Publication Information

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4002, 4072], 'FXR2P': [10, 714, 724, 738, 782, 802, 1403, 1412, 1467, 1510, 1568, 1604, 1658, 1674, 1690, 1912, 2058, 2827, 2857, 2863, 2896, 2916, 2996, 3120, 3138, 3140, 3239, 3301, 3306, 3316, 3331, 3348, 3389, 3427, 3444, 3489, 3501, 3515, 3576, 3708, 3734, 3743, 3764, 3799, 3804, 3844, 4126, 4376], 'prevents': [11, 809], 'prolonged': [12, 844, 1550, 2727], 'phase': [13, 1646, 4030, 4057, 4064], 'kainate-induced': [15, 813], 'seizures': [16, 659, 814, 846, 929, 950, 1167, 1198, 1211, 1320, 1353, 1493, 1551, 1635, 1686, 1746, 1762, 1786, 1914, 1921, 1996, 2073, 2116, 2294, 2305, 2728, 2806, 3063, 3506, 4065], 'Adrian': [17, 20, 265, 268, 515], 'C': [18, 21, 266, 269, 516, 2872], 'Lo': [19, 22, 267, 270], 'orcid.org/0000-0001-9104-5949': [23, 271], 'Department': [24, 50, 79, 100, 122, 142, 164, 199, 226, 235, 246, 272, 298, 327, 348, 370, 390, 412, 447, 474, 483, 494], 'Fundamental': [26, 81, 102, 124, 201, 228, 274, 329, 350, 372, 449, 476, 540], 'Neurosciences,': [27, 82, 103, 125, 202, 229, 275, 330, 351, 373, 450, 477, 541], 'University': [28, 83, 104, 126, 147, 169, 203, 230, 251, 276, 331, 352, 374, 395, 417, 451, 478, 499, 542, 563, 582], 'Lausanne,': [30, 31, 85, 86, 106, 107, 128, 129, 205, 206, 232, 233, 278, 279, 333, 334, 354, 355, 376, 377, 453, 454, 480, 481, 544, 545], 'SwitzerlandThese': [32, 280], 'authors': [33, 61, 281, 309], 'contributed': [34, 62, 282, 310], 'equally': [35, 63, 283, 311, 3408], 'to': [36, 64, 284, 312, 638, 641, 669, 708, 716, 757, 815, 1005, 1027, 1165, 1195, 1232, 1235, 1400, 1413, 1428, 1492, 1634, 1659, 1692, 1859, 1865, 1961, 1988, 2050, 2127, 2266, 2328, 2390, 2448, 2479, 2513, 2607, 2626, 2726, 2824, 2906, 2929, 3014, 3172, 3260, 3406, 3422, 3428, 3440, 3481, 3505, 3590, 3687, 3762, 3963, 4311, 4322], 'this': [37, 44, 65, 72, 93, 114, 136, 157, 188, 213, 263, 285, 292, 313, 320, 341, 362, 384, 405, 436, 461, 511, 790, 1314, 1803, 1822, 1990, 2515, 3702], 'work': [38, 66, 286, 314], 'Search': [39, 67, 88, 109, 131, 152, 183, 208, 258, 287, 315, 336, 357, 379, 400, 431, 456, 506], 'for': [40, 68, 89, 110, 132, 153, 184, 209, 259, 288, 316, 337, 358, 380, 401, 432, 457, 507, 690, 1047, 1051, 1190, 1297, 1391, 1602, 1747, 1871, 2357, 2952, 2963, 3028, 3087, 3089, 3129, 3252, 3277, 3447, 3525, 3796, 3826, 3900, 4234], 'more': [41, 69, 90, 111, 133, 154, 185, 210, 260, 289, 317, 338, 359, 381, 402, 433, 458, 508, 953, 971, 1080, 1788], 'papers': [42, 70, 91, 112, 134, 155, 186, 211, 261, 290, 318, 339, 360, 382, 403, 434, 459, 509], 'by': [43, 71, 92, 113, 135, 156, 187, 212, 262, 291, 319, 340, 361, 383, 404, 435, 460, 510, 763, 848, 2564, 2696, 2846, 2995, 3160, 3290, 3462, 3469, 3685, 3778, 3954, 3959, 4006, 4294], 'author': [45, 73, 94, 115, 137, 158, 189, 214, 264, 293, 321, 342, 363, 385, 406, 437, 462, 512, 636], 'Nicholas': [46, 48, 294, 296, 518], 'Rajan': [47, 49, 295, 297], 'Neurosciences': [52, 237, 300, 485, 549], 'and': [53, 145, 167, 238, 249, 301, 393, 415, 486, 497, 534, 550, 561, 580, 617, 635, 663, 681, 747, 765, 789, 808, 965, 988, 1034, 1076, 1082, 1101, 1153, 1250, 1311, 1319, 1394, 1441, 1479, 1569, 1587, 1612, 1668, 1696, 1751, 1830, 1879, 1939, 1968, 1980, 2013, 2084, 2110, 2233, 2276, 2291, 2297, 2316, 2346, 2398, 2436, 2487, 2524, 2539, 2568, 2592, 2635, 2679, 2700, 2743, 2774, 2782, 2788, 2790, 2922, 2933, 2937, 2943, 2948, 2979, 2983, 3032, 3145, 3158, 3303, 3391, 3507, 3527, 3552, 3575, 3603, 3634, 3725, 3745, 3765, 3792, 3802, 3846, 3867, 3874, 3886, 3895, 3956, 3976, 3990, 4000, 4008, 4022, 4048, 4116, 4132, 4138, 4145, 4171, 4231, 4239, 4248, 4333, 4361], 'Leuven': [54, 239, 302, 487, 551], 'Brain': [55, 240, 303, 488, 552], 'Institute,': [56, 241, 304, 489, 553], 'KU': [57, 242, 305, 490, 554], 'Leuven,': [58, 59, 243, 244, 306, 307, 491, 492, 555, 556], 'BelgiumThese': [60, 308], 'Denise': [74, 76, 322, 324, 520], 'Gastaldo': [75, 77, 323, 325], 'orcid.org/0000-0003-2714-6272': [78, 326], 'Switzerland': [87, 108, 130, 207, 234, 335, 356, 378, 455, 482, 546], 'Ludovic': [95, 97, 343, 345, 522], 'Telley': [96, 98, 344, 346], 'orcid.org/0000-0002-5041-1997': [99, 347], 'Muna': [116, 119, 364, 367, 524], 'L': [117, 120, 365, 368, 525], 'Hilal': [118, 121, 366, 369], 'Andrea': [138, 140, 386, 388, 527], 'Buzzi': [139, 141, 387, 389], 'Neuroscience': [144, 166, 392, 414, 560], 'Rehabilitation,': [146, 168, 394, 416, 562], 'Ferrara,': [149, 150, 171, 172, 397, 398, 419, 420, 565, 566], 'Italy': [151, 173, 182, 257, 399, 421, 430, 505, 567, 576, 588], 'Michele': [159, 161, 407, 409, 529], 'Simonato': [160, 162, 408, 410], 'orcid.org/0000-0002-3586-2693': [163, 411], 'Division': [174, 422], 'Neuroscience,': [176, 424, 570], 'IRCCS': [177, 425, 571], 'San': [178, 426, 572], 'Raffaele': [179, 427, 573], 'Hospital,': [180, 428, 574], 'Milan,': [181, 429, 575], 'Tilmann': [190, 194, 438, 442, 531], 'Achsel': [191, 195, 439, 443, 532], 'Corresponding': [192, 217, 440, 465], 'Author': [193, 218, 441, 466, 513], '[email': [196, 221, 223, 444, 469, 471, 595, 605, 607], 'protected]': [197, 222, 224, 445, 470, 472, 596, 608], 'orcid.org/0000-0002-1190-4481': [198, 446], 'Claudia': [215, 219, 463, 467, 535], 'Bagni': [216, 220, 464, 468, 536, 1121, 1262], 'orcid.org/0000-0002-4419-210X': [225, 473], 'Belgium': [245, 493, 557], 'Biomedicine': [248, 496, 579], 'Prevention,': [250, 498, 581], 'Rome': [253, 501, 584], '"Tor': [254, 502, 585], 'Vergata",': [255, 503, 586], 'Rome,': [256, 504, 587], 'Information': [514], 'Lo1,': [517], 'Rajan2,': [519], 'Gastaldo1,': [521], 'Telley1,': [523], 'Hilal1,': [526], 'Buzzi3,': [528], 'Simonato3,4,': [530], '*,1': [533], '*,*,1,2,5': [537], '1Department': [538], '2Department': [547], '3Department': [558], '4Division': [568], '5Department': [577], '*Corresponding': [589, 597], 'author.': [590, 598], 'Tel:': [591, 599], '+41': [592, 600], '216925268;': [593], 'E-mail:': [594], '216925120;': [601], '+39': [602], '0672596063;': [603], 'E-mails:': [604], 'protected];': [606], 'EMBO': [609], 'Reports': [610], '(2021)22:e51404https://doi.org/10.15252/embr.202051404': [611], 'PDFDownload': [612], 'PDF': [613], 'article': [615], 'text': [616], 'main': [618], 'figures.': [619], 'Peer': [620], 'ReviewDownload': [621], 'a': [622, 655, 666, 688, 742, 855, 889, 925, 996, 1002, 1295, 1368, 1457, 1512, 1546, 1558, 1575, 1607, 1670, 1814, 1850, 1895, 1908, 1937, 1942, 2028, 2038, 2079, 2085, 2146, 2189, 2241, 2724, 2894, 2904, 3067, 3170, 3423, 3497, 3565, 3606, 3648, 3689, 3713, 4071, 4109], 'summary': [623], 'the': [625, 670, 691, 737, 771, 779, 784, 810, 816, 849, 865, 877, 892, 903, 906, 959, 1006, 1019, 1028, 1067, 1126, 1137, 1169, 1208, 1223, 1269, 1274, 1291, 1348, 1375, 1386, 1409, 1418, 1432, 1454, 1464, 1470, 1500, 1507, 1543, 1563, 1572, 1599, 1631, 1639, 1644, 1660, 1664, 1693, 1701, 1748, 1767, 1775, 1791, 1797, 1840, 1876, 1882, 1899, 1952, 2010, 2014, 2031, 2055, 2076, 2130, 2136, 2159, 2167, 2197, 2203, 2211, 2214, 2222, 2271, 2386, 2529, 2573, 2578, 2670, 2705, 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[654, 862, 884, 905, 995, 1155, 1168, 1216, 1230, 1273, 1288, 1753, 1770, 1777, 1794, 2178, 2807, 3052, 3382, 3460], 'condition': [656], 'in': [657, 699, 728, 770, 827, 834, 887, 1071, 1212, 1222, 1305, 1378, 1431, 1460, 1499, 1542, 1552, 1590, 1624, 1675, 1755, 1827, 1832, 1913, 1915, 1922, 1931, 1997, 2009, 2022, 2059, 2063, 2129, 2174, 2217, 2228, 2240, 2248, 2283, 2295, 2533, 2674, 2729, 2737, 2834, 3004, 3026, 3046, 3053, 3185, 3264, 3280, 3346, 3385, 3401, 3494, 3502, 3546, 3701, 3721, 3788, 3858, 3891, 3896, 3966, 3972, 3984, 4010, 4041, 4045, 4062, 4086, 4111, 4147, 4243, 4285, 4356], 'which': [658, 1628, 1934, 2751, 2879, 3005, 3592], 'are': [660, 678, 726, 832, 841, 920, 933, 1095, 1135, 1316, 1398, 1582, 1763, 1787, 2125, 2378, 2424, 2472, 2501, 2560, 2619, 2661, 2692, 3110, 3207, 3254, 3399, 3467, 3479, 3492, 3597, 3770, 3781, 3824, 4024, 4037, 4207, 4216, 4262, 4309], 'not': [661, 682, 1531, 1684, 1831, 2263, 4101], 'self-terminating': [662], 'thereby': [664, 3604], 'pose': [665], 'serious': [667, 1003], 'threat': [668, 1004], "patient's": [671, 1007], 'life.': [672], 'The': [673, 900, 938, 1044, 1300, 1535, 1741, 2002, 2301, 2570, 2702, 3040, 3270, 3532], 'molecular': [674, 1455], 'mechanisms': [675], 'underlying': [676], 'SE': [677, 748, 948, 969, 994, 1523, 1613, 2209, 3668], 'likely': [679, 4092], 'heterogeneous': [680], 'well': [683, 1637, 3705], 'understood.': [684], 'Here,': [685, 1406], 'we': [686, 1407, 1561, 1596, 1699, 1838, 1869, 1887, 2065, 2279, 2840, 2946, 2987, 3018, 3060, 3079, 3334, 3509, 3585, 3679, 3849, 4281, 4319], 'reveal': [687], 'role': [689, 1068, 1910, 3499], 'Fragile': [694, 1170, 1178, 1270, 1276], 'X-Related': [695, 1277], 'Protein': [696, 1174, 1278, 3612], '2': [697, 1279, 2329, 2449, 2553, 2608, 2973], '(FXR2P)': [698, 1280], 'SE.': [700, 711, 1516, 1676, 3531], 'Fxr2': [701, 753, 835, 838, 1419, 1501, 1517, 1553, 1625, 2044, 2111, 2142, 2175, 2185, 2204, 2234, 2249, 2259, 2298, 2317, 2371, 2399, 2411, 2437, 2465, 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'sequencing': [718, 1023, 2849, 2934], 'associated': [720, 1566, 3112, 3529, 3666], 'mRNAs': [721, 824, 1112, 1255, 1564, 1581, 2818, 3122, 3241, 3308, 3318, 3699, 3823, 3841, 3854], 'shows': [722, 3219], 'that': [723, 730, 778, 914, 951, 1000, 1134, 1346, 1373, 1422, 1463, 1506, 1571, 1598, 1705, 1809, 1844, 1889, 2124, 2795, 2830, 2869, 2991, 3020, 3081, 3104, 3223, 3433, 3454, 3466, 3622, 3769, 3922, 4375], 'targets': [725, 1605, 3491, 3548, 3736, 3744, 3800, 3845, 4099, 4128], 'enriched': [727, 3025, 3086], 'genes': [729, 1045, 1130, 1152, 1600, 2990, 3008, 3022, 3083, 3109, 3221, 3517, 3524, 3528, 3537, 3570, 3574, 3578, 3596, 3641, 3663, 3748, 3768, 3865], 'encode': [731, 1050], 'glutamatergic': [732, 787, 806, 828, 850, 1474, 1585, 1618, 1665, 2081, 3034, 3068, 3091, 3859, 3871, 3883, 4125, 4279, 4338], 'post-synaptic': [733, 3029], 'components.': [734, 829, 3247], 'Of': [735, 3394], 'note,': [736, 3395], 'target': [739, 2897, 3121, 3302, 3307, 3390, 3402, 3516], 'transcriptome': [740, 3349], 'has': [741, 976, 1078, 1494, 1511, 1974], 'significant': [743, 1608, 3278, 3566, 3714, 4167], 'overlap': [744, 1609, 3513, 3567], 'with': [745, 1177, 1214, 1307, 1341, 1367, 1383, 1404, 1526, 1532, 1539, 1557, 1567, 1610, 1680, 1714, 1730, 1745, 1761, 1773, 1785, 1853, 1898, 1924, 1963, 1977, 1999, 2219, 2252, 2270, 2335, 2410, 2749, 2966, 3049, 3055, 3113, 3193, 3367, 3404, 3522, 3530, 3600, 3667, 3737, 3893, 4016, 4039, 4155, 4209, 4365], 'epilepsy': [746, 861, 883, 1077, 1611, 3495, 3526, 3535, 3542, 3573, 3662, 3697, 3738, 3746, 3766, 3894, 3901], 'risk': [749, 1614, 3523, 3536, 3747, 3767], 'genes.': [750, 1615], 'In': [751, 1064, 1125, 1363, 1594, 1758, 1782, 1836, 2135, 2165, 3365, 3996, 4068], 'addition,': [752, 1595, 1837, 4069], 'fail': [756], 'show': [758, 777, 1182, 2047, 3309], 'sustained': [759], 'ERK1/2': [760, 1239, 1540, 1641], 'phosphorylation': [761, 1243, 1541, 1642], 'induced': [762, 847, 1197, 2071, 4293], 'KA': [764, 2139, 2391, 2547, 2627], 'present': [766, 1778], 'burst': [768, 4359, 4362], 'activity': [769, 2157, 3932, 4355], 'hippocampus.': [772], 'Taken': [773, 1653, 3098], 'together,': [774, 1654, 3099], 'our': [775, 3100], 'findings': [776, 1906, 2793, 4036], 'absence': [780, 966, 1465], 'decreases': [783], 'expression': [785, 1471, 1622, 3945, 3987, 4003], 'proteins,': [788, 1475], 'decrease': [791], 'might': [792, 1812, 3438], 'prevent': [793], 'self-sustained': [794, 817], 'seizures.': [795, 1384, 1405, 4032], 'Synopsis': [796], 'Loss': [797], 'RNA': [799, 2842, 2848], 'binding': [800, 3332, 3425], 'reduces': [803], 'components': [804, 831], 'synapses': [807, 1586], 'transition': [811], 'status': [818, 935], 'epilepticus.': [819], 'Identification': [820, 3118], '488': [822, 2989, 3106, 3220, 3238, 3355, 3742], 'FXR2P-associated': [823], 'reveals': [825], 'enrichment': [826, 3047, 3101, 3279, 3718, 3786], 'Glutamatergic': [830], 'downregulated': [833], 'hippocampi.': [837], 'protected': [842], 'from': [843, 916, 1951, 1959, 2017, 2181, 2322, 2442, 2601, 2851, 2918, 3143, 3540], 'motor': [845, 2115, 2208], 'agonist': [851, 2082, 2088], 'kainate.': [852], 'Introduction': [853], 'With': [854, 3012], 'disease': [856, 904, 1948], 'prevalence': [857, 1209], 'about': [859, 888], '1%,': [860], 'one': [863, 1806, 3773], 'most': [866, 3010, 3024, 3085], 'common': [867], 'neurological': [868, 1302], 'disorders': [869, 1072], '(Pugliatti': [870], 'et': [871, 874, 895, 898, 945, 992, 1042, 1085, 1092, 1118, 1202, 1205, 1245, 1248, 1257, 1260, 1282, 1285, 1322, 1325, 1328, 1331, 1334, 1337, 1355, 1358, 1361, 1445, 1448, 1451, 1482, 1485, 1488, 1648, 1651, 1722, 2091, 2098, 2101, 2122, 2133, 2867, 2889, 2899, 3156, 3292, 3344, 3363, 3373, 3555, 3558, 3561, 3903, 3906, 3909, 3912, 3915, 3934, 3970, 4078, 4081, 4304], 'al,2007;': [872, 1649, 3904], 'Fiest': [873], 'al,2017).': [875, 1206, 3562], 'Despite': [876], 'availability': [878], 'many': [880, 1031], 'anti-epileptic': [881], 'drugs,': [882], 'inadequately': [885], 'controlled': [886], 'third': [890], 'cases': [893, 1366, 1713, 1729, 1760, 1784], '(Pitkänen': [894], 'al,2016;': [896, 1086, 2099], 'Devinsky': [897], 'al,2018).': [899, 1043, 2102], 'hallmark': [901], 'occurrence': [907, 3337], 'sudden,': [909], 'transient,': [910], 'recurrent': [911], 'seizure': [912, 1145, 1184, 1414, 1536, 1818, 2061, 2156, 2171, 2229, 2246, 2311, 2431, 2583, 2771, 3931], 'episodes': [913], 'result': [915], 'neuronal': [917, 980, 982, 986, 1132, 3114], 'hyperexcitability.': [918], 'Seizures': [919], 'generally': [921], 'self-limiting': [922], 'events,': [923], 'lasting': [924], 'few': [926, 1458], 'minutes.': [927], 'If': [928, 968], 'last': [930, 952, 1020], 'longer,': [931], 'they': [932], 'called': [934], '(SE).': [937], 'International': [939], 'League': [940], 'Against': [941], 'Epilepsy': [942], '(ILAE)': [943], '(Trinka': [944, 991, 1014], 'al,2015)': [946, 3157, 3971], 'defines': [947], 'as': [949, 1477, 1636, 1638, 2184, 2380, 2426, 2474, 2503, 2621, 2663, 2903, 3169, 3209, 3288, 3630, 3645, 3704, 3706, 4218, 4264, 4300], 'than': [954, 972, 1221, 3315], '5–15': [955], 'min': [956], 'depending': [957], 'on': [958, 1515, 1708, 1817, 2075, 2307, 2522, 3062, 3310, 3617, 3852, 3863, 4330, 4336], 'types': [960], '(tonic–clonic': [961], 'SE,': [962, 964, 2762, 3508], 'focal': [963], 'SE).': [967], 'lasts': [970], '60': [973], 'min,': [974], 'it': [975, 3450, 3918], 'long-term': [977], 'consequences': [978], 'injury,': [981], 'death,': [983], 'alteration': [984], 'networks,': [987], 'functional': [989], 'deficits': [990], 'al,2015).': [993, 1489], 'major': [997], 'clinical': [998, 1718], 'emergency': [999], 'poses': [1001], 'life': [1008], '(on': [1009], 'average': [1010, 3311, 3828, 4236], '20%': [1011], 'mortality': [1012], 'rate)': [1013], 'Kälviäinen,': [1016], '2017).': [1017, 3939], 'During': [1018], 'decade,': [1021], 'techniques': [1024], 'have': [1025, 1380, 1685, 1813, 2958, 3888], 'led': [1026], 'identification': [1029, 2815], 'monogenic': [1032], 'epilepsies': [1033, 1049], 'epileptic': [1035, 1166, 1892, 2168, 2293, 2837], 'encephalopathies': [1036], '(Thomas': [1037], 'Berkovic,': [1039], '2014;': [1040], 'Zhou': [1041], 'responsible': [1046], 'these': [1048, 1392, 1579, 1603, 1655, 1905, 2106, 2757, 3007, 3021, 3281, 3594, 3677, 4035, 4097, 4347], 'channel': [1052], 'receptor,': [1053], 'cell': [1054, 1056], 'migration,': [1055], 'metabolism,': [1057], 'or': [1058, 1104, 1734, 3620, 3924, 4212], 'proteins': [1060, 3610, 3652, 3856], '(RBPs)': [1061], '(Toth,': [1062], '2001).': [1063], 'recent': [1065], 'years,': [1066], 'RBPs': [1070, 1094, 1141, 3472], 'neurodevelopment,': [1074], 'neurodegeneration,': [1075], 'gained': [1079], 'interest': [1081], 'importance': [1083], '(Pernice': [1084], 'Conlon': [1087], 'Manley,': [1089], '2017;': [1090], 'Chen': [1091, 1650], 'al,2019).': [1093, 3916], 'essential': [1096], 'regulators': [1097], 'expression,': [1100], 'their': [1102, 1715], 'loss': [1103, 1163], 'mutation': [1105], 'can': [1106, 1142, 1351, 3451, 3642, 3927], 'cause': [1107], 'aberrant': [1108], 'translation': [1109, 1252, 4113], 'different': [1111, 1854, 2048, 2180, 2302, 2530, 2671, 3897, 4102], '(Achsel': [1113, 3473], 'Bagni,': [1115, 3475], '2016;': [1116], 'Hentze': [1117], 'al,': [1119, 2890], '2018;': [1120], 'Zukin,': [1123, 1264], '2019).': [1124, 1265], 'case': [1127, 2137], 'epilepsy,': [1129, 2741], 'controlling': [1131], 'excitability': [1133], 'under': [1136], 'control': [1138, 2905, 3171], 'such': [1140, 1150, 1476, 2723, 3629], 'manifestly': [1143], 'affect': [1144], 'susceptibility.': [1146, 1415], 'Fine-tuned': [1147], 'regulation': [1148], 'epilepsy-associated': [1151], 'pathways': [1154], 'therefore': [1156, 3941], 'critical.': [1157], 'A': [1158, 1724, 3418], 'prime': [1159], 'example': [1160], 'RBP': [1162, 1275], 'leading': [1164], 'X': [1171, 1179], 'Mental': [1172], 'Retardation': [1173], '(FMRP).': [1175], 'Individuals': [1176], 'syndrome': [1180], '(FXS)': [1181], 'increased': [1183, 1193, 2308], 'susceptibility': [1185, 1491, 1633, 2049, 2062, 2230, 3504], 'and,': [1186], 'likewise,': [1187], 'mouse': [1188], 'models': [1189, 2068, 3899], 'FXS': [1191, 1215], 'audiogenic': [1196], '(Berry-Kravis,': [1199, 1226], '2002;': [1200], 'Curia': [1201], 'al,2013;': [1203, 1246, 1261, 3374], 'Sethna': [1204, 1247], 'Indeed,': [1207], 'individuals': [1213, 1744], 'around': [1217], '14%,': [1218], 'significantly': [1219, 2959, 4084], 'higher': [1220, 3312, 3419], 'general': [1224], 'population': [1225], '2002).': [1227], 'This': [1228, 2225, 3710], 'difference': [1229, 2227, 3981, 4110, 4168], 'thought': [1231, 2126], 'be': [1233, 2735, 2832, 3452, 3643, 3964], 'due': [1234], 'elevated': [1236], 'levels': [1237, 1623, 3880, 4227, 4242], '(extracellular': [1240], 'kinase': [1241], '1/2)': [1242], '(Curia': [1244, 2090], 'al,2017)': [1249], 'altered': [1251, 1437], 'specific': [1254, 3251], '(Darnell': [1256, 2866], 'al,2011;': [1258, 4079], 'Fernández': [1259], 'Another': [1266], 'member': [1267], 'X-related': [1271], 'family': [1272, 2887], '(Zhang': [1281], 'al,1995;': [1283], 'Tamanini': [1284], 'al,1999).': [1286], 'FXR2': [1287, 1349, 1376, 1768, 1793, 1810, 1877, 1900, 1973, 3107, 3459, 3486], 'encoded': [1289, 3953], 'at': [1290, 1584, 1643, 2210, 3231, 4103, 4379], 'human': [1292], 'locus': [1293, 1315, 2033], '17p13.1,': [1294], 'hotspot': [1296], 'chromosomal': [1298], 'rearrangements.': [1299], 'primary': [1301], 'phenotypes': [1303], 'described': [1304, 1930, 2008, 3289, 4302], 'patients': [1306, 1679, 2036, 3892], 'de': [1308, 1342, 1369], 'novo': [1309, 1343, 1370], 'microdeletions': [1310, 1393], 'microduplications': [1312, 1345], 'intellectual': [1317, 1978], 'disability': [1318, 1979], '(Komoike': [1321], 'al,2010;': [1323, 1326], 'Schluth-Bolard': [1324], 'Belligni': [1327], 'al,2012;': [1329, 1332, 1356, 3907], 'Zeesman': [1330], 'Giordano': [1333], 'al,2014;': [1335, 1359], 'Kuroda': [1336], 'al,2014).': [1338, 3364, 4305], 'Interestingly,': [1339, 2257, 3636, 4096], 'males': [1340, 1923, 2282], '17p13.1': [1344, 1371, 1681, 1694, 1731, 1925, 2000, 2032], 'included': [1347], 'region': [1350, 1377], 'develop': [1352], '(Belligni': [1354], 'Mooneyham': [1357], 'Maini': [1360], 'al,2016).': [1362], 'contrast,': [1364, 3997], 'no': [1365, 1860, 1966, 2778], 'microdeletion': [1372, 1682, 1695, 1750, 2029], 'includes': [1374], 'men': [1379], 'been': [1381, 1496, 3889], 'reported': [1382], 'Given': [1385, 3496], 'large': [1387, 1576, 3057], 'inter-individual': [1388], 'size': [1389], 'variability': [1390], 'microduplications,': [1395, 1783], 'further': [1396, 2953, 3072, 4273], 'studies': [1397, 1459, 3478], 'needed': [1399], 'clearly': [1401], 'associate': [1402], 'investigated': [1408, 1498, 3003, 3942, 4282], 'contribution': [1410, 2056], 'We': [1416, 1504, 2819, 3001, 3563, 3861, 3940], 'used': [1417, 1839, 2066, 2820, 2902, 3168, 3586, 3761, 4320], 'model': [1421, 2739], 'displays': [1423], 'several': [1424, 1617, 3541], 'phenotypic': [1425], 'traits': [1426], 'similar': [1427], 'those': [1429], 'observed': [1430, 1717, 1825, 1888, 2613, 2736, 2797, 2836, 3061, 3787, 3890, 3983], 'Fmr1': [1433], 'model,': [1435], 'like': [1436], 'synaptic': [1438], 'plasticity,': [1439], 'hyperactivity,': [1440], 'impaired': [1442], 'learning': [1443], '(Bontekoe': [1444], 'al,2002;': [1446], 'Spencer': [1447], 'al,2006;': [1449], 'Zhang': [1450], 'al,2009).': [1452, 1723], 'At': [1453], 'level,': [1456], 'indicate': [1462], 'negatively': [1468], 'affects': [1469], 'hippocampal': [1473, 4289, 4351, 4367], 'PSD-95': [1478, 2892, 2964, 3165, 3179, 3957], 'GluA1': [1480], '(Cavallaro': [1481], 'al,2008;': [1483, 2092], 'Fernandez': [1484, 3969], 'al,2015;': [1486, 3556], 'Guo': [1487, 3557], 'However,': [1490], 'never': [1495], 'previously': [1497, 3921, 3961, 4301], 'mice.': [1503, 1555, 2224, 2856, 3979], 'found': [1505, 1570, 1597, 3080, 3384, 3564], 'lack': [1508], 'profound': [1513, 1815], 'effect': [1514, 1816, 1823, 2343, 3059], 'displayed': [1520, 2207], 'less': [1521, 1764, 2960], 'protracted': [1522], 'upon': [1524, 2546, 2686, 3071], 'treatment': [1525], 'acid': [1528], '(KA),': [1529], 'but': [1530, 4059], 'pilocarpine': [1533, 2480, 2687], 'administration.': [1534], 'severity': [1537], 'correlated': [1538], 'hippocampus,': [1544], 'suggesting': [1545, 3432, 4108], 'pathway-specific': [1547], 'protection': [1548], 'toward': [1549, 2805], 'Furthermore,': [1556, 3657], 'high-throughput': [1559], 'approach': [1560, 2823], 'identified': [1562, 2947, 2988, 3019, 3700], 'products': [1573], 'subset': [1577], 'FXR2P-bound': [1580, 2817], 'located': [1583], 'mostly': [1588], 'involved': [1589, 2833, 3493, 3857], 'glutamate': [1591, 3253], 'receptor': [1592, 2809, 3951], 'signaling.': [1593, 3860, 4095], 'coding': [1601], 'share': [1606], 'Notably,': [1616], 'receptors/proteins': [1619], 'lower': [1621, 2242, 3045, 3182, 4354], 'hippocampi,': [1627, 4013], 'may': [1629], 'explain': [1630], 'downstream': [1640], 'late': [1645, 4029, 4063], '(Nateri': [1647, 3902], 'al,2016b).': [1652], 'data': [1656], 'link': [1657], 'proper': [1661], 'functioning': [1662], 'signaling': [1666, 2811, 3092, 4076], 'pathway': [1667, 2812, 3093], 'highlight': [1669], 'possible': [1671, 1873, 1909, 3330], 'involvement': [1672, 4276], 'Results': [1677], 'Male': [1678], 'do': [1683], 'To': [1687, 2053, 2718, 3328, 3675, 4272], 'investigate': [1688, 2054, 4274], 'whether': [1689, 2722], 'contributes': [1691], 'microduplication': [1697, 1752], 'phenotype,': [1698], 'assessed': [1700], 'online': [1702], 'database': [1703, 2012, 2016, 2273, 3589, 3759], 'DECIPHER': [1704, 1932, 2011, 2272], 'contains': [1706], 'information': [1707], 'copy': [1709], 'number': [1710], 'variation': [1711], '(CNV)': [1712], 'respectively': [1716], 'symptoms': [1719], '(decipher.sanger.ac.uk)': [1720], '(Firth': [1721], 'total': [1725], '58': [1727, 1927], 'male': [1728, 1828, 2141, 2730], 'loci': [1732], 'deleted': [1733, 1771], 'duplicated': [1735], '(<': [1736], '10': [1737, 3245], 'Mb)': [1738], 'were': [1739, 1929, 2747, 2926, 2992, 3009, 3023, 3084, 3257, 3664, 4004, 4100], 'found.': [1740], 'percentage': [1742], 'categories': [1749], 'summarized': [1754], 'Figure': [1756, 1917, 1992, 2287, 2517, 3116, 3375, 3580, 3655, 3730, 4121], '1A.': [1757], 'microdeletions,': [1759], 'frequent': [1765, 1789], 'when': [1766, 1774, 1790], 'gene': [1769, 1776, 1792, 1852, 1878, 1901, 3234, 3268, 3282, 3543], 'compared': [1772, 2251, 2334, 2409, 2965, 3048, 3192, 3511, 4015, 4154, 4364], '(0%': [1779], 'versus': [1780, 1800], '10.5%).': [1781], 'part': [1795, 3646, 3771], 'duplication': [1798], '(30%': [1799], '16.7%).': [1801], 'From': [1802], 'exploratory': [1804], 'analysis,': [1805], 'could': [1807, 2734, 2831], 'speculate': [1808], 'deletion': [1811], 'manifestation,': [1819], 'even': [1820, 3042], 'if': [1821], 'was': [1824, 2237, 2858, 2901, 3141, 3167, 3538, 3615, 3760, 3919, 3982, 4083, 4292], 'only': [1826, 2280, 4060, 4335], 'individuals,': [1829], 'females': [1833, 1998, 2007], '(Figure': [1834, 1902, 2117, 2163, 2199, 2255, 2274, 2914, 2968, 2997, 3036, 3094, 3350, 3414, 3728, 3994, 4018, 4066, 4090, 4119, 4369], 'EV1).': [1835, 3000], 'Open': [1841, 1953], 'Targets': [1842], 'Platform': [1843], 'provides': [1845], 'an': [1846, 2150, 2821, 2862, 3407, 3810, 4210], 'association': [1847, 1874, 1897, 1976], 'index': [1848], 'certain': [1851], 'diseases': [1855, 1880], '(value': [1856], '0': [1857, 1960, 1964, 2193, 2325, 2445, 2604], 'equals': [1858, 1864], 'association,': [1861, 1967], 'value': [1862], '1': [1863, 1969], 'substantial': [1866], 'evidence).': [1867], 'When': [1868], 'searched': [1870], 'any': [1872, 4325], 'between': [1875, 2231, 2780, 2881, 2977, 3300, 3572, 3716, 3740, 3843, 3988, 4114, 4169], 'central': [1883], 'nervous': [1884, 1945], 'system': [1885, 1946], '(CNS),': [1886], 'early': [1890, 4056], 'infantile': [1891], 'encephalopathy': [1893], 'shares': [1894], 'considerable': [1896], '1B).': [1903], 'Altogether': [1904], 'suggest': [1907, 2794, 4374], 'humans.': [1916], '1.': [1918], 'Frequency': [1919, 1994], 'deletion/duplication': [1926, 2001], 'Males': [1928], '24': [1935], 'carried': [1936, 1941, 2027, 2037], 'microdeletion,': [1938], '34': [1940], 'microduplication.': [1943, 2039], 'Central': [1944], '(CNS)': [1947], 'associations': [1949], 'derived': [1950], 'Target': [1954], 'Platform.': [1955], 'Association': [1956, 3732], 'score': [1957, 2191, 2244, 2312, 2432, 2584, 2776, 3420], 'ranges': [1958], '1,': [1962], 'indicating': [1965, 1970], 'full': [1971], 'association.': [1972], 'highest': [1975], 'epilepsy.': [1981], 'Download': [1982, 1984, 2040, 2042, 2507, 2509, 2714, 2716, 3324, 3326, 3834, 3836, 4268, 4270], 'figure': [1983, 2041, 2508, 2715, 3325, 3835, 4269], 'PowerPoint': [1985, 2043, 2510, 2717, 3327, 3837, 4271], 'Click': [1986, 2511], 'here': [1987, 2512], 'expand': [1989, 2514], 'figure.': [1991, 2516], 'EV1.': [1993], 'analysis': [2003, 3102, 3214, 3614, 3711], 'consists': [2004], '43': [2006], 'CNV': [2015], 'center': [2018], 'Medical': [2020], 'Genetics': [2021], 'Antwerp': [2023], '(Belgium).': [2024], '23': [2025], 'Patients': [2026], 'whereas': [2034, 2152], '20': [2035, 4007], 'seizure-inducing': [2051], 'convulsants': [2052], 'regulating': [2060], 'vivo,': [2064], 'two': [2067], 'chemically': [2070], 'acute': [2072], 'based': [2074, 2306, 2521, 3616], 'administration': [2077, 2104, 2548, 2688, 3065], 'neuro-excitatory': [2080], '(KA)': [2083], 'muscarinic': [2086, 2754], 'cholinergic': [2087], '(pilocarpine)': [2089], 'Lévesque': [2093, 2097], 'Avoli,': [2095], '2013;': [2096], 'Jie': [2100], 'Upon': [2103, 2939], 'compounds,': [2107], 'both': [2108, 3815, 3998, 4053], 'WT': [2109, 2153, 2182, 2223, 2232, 2253, 2296, 2315, 2336, 2365, 2393, 2435, 2459, 2483, 2534, 2588, 2630, 2645, 2675, 2742, 2781, 2921, 2967, 2978, 3144, 3194, 3975, 3989, 4017, 4047, 4115, 4156, 4170, 4244, 4366], 'animals': [2113, 2925], '2A)': [2118], '(Racine,': [2119], '1972;': [2120], 'Janumpalli': [2121], 'al,1998)': [2123], 'originate': [2128], 'hippocampus': [2131], '(Nadler': [2132], 'al,1981).': [2134], 'administration,': [2140], 'showed': [2145, 2777, 4055, 4353], 'remarkable': [2147], 'recovery': [2148], 'within': [2149], 'hour,': [2151], 'continued': [2155], 'throughout': [2158], '2-h': [2160], 'observation': [2161, 2215], 'period': [2162], '2B).': [2164, 4067], 'fact,': [2166], 'profile': [2169], '(i.e.,': [2170], 'class': [2172, 2772], 'distribution)': [2173], 'very': [2179], 'mice,': [2183, 4051], 'had': [2188, 3181], 'Racine': [2190, 2531, 2672], 'during': [2194, 4027], '80%': [2195], 'experiment': [2198, 3724], 'EV2A).': [2200], 'None': [2201], 'end': [2212], 'period,': [2216], 'contrast': [2218], '67%': [2220], 'drastic': [2226], 'also': [2238, 3550, 3665], 'reflected': [2239], 'cumulative': [2243, 2775], 'events': [2247], '2C).': [2256], 'female': [2258, 2586, 2629, 2636], 'did': [2262], 'resistance': [2265, 2725], 'KA-induced': [2267, 3930, 4094], 'seizures,': [2268, 2770, 4058], 'coherent': [2269], 'EV2B': [2275], 'C).': [2277], 'Therefore,': [2278], 'considered': [2281, 2949, 3644], 'all': [2284, 2759, 3830], 'subsequent': [2285], 'analyses.': [2286], '2.': [2288], 'Kainic': [2289], 'acid-': [2290], 'pilocarpine-induced': [2292], 'stages': [2303], 'severity.': [2309], 'Average': [2310, 2430, 2582], 'KA-treated': [2314, 2364, 2370, 2587, 2644, 2650, 4046], 'over': [2320, 2440, 2599], 'time': [2321, 2345, 2359, 2441, 2600], 't': [2323, 2443, 2602], '=': [2324, 2349, 2352, 2368, 2375, 2396, 2404, 2418, 2444, 2456, 2462, 2469, 2485, 2492, 2498, 2537, 2544, 2554, 2590, 2597, 2603, 2633, 2642, 2648, 2655, 2677, 2684, 3190, 3197, 3818, 4152, 4159, 4179, 4182, 4186, 4193, 4200, 4246, 4252, 4259], '(injection': [2326, 2446, 2605], 'time)': [2327, 2447, 2606], 'h.': [2330, 2609], '*P': [2331, 4161], '<': [2332, 2362, 2407, 2421, 2557, 3201, 3322, 3756, 3821, 4162, 4165, 4189, 4196, 4203], '0.05': [2333], '(two-way': [2338, 2451, 2614], 'Repeated': [2339, 2452], 'Measures': [2340, 2453], 'ANOVA;': [2341], 'interaction': [2342, 3613], 'genotype;': [2347], 'F1,666': [2348], '10.05,': [2350], 'P': [2351, 2361, 2420, 2455, 2497, 2556, 3200, 3321, 3755, 4181, 4188, 4195, 4202, 4258], '0.0016;': [2353], 'post': [2354], 'hoc': [2355], 'tests': [2356], 'indicated': [2358], 'points,': [2360], '0.05).': [2363], '(n': [2367, 2374, 2461, 2468, 2484, 2491, 2589, 2596, 2647, 2654, 2676, 2683, 3189, 3196, 4151, 4158, 4245, 4251], '16),': [2369], '12).': [2376, 2405], 'Data': [2377, 2423, 2471, 2500, 2559, 2618, 2660, 2691, 3206, 4215, 4261], 'presented': [2379, 2425, 2473, 2502, 2561, 2620, 2662, 2693, 3208, 4217, 4263], 'mean': [2381, 2427, 2475, 2504, 2622, 2664, 3210, 4219, 4265], '±': [2382, 2428, 2476, 2505, 2623, 2665, 3211, 4220, 4266], 'Standard': [2383], 'Error': [2384], 'Mean': [2387], '(SEM).': [2388], 'Responsiveness': [2389, 2478, 2625], '(black,': [2394, 2535, 2631], 'n': [2395, 2403, 2536, 2543, 2632, 2641], '16)': [2397, 2538], '(magenta,': [2402, 2542], '***P': [2406, 3820], '0.001': [2408], '(two-tailed': [2414, 2494, 4174, 4255], "Student's": [2415, 2495, 2658, 3204, 4175, 4256], 't-test;': [2416], 't26': [2417], '5.72,': [2419], '0.001).': [2422, 2558, 3323, 3757, 3822], 'SEM.': [2429, 2477, 2506, 2624, 2666, 3212, 4221, 4267], 'pilocarpine-treated': [2434, 2464], 'h': [2450], 'ANOVA,': [2454], 'n.s.).': [2457, 2499, 4260], 'Pilocarpine-treated': [2458], '6),': [2463], '6).': [2470, 2493], '(PC)': [2481], '6)': [2486, 2678, 2685], 't-test,': [2496, 4257], 'EV2.': [2518], 'Seizure': [2519], 'distribution': [2520, 3296], 'convulsant': [2523], 'gender': [2525], 'Relative': [2526, 2667], 'frequency': [2527, 2668, 4360], 'scores': [2532, 2673, 3299, 3314], '12)': [2545], '(Chi-square': [2549, 2689], 'test;': [2550], 'χ': [2551], '7': [2552], '175.67,': [2555], 'boxplots': [2562, 2694], 'defined': [2563, 2695], 'median,': [2565, 2697], 'quantiles': [2566, 2698], '0.25': [2567, 2699], '0.75.': [2569, 2701], 'length': [2571, 2703], 'whiskers': [2574, 2706], 'indicates': [2575, 2707, 3274], '1.5': [2576, 2708], 'times': [2577, 2709], 'interquantile': [2579, 2711], 'range': [2580, 2712], '(IQR).': [2581, 2713], '9)': [2591, 2634, 4153], '10)': [2598], 'No': [2610, 3980], 'genotype-dependent': [2611], 'differences': [2612, 2779], 'repeated': [2615], 'measures': [2616], 'ANOVA).': [2617], '(orange,': [2640], '10).': [2643], '9),': [2649], '10;': [2656], 'two-tailed': [2657, 3203], 't-test).': [2659, 3205], 'test).': [2690], 'address': [2719], 'question': [2721], 'another': [2738], 'treated': [2748], 'pilocarpine,': [2750], 'activates': [2752], 'M1': [2753], 'receptors.': [2755], 'Under': [2756, 4346], 'conditions,': [2758, 4348], 'reached': [2761], 'irrespective': [2763], 'genotype.': [2766], 'Specifically,': [2767, 2839], 'time-lapse': [2768], 'distribution,': [2773], '(Figures': [2786], '2D': [2787], 'E,': [2789], 'EV2D).': [2791], 'These': [2792, 4372], 'protective': [2798], 'nature': [2799, 3371], 'possibly': [2808], 'and/or': [2810], 'specific.': [2813], 'Transcriptome-wide': [2814], 'unbiased': [2822], 'identify': [2825, 3329, 3483], 'brain': [2828, 3149], 'regulon': [2829], 'phenotype.': [2838], 'performed': [2841, 3680], 'immunoprecipitation': [2843, 3682], '(RIP)': [2844], 'followed': [2845, 3684], 'second-generation': [2847], '(RIP-seq)': [2850], 'forebrain': [2853], 'adult': [2855], 'efficiently': [2859], 'immunoprecipitated': [2860], 'using': [2861, 3151, 3357, 3814], 'antibody': [2864, 3154], '(1G2)': [2865], 'al,2009)': [2868], 'recognizes': [2870], 'terminus': [2873], '(a.a.': [2877], '414–658),': [2878], 'diverges': [2880], 'members': [2882], 'FMRP': [2885], '(Ferrari': [2888], '2007).': [2891], 'mRNA,': [2893, 3812, 4107], 'well-established': [2895], '(Fernandez': [2898, 3155], 'al,2015),': [2900], 'verify': [2907, 3173], 'specificity': [2909, 3175], 'RIP': [2912], 'assay': [2913], '3A).': [2915], 'RNA-IP': [2917], 'three': [2919, 4098], 'independent': [2920, 3681], 'each': [2927, 3601], 'subjected': [2928], 'amplification,': [2930], 'library': [2931], 'preparation,': [2932], '(see': [2935, 3549], 'Material': [2936, 3551], 'Methods).': [2938], 'read': [2940, 3183], 'count': [2941], 'normalization': [2942], 'threshold': [2944, 3227, 3276], 'cutoff,': [2945, 2986], '14,809': [2950, 3217], 'transcripts': [2951, 3218], 'analysis.': [2954], 'samples': [2957, 2982, 3188, 3195], 'normalized': [2961, 3258, 3825, 4233], 'reads': [2962], '3B).': [2969], 'Subsequently': [2970], 'after': [2971, 3064], '≥': [2972], 'log2': [2974, 3789, 3793], 'fold': [2975], 'change': [2976], 'appropriate': [2984], 'FDR': [2985, 3226], 'differentially': [2993], 'bound': [2994], '3C,': [2998, 3351], 'Dataset': [2999, 3038, 3096, 3520, 3582], 'then': [3002], 'ontologies': [3006, 3027, 3088], 'enriched.': [3011], 'respect': [3013, 3405], 'cellular': [3016, 3246], 'component,': [3017], 'density,': [3030], 'neurons,': [3031], 'synapse': [3035], '3D,': [3037, 3095], 'EV2).': [3039], 'latter,': [3041], 'though': [3043], 'slightly': [3044], 'others,': [3051], 'agreement': [3054], 'genotype': [3058], 'agonist.': [3069], 'Then,': [3070], 'investigating': [3073], 'biological': [3074, 3249], 'processes': [3075, 3250], 'involving': [3077], 'glutamate,': [3078], 'EV3).': [3097], 'highlights': [3103], 'candidate': [3108, 3240, 3577], 'strongly': [3111], 'excitation.': [3115], '3.': [3117], 'Schematic': [3123], 'representation': [3124], 'experimental': [3127], 'strategy': [3128], 'RIP-seq': [3131, 3723, 3777, 3790], 'pipeline.': [3132], 'Representative': [3133, 4129], 'Western': [3134, 3161, 4130], 'blot': [3135, 4131], 'showing': [3136, 4224], 'pull-down.': [3139], 'precipitated': [3142], 'extracts': [3150], '1G2': [3153], 'analyzed': [3159, 3335], 'blotting.': [3162], 'Input,': [3163], '10%.': [3164], 'mRNA': [3166, 3180, 3490, 3735, 4112, 4127, 4226, 4241], 'RIP-seq.': [3178], 'counts': [3184], '3)': [3191], '3;': [3198], '+adjusted': [3199], '0.1,': [3202], 'Enrichment': [3213], '(red)': [3222, 3801], 'pass': [3224], '(adjusted': [3228], 'P-value': [3229], 'cut-off': [3230], '0.1).': [3232], 'Left,': [3233, 3284], 'ontology': [3235], 'across': [3242], 'top': [3244], 'Right,': [3248, 3295], 'highlighted.': [3255], '−Log10q-values': [3256], 'according': [3259], 'maximum': [3262], 'q-value': [3263], 'list': [3266, 3533], 'ontologies.': [3269, 3283], 'red': [3271], 'dashed': [3272], 'line': [3273], 'FXR2P-binding': [3285, 3341, 3380, 3397], 'motif': [3286, 3381], 'sequence': [3287, 3437, 3456], 'Ray': [3291], 'al': [3293], '(2013).': [3294], 'match': [3298, 3313], 'non-target': [3304, 3317, 3392, 3412], 'mRNAs.': [3305, 3393, 3833], '(Kolmogorov–Smirnov': [3319], 'test,': [3320, 3754], 'sites,': [3333], 'putative': [3340, 3435], 'sequences': [3342, 3398], '(Ray': [3343, 3372], 'al,2013)': [3345], '3′UTR': [3352], 'targets)': [3356], 'RBPmap': [3359], 'tool': [3360], '(http://rbpmap.technion.ac.il;': [3361], 'Paz': [3362], 'accordance': [3366], 'its': [3368], 'highly': [3369], 'degenerate': [3370], '3E,': [3376, 3415], 'left': [3377], 'panel),': [3378], 'frequently': [3383], '3′UTRs': [3387, 3403, 3413], 'higher-scoring': [3396], 'overrepresented': [3400], 'sized': [3409], 'set': [3410], 'right': [3416], 'panel).': [3417], 'corresponds': [3421], 'stronger': [3424], 'respective': [3430], 'sequence,': [3431], 'consensus': [3436], 'contribute': [3439], 'recognition': [3442, 3487], 'targets.': [3445], 'As': [3446, 4033, 4306], 'other': [3448, 3602], 'RBPs,': [3449], 'hypothesized': [3453], 'domain': [3457], 'surrounded': [3461], 'additional': [3463], 'cis-acting': [3464], 'elements': [3465], 'recognized': [3468], 'other,': [3470], 'cooperating': [3471], '2016).': [3476], 'Additional': [3477], 'required': [3480], 'conclusively': [3482], 'bona-fide': [3485], 'domain/s.': [3488], 'potential': [3498], 'increasing': [3503], 'next': [3510, 3850], '(488': [3518], 'targets,': [3519], 'EV1)': [3521], 'compiled': [3539], 'databases,': [3544], 'resulting': [3545], '1,089': [3547], 'Methods;': [3553], 'Ran': [3554], 'al,2017;': [3559], 'Wang': [3560], '75': [3569, 3595, 3661, 3840], 'shared': [3571, 3640, 3842], '(15.4%,': [3579], '4A,': [3581], 'EV4).': [3583, 4371], 'Next,': [3584], 'String': [3588, 3758], 'determine': [3591], 'closely': [3598], 'interacting': [3599], 'define': [3605], 'tight': [3607, 3649], 'network': [3608, 3650, 3698], '(http://string-db.org).': [3611], 'curated': [3618], 'databases': [3619], 'literature': [3621], 'provide': [3623], 'high': [3624, 3879], 'confidence': [3625], 'inter-protein': [3627], 'actions': [3628], 'activation,': [3631], 'inhibition,': [3632], 'binding,': [3633], 'reaction.': [3635], '48%': [3637], '(36': [3653], 'targets;': [3654], '4B).': [3656], '12': [3658], 'out': [3659, 3693, 4324], '(Dataset': [3669], 'EV4)': [3670], '(Bhatnagar': [3671], 'Shorvon,': [3673], '2015).': [3674], 'validate': [3676], 'findings,': [3678], 'experiments': [3683], 'qPCR': [3686], 'detect': [3688], 'selection': [3690], 'eight': [3692, 3707, 3797, 3803], '36': [3696], 'study,': [3703], 'non-targets.': [3709], 'revealed': [3712], 'correlation': [3715, 3783], 'values': [3719], 'obtained': [3720, 4044], 'RT–qPCR': [3727, 3794], '4C).': [3729], '4.': [3731], 'Overlap': [3739], '(75': [3749], '1,089;': [3751], "Fisher's": [3752], 'exact': [3753], 'classify': [3763], 'network.': [3774], 'Validation': [3775, 4123], 'RT–qPCR.': [3779], 'Shown': [3780], '(X-axis)': [3791], '(Y-axis)': [3795], 'epilepsy-relevant': [3798], 'non-targets': [3805], '(black).': [3806], 'Each': [3807], 'point': [3808], 'represents': [3809], 'individual': [3811], 'quantified': [3813], 'methods': [3816], '(r': [3817], '0.8551,': [3819], '16': [3832], 'Among': [3838], 'epilepsy-risk': [3847], 'genes,': [3848], 'focused': [3851, 3862, 4334], 'selected': [3853], 'encoding': [3855, 3869], 'Grin2b': [3866], 'Grm5': [3868, 4230], 'receptors': [3872, 3884, 4308, 4329], 'GluN2B': [3873, 3885, 3923, 3999, 4021, 4075], 'mGluR5,': [3875, 3948], 'respectively,': [3876, 4014], 'because': [3877], 'aberrantly': [3878], 'mGluR5': [3887, 3925, 4001, 4023, 4139, 4146], 'animal': [3898], 'Das': [3905], 'Kelly': [3908], 'al,2018;': [3910, 3913], 'Egbenya': [3911], 'Lam': [3914], 'Moreover,': [3917], 'shown': [3920, 3962], 'inhibition': [3926], 'modulate': [3928], '(Chen': [3933], 'al,2016a;': [3935], 'Medina-Ceja': [3936], 'García-Barba,': [3938], 'GluN2B,': [3947, 4137, 4144], 'GluK5': [3949, 3985], '(kainate': [3950], '5,': [3952], 'Grik5),': [3955], '(encoded': [3958], 'Dlg4,': [3960, 4232], 'KO;': [3968], 'hippocampi': [3973, 3993, 4089, 4254], '5A).': [3995, 4019], '40%': [4009], 'Both': [4020], 'important': [4025], 'players': [4026], 'such,': [4034], 'consistent': [4038], 'vivo': [4042], 'results': [4043, 4373], 'where': [4052], 'groups': [4054], 'differed': [4061], 'PSD-95,': [4070, 4136, 4143], 'affecting': [4073], "(D'Mello": [4077], 'Lin': [4080], 'al,2016),': [4082], '5A),': [4091], 'buffering': [4093], 'level': [4105], '5B).': [4120], '5.': [4122], 'quantification': [4133], 'GluK5,': [4135, 4142], 'proteins.': [4140], 'Endogenous': [4141], '11).': [4160], '0.05,': [4163], '**P': [4164], '0.01,': [4166], 't-test:': [4176], 'GluK5:': [4177], 't18': [4178, 4185, 4192, 4199], '0.87,': [4180], '0.394;': [4183], 'PSD-95:': [4184], '2.29,': [4187], '0.05;': [4190], 'GluN2B:': [4191], '3.09,': [4194], '0.01;': [4197], 'mGluR5:': [4198], '3.74,': [4201], '0.01).': [4204], 'Quantified': [4205], 'bands': [4206], 'highlighted': [4208], 'asterisk': [4211], 'squared': [4213], 'bracket.': [4214], 'Bar': [4222], 'plot': [4223], 'Grin2b,': [4229], 'Vinculin': [4238], 'Gusb': [4240], '5)': [4247, 4253], 'system,': [4280], 'epileptiform': [4283, 4313], 'bursting': [4284], 'disinhibited': [4288], 'slices.': [4290], 'Bursting': [4291], 'removal': [4296], 'external': [4298], 'magnesium,': [4299], '(Gong': [4303], 'GABA': [4307, 4328], 'known': [4310], 'impact': [4312], 'bursts': [4314], '(Gafurov': [4315], 'Bausch,': [4317], '2013),': [4318], 'picrotoxin': [4321], 'rule': [4323], 'influence': [4326], 'recordings': [4332], 'output': [4339], '(Newland': [4340], 'Cull-Candy,': [4342], '1992;': [4343], 'Olsen,': [4344], '2006).': [4345], 'slices': [4352, 4368], 'terms': [4357], 'duration': [4363], 'EV3,': [4370], 'deficiency': [4377], 'alters,': [4378], 'b': [4381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3149530220', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-15T07:03:46.825977', 'created_date': '2021-04-13'}