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207, 219, 231, 246, 266, 291, 323, 328, 349, 359, 367, 427, 435, 438, 446, 461, 473, 485, 500, 518, 527, 536, 557, 583, 627, 669, 679, 780, 810, 913, 927, 937, 972, 976, 1000, 1004, 1089, 1156, 1164, 1207, 1248, 1253, 1266, 1273, 1283, 1289, 1301, 1341, 1376, 1449, 1472, 1503, 1526, 1543, 1567, 1579, 1606, 1661, 1674, 1687, 1700, 1745, 1771, 1839, 1864, 1884, 1964, 2038, 2068, 2095, 2164, 2186, 2193, 2210, 2331, 2360, 2388, 2395, 2490, 2493, 2510, 2545, 2560, 2596, 2659, 2687, 2696, 2704, 2709, 2748, 2755, 2784, 2793, 2800, 2824, 2832, 2841, 2892, 2903, 2942, 3001, 3028, 3054, 3081, 3159, 3223, 3228, 3245, 3253, 3259, 3283, 3380, 3436, 3492, 3573, 3683, 3700, 3708, 3716, 3778, 3882, 3984, 4012, 4024, 4078, 4083, 4094, 4135, 4178, 4191, 4246, 4253, 4260, 4301, 4310, 4321, 4329, 4336, 4338], 'gene': [13, 267, 1568, 1662, 1840, 2130, 2943], 'expression': [14, 268, 1288], 'most': [16, 270, 4070], 'known': [17, 271], 'bacteria.': [18, 272, 525], 'transient': [20, 274], 'intermediates': [21, 275, 2577], 'forms': [23, 277], 'with': [24, 51, 278, 305, 542, 907, 1118, 1495, 1588, 1690, 1791, 1818, 1876, 1967, 2479, 2566, 3385, 3441, 3497, 3578, 3657, 3783, 3845, 3963, 3992, 4022, 4064, 4107, 4163, 4256], 'RNA': [25, 194, 279, 448, 521, 546, 684, 731, 908, 929, 980, 1093, 1208, 1305, 1337, 1423, 1473, 1507, 1590, 1798, 1914, 1994, 2166, 2253, 2603, 2817, 2869, 3034, 3056, 3085, 3111, 3382, 3388, 3405, 3438, 3444, 3461, 3494, 3500, 3517, 3575, 3581, 3598, 3622, 3780, 3786, 3803, 3838, 3876, 4025, 4180], 'support': [26, 280], 'intricate': [27, 281], 'and': [28, 49, 78, 99, 132, 147, 199, 227, 282, 303, 332, 353, 386, 401, 453, 481, 514, 520, 554, 645, 730, 786, 837, 864, 885, 909, 935, 969, 985, 1021, 1023, 1028, 1246, 1268, 1362, 1367, 1422, 1491, 1539, 1768, 1789, 1869, 2028, 2034, 2223, 2305, 2321, 2327, 2368, 2404, 2451, 2495, 2550, 2569, 2608, 2691, 2732, 2765, 2826, 2835, 2889, 3036, 3049, 3216, 3256, 3308, 3318, 3328, 3338, 3359, 3362, 3397, 3415, 3453, 3471, 3509, 3527, 3590, 3608, 3648, 3651, 3666, 3669, 3711, 3736, 3746, 3762, 3765, 3795, 3813, 3854, 3857, 3910, 3912, 3920, 3930, 3940, 3956, 3969, 3981, 4091, 4102, 4128, 4157, 4213, 4249, 4293, 4325], 'robust': [29, 283], 'regulatory': [30, 284, 544], 'networks.': [31, 285], 'In': [32, 286, 1068, 1219, 1762, 1849, 3015, 3165, 3239, 3694, 3768, 4264, 4340], 'Pseudomonas,': [33, 287, 1220], 'recognizes': [35, 289, 2814], 'repeats': [36, 230, 290, 484, 1006, 1278, 1773, 2796, 3290, 3552, 3723, 3829, 3886, 3986], 'adenine–purine–any': [38, 292], 'nucleotide': [39, 146, 293, 400, 1005, 2714, 3379, 3435, 3491, 3572, 3777], '(ARN)': [40, 294], 'target': [42, 296, 537, 938, 1008, 1284, 1496, 2573], 'mRNAs': [43, 297, 538, 670, 1375], 'via': [44, 298, 603, 766, 1116, 2075, 2739, 3399, 3455, 3511, 3592, 3797], 'its': [45, 75, 299, 329, 528, 555, 1450, 2600, 2619, 3409, 3465, 3521, 3602, 3807], 'distal': [46, 130, 300, 384, 1036, 2609, 2684, 2782], 'binding': [47, 140, 161, 301, 394, 415, 626, 661, 1209, 1272, 1474, 2093, 2401, 2494, 2513, 2583, 2778, 3928], 'side,': [48, 302], 'together': [50, 304], 'catabolite': [53, 307, 724, 1099, 1182, 1200, 1249, 1311, 1343, 1416, 1465, 1513, 3674, 3867], 'repression': [54, 308, 725, 1183, 1201, 1250, 1344, 1417, 1466, 3675, 3868], '(Crc)': [56, 310, 1185], 'protein,': [57, 311], 'assembles': [58, 312], 'into': [59, 313, 1640, 2284, 3421, 3477, 3533, 3614, 3819, 4274], 'translation–repression': [61, 315], 'complex.': [62, 107, 169, 316, 361, 423], 'Earlier': [63, 317], 'experiments': [64, 318, 2628], 'yielded': [65, 319], 'static,': [66, 320], 'ensemble-averaged': [67, 321, 2306], 'structures': [68, 322, 1673, 1686, 2895, 3255, 3710], 'complex,': [71, 325, 2758], 'but': [72, 326], 'details': [73, 327], 'interface': [76, 98, 330, 352, 2408, 2686], 'dynamics': [77, 88, 94, 331, 342, 348, 1856, 1916, 1996, 2128, 2169, 2191, 2255, 2286, 2380, 2409, 2679, 2871, 3113], 'assembly': [79, 104, 212, 245, 333, 358, 466, 499, 2807], 'pathway': [80, 334, 2808], 'remained': [81, 335], 'elusive.': [82, 336], 'Using': [83, 337], 'explicit': [84, 338], 'solvent': [85, 339], 'atomistic': [86, 340, 1854, 2999], 'molecular': [87, 341, 1855, 1887, 1920, 2000, 2029, 2168, 2259, 2322, 2875, 3117], 'simulations,': [89, 343, 3241, 3376, 3432, 3488, 3569, 3696, 3774, 3955, 4266], 'we': [90, 344, 1852, 2803, 2964, 2995, 3167, 3974, 4042], 'modeled': [91, 345, 3402, 3458, 3514, 3595, 3800], 'extensive': [93, 347, 2676], 'Hfq–RNA': [97, 167, 175, 252, 351, 421, 429, 506, 788, 1489, 1614, 1866, 2689, 2825, 4079], 'found': [100, 354], 'implications': [101, 355], 'for': [102, 242, 356, 496, 643, 861, 1224, 1564, 1658, 1836, 1943, 2298, 2384, 2447, 2486, 2572, 2939, 2957], 'We': [108, 135, 362, 389, 1616, 2588, 2772], 'predict': [109, 363], 'that': [110, 142, 149, 364, 396, 403, 1808, 1957, 2287, 2590, 2675, 2700, 2759, 3147, 3315, 3335, 3743], 'syn/anti': [111, 365, 2725, 4345], 'flips': [112, 366, 2750, 4286, 4312, 4331, 4346], 'adenine': [115, 369, 1020], 'nucleotides': [116, 370, 1770, 1783, 1811, 2792, 3286, 3413, 3469, 3525, 3548, 3606, 3719, 3811, 3825, 3899, 3983, 4026, 4048, 4104], 'each': [118, 372, 1586, 2716, 4341], 'ARN': [119, 229, 373, 483, 1277, 1594, 1772, 2717, 2795, 3289, 3551, 3722, 3828, 3884, 3897, 4002], 'repeat': [120, 374, 1014, 2718], 'contribute': [121, 375], 'to': [122, 376, 533, 632, 647, 753, 815, 1081, 1276, 1364, 1384, 1488, 1619, 1632, 1705, 1859, 2032, 2217, 2325, 2364, 2613, 2618, 2908, 2968, 3132, 3172, 3293, 3311, 3331, 3555, 3626, 3726, 3739, 3832, 3842, 3978, 4045, 4182, 4196, 4299], 'dynamic': [124, 236, 378, 490, 970, 2030, 2323, 2358, 2474, 2597, 4087], 'recognition': [125, 176, 218, 238, 379, 430, 472, 492, 1003, 1680, 1799, 2074, 2450, 2533, 2544, 2598], 'mechanism': [126, 380, 1265, 2554], 'between': [127, 224, 381, 478, 722, 1414, 1611, 2410, 4089, 4155, 4243, 4284], 'side': [131, 385, 1037, 2685, 2783], 'mRNA': [133, 387, 578, 1371, 1545, 2096], 'targets.': [134, 388], 'identify': [136, 390, 2774], 'previously': [138, 392, 2776], 'unknown': [139, 393, 2777], 'pocket': [141, 395, 2779], 'can': [143, 177, 397, 431, 763, 904, 1486, 1637, 2224, 2281, 2381, 2412, 2534, 2563, 2578, 2701, 2722, 2787, 3077, 3139], 'accept': [144, 398], 'any': [145, 399, 1029, 2218], 'propose': [148, 402, 2589], 'it': [150, 404, 1485, 2399, 2539], 'may': [151, 405, 2483], 'serve': [152, 406], 'as': [153, 407, 834, 1011, 1077, 1338, 1381, 1622, 1917, 1997, 2256, 2393, 2538, 2623, 2872, 2953, 3033, 3114, 3235, 3690, 3987, 4124, 4142, 4222, 4224], "'status": [155, 409], "quo'": [156, 410], 'staging': [157, 411], 'point,': [158, 412], 'providing': [159, 413], 'nonspecific': [160, 414, 1816], 'affinity,': [162, 416, 2622], 'until': [163, 417], 'Crc': [164, 208, 418, 462, 1204, 1221, 1269, 1368, 1441, 1469, 1608, 1635, 1820, 2728, 2762, 2812, 3313, 3333, 3741, 4058], 'engages': [165, 419], 'binary': [168, 422, 1867], 'dynamical': [171, 425, 2481], 'components': [172, 426], 'speed': [178, 432], 'up': [179, 433, 1631, 3171], 'screening': [180, 434], 'pool': [183, 437, 2559], 'surrounding': [186, 440], 'RNAs,': [187, 441, 1009], 'participate': [188, 442], 'rapid': [190, 444], 'accommodation': [191, 445], 'on': [195, 449, 636, 1034, 1111, 1629, 2072, 2642, 2661, 3185, 3199, 3211], 'surface,': [198, 452], 'facilitate': [200, 454, 2541], 'competition': [201, 455, 642, 934], 'among': [202, 456, 4039, 4289], 'different': [203, 457, 634, 1112, 2582], 'RNAs.': [204, 458], 'register': [206, 460], 'ternary': [211, 465], 'could': [213, 467, 2540], 'be': [214, 468, 1385, 1638, 2382, 2484, 2535, 2564, 2579, 2614, 3140, 3294, 3556, 3727, 3833], 'defined': [215, 469, 3935], 'by': [216, 251, 470, 505, 539, 599, 659, 1091, 1303, 1505, 1533, 1777, 1919, 1999, 2098, 2258, 2295, 2453, 2547, 2555, 2581, 2625, 2737, 2874, 3116, 3392, 3411, 3448, 3467, 3504, 3523, 3585, 3604, 3790, 3809, 3936, 4049, 4116, 4317], 'guanine-specific': [221, 475], 'base–phosphate': [222, 476], 'interaction': [223, 477, 859, 1052, 2576, 2818], 'first': [226, 480, 2713, 3980], 'last': [228, 482], 'bound': [233, 487, 814, 1704, 1776, 2907, 3625, 3841, 3875, 3924, 4181, 4195], 'RNA.': [234, 488, 2710], 'This': [235, 489, 4169], 'substrate': [237, 491], 'provides': [239, 493], 'structural': [240, 494, 1524, 1915, 1995, 2254, 2296, 2833, 2870, 3112], 'rationale': [241, 495], 'stepwise': [244, 498], 'multicomponent': [247, 501], 'ribonucleoprotein': [248, 502], 'complexes': [249, 503, 1163, 1490, 1874, 1966, 2828], 'nucleated': [250, 504], 'binding.': [253, 507, 2729], 'RNA-binding': [512, 1445, 2621], 'pleiotropic': [516, 782], 'regulator': [517, 784, 1340], 'translation': [519, 535], 'stability': [522], 'diverse': [524], 'Some': [526], 'best': [529], 'studied': [530], 'roles': [531], 'are': [532, 1025, 1114, 1774, 1784, 1812, 2276, 2288, 2302, 2735, 3196, 3217, 3923, 3933, 4062], 'suppress': [534], 'annealing': [540, 646], 'them': [541], 'small': [543, 601], 'noncoding': [545], 'molecules': [547], '(sRNAs)': [548], '(1Vogel': [549], 'J.': [550, 585, 618, 794, 959, 965, 1043, 1129, 1137, 1891, 1971, 2019, 2052, 2159, 2230, 2312, 2351, 2353, 2426, 2440, 2632, 2846, 2989, 2993, 3088], 'Luisi': [551, 715, 1407, 1560, 1654, 1832, 2935], 'B.F.': [552, 716, 1408, 1561, 1655, 1833, 2936], 'constellation': [556], 'RNA.Nat.': [558], 'Rev.': [559, 1925, 2005, 2264, 2880, 3122], 'Microbiol.': [560, 889], '2011;': [561], '9:': [562], '578-589Crossref': [563], 'PubMed': [564, 588, 653, 690, 744, 798, 827, 873, 893, 949, 994, 1063, 1104, 1172, 1214, 1261, 1316, 1357, 1436, 1479, 1518, 1572, 1666, 1717, 1757, 1844, 1929, 1952, 2009, 2080, 2108, 2146, 2176, 2201, 2268, 2374, 2467, 2527, 2651, 2667, 2884, 2920, 2947, 3010, 3062, 3126, 4208], 'Scopus': [565, 589, 613, 654, 691, 745, 799, 828, 874, 894, 950, 1064, 1105, 1173, 1215, 1317, 1358, 1437, 1480, 1519, 1573, 1667, 1718, 1758, 1845, 1930, 1953, 2010, 2081, 2109, 2147, 2177, 2202, 2269, 2375, 2468, 2528, 2652, 2668, 2885, 2921, 2948, 3011, 3063, 3127, 4209], '(672)': [566], 'Google': [567, 591, 615, 656, 693, 747, 801, 830, 876, 896, 952, 995, 1066, 1107, 1175, 1217, 1262, 1319, 1360, 1439, 1482, 1521, 1575, 1669, 1720, 1760, 1847, 1932, 1955, 2012, 2083, 2111, 2149, 2179, 2204, 2271, 2377, 2470, 2530, 2654, 2670, 2887, 2923, 2950, 3013, 3065, 3129, 4211], 'Scholar,': [568, 592, 616, 694, 802, 877, 953, 1721, 1933, 2013, 2050, 2084, 2112, 2150, 2180, 2343, 2655, 2924], '2Hoekzema': [569], 'M.': [570, 624, 1741, 1895, 1913, 1975, 1993, 2017, 2086, 2182, 2234, 2252, 2310, 2347, 2355, 2432, 2434, 2508, 2850, 2868, 2979, 2981, 2987, 3092, 3110], 'Romilly': [571], 'C.': [572, 2502, 3039], 'Holmqvist': [573], 'E.': [574, 696, 1085, 1192, 1297, 1331, 1388, 1457, 1499, 1555, 1649, 1725, 1827, 2060, 2930], 'Wagner': [575, 2637], 'E.G.H.': [576, 2638, 2657], 'Hfq-dependent': [577, 606, 733, 1425], 'unfolding': [579], 'promotes': [580], 'sRNA-based': [581], 'inhibition': [582], 'translation.EMBO': [584], '2019;': [586, 1570, 1664, 1842, 2078, 2105, 2173, 2372, 2464, 2945], '38e101199Crossref': [587], '(20)': [590], '3Azam': [593], 'M.S.': [594], 'Vanderpool': [595], 'C.K.': [596], 'Translational': [597, 677], 'regulation': [598, 735, 1083, 1427, 1566, 1660, 1838, 2941], 'bacterial': [600, 791], 'RNAs': [602, 765, 1497, 1692, 2546, 2562, 2639, 2660], 'an': [604, 662, 787, 1019, 1589, 2815, 4065, 4322], 'unusual': [605], 'mechanism.Nucleic': [607], 'Acids': [608, 739, 1058, 1431, 2103], 'Res.': [609, 740, 1059, 1168, 1432, 2104], '2017;': [610, 991, 2199], '46:': [611, 742, 1434], '2585-2599Crossref': [612], '(18)': [614], '4Kwiatkowska': [617], 'Wroblewska': [619], 'Z.': [620, 967], 'Johnson': [621], 'K.A.': [622], 'Olejniczak': [623], 'class': [628], 'II': [629], 'sRNA': [630, 933, 1326], 'MgrR': [631], 'two': [633, 1583, 1607, 1613, 1633], 'sites': [635], 'matchmaker': [637], 'enables': [640], 'efficient': [641, 2369], 'regulated': [648], 'mRNAs.RNA.': [649], '2018;': [650, 741, 1433, 1926, 1949, 2006, 2143, 2265, 2881, 3123], '24:': [651, 2649], '1761-1784Crossref': [652], '(9)': [655], 'Scholar)': [657, 1108, 1361, 1956, 2888, 2951, 3130, 4212], 'or': [658, 840, 1446, 3175, 3374, 3417, 3430, 3473, 3486, 3529, 3567, 3610, 3772, 3815, 3990, 4032], 'directly': [660, 4044], 'A-rich': [663], 'sequence': [664, 2366], '5′-untranslated': [667, 1281], 'region': [668, 975, 1282], '(5Vecerek': [671], 'B.': [672, 955, 1145, 2636], 'Moll': [673, 1732], 'I.': [674, 1190, 1455, 1729, 1733], 'BLASI': [675], 'U.': [676, 720, 821, 943, 1087, 1196, 1299, 1351, 1412, 1461, 1501, 1559, 1653, 1711, 1731, 1831, 2120, 2140, 2461, 2521, 2914, 2934, 4202], 'autocontrol': [678], 'Escherichia': [681, 811, 854, 978, 1701, 2904, 4192], 'coli': [682, 812, 855, 979, 1702, 2905, 4193], 'chaperone': [685, 758, 930, 981], 'gene.RNA.': [686], '2005;': [687, 1754], '11:': [688, 871, 3008], '976-984Crossref': [689], '(73)': [692], '6Sonnleitner': [695], 'Wulf': [697, 1389], 'A.': [698, 712, 823, 916, 945, 1124, 1143, 1353, 1390, 1404, 1713, 1723, 1727, 1903, 1983, 2054, 2056, 2064, 2090, 2118, 2122, 2142, 2156, 2242, 2349, 2430, 2436, 2463, 2523, 2630, 2858, 2916, 3100, 4204], 'Campagne': [699, 1391], 'S.': [700, 822, 922, 944, 1352, 1392, 1557, 1651, 1712, 1737, 1743, 1829, 1899, 1907, 1979, 1987, 2015, 2088, 2141, 2238, 2246, 2308, 2462, 2522, 2854, 2862, 2915, 2932, 3096, 3104, 4203], 'Pei': [701, 1393], 'X.-Y.': [702, 1394], 'Wolfinger': [703, 1395], 'M.T.': [704, 1396], 'Forlani': [705, 1397], 'G.': [706, 1398, 1735, 1893, 1905, 1973, 1985, 2058, 2116, 2152, 2232, 2244, 2506, 2848, 2860, 3090, 3102], 'Prindl': [707, 1399], 'K.': [708, 918, 1149, 1194, 1400, 1459, 2634], 'Abdou': [709, 1332, 1401], 'L.': [710, 1147, 1333, 1402, 2062, 2114, 2154], 'Resch': [711, 1403], 'Allain': [713, 1405, 2020, 2313, 2443], 'F.H.-T.': [714, 1406, 2444], 'Urlaub': [717, 1409], 'H.': [718, 1131, 1133, 1410], 'Bläsi': [719, 1086, 1195, 1298, 1411, 1460, 1500, 1558, 1652, 1830, 2933], 'Interplay': [721, 1413], 'Crc,': [728, 1420, 1538, 3866, 4084], 'translational': [734, 783, 1426], 'Pseudomonas': [737, 1072, 1096, 1165, 1198, 1254, 1308, 1346, 1429, 1463, 1510, 1746], 'aeruginosa.Nucleic': [738, 1430], '1470-1485Crossref': [743, 1435], '(37)': [746, 1438], 'Scholar).': [748, 897, 996, 1067, 1176, 1218, 1263, 1320, 1440, 1522, 1576, 1670, 1761, 1848, 2205, 2272, 2378, 2531, 2671, 3014, 3066], 'Six': [749], 'protomers': [751], 'assemble': [752], 'form': [754, 2595], 'hexameric,': [756], 'ring-like': [757], '(Fig.': [759, 1038, 1626, 3323, 3343, 3751, 3894, 3946, 4053, 4146, 4167, 4262, 4303, 4313], '1A).': [760], 'hexamer': [762, 3893], 'bind': [764, 1487, 2789, 3316, 3336, 3744], 'three': [767], 'surfaces': [768, 860, 1053], '(7Schumacher': [769], 'M.A.': [770], 'Pearson': [771], 'R.F.': [772], 'Møller': [773], 'T.': [774, 1188, 1453, 1553, 1647, 1825, 1937, 2928], 'Valentin-Hansen': [775, 805, 1695, 2898, 4186], 'P.': [776, 806, 1696, 1897, 1909, 1977, 1989, 2236, 2248, 2852, 2864, 2899, 2983, 2985, 3094, 3106, 4187], 'Brennan': [777, 807, 1048, 1697, 2900, 4188], 'R.G.': [778, 808, 879, 1049, 1698, 2901, 4189], 'Structures': [779], 'complex:': [789], 'A': [790, 1017, 1767, 1922, 2002, 2261, 2877, 3119, 3835], 'Sm-like': [792, 2644], 'protein.EMBO': [793], '2002;': [795], '21:': [796, 3060], '3546-3556Crossref': [797], '(320)': [800], '8Link': [803], 'T.M.': [804, 881, 1047, 1694, 2897, 4185], 'Structure': [809, 1699, 1744, 2509, 2902, 4190], 'polyriboadenylate': [816, 1706, 2909, 4197], 'RNA.Proc.': [817, 939, 1707, 2910, 4198], 'Natl.': [818, 940, 1348, 1708, 2137, 2458, 2518, 2911, 4199], 'Acad.': [819, 941, 1349, 1709, 2138, 2459, 2519, 2912, 4200], 'Sci.': [820, 942, 1350, 1710, 2139, 2460, 2520, 2913, 4201], '2009;': [824, 1354, 1714, 2917, 4205], '106:': [825, 1355, 1715, 2918, 4206], '19292-19297Crossref': [826, 1716, 2919, 4207], '(243)': [829, 1719, 2922, 4210], 'Scholar),': [831, 1483, 2471], 'commonly': [832], 'termed': [833], 'proximal,': [835], 'distal,': [836], 'rim': [838], 'faces': [839], 'sides': [841, 2610], '(9Mikulecky': [842], 'P.J.': [843], 'Kaw': [844], 'M.K.': [845], 'Brescia': [846], 'C.C.': [847], 'Takach': [848], 'J.C.': [849], 'Sledjeski': [850], 'D.D.': [851], 'Feig': [852], 'A.L.': [853], 'has': [857, 1442, 1530], 'distinct': [858], 'DsrA,': [862], 'rpoS': [863], 'poly(A)': [865], 'RNAs.Nat.': [866], 'Struct.': [867, 1947, 2171], 'Mol.': [868], 'Biol.': [869, 1752, 1948, 2172, 2663], '2004;': [870], '1206-1214Crossref': [872], '(200)': [875], '10Brennan': [878], 'Link': [880, 1046], 'structure,': [883], 'function': [884], 'ligand': [886], 'binding.Curr.': [887], 'Opin.': [888, 1946], '2007;': [890], '10:': [891, 2665], '125-133Crossref': [892], '(304)': [895], 'Furthermore,': [898], 'intrinsically': [900], 'disordered': [901], 'C-terminal': [902, 925, 974, 2456], 'regions': [903], 'also': [905, 2773, 4150], 'interact': [906, 1790], 'autoregulate': [910], 'activity': [912], '(11Santiago-Frangos': [915], 'Kavita': [917], 'Schu': [919], 'D.J.': [920], 'Gottesman': [921], 'Woodson': [923], 'S.A.': [924], 'domain': [926, 2188], 'drives': [932], 'release': [936], '2016;': [946, 2524], '113:': [947, 2525], 'E6089-E6096Crossref': [948], '(42)': [951], '12Wen': [954], 'Wang': [956], 'W.': [957, 1141], 'Zhang': [958, 966], 'Gong': [960], 'Q.': [961], 'Shi': [962], 'Y.': [963], 'Wu': [964], 'Structural': [968], 'properties': [971], 'Hfq:': [982], 'Integrative': [983], 'experimental': [984, 2221, 2227, 2894, 3133, 3230, 3247, 3685, 3702], 'computational': [986, 2976], 'studies.Phys.': [987], 'Chem.': [988, 989, 3004], 'Phys.': [990], '19:': [992], '21152-21164Crossref': [993], 'homo-oligomeric': [998], 'nature': [999, 2387], 'favors': [1002], 'such': [1010, 1178, 1380, 2392, 2961, 3017, 3032], 'ARN-triplet': [1013], 'motif': [1015, 1681, 3898], '(where': [1016], 'R': [1022, 1769], 'N': [1024, 1782, 1810, 2791], 'purine': [1027], 'nucleotide,': [1030], 'respectively),': [1031], 'which': [1032, 1535, 2299, 2556, 2786, 2810, 2837, 3232, 3687, 4159], 'binds': [1033], '1B)': [1039], '(13Robinson': [1040], 'K.E.': [1041], 'Orans': [1042], 'Kovach': [1044], 'A.R.': [1045], 'Mapping': [1050], 'Hfq-RNA': [1051], 'using': [1054], 'tryptophan': [1055], 'fluorescence': [1056], 'quenching.Nucleic': [1057], '2014;': [1060, 1102, 1169, 1314, 1516], '42:': [1061], '2736-2749Crossref': [1062], '(51)': [1065], 'gram-negative': [1070], 'bacterium': [1071], 'aeruginosa,': [1073], 'was': [1075, 2611, 3233, 3383, 3390, 3406, 3419, 3439, 3446, 3462, 3475, 3495, 3502, 3518, 3531, 3576, 3583, 3599, 3612, 3624, 3661, 3688, 3781, 3788, 3804, 3817, 3840, 3849, 4085, 4114, 4140, 4214, 4226, 4315, 4332], 'identified': [1076], 'versatile': [1079], 'contributor': [1080], 'metabolic': [1082, 1227, 1294, 1378], '(14Sonnleitner': [1084, 1296, 1498], 'Regulation': [1088, 1300, 1502], 'CrcZ': [1094, 1306, 1327, 1508], 'aeruginosa': [1097, 1199, 1255, 1309, 1464, 1511, 1747], 'carbon': [1098, 1235, 1310, 1342, 1512], 'repression.PLoS': [1100, 1312, 1514], 'Genet.': [1101, 1313, 1515], '10e1004440Crossref': [1103, 1315, 1517], '(98)': [1106, 1318, 1520], 'whose': [1109], 'influences': [1110], 'pathways': [1113, 1228, 1295], 'facilitated': [1115], 'interactions': [1117, 1494, 1817, 2742, 3945, 3959, 4106], 'other': [1119, 1233], 'proteins': [1120, 1159, 1275, 1609, 1636, 1821, 3314, 3334, 3742], '(15Van': [1121], 'den': [1122], 'Bossche': [1123], 'Ceyssens': [1125], 'P.-J.': [1126], 'De': [1127], 'Smet': [1128], 'Hendrix': [1130], 'Bellon': [1132], 'Leimer': [1134], 'N.': [1135, 2424], 'Wagemans': [1136], 'Delattre': [1138], 'A.-S.': [1139], 'Cenens': [1140], 'Aertsen': [1142], 'Landuyt': [1144], 'Minakhin': [1146], 'Severinov': [1148], 'Noben': [1150], 'J.-P.': [1151], 'Lavigne': [1152], 'R.': [1153, 2991], 'Systematic': [1154], 'identification': [1155], 'hypothetical': [1157], 'bacteriophage': [1158], 'targeting': [1160], 'aeruginosa.J.': [1166], 'Proteome': [1167], '13:': [1170], '4446-4456Crossref': [1171], '(35)': [1174], 'One': [1177], 'partner': [1179], '(16Milojevic': [1187, 1452], 'Grishkovskaya': [1189, 1454], 'Sonnleitner': [1191, 1456, 1554, 1648, 1826, 2929], 'Djinovic-Carugo': [1193, 1458], 'devoid': [1206, 1471], 'activity.PLoS': [1210, 1475], 'One.': [1211, 1476], '2013;': [1212, 1477, 2664], '8e64609Crossref': [1213, 1478], '(36)': [1216, 1481], 'responsible': [1223], 'directing': [1225], 'toward': [1229], 'preferring': [1230], 'succinate': [1231, 1322], 'over': [1232], 'potential': [1234, 2806], 'sources': [1236], '(17Wolff': [1237], 'J.A.': [1238], 'MacGregor': [1239], 'C.H.': [1240], 'Eisenberg': [1241], 'R.C.': [1242], 'Phibbs': [1243], 'P.V.': [1244], 'Isolation': [1245], 'characterization': [1247], 'mutants': [1252], 'PAO.J.': [1256], 'Bacteriol.': [1257], '1991;': [1258], '173:': [1259], '4700-4706Crossref': [1260], 'cooperation': [1270], 'involves': [1271], 'both': [1274, 2606, 2744], 'mRNAs,': [1285], 'thus': [1286, 4276], 'repressing': [1287], 'enzymes': [1290], 'involved': [1291], 'alternative': [1293, 1377], 'When': [1321], 'depleted,': [1324], 'expressed': [1329], '(18Sonnleitner': [1330], 'Haas': [1334], 'D.': [1335, 1739], 'Small': [1336], 'global': [1339], 'aeruginosa.Proc.': [1347], '21866-21871Crossref': [1356], '(177)': [1359], 'proceeds': [1363], 'sequester': [1365], 'from': [1369, 1787, 2291, 3320, 3340, 3408, 3464, 3520, 3601, 3748, 3806, 4297], 'their': [1370, 3931, 3957, 4050], 'targets,': [1372], 'allowing': [1373], 'genes,': [1379], 'amiE,': [1383], 'translated': [1386], '(6Sonnleitner': [1387], 'no': [1443, 2830], 'intrinsic': [1444], 'Hfq-binding': [1447], 'capabilities': [1448], 'own': [1451], 'yet': [1484], 'strengthen': [1492], 'basis': [1525, 2163, 2446], 'this': [1527, 1580, 1620, 1850, 4113], 'cooperative': [1528], 'action': [1529], 'been': [1531, 1959], 'unraveled': [1532], 'cryo-EM,': [1534], 'showed': [1536, 2829], 'Hfq,': [1537, 1779], 'short': [1541], 'segment': [1542], 'amiE': [1544], 'forming': [1546, 4020], 'quaternary': [1548, 1624, 1642, 1676, 1805, 1873, 2586, 2757, 2827, 3879], 'complex': [1549, 1581, 1625, 1643, 1677, 1806, 1868, 2389, 2690, 3264, 3367, 3880], '(19Pei': [1550, 1644, 1822], 'X.Y.': [1551, 1645, 1823, 2926], 'Dendooven': [1552, 1646, 1824, 2927], 'Chen': [1556, 1650, 1828, 2931], 'Architectural': [1562, 1656, 1834, 2937], 'principles': [1563, 1657, 1835, 2938], 'Hfq/Crc-mediated': [1565, 1659, 1837, 2940], 'expression.Elife.': [1569, 1663, 1841, 2944], '8e43158Crossref': [1571, 1665, 1843, 2946], '(22)': [1574, 1668, 1846, 2949], 'structure': [1578, 1621, 2037, 2330, 3231, 3248, 3686, 3703, 4177], 'encompasses': [1582], 'hexamers,': [1585], 'complexed': [1587, 1689], 'octadecamer': [1591, 3623, 3839], 'containing': [1592], 'six': [1593, 3883], 'repeats,': [1595, 4041], 'amiE6ARN': [1597], 'fragment.': [1598], 'At': [1599], 'minimum,': [1601], 'there': [1602, 4235], 'homodimer': [1605], 'positioned': [1610], 'complexes.': [1615, 2587], 'henceforth': [1617], 'refer': [1618, 3310, 3330, 3738, 3977, 4043], '1C).': [1627], 'Depending': [1628], 'availability,': [1630], 'additional': [1634], 'recruited': [1639], 'cryo-EM': [1672], 'reveal': [1678], 'seen': [1682], 'earlier': [1684], 'X-ray': [1685, 4176], 'polyadenine': [1691, 3621, 3837], '(8Link': [1693, 2896, 4184], '20Nikulin': [1722], 'Stolboushkina': [1724], 'Perederina': [1726], 'Vassilieva': [1728], 'Blaesi': [1730], 'Kachalova': [1734], 'Yokoyama': [1736], 'Vassylyev': [1738], 'Garber': [1740], 'Nikonov': [1742], 'protein.Acta': [1749], 'Crystallogr.': [1750, 1753], 'D': [1751], '61:': [1755], '141-146Crossref': [1756], '(61)': [1759], 'crystal': [1764], 'structures,': [1765], 'specifically': [1775], 'whereas': [1780, 4131], 'bulged': [1785], 'away': [1786, 3319, 3339, 3747], 'neighboring': [1793], 'crystallographic': [1794], 'cells.': [1795], 'same': [1797, 3149, 3182, 4109], 'pattern': [1800], 'present': [1802, 4173], 'except': [1807], 'instead': [1813], 'engaged': [1814], 'study,': [1851], 'used': [1853, 2952, 3250, 3705], '(MD)': [1857], 'simulations': [1858, 1880, 2031, 2124, 2192, 2280, 2324, 2823, 3000, 3027, 3076, 3136, 3170, 3260, 3265, 3538, 4077, 4221, 4292], 'explore': [1860], 'conformational': [1862, 2416, 2698, 4072], 'variation': [1863], 'higher': [1871], 'order': [1872], 'formed': [1875, 4161], 'Crc.': [1877, 2801], 'Our': [1878, 2672], 'MD': [1879, 2206, 3026, 3075, 4220, 4265], 'utilize': [1881, 2593], 'set': [1883], 'carefully': [1885], 'calibrated': [1886], 'mechanics': [1888], 'models': [1889, 2293], '(21Šponer': [1890, 1970, 2229, 2845, 3087], 'Bussi': [1892, 1972, 2231, 2847, 3089], 'Krepl': [1894, 1974, 2016, 2233, 2309, 2346, 2433, 2849, 3091], 'Banáš': [1896, 1976, 2235, 2851, 3093], 'Bottaro': [1898, 1978, 2237, 2853, 3095], 'Cunha': [1900, 1980, 2239, 2855, 3097], 'R.A.': [1901, 1981, 2240, 2856, 3098], 'Gil-Ley': [1902, 1982, 2241, 2857, 3099], 'Pinamonti': [1904, 1984, 2243, 2859, 3101], 'Poblete': [1906, 1986, 2245, 2861, 3103], 'Jurečka': [1908, 1988, 2247, 2863, 3105], 'Walter': [1910, 1990, 2249, 2865, 3107], 'N.G.': [1911, 1991, 2250, 2866, 3108], 'Otyepka': [1912, 1992, 2251, 2867, 2986, 3109], 'captured': [1918, 1998, 2257, 2873, 3115], 'simulations:': [1921, 2001, 2260, 2876, 3118], 'comprehensive': [1923, 2003, 2262, 2878, 3120], 'overview.Chem.': [1924, 2004, 2263, 2879, 3121], '118:': [1927, 2007, 2266, 2882, 3124], '4177-4338Crossref': [1928, 2008, 2267, 2883, 3125], '(173)': [1931, 2011, 2270, 2886, 3128], '22Nerenberg': [1934], 'P.S.': [1935], 'Head-Gordon': [1936], 'New': [1938], 'developments': [1939], 'force': [1941, 2843, 3057], 'fields': [1942], 'biomolecular': [1944, 2285], 'simulations.Curr.': [1945], '49:': [1950], '129-138Crossref': [1951], '(90)': [1954], 'have': [1958], 'applied': [1960], 'many': [1962], 'studies': [1963], 'protein–RNA': [1965, 2039, 2332, 2396, 3958], 'predictive': [1968], 'power': [1969], '23Campagne': [2014], 'Sponer': [2018, 2311, 2992], 'F.H.T.': [2021, 2314], 'Chapter': [2022, 2315], 'fourteen': [2023, 2316], '-': [2024, 2317], 'combining': [2025, 2318], 'NMR': [2026, 2319], 'spectroscopy': [2027, 2320], 'solve': [2033, 2326], 'analyze': [2035, 2328], 'complexes.in:': [2040, 2333], 'Wand': [2041, 2334], 'A.J.': [2042, 2335], 'Methods': [2043, 2336], 'Enzymol.': [2044, 2337], 'Academic': [2045, 2338], 'Press,': [2046, 2339], 'Cambridge,': [2047, 2340], 'MA2019:': [2048, 2341], '393-422Google': [2049, 2342], '24Borišek': [2051], 'Saltalamacchia': [2053], 'Gallì': [2055], 'Palermo': [2057, 2115], 'Molteni': [2059], 'Malcovati': [2061], 'Magistrato': [2063, 2121, 2155], 'Disclosing': [2065], 'impact': [2067], 'carcinogenic': [2069], 'SF3b': [2070], 'mutations': [2071], 'pre-mRNA': [2073], 'all-atom': [2076], 'simulations.Biomolecules.': [2077], '9e633Crossref': [2079], '(6)': [2082], '25Sharma': [2085], 'Sharma': [2087], 'Alawada': [2089], 'Understanding': [2091, 2160], 'specificities': [2094], 'targets': [2097], 'mammalian': [2100, 2194], 'quaking': [2101, 2195], 'protein.Nucleic': [2102], '47:': [2106], '10564-10579Crossref': [2107], '(3)': [2110], '26Casalino': [2113], 'Spinello': [2117], 'Rothlisberger': [2119], 'All-atom': [2123], 'disentangle': [2125], 'functional': [2127], 'underlying': [2129], 'maturation': [2131], 'intron': [2134], 'lariat': [2135], 'spliceosome.Proc.': [2136], '115:': [2144], '6584-6589Crossref': [2145], '(34)': [2148], '27Palermo': [2151], 'Casalino': [2153], 'Andrew': [2157], 'McCammon': [2158], 'mechanistic': [2162], 'non-coding': [2165], 'through': [2167], 'simulations.J.': [2170], '206:': [2174], '267-279Crossref': [2175], '(14)': [2178], '28Sharma': [2181], 'Anirudh': [2183], 'C.R.': [2184], 'Mechanism': [2185], 'mRNA-STAR': [2187], 'interaction:': [2189], 'Molecular': [2190, 2445], 'STAR': [2196], 'protein.Sci.': [2197], 'Rep.': [2198], '7e12567Crossref': [2200], '(8)': [2203], 'allows': [2207], 'study': [2209], 'atomic': [2211, 4241], 'movements': [2212], 'at': [2213, 2605, 2682, 2780], 'spatiotemporal': [2214], 'resolutions': [2215], 'inaccessible': [2216, 3131], 'currently': [2219], 'available': [2220], 'method': [2222], 'help': [2225, 4056], 'rationalize': [2226], 'observations': [2228], 'Although': [2273], 'simulation': [2274, 3150, 3214, 3300, 3360, 3649, 3667, 3733, 3763, 3855, 4282], 'timescales': [2275], 'generally': [2277], 'short,': [2278], 'well-executed': [2279], 'provide': [2282, 2552, 3078], 'insights': [2283], 'not': [2289, 2966, 3020], 'apparent': [2290], 'static': [2292], 'obtained': [2294], 'experiments,': [2297], 'data': [2301], 'typically': [2303], 'time-': [2304], '(23Campagne': [2307], '29Górecka': [2344], 'K.M.': [2345], 'Szlachcic': [2348], 'Poznański': [2350], 'Šponer': [2352, 2439], 'Nowotny': [2354], 'RuvC': [2356], 'uses': [2357], 'probing': [2359], 'holliday': [2362], 'junction': [2363], 'achieve': [2365, 2969], 'specificity': [2367], 'resolution.Nat.': [2370], 'Commun.': [2371], '10e4102Crossref': [2373], '(7)': [2376], 'Biomolecular': [2379], 'invaluable': [2383], 'understanding': [2385], 'intramolecular': [2390, 2816], 'interfaces,': [2391], 'those': [2394], 'complexes,': [2397, 4080], 'where': [2398], 'underpins': [2400], 'affinities,': [2402], 'specificities,': [2403], 'formation': [2405, 2754, 4320], 'rates.': [2406], 'biomolecules': [2411], 'involve': [2413], 'competing': [2414], 'local': [2415, 2678], 'substates': [2417, 2477], 'rather': [2418], 'than': [2419], 'fixed': [2421], 'geometry': [2422], '(30Ripin': [2423], 'Boudet': [2425], 'Duszczyk': [2427], 'M.M.': [2428], 'Hinniger': [2429], 'Faller': [2431], 'Gadi': [2435], 'Schneider': [2437], 'R.J.': [2438], 'Meisner-Kober': [2441], 'N.C.': [2442], 'AU-rich': [2448], 'element': [2449], 'dimerization': [2452], 'HuR': [2455], 'RRM.Proc.': [2457], '116:': [2465], '2935-2944Crossref': [2466], '(19)': [2469], 'resulting': [2472], 'recognition.': [2475], 'associated': [2478, 4255], 'ensemble': [2482, 3215], 'important': [2485], 'detailed': [2488], 'mechanisms': [2489], 'process': [2492], 'unbinding': [2496], '(31Borkar': [2497], 'A.N.': [2498], 'Bardaro': [2499], 'M.F.': [2500], 'Camilloni': [2501], 'Aprile': [2503], 'F.A.': [2504], 'Varani': [2505], 'Vendruscolo': [2507], 'low-population': [2512], 'intermediate': [2514, 4309], 'protein-RNA': [2516, 3002], 'recognition.Proc.': [2517], '7171-7176Crossref': [2526], '(39)': [2529], 'Dynamic': [2532], 'biologically': [2536], 'significant': [2537, 4071], 'highly': [2542, 3951], 'specific': [2543, 4047], 'would': [2551], 'large': [2558, 2962], 'cellular': [2561], 'interrogated': [2565], 'speed,': [2567], 'specificity,': [2568], 'high': [2570], 'affinity': [2571], 'sequences.': [2574], 'Different': [2575], 'preferred': [2580], 'partners': [2584], 'must': [2592], 'because': [2599], 'vivo': [2602], 'cycling': [2604], 'proximal': [2607], 'shown': [2612], 'disproportionally': [2615], 'fast': [2616], 'relative': [2617], 'low-nanomolar': [2620], 'measured': [2624], 'vitro': [2627], '(32Fender': [2629], 'Elf': [2631], 'Hampel': [2633], 'Zimmermann': [2635], 'actively': [2640], 'cycle': [2641], 'Hfq.Genes': [2646], 'Dev.': [2647], '2010;': [2648], '2621-2626Crossref': [2650], '(120)': [2653], '33Wagner': [2656], 'Cycling': [2658], 'Hfq.RNA': [2662], '619-626Crossref': [2666], '(75)': [2669], 'results': [2673], 'suggest': [2674, 2804], 'equilibrium': [2677, 4088], 'indeed': [2680], 'occur': [2681], 'offer': [2692], 'concrete': [2694], 'example': [2695], 'switch': [2699], 'influence': [2702], 'rates': [2703], 'translocation': [2705], 'along': [2706], 'length': [2708, 3262], 'Namely,': [2711], '(i.e.,': [2719], 'adenines)': [2721], 'undergo': [2723], 'frequent': [2724], 'flips,': [2726], 'before': [2727, 3298, 3731], 'anti': [2731, 4090, 4166, 4228, 4258], 'syn': [2733, 2767, 3296, 3729, 4092], 'conformations': [2734, 4093], 'supported': [2736], 'unique': [2740], 'adenine-specific': [2741], 'positions.': [2745], 'frequency': [2747], 'lowered': [2752], 'upon': [2753], 'is,': [2760], 'after': [2761], 'bound,': [2764], 'conformation': [2768, 3297, 3730, 4259], 'becomes': [2769], 'less': [2770], 'favored.': [2771], 'weakly': [2788], 'absence': [2799, 4082], 'Finally,': [2802, 4234], 'initially': [2813], 'amiE6ARN.': [2821], 'loss': [2831], 'compactness': [2834], 'integrity,': [2836], 'indicates': [2838], 'good': [2839], 'performance': [2840], 'field': [2844], 'sufficient': [2890], 'quality': [2891], '19Pei': [2925], 'starting': [2955], 'states': [2956], 'simulations.': [2959], 'For': [2960, 3203, 4004], 'systems,': [2963, 3206], 'did': [2965], 'expect': [2967], 'full': [2971, 3071], 'thermodynamic': [2972], 'convergence': [2973, 3018], 'within': [2974, 3287, 3549, 3720, 3826, 4000], 'affordable': [2975], 'time': [2977, 4283, 4328], '(34Krepl': [2978], 'Havrila': [2980], 'Stadlbauer': [2982], 'Banas': [2984], 'Pasulka': [2988], 'Stefl': [2990], 'Can': [2994], 'execute': [2996], 'stable': [2997], 'microsecond-scale': [2998], 'complexes?.J.': [3003], 'Theor.': [3005], 'Comput.': [3006], '2015;': [3007, 3059], '1220-1243Crossref': [3009], '(43)': [3012], 'fact,': [3016], 'fully': [3021], 'achieved': [3022], 'even': [3023, 3068, 3184], 'longer': [3025, 3187], 'much': [3029], 'smaller': [3030], 'systems': [3031, 3086, 3162, 3369], 'tetraloops': [3035], 'tetranucleotides': [3037], '(35Bergonzo': [3038], 'Henriksen': [3040], 'N.M.': [3041], 'Roe': [3042], 'D.R.': [3043], 'Cheatham': [3044], 'T.E.': [3045], 'Highly': [3046], 'sampled': [3047], 'tetranucleotide': [3048], 'tetraloop': [3050], 'motifs': [3051], 'enable': [3052], 'evaluation': [3053], 'common': [3055], 'fields.RNA.': [3058], '1578-1590Crossref': [3061], '(76)': [3064], 'Nevertheless,': [3067], 'without': [3069, 3353, 3642, 3756], 'achieving': [3070], 'quantitative': [3072], 'convergence,': [3073], 'wealth': [3080], 'information': [3082], 'about': [3083], 'methods.': [3134], 'presented': [3137, 3191], 'here': [3138], 'considered': [3141], 'qualitatively': [3142], 'converged': [3143], 'sense': [3146], 'trends': [3151, 3183], 'were': [3152, 3209, 3249, 3291, 3351, 3553, 3640, 3704, 3724, 3754, 3830, 3960, 4347], 'observed': [3153, 4074, 4216], 'multiple': [3155], 'independent': [3156], 'parallel': [3157], 'trajectories': [3158], 'individual': [3161, 4017, 4291], '(Table': [3163, 3178], '1).': [3164, 4054], 'addition,': [3166], 'extended': [3168, 3201, 3407, 3463, 3519, 3600, 3805], 'selected': [3169, 3243, 3698], '5,': [3173, 3268, 3277, 3303], '10,': [3174, 3559], '15': [3176], 'μs': [3177], '1),': [3179], 'observing': [3180], 'these': [3186, 3200, 4311], 'timescales.': [3188], 'analyses': [3190, 3208], 'main': [3194], 'text': [3195], 'based': [3197], 'mainly': [3198], 'trajectories.': [3202], 'remaining': [3205], 'performed': [3210], 'combined': [3213], 'described': [3218], 'Supporting': [3220, 3363, 3652, 3670, 3766, 3858], 'information.Table': [3221], '1List': [3222], 'simulationsSimulation': [3224], 'nameSource': [3225], 'PDBaPDB': [3226], 'ID': [3227, 3682], 'utilized': [3234, 3662, 3689, 3850, 4141], 'initial': [3237, 3254, 3692, 3709], 'structure.': [3238, 3693], 'some': [3240, 3695], 'only': [3242, 3697, 3964], 'parts': [3244, 3699], '(see': [3251, 3356, 3645, 3663, 3706, 3759, 3851], 'Selection': [3252, 3707], 'Fig.': [3257, 3712, 4305], 'S1).#Hfq#RNA#CrcNumber': [3258], '×': [3261, 3267, 3270, 3273, 3276, 3279, 3302, 3305, 3325, 3345, 3348, 3365, 3424, 3480, 3536, 3540, 3543, 3558, 3561, 3617, 3628, 3631, 3634, 3637, 3654, 3672], '(μs)Quaternary': [3263], '2Hfq_2Crc_2RNA6o1k2221': [3266], '2': [3269, 3326, 3346, 3542, 3560, 3562, 3629, 3638, 3655, 3658, 3846], '1': [3271, 3274, 3278, 3280, 3304, 3306, 3349, 3425, 3481, 3544, 3618, 3632, 3635], '2Hfq_3Crc_2RNA6o1l2232': [3272], '2Hfq_4Crc_2RNA6o1m2241': [3275], '2Hfq_4Crc_2RNA_AA-synbAll': [3281], 'bases': [3282, 3715], '"A"': [3285, 3718, 3903], 'modified': [3292, 3554, 3725, 3831], 'start.6o1m2242': [3301], 'Hfq_Crc1_RNAcCrc1': [3307], 'Crc2': [3309, 3329, 3737], 'near': [3317, 3337, 3745], 'G18,': [3321, 3341, 3749], 'respectively': [3322, 3342, 3750], 'S1).6o1k1112': [3324, 3344], 'Hfq_Crc2_RNAcCrc1': [3327], 'Hfq_2Crc_RNA6o1k1122': [3347], '2Hfq_4Crc_2RNA_noHBfixdSimulations': [3350], 'done': [3352, 3641, 3755], 'HBfix': [3355, 3644, 3758, 3844], 'System': [3357, 3646, 3664, 3760, 3852], 'building': [3358, 3647, 3665, 3761, 3853], 'protocol': [3361, 3650, 3668, 3764, 3856], 'information).6o1m2241': [3364], '1Quaternary': [3366], 'simulations–modified': [3368], '2Hfq_2Crc_2RNA_G18CeIn': [3370], '"G18C",': [3371, 3427, 3483, 3564, 3769], '"circ",': [3372, 3428, 3484, 3565, 3770], '"ext",': [3373, 3429, 3485, 3566, 3771], '"I30A"': [3375, 3431, 3487, 3568, 3773], 'G18': [3378, 3434, 3490, 3571, 3776], 'replaced': [3384, 3440, 3496, 3577, 3782], 'C18,': [3386, 3442, 3498, 3579, 3784], 'chain': [3389, 3445, 3501, 3582, 3787], 'circularized': [3391, 3447, 3503, 3584, 3789], 'covalently': [3393, 3449, 3505, 3586, 3791], 'connecting': [3394, 3450, 3506, 3587, 3792], '5′-': [3396, 3452, 3508, 3589, 3794], '3′-nucleotides': [3398, 3454, 3510, 3591, 3796], 'newly': [3401, 3457, 3513, 3594, 3799], 'phosphate,': [3403, 3459, 3515, 3596, 3801], '3′-end': [3410, 3466, 3522, 3603, 3808], 'adding': [3412, 3468, 3524, 3605, 3810], 'U19': [3414, 3470, 3526, 3607, 3812], 'G20,': [3416, 3472, 3528, 3609, 3814], 'I30': [3418, 3474, 3530, 3611, 3816], 'mutated': [3420, 3476, 3532, 3613, 3818], 'alanine,': [3422, 3478, 3534, 3615, 3820], 'respectively.6o1k2222': [3423, 3479, 3535], '2Hfq_2Crc_2RNA_circeIn': [3426], '2Hfq_2Crc_2RNA_exteIn': [3482], '1Other': [3537], 'Hfq_RNA6o1k1101': [3539], '15,': [3541], 'Hfq_RNA_allGRfAll': [3545], '"R"': [3547, 3824, 3913], 'guanosines.6o1k1101': [3557], 'Hfq_RNA_I30AeIn': [3563], 'respectively.6o1k1102': [3616], 'Hfq_RNA_pol-AgA': [3619], 'circular': [3620, 3836], 'Hfq.3gib1101': [3627], '2Crc6o1k0022': [3630], '2Crc_4jg34jg30022': [3633], '4Crc6o1m0041': [3636], 'Hfq_RNA_noHBfixdSimulations': [3639], 'information).6o1k1102': [3653], 'Hfq_RNA_2×HBfixhHBfix': [3656], 'kcal/mol': [3659, 3847], 'penalty': [3660, 3848], 'information).6o1k1101': [3671], '2Crc,': [3673], 'control;': [3676, 3869], 'PDB,': [3677, 3870], 'Protein': [3678, 3871], 'Data': [3679, 3872], 'Bank.a': [3680], 'PDB': [3681], 'S1).b': [3713], 'All': [3714, 3822, 3896], 'start.c': [3734], 'Crc1': [3735], 'S1).d': [3752], 'Simulations': [3753], 'information).e': [3767], 'respectively.f': [3821], 'guanosines.g': [3834], 'Hfq.h': [3843], 'information).': [3859], 'Open': [3860], 'table': [3861], 'new': [3864], 'tab': [3865], 'Bank.': [3873], 'consists': [3881], 'trinucleotide': [3885], 'while': [3887, 4229], 'itself': [3890], '1B).': [3895], 'positions': [3902, 3932], '(includes': [3904, 3914], 'A1,': [3905, 4027], 'A4,': [3906, 4028], 'A7,': [3907, 4029], 'A10,': [3908, 4030], 'A13,': [3909, 4031], 'A16)': [3911], 'A2,': [3915], 'A5,': [3916], 'A8,': [3917], 'A11,': [3918], 'A14,': [3919], 'G17),': [3921], 'respectively,': [3922], 'identically': [3926], 'organized': [3927], 'pockets,': [3929], 'clearly': [3934], 'H-bonds,': [3937], 'base': [3938], 'stacking,': [3939], 'van': [3941], 'der': [3942], 'Waals': [3943], '(vdW)': [3944], '2A).': [3947], 'pockets': [3949], 'exhibited': [3950], 'similar': [3952], 'behavior': [3953, 4036], 'all': [3961, 4218], 'maintained': [3962], 'reversible': [3965], 'fluctuations': [3966], '(Tables': [3967], 'S1': [3968], 'S2).': [3970, 4306], 'To': [3971, 4055], 'simplify': [3972], 'descriptions,': [3973], 'will': [3975], 'collectively': [3976], 'second': [3982, 4133], 'either': [3988], 'AA': [3989, 4096, 4156, 4164, 4225, 4247, 4261, 4272, 4294], 'AR/GR,': [3991], 'lower': [3994], 'index': [3995], 'signifying': [3996], "nucleotide's": [3998], 'position': [3999], 'repeat.': [4003], 'example,': [4005], 'notation': [4006], 'Q33(N)–AA(N7)': [4007], 'describes': [4008], 'backbone': [4009, 4251], 'amide': [4010], 'nitrogen': [4011], 'residues': [4013], 'Q33': [4014], 'chains': [4019], 'H-bonds': [4021], 'N7': [4023, 4118], 'A16.': [4033], 'Wherever': [4034], 'significantly': [4037, 4288], 'differed': [4038, 4287], 'residue': [4051], 'numbering': [4052], 'distinguish': [4057], 'amino': [4059, 4110, 4138], 'acids,': [4060], 'they': [4061], 'labeled': [4063], 'accent': [4066], '(e.g.,': [4067], 'R162′).': [4068], 'change': [4073], 'nucleobases.': [4097], 'Most': [4098], 'strikingly,': [4099], 'anti-AA': [4101], 'syn-AA': [4103], 'established': [4105], 'acids.': [4111], 'Structurally,': [4112], 'possible': [4115], 'atom': [4119, 4123, 4245], 'replacing': [4120], 'N1': [4122], 'H-bond': [4126, 4144], 'acceptor': [4127], 'vice': [4129], 'versa,': [4130], 'hydrogen': [4134], 'N6': [4137], 'group': [4139], 'donor': [4145], '2).': [4147], 'There': [4148], 'single': [4152], 'water': [4153, 4170], 'bridge': [4154, 4171], 'AR,': [4158], 'solely': [4162], '3B).': [4168, 4263], 'poly-A': [4179], 'regularly': [4215], 'our': [4219], 'long': [4223], 'being': [4230], 'abolished': [4231], 'syn.': [4233], 'close': [4238], 'presumable': [4239], 'repulsive': [4240], 'contact': [4242], 'O4′': [4244], 'ribose': [4248], 'carbonyl': [4252], 'K31': [4254], 'K31(O)-AA(O4′)': [4268], 'distance': [4269], 'increased': [4270], 'when': [4271], 'flipped': [4273], 'syn,': [4275], 'relieving': [4277], 'repulsion.': [4279], 'average': [4281], 'nucleotides,': [4295], 'ranging': [4296], 'tens': [4298, 4337], 'hundreds': [4300], 'nanoseconds': [4302], '3;': [4304], 'transition': [4308, 4327], '2B)': [4314], 'stabilized': [4316], 'temporary': [4319], 'intranucleotide': [4323], 'H-bond,': [4324], 'range': [4335], 'picoseconds.': [4339], 'simulation,': [4342], 'several': [4343], 'back-and-forth': [4344], 'ob': [4348]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3153090639', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-31T07:15:43.006018', 'created_date': '2021-04-26'}