Publication Information

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786, 831, 1188], 'evolves': [216, 1267], 'erode': [219], 'immunity,': [221], 'whereas': [222, 303, 1396], 'stable': [226, 958], 'such': [227, 272, 510, 753, 942, 1087], 'vaccine': [230], 'developed': [231], 'over': [232], 'half-century': [234], 'ago': [235], 'still': [236], 'provides': [237], 'full': [238], 'protection': [239], 'against': [240], 'all': [241], 'currently': [242], 'circulating': [243], 'strains.': [245], 'One': [246], 'hypothesis': [247, 356], 'the': [250, 265, 287, 304, 338, 362, 451, 470, 502, 570, 634, 637, 674, 679, 730, 737, 747, 768, 776, 934, 947, 1003, 1061, 1069, 1072, 1118, 1196, 1206, 1277, 1372, 1385, 1476], 'proteins': [252, 267, 758], 'functionally': [258, 923], 'tolerant': [259, 278], 'mutations': [261, 514, 547, 664, 685, 755, 825, 849, 864, 920, 1091, 1116], 'others.': [263], 'Indeed,': [264], 'rapidly': [269], 'evolving': [270], 'as': [273, 872, 930, 943], 'hemagglutinin': [275, 307, 1477], 'quite': [277], 'mutations,3Doud': [280], 'M.B.': [281], 'Bloom': [282, 386, 1111, 1262], 'J.D.': [283, 1112, 1263], 'Accurate': [284], 'Measurement': [285], 'Effects': [288], 'All': [290], 'Amino-Acid': [291], 'Mutations': [292], 'Hemagglutinin.Viruses.': [295], '2016;': [296], '8:': [297, 556, 834], '8Crossref': [298], '(104)': [300], '(H)': [308], 'protein': [309, 739, 1172], 'less': [311], 'mutationally': [312], 'tolerant.4Fulton': [313], 'B.O.': [314], 'Sachs': [315], 'D.': [316, 1153], 'Beaty': [317], 'S.M.': [318], 'Won': [319], 'S.T.': [320], 'Lee': [321], 'B.': [322], 'Palese': [323], 'P.': [324, 1219], 'Heaton': [325], 'N.S.': [326], 'Mutational': [327], 'Analysis': [328], 'Measles': [330], 'Virus': [331], 'Suggests': [332], 'Constraints': [333], 'Antigenic': [335, 388], 'Variation': [336], 'Glycoproteins.Cell': [339], '2015;': [341], '11:': [342], '1331-1338Abstract': [343], '(41)': [351], 'this': [355, 1078, 1359], 'does': [357], 'not': [358], 'seem': [359], 'be': [361, 479, 956, 1084, 1345], 'whole': [363], 'story,': [364], 'since': [365], 'possible': [368], 'select': [370], 'mutants': [373], 'neutralization': [376, 517, 667, 700, 724, 745, 1236, 1465], 'individual': [378], 'monoclonal': [379, 669], 'antibodies.5Birrer': [380], 'M.J.': [381, 1261], 'Udem': [382], 'S.': [383, 385, 528, 806], 'Nathenson': [384], 'B.R.': [387], 'variants': [389, 662], 'virus.Nature.': [392], '1981;': [393], '293:': [394], '67-69Crossref': [395], '(39)': [398], 'In': [401], 'new': [403, 940, 1484], 'study,': [404], 'Muñoz-Alía': [405, 563, 582, 873, 1006, 1280, 1457], 'characteristics': [449], 'polyclonal': [452, 471, 503, 550, 702, 726, 828, 1073, 1097, 1126], 'response': [454, 473, 506, 573, 1079, 1199, 1388], 'play': [458], 'an': [459, 625, 866, 1379], 'important': [460, 928], 'role': [461], 'in': [462, 545, 568, 654, 693, 723, 764, 823, 946, 1117, 1182, 1475], 'constraining': [463], 'evolution.': [465], 'activity': [468], 'infection': [475], 'or': [476, 485, 490, 520, 846], 'vaccination': [477], 'either': [480], 'narrowly': [481, 508, 1085], 'focused': [482, 1086, 1402], 'one': [484, 1054], 'few': [487], 'immunodominant': [488, 1407], 'epitopes,': [489, 1395], 'broadly': [491], 'reactive': [492], 'codominant': [495, 579, 650, 714, 742, 772, 1394], '(Figure': [497], '1).': [498], 'For': [499], 'virus,': [501, 860], 'focused,': [509], 'single': [512, 798, 1089, 1406], 'reduce': [516], '10-fold': [519], 'more.6Lee': [521], 'J.M.': [522, 800], 'Eguia': [523, 801], 'Zost': [525, 803], 'Choudhary': [527, 805], 'Wilson': [529, 807], 'P.C.': [530, 808], 'Bedford': [531, 809], 'T.': [532, 534, 810, 812, 1215, 1229, 1253], 'Stevens-Ayers': [533, 811, 1252], 'Boeckh': [535, 813, 1260], 'M.': [536, 814, 1159, 1217, 1223, 1231], 'Hurt': [537, 815], 'A.C.': [538, 816], 'Lakdawala': [539, 817], 'S.S.': [540, 818], 'et': [541, 819, 1164, 1232, 1432, 1458], 'al.Mapping': [542, 820], 'person-to-person': [543, 821], 'variation': [544, 822], 'serum': [551, 703, 727, 829, 1464], 'targeting': [552, 671, 830, 1337], 'hemagglutinin.eLife.': [554, 832], '2019;': [555, 833], 'e49324Crossref': [557, 835], '(30)': [560, 838], 'colleagues': [565], 'show': [566, 707, 1460], 'contrast,': [569], 'Specifically,': [581], 'employ': [624], 'elegant': [626], 'series': [627], 'mutagenesis': [629], 'experiments': [630], 'ability': [635], 'H': [640, 680, 731, 738], 'glycoprotein': [641, 751], 'antibodies': [645, 670, 1168, 1336], 'They': [652, 682, 1479], 'use': [653], 'vitro': [655], 'selections': [657], 'identify': [659], 'each': [672, 687], 'eight': [675], 'protein.': [681, 732], 'then': [683], 'introduce': [684], 'these': [689, 916], 'one-by-one': [691], 'combination': [694], 'test': [696], 'how': [697], 'they': [698, 734, 963], 'affect': [699, 1123], 'antibodies.': [704], 'results': [706, 926], 'ablation': [709], 'at': [711, 1469], 'least': [712, 1470], 'five': [713, 845, 862, 1471], 'required': [717, 760], 'observe': [719], 'substantial': [721], 'decrease': [722], 'directed': [728], 'Furthermore,': [733], 'itself': [740], 'for': [743, 761, 856, 936, 1063, 1397, 1447], 'other': [748, 970, 1246], 'major': [749, 1203], '(F),': [752], 'large': [762, 791, 1094], 'drops': [763], 'neutralization.': [766], 'Thus,': [767], 'existence': [769], 'constrains': [775], 'virus.': [781, 1191], 'While': [782], 'like': [785, 1353], 'often': [788], 'gain': [789, 851], 'immune': [792], 'benefit': [794], 'via': [795], 'just': [796, 1053, 1404], 'mutation,6Lee': [799], 'may': [843, 1344], 'require': [844], 'specific': [848, 863], 'comparable': [853], 'benefit.': [854], 'Even': [855], 'mutation-prone': [858], 'acquiring': [861], 'extraordinarily': [867], 'low': [868], 'probability': [869], 'event—especially': [870], 'because,': [871], 'report,': [915], 'combinations': [917], 'highly': [922, 1401, 1487], 'deleterious.': [924], 'These': [925], 'have': [927, 964, 1093, 1444, 1453], 'implications': [929], 'we': [931, 1328], 'think': [932], 'about': [933], 'potential': [935, 1062], 'viruses,': [941], 'SARS-CoV-2.': [944], 'Early': [945], 'pandemic,': [948], 'suggested': [950], 'coronaviruses': [952, 1081], 'were': [953], 'likely': [954], '(like': [959], 'virus)': [961], 'lower': [966], 'rate': [968, 1051], 'due': [973], 'possessing': [975], 'polymerase': [977], '"proofreading"': [979], 'activity.2Sanjuán': [980], 'But': [1002, 1365], 'result': [1004], 'shows': [1048], 'factor': [1055, 1204], 'affecting': [1056], 'evolution,': [1059, 1327, 1352], 'also': [1066], 'depends': [1067], 'immunodominance': [1070], 'response.': [1076], 'Unfortunately,': [1077], 'appears': [1082], 'effects': [1095], 'neutralization7Greaney': [1099], 'A.J.': [1100], 'Loes': [1101], 'A.N.': [1102], 'Crawford': [1103, 1250], 'K.H.D.': [1104, 1251], 'Starr': [1105], 'T.N.': [1106], 'Malone': [1107], 'K.D.': [1108], 'Chu': [1109], 'H.Y.': [1110], 'Comprehensive': [1113], 'mapping': [1114], 'SARS-CoV-2': [1119, 1170], 'receptor-binding': [1120], 'domain': [1121], 'recognition': [1124], 'human': [1127, 1247, 1265], 'plasma': [1128], 'antibodies.Cell': [1129], 'Host': [1130], 'Microbe.': [1131], '29:': [1133], '463-476.e6Abstract': [1134], '(338)': [1142], 'Scholar,8Weisblum': [1144], 'Y.': [1145], 'Schmidt': [1146], 'F.': [1147, 1149, 1157, 1213], 'DaSilva': [1150], 'J.': [1151], 'Poston': [1152], 'Lorenzi': [1154], 'J.C.': [1155], 'Muecksch': [1156], 'Rutkowska': [1158], 'Hoffmann': [1160], 'H.-H.': [1161], 'Michailidis': [1162], 'E.': [1163], 'al.Escape': [1165], 'from': [1166, 1369, 1463], 'spike': [1171], 'variants.eLife.': [1173], '2020;': [1174], '9:': [1175], 'e61312Crossref': [1176], '(521)': [1179], 'manner': [1184], 'similar': [1186], 'This': [1192], 'narrow': [1193], 'focusing': [1194], 'probably': [1201], 'enabling': [1205], 'SARS-CoV-29Wibmer': [1210], 'C.K.': [1211], 'Ayres': [1212], 'Hermanus': [1214], 'Madzivhandila': [1216], 'Kgagudi': [1218], 'Lambson': [1220], 'B.E.': [1221], 'Vermeulen': [1222], 'Berg': [1224], 'K.': [1225], 'van': [1226], 'den': [1227], 'Rossouw': [1228], 'Boswell': [1230], 'al.SARS-CoV-2': [1233], '501Y.V2': [1234], 'escapes': [1235], 'South': [1238], 'African': [1239], 'COVID-19': [1240], 'donor': [1241], 'plasma.': [1242], 'bioRxiv.2021Google': [1243], 'coronaviruses.10Eguia': [1248], 'Kelnhofer-Millevolte': [1254], 'Greninger': [1256], 'A.L.': [1257], 'Englund': [1258], 'J.A.': [1259], 'A': [1264], 'coronavirus': [1266], 'bioRxiv.2020Google': [1273], 'More': [1275], 'generally,': [1276], 'suggests': [1322], 'counter': [1325], 'should': [1329], 'strive': [1330], 'develop': [1332, 1378], 'vaccines': [1333, 1443], 'elicit': [1335], 'thus': [1343], 'resistant': [1346], 'through': [1349], 'natural': [1354], 'anti-measles': [1355], 'Of': [1357], 'course,': [1358], 'easier': [1361], 'said': [1362], 'done!': [1364], 'progress': [1366], 'could': [1367], 'come': [1368], 'building': [1370], 'comparative': [1373], 'studies': [1374], 'described': [1375], 'above': [1376], 'improved': [1380], 'mechanistic': [1381], 'epitope.': [1408], 'authors': [1410], 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