Title: Protein S-nitrosylation: A role of nitric oxide signaling in cardiac ischemic preconditioning
Abstract: Nitric oxide (NO) has been shown as an important signaling messenger involved in cardioprotection of ischemic precondi- tioning (IPC). To date, most studies suggest that NO might provide its protective effects by regulating the mitochondrial ATP-sensitive potassium (KATP) channel via the classic NO/cGMP-dependent pathway. However, there is emerging data suggesting that NO might also elicit its physiological role through protein S-nitrosylation. Protein S-nitrosylation, the covalent attachment of an NO moiety to sulfhydryl group(s) of cysteine residue(s) of proteins, is a reversible post-translational protein modification involved in redox-based cellular signaling. IPC has been found to increase S-nitrosothiol content and result in increased S-nitrosylation of proteins, which not only induces the structural and functional changes of modified proteins, but also prevents the target cysteine residue(s) from the further oxidative modification. In addition, S-nitrosothiols could elicit pharmacological preconditioning effect and protect against myocardial ischemia-reperfusion injury. Thus, protein S-nitrosylation is emerging as an important contributor to cardioprotection in IPC, pro- viding protection from cellular oxidative and nitrosative stress.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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