Publication Information

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176, 205, 232], 'cyclooxygenase-2': [4], '(COX-2)expression': [5], 'level': [6], 'in': [7, 39, 121, 138, 223, 248], 'human': [8], 'HepG2,': [9, 180, 224], 'Bel-7402': [10, 225], 'and': [11, 15, 27, 34, 43, 51, 58, 94, 101, 116, 133, 141, 148, 164, 210, 220, 226, 241, 251], 'SMMC-7721hepatoma': [12], 'cell': [13, 24, 28, 55, 81, 125, 131, 228, 234, 246], 'lines': [14, 229], 'molecular': [17], 'mechanism': [18], 'of': [19, 104, 162, 179, 195, 199, 207, 244], 'COX-2': [20, 49, 114, 218], 'selective': [21], 'inhibitor': [22], 'celecoxib-induced': [23], 'growth': [25, 68, 132, 235], 'inhibition': [26], 'apoptosis.METHODS:': [29], 'Hepatoma': [30], 'cells': [31, 183], 'were': [32, 45, 61, 70, 107, 119], 'cultured': [33], 'treated': [35], 'with': [36, 158, 216, 231], 'celecoxib.': [37], 'Cell': [38, 67], 'situ': [40], 'hybridization': [41], '(ISH)': [42], 'immunocytochemistry': [44, 65], 'used': [46], 'to': [47], 'detect': [48], 'mRNA': [50, 115, 219], 'protein': [52, 117, 221], 'expression.': [53], 'Proliferating': [54], 'nuclear': [56], 'antigen': [57], 'phosphorylated': [59, 99], 'Akt': [60, 100, 200, 212], 'also': [62, 203], 'detected': [63, 120], 'by': [64, 72, 85, 109, 145, 154], 'assay.': [66, 79], 'rates': [69], 'assessed': [71], '3-(4,': [73], '5-dimethylthiazol-2-yl-2,': [74], '5-diphenyltetrazolium': [75], '(MTT)': [76], 'bromide': [77], 'colorimetric': [78], 'Celecoxibinduced': [80], 'apoptosis': [82, 243], 'was': [83, 137, 184], 'measured': [84, 153], 'terminal': [86], 'deoxynucleotidyl': [87], 'transferase-mediated': [88], 'dUTP': [89], 'nick': [90], 'end': [91], 'labeling': [92], '(TUNEL)': [93], 'flow': [95], 'cytometry': [96], '(FCM).': [97], 'The': [98], 'activated': [102], 'fragments': [103], 'caspase-9,': [105, 196], 'caspase-3': [106], 'examined': [108], 'Western': [110, 189], 'blotting': [111, 190], 'analysis.RESULTS:': [112], 'Increased': [113], 'expression': [118, 209], 'all': [122], 'three': [123], 'hepatoma': [124, 245], 'lines.': [126], 'Celecoxib': [127, 237], 'could': [128], 'significantly': [129], 'inhibit': [130, 239], 'inhibitory': [135], 'effect': [136], 'a': [139, 249], 'dose-': [140, 250], 'time-dependent': [142, 252], 'manner': [143], 'evidenced': [144], 'MTr': [146], 'assays': [147], 'morphological': [149], 'changes.The': [150], 'apoptotic': [151, 177], 'index': [152, 178], 'TUNEL': [155], 'increased': [156, 160, 233], 'correspondingly': [157], 'concentration': [161], 'celecoxib': [163, 171], 'reaction': [166], 'time.': [167], 'With': [168], '50': [169], 'μmol/L': [170], 'treatment': [172, 215], 'for': [173], '24': [174], 'h,': [175], 'BEL-7402and': [181], 'SMMC-7721': [182, 227], '25.01±3.08%,': [185], '26.40±3.05%,and': [186], '30.60±2.89%,': [187], 'respectively.': [188], 'analysis': [191], 'showed': [192, 204], 'remarkable': [193], 'activation': [194], 'caspase-3and': [197], 'dephosphorylation': [198], '(Thr308).': [201], 'Immunocytochemistry': [202], 'reduction': [206], 'PCNA': [208], 'phosphorylation': [211], '(Thr308)': [213], 'after': [214], 'celecoxib.CONCLUSION:': [217], 'overexpression': [222], 'correlate': [230], 'rate.': [236], 'can': [238], 'proliferation': [240], 'induce': [242], 'strains': [247], 'manner.': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3149411893', 'counts_by_year': [], 'updated_date': '2024-12-06T04:57:36.627555', 'created_date': '2021-04-13'}