161], 'death': [3166], 'emitted,': [3172], 'luminometer.': [3178], 'caused': [3183], '20%': [3185], 'considered': [3190], 'cytotoxic': [3191], 'excluded': [3194], 'assessment': [3196], 'lack': [3199], 'viability': [3202], 'test': [3205], 'misinterpreted': [3209], '(van': [3212], 'der': [3213], 'Linden': [3214], '2014).': [3217], 'conducted': [3222], 'cells/mL': [3229], 'treatment': [3231], 'length': [3232], 'h.To': [3235], 'analysis': [3238, 3863, 4011], 'results,': [3239], 'assay-specific': [3246], 'plate.': [3253], '17β-estradiol': [3258], '(#E2758;': [3259], 'Sigma-Aldrich)': [3260, 3284], 'agonism,': [3263, 3316, 3402, 3449], 'flutamide': [3264], '(#F9397;': [3268], 'GW9662': [3270], '(#70785-50;': [3274], 'Cayman),': [3275], 'deoxynivalenol': [3276], '(#D0156;': [3280], 'perfluorooctanoate': [3282, 3654], '(#171468;': [3283], 'interference,': [3288, 3420], 'tributyltin': [3290], 'acetate': [3291, 3839], '(#8216500050;': [3292], 'Merck)': [3293], 'cytotoxicity.The': [3295], 'LOQs': [3297, 3318, 3394], 'defined': [3301, 3485], '80%': [3310], 'response.': [3314], 'blank': [3328, 3530, 3561], 'times': [3331], 'deviation': [3334], 'triplicate': [3337, 3477], 'measurements': [3338], 'blank.': [3342], 'Each': [3343, 3488], 'plate': [3344, 3361, 3489], 'slightly': [3355], 'LOQ': [3357, 3378, 3508], 'depending': [3358], 'they': [3362, 4212], 'on.': [3365], 'producing': [3371], 'LOQ,': [3376], 'reported,': [3380], 'corrected': [3381], 'represent': [3383], 'if': [3390], 'needed.': [3391], '0.099ng-eq/g-dust': [3399], '8.3μg-eq/g-dust': [3403], '13μg-eq/g-dust': [3407], '0.022μg-eq/g-dust': [3411], '0.94μg-eq/g-dust': [3416], 'taking': [3422], 'dilutions.': [3430], 'catalog': [3432], 'numbers': [3433], 'Systems': [3441], '#44': [3442], '#60': [3446], '#82': [3450], '#88': [3455], 'antagonism.For': [3458], 'quality': [3459, 3462], 'assurance': [3460], 'control,': [3463], 'extracts,': [3467], 'series,': [3470], 'acceptable': [3480], 'maximum': [3481], 'coefficient': [3482], 'variation': [3484], '<15%.': [3487], 'contained': [3490], 'own': [3492], 'blanks.': [3498], 'below': [3506, 3518, 3552, 3999, 4004], '(plus': [3513], 'cytotoxicity)': [3514], 'otherwise': [3516], 'minimum': [3520], 'except': [3526], 'median': [3542, 4018], '(all': [3546], 'responses': [3551, 3562], 'LOQ)': [3554], 'S1).': [3556], 'subtracted': [3558], 'responses,': [3566], '"Statistical': [3571], 'Analyses"': [3572], 'section.': [3573], 'More': [3574], 'procedures': [3585], '2005),': [3595], '(Gijsbers': [3598], '2011),': [3601], '(Collet': [3608], '2019).Chemical': [3611], 'Analyses': [3612], 'DustThe': [3614], '15': [3623], '(Kim': [3625, 3631], '2007),': [3628], '19': [3629], '8': [3636], '2009)': [3641], 'protocols.': [3645], 'Specifically,': [3646], 'perfluorooctane': [3651, 3661, 3686], 'sulfonate': [3652, 3659, 3671, 3674], '(PFOS),': [3653], '(PFOA),': [3655], 'perfluorohexanoate': [3656], '(PFHxA),': [3657], 'perfluorohexane': [3658], '(PFHxS),': [3660], 'sulfonamide': [3662], '(FOSA),': [3663], 'perfluoroheptanoate': [3664], '(PFHpA),': [3665], 'perfluoropentanoate': [3666], '(PFPeA),': [3667], 'perfluorononanoate': [3668], '(PFNA),': [3669], 'perfluorobutane': [3670], '(PFBS),': [3672], 'perfluorodecane': [3673], '(PFDS),': [3675], 'perfluorobutanoate': [3676], '(PFBA),': [3677], 'perfluorodecanoate': [3678], '(PFDA),': [3679], 'perfluoroundecanoate': [3680], '(PFUnDA),': [3681], 'perfluorododecanoate': [3682], '(PFDoDA),': [3683], 'n-methyl': [3685], 'sulfonamidoacetic': [3687], 'acid': [3688], '(N-MeFOSAA).': [3689], 'analytes': [3691, 3705], 'congeners': [3693], '28,': [3694], '47,': [3695], '99,': [3696], '100,': [3697], '153,': [3698], '154,': [3699], '183,': [3700], '209.': [3702], 'tris(2-butoxyethyl)': [3707], 'phosphate': [3708, 3711, 3714, 3717, 3720, 3724, 3728, 3731, 3734, 3738, 3742, 3745, 3761, 3764, 3767, 3771], '(TBOEP),': [3709], 'tris(1-chloro-2-propyl)': [3710], '(TCIPP),': [3712], 'tris(1,3-dichloro-2-propyl)': [3713], '(TDCIPP),': [3715], 'triphenyl': [3716], '(TPHP),': [3718], 'tris(2-chloroethyl)': [3719], '(TCEP),': [3721], '2-ethylhexyl': [3722], '(EHDPP),': [3725], 'isodecyl': [3726], '(IDDP),': [3729], 'tri-iso-butyl': [3730], '(TIBP),': [3732], 'tripropyl': [3733], '(TPP),': [3735], 'cresyl': [3736], '(CDPP),': [3739], 'tert-butylphenyl': [3740], '(BPDP),': [3743], 'tri-n-butyl': [3744], '(TNBP),': [3746], 'tetrakis(2-chloroethyl)': [3747], 'dichloroisopentyl': [3748], 'diphosphate': [3749], '(V6),': [3750], 'bisphenol': [3751], 'bis(diphenyl': [3753, 3757], 'phosphate)': [3754, 3758], '(BDP),': [3755], 'resorcinol': [3756], '(RDP),': [3759], 'tris(2-ethylhexyl)': [3760], '(TEHP),': [3762], 'tris(methylphenyl)': [3763], '(TMPP),': [3765], 'triethyl': [3766], '(TEP),': [3768], 'tris(p-tert-butylphenyl)': [3770], '(TBPHP).First,': [3772], 'through': [3778, 3900], '150-μm': [3780], 'stainless': [3781], 'steel': [3782], 'mesh.': [3783], '(0.2–0.5g)': [3787], 'spiked': [3789], '30': [3791], 'ng': [3792], 'labeled': [3795], 'surrogate': [3796], 'methanol': [3802, 3884], '(3mL)': [3803, 3836], 'mechanical': [3805], 'oscillation': [3806], '(1': [3807], 'h)': [3808], 'ultrasonication': [3811], '(30': [3812], 'min).': [3813], 'resultant': [3815], '(3,500×g,': [3819], 'min)': [3821], 'tubes.': [3827], 'repeated': [3832], 'twice': [3833], 'acetonitrile': [3835], 'ethyl': [3838], '(3mL),': [3840], 'evaporated': [3848, 3872], '3mL': [3850], 'stream': [3854], 'nitrogen': [3856], 'divided': [3858], 'aliquots': [3861, 3870], 'PBDEs.': [3868, 3895, 4044], 'near': [3874], 'dryness': [3875], 'reconstituted': [3878], 'solvents:': [3883], 'water:methanol': [3887], '(4:6;': [3888], 'vol/vol)': [3889], 'filtered': [3899], '0.2-mm': [3901], 'nylon': [3902], 'filters': [3903], 'glass': [3905], 'vials': [3906], 'instrumental': [3909], 'analysis.OPEs': [3910], 'high-performance': [3914], 'liquid': [3915], 'chromatography': [3916], '(HPLC)': [3917], 'coupled': [3918, 3942, 3958], 'electrospray': [3920, 3929], 'ionization': [3921, 3931, 3951], '(ESI)': [3922], 'triple': [3923], 'quadrupole': [3924], 'spectrometry': [3926], '(ESI-MS/MS),': [3927], 'positive': [3930], 'multiple': [3932, 3966], 'reaction': [3933, 3967], 'monitoring.': [3934], 'gas': [3940], 'chromatographer': [3941], 'spectrometer': [3946], '(GC-MS)': [3947], 'electron': [3949], 'impact': [3950], 'mode.': [3952], 'HPLC': [3957], 'ESI-MS/MS.': [3960], 'Target': [3961], 'monitored': [3964], 'monitoring': [3968], 'mode': [3969], 'negative': [3971], 'ionization.': [3972], 'Limits': [3973], 'detection': [3975], '0.1–0.8': [3978], 'ng/g': [3979, 3983, 3988], '0.09–4.5': [3982], '0.06–1.5': [3987], 'PFAS.Chemical': [3990], 'LOD': [4001], 'far': [4003], 'Duplicate': [4010], 'seven': [4013], 'showed': [4016], 'relative': [4019, 4096], 'percentage': [4020], 'differences': [4021], '0%': [4023, 4030], '(range:': [4024, 4031, 4039], '−62': [4025], '190%)': [4027], '−96': [4032], '52%)': [4034], '−3.2%': [4038], '−50': [4040], '80%)': [4042], 'variability': [4046], 'likely': [4047], 'reflects': [4048], 'natural': [4050], 'heterogeneity': [4051], 'Another': [4054], 'publication': [4055], 'describes': [4056], 'depth': [4067], '2021).Potency-Weighted': [4071], 'Concentrations': [4072], 'ChemicalsTo': [4074], 'degrees': [4078], 'present': [4085], 'mixtures,': [4088], 'potency': [4097, 4199, 4219], 'factors': [4098], '(RPFs),': [4099], 'weights': [4102], 'bioactivity': [4109], 'compared': [4114], 'points,': [4125], 'downloaded': [4127], 'vitro': [4133], 'thousands': [4137], 'U.S.': [4142], 'Protection': [4144], "Agency's": [4145], 'ToxCast': [4146], 'Chemistry': [4147], 'Dashboard': [4148], '(Huang': [4149], 'relevance,': [4164], 'availability,': [4165], 'sensitivity:': [4169], '"TOX21_PPARg_BLA_antagonist_ratio"': [4170], '(beta-lactamase': [4171], 'reporter;': [4172, 4179], 'embryonic': [4174], 'cells),': 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