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457, 1153, 1198, 1252, 1588, 1665, 2039, 2097], 'characterized': [248, 276, 1185], 'primarily': [249, 500], 'stem': [251, 1548, 1583], 'progenitor': [253, 1957], 'populations': [255], 'associated': [258, 424, 982, 1109], 'with': [259, 318, 375, 425, 494, 552, 557, 566, 580, 696, 968, 979, 983, 1045, 1110, 1129, 1230, 1430, 1601, 1738], 'canonical': [260], 'β-catenin': [261], 'mediated': [262], 'transcriptional': [263], 'regulation': [264, 289, 1789], 'nucleated': [266], 'cells.2,4–6': [267], 'In': [268, 1070], 'volume': [270, 940], 'ATVB,': [272], 'Siman-Tov': [273, 478, 600, 1102, 1156, 1271, 1330, 1641], 'et': [274, 368, 479, 601, 1103, 1272, 1331, 1837, 2068], 'al7': [275, 369, 480, 602, 1273], 'novel': [278, 1251], 'enucleated': [284, 1279], 'erythrocytes': [285, 374, 392, 591, 694, 904, 946, 1786], 'uncovered': [287], 'that': [288, 371, 640, 683, 741, 790, 1005, 1117, 1158, 1176], 'red': [292, 1324, 1735, 1765], 'blood': [293, 361, 674, 691, 733, 753, 851, 897, 915, 1078, 1088, 1116, 1182, 1325, 1409, 1736, 1766, 1791], '(RBC)': [295, 1327], 'cytoskeleton': [296, 328, 347, 935, 1375], 'erythrocyte': [298, 327, 486, 511, 561, 744, 1021, 1280, 1377, 1394, 1423, 1692], 'survival': [299, 331, 381, 469, 487, 562, 1201, 1378, 1424], 'was': [300, 492], 'controlled': [301], 'by': [302, 434, 441, 446, 515, 1003, 1101, 1186, 1270, 1329, 1340, 1586, 1689, 1743, 1764], 'noncanonical': [303, 427, 455, 505, 929, 1287, 1317, 1337], 'signals.7': [305], 'undergo': [307], 'tremendous': [308], 'strain': [309], 'when': [310, 490, 771], 'traveling': [311], 'through': [312, 902, 944, 1019, 1282], 'pressurized': [313], 'capillaries': [314], 'where': [315], 'gas': [316], 'exchange': [317], 'tissues': [319, 595], 'can': [320, 353, 791, 905, 947], 'occur.8,9': [321], 'elastic': [323], 'properties': [324, 1741], 'permit': [329], 'RBC': [330, 380, 491, 547, 555, 579, 652, 934, 995, 1137, 1152, 1200, 1374], 'strenuous': [334], 'microenvironment,': [335], 'traversing': [336], 'vessels': [337, 950, 1012], 'multiple': [339], 'diameters,': [340], 'flow': [341, 1740], 'rates,': [342], 'pressures.9': [344], 'If': [345], 'cannot': [348], 'accommodate': [349], 'elasticity,': [351], 'hemolysis': [352, 1685], 'result': [354], 'contribute': [356], 'anemias': [358], 'or': [359, 445, 853, 1031, 1041, 1075, 1445], 'other': [360], 'disorders.8See': [362], 'accompanying': [363], 'page': [366, 1453], 'e243Siman-Tov': [367], 'hypothesized': [370], 'treatment': [372, 1128], 'ligands': [377, 728, 1661], 'would': [378, 609, 917], 'improve': [379, 821], 'while': [382, 570, 937, 951], 'allowing': [383], 'for': [384, 590, 712, 719, 762, 803, 840, 1057, 1061, 1086, 1166, 1265, 1299, 1313, 1541, 1951, 1978], 'an': [388, 1211, 1261, 1982], 'adaptable': [389], 'morphology.': [390], 'Indeed,': [391, 783, 986], 'have': [393], 'previously': [395, 672], 'shown': [396], 'contain': [398], 'JNK': [399], '(c-Jun': [400], 'N-terminal': [401], 'kinase),': [402], 'Rac1': [403], '(Ras-related': [404, 1347], 'C3': [405, 1348], 'botulinum': [406, 1349], 'toxic': [407, 1350], 'substrate': [408, 1351], '1),': [409, 1352], 'RhoA': [410, 1353], '(Ras': [411, 1354], 'homolog': [412, 1355], 'family': [413, 1356], 'member': [414, 1357], 'A),': [415, 1358], 'PKC': [417, 435, 1360], '(protein': [418, 1361], 'kinase': [419, 1362], 'C),': [420], 'all': [421], 'integral': [422], 'components': [423], 'pathway.': [429, 1289], 'Specifically,': [430, 650], 'RAC': [431], 'GTPases,': [432], 'stimulated': [433], 'activation,': [436], 'physically': [437], 'increased': [438, 516, 560, 657, 663, 699, 960, 1016, 1107, 1167, 1191, 1342, 1380, 1422], 'actin': [439, 449, 452, 459, 1365], 'polymerization': [440, 1366], 'elongating': [442], 'preexisting': [443], 'filaments': [444], 'synthesizing': [447], 'new': [448], 'from': [450, 1846], 'globular': [451], 'stores.7': [453], 'Thus,': [454, 575, 814, 1236], 'induced': [458, 1742], 'polymerization,': [460], 'key': [462], 'regulator': [463], 'maintaining': [465, 571, 938], 'shape': [467], 'erythrocytes.7In': [471], 'series': [473], 'elegant': [475], 'molecular': [476], 'experiments,': [477], 'revealed': [481], 'significant': [483, 585, 837, 920, 1134], 'improvement': [484, 586, 1277], 'function': [489, 745, 768], 'incubated': [493], 'Wnt5,': [495, 1130, 1341], 'unique': [497], 'ligand': [498], 'involved': [499], 'activation': [503, 606, 931, 1315, 1334], 'pathways': [507, 2040], '(Figure).': [508], 'Enhancements': [509], 'morphology': [512], 'were': [513, 1133], 'demonstrated': [514, 559, 653, 698], 'levels': [517], 'filamentous': [519], 'actin,': [520], 'greater': [521], 'hemoglobin': [522], 'concentration,': [523], 'enlarged': [525], 'mean': [526], 'corpuscle': [527], 'volume.': [528], 'To': [529], 'determine': [530], 'whether': [531], 'these': [532], 'beneficial': [533, 1223], 'morphologies': [535], 'could': [536], 'increase': [537, 994], 'oxygen-carrying': [538], 'capacity': [539, 589, 1953], 'mature': [541, 1368, 1668], 'erythrocytes,': [542], 'group': [544], 'transfused': [545, 554], 'Wnt-activated': [546], 'into': [548, 675], 'C57BL/6J': [549], 'mice.7': [550], 'Compared': [551], 'control,': [553], 'pretreated': [556], 'Wnt5': [558, 581, 697, 1197, 1391], 'at': [563], '7-day': [564], 'postinjection': [565], 'improved': [567, 923, 1020, 1303, 1398, 1408, 1415], 'oxygen': [568, 598, 648, 655, 758, 822, 908, 954, 1017, 1123, 1381, 1399, 1762, 1781], 'delivery': [569, 763, 823, 1018, 1114, 1400], 'normal': [572], 'morphology.7': [574], 'stimulation': [576, 1284], 'circulating': [578, 1955], 'resulted': [582], 'perfuse': [593], 'ischemic': [594, 787, 835, 1842], 'deliver': [597, 907], 'systemically.Next,': [599], 'investigated': [603], 'how': [604], 'ex': [607, 1063], 'vivo': [608, 1064], 'affect': [610, 859], 'performance': [612], 'cryopreserved': [614, 673, 695, 1087, 1418], 'erythrocytes.7': [615], 'Typically,': [616], 'RBCs': [617, 718, 1006], 'stored': [619, 651], 'CPDA': [621], '(citrate': [622], 'phosphate': [623], 'dextrose-adenine)-1': [624], 'media.': [625], 'However,': [626], 'storage': [628, 702, 1065], 'buffer': [629], 'routinely': [630], 'increases': [631], 'risk': [633, 664, 686, 838, 1037, 1730], 'lesions': [635], 'membrane': [639], 'lead': [641], 'osmotic': [643], 'fragility': [644], 'impaired': [646, 1739], 'transport.': [649], 'reduced': [654, 1122, 1404], 'affinity,': [656], 'adhesions': [658], 'endothelial': [660, 1956], 'cells,': [661], 'bacterial': [666], 'contamination.10': [667], 'As': [668, 875, 1099], 'such,': [669, 876], 'transfusion': [670, 1067, 1733], 'recipients': [676], 'potential': [679, 710], 'introduce': [681], 'damage': [682, 1138], 'elevates': [684], 'deleterious': [688], 'reactions': [689], 'products.': [692], 'Interestingly,': [693], 'viability': [700], 'following': [701, 1139], 'both': [704], 'PBS': [705], 'CPDA-1,': [707], 'highlighting': [708], 'supplementation': [714], 'better': [716, 1007], 'preserve': [717, 1306], 'storage.': [720], 'Testing': [721], 'next': [723], 'generation,': [724], 'pathway-specific': [725], 'synthetic': [726], 'now': [730], 'warranted': [731], 'during': [732, 1254], 'product': [734], 'cryopreservation': [735, 1426], 'delivery.10It': [737], 'well': [739], 'established': [740, 1157], 'preservation': [743, 1112], 'extremely': [747], 'important': [748], 'vessel': [754, 898, 1183, 1188, 1410], 'homeostasis.11,12': [755], 'carry': [757], 'throughout': [759, 955], 'systemic': [760], 'vasculature': [761, 1209], 'tissues.': [765], 'This': [766, 1290, 1370], 'often-overlooked': [767], 'required': [770], 'attempting': [772], 'activate': [774, 1662], 'endogenous': [775, 1213], 'mechanisms': [776, 901, 1564], 'mitigate': [778, 1511], 'hypoxia': [779, 1002], 'tissue': [781, 984, 1226, 1405], 'ischemia.': [782], 'atherosclerosis': [784, 963, 1885], 'contributes': [785], 'cardiovascular': [788, 799, 844, 924, 1119, 1307, 1887], 'disease': [789, 800, 845, 970, 1058, 1851], 'culminate': [792], 'myocardial': [794, 1039], 'infarction': [795, 1040], 'stroke.13': [797], 'Ischemic': [798], 'responsible': [802], '≈9': [804], 'million': [805, 810], 'deaths': [806], 'globally': [807], '126': [809], 'cases': [811], 'per': [812], 'year.14': [813], 'development': [816, 842, 1026, 1301], 'translational': [818, 1508], 'techniques': [819], 'after': [824, 1425], 'surgery': [825], 'may': [826, 997, 1023, 1221, 1246, 1292], 'prove': [827, 998, 1222, 1247], 'instrumental': [828], 'reducing': [830], 'global': [832, 1848], 'incidence': [833], 'comorbidities.Another': [836], 'factor': [839], 'presence': [848], 'high': [850, 914], 'pressure': [852, 916], 'hypertension.14': [854], 'Hypertension': [855, 1866], 'estimated': [857], '≈50%': [860], 'US': [862], 'adults': [863, 1869], 'according': [864], 'National': [867], 'Health': [868], 'Nutrition': [870], 'Examination': [871], 'Survey,': [872], '2018.15': [874], 'use': [877], 'antihypertensive': [879], 'agents': [880], 'become': [882], 'increasingly': [883, 1097], 'prevalent': [884], 'clinical': [886, 1388, 1988], 'practice': [887], 'limit': [889], 'adverse': [891], 'effects': [892], 'chronic': [894], 'hypertension': [895, 965], 'health.': [899], 'Uncovering': [900], 'which': [903, 945], 'effectively': [906], 'under': [909], 'added': [911], 'stress': [912, 1612], 'represent': [918, 1162], 'step': [921], 'towards': [922], 'outcomes.': [925], 'ability': [927, 988], 'Wnt-pathway': [930], 'modulate': [933], 'adaptability': [936], 'cellular': [939], 'provides': [941, 1052], 'mechanism': [943, 1214], 'navigate': [948], 'high-pressured': [949], 'still': [952], 'delivering': [953], 'peripheral': [957, 1231, 1385], 'circulation.Additionally,': [958], 'prevalence': [961, 1867], 'patients': [967, 1044], 'metabolic': [969], 'such': [971], 'as': [972], 'obesity': [973], 'type': [975], '2': [976], 'diabetes': [977], 'brings': [978], 'it': [980], 'challenges': [981], 'perfusion.16': [985], 'flexibility': [996], 'essential': [999, 1212], 'combatting': [1001], 'ensuring': [1004], 'traverse': [1008], 'occluded': [1009], 'inflamed': [1011], 'capillaries.': [1014], 'Perhaps': [1015], 'health': [1022, 1395], 'slow': [1024], 'unstable': [1028], 'plaque': [1029], 'formation': [1030], 'thrombotic': [1032], 'release': [1033, 1168], 'reduce': [1035], 'stroke': [1042], 'advanced': [1046], 'atherosclerosis.Manipulation': [1047], 'immediate': [1053], 'benefits': [1054], 'not': [1055, 1439], 'only': [1056], 'manifestation': [1059], 'but': [1060], 'RBC.': [1069], 'individuals': [1071, 1229], 'receiving': [1072], 'emergent': [1073], 'care': [1074], 'major': [1076, 1082], 'surgery,': [1077], 'loss': [1079], 'remains': [1080], 'complication.17,18': [1083], 'demand': [1085], 'plasma': [1090], 'products': [1091], 'ensure': [1093], 'adequate': [1094], 'perfusion': [1095], 'high.': [1098], 'mentioned': [1100], 'al,7': [1104], 'there': [1105, 1132], 'hazards': [1108], 'impact': [1118], 'health,': [1120], 'affinity': [1124], 'RBCs.': [1126], 'After': [1127], 'however,': [1131], 'reductions': [1135], 'irradiation': [1140], 'transfusion.Finally,': [1142], 'discusses': [1145], 'possible': [1147], 'application': [1148], 'augmenting': [1150], 'Wnt5-mediated': [1151], 'situ.': [1155], 'monocytes': [1159], 'lymphocytes': [1161], 'vital': [1164], 'source': [1165], 'Wnt5.7': [1170], 'Monocytes': [1171], 'give': [1172], 'rise': [1173], 'macrophages': [1175], 'stimulate': [1177, 1364], 'arteriogenesis,': [1178], 'form': [1180], 'remodeling': [1184], 'collateral': [1187], 'widening': [1189], 'perfusion.19–21': [1192], 'Understanding': [1193], 'implications': [1195, 1312], 'growth': [1204], 'healthy': [1208], 'represents': [1210, 1260], 'used': [1215], 'avert': [1217], 'capillary': [1218], 'occlusion': [1219], 'mitigating': [1225], 'ischemia': [1227], 'coronary': [1233], 'artery': [1234], 'disease.': [1235], 'realization': [1238], 'active': [1240, 1783], 'Wnt-signaling': [1241], 'axis': [1242], 'circulation': [1245], 'be': [1249], 'paradigm': [1253], 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