Title: Balloon dilatation of Forley catheter in establishing a reflux esophagitis model
Abstract: Objective To explore a safe and effective way to establish reflux esophagitis model consistent with the anatomical structure.Methods Forty-five New Zealand rabbits aged 5 months were randomly divided into three groups.The rabbits undergoing lower esophageal sphincter incision were assigned to A group,those undergoing partial cardiomyectomy to B group,and those undergoing balloon dilatation by Forley catheter to C group.All the rabbits underwent esophageal fistulation before establishment of reflux esophagitis model.24hour-pH monitoring was performed to all the rabbits before and at 2weeks postoperatively.At 4 weeks postoperatively,the animals were sacrificed for histological and electron microscopic results.Results The mortality rate in B group was higher than those of the other 2groups(P=0.057).With respect to the total time ratio of pH4(%)in 24 hours,number of reflux episodes and number of reflux episodes5min,a clear trend was seen as B group C group A group;however,there were no significant differences among the 3groups.The success rates of establishing reflux esophagitis model were similar among the 3groups.For the reflux esophagitis models,moderate/severe esophagitis was more commonly-seen in B group than in the other 2groups,but showing no significant difference.Conclusion Partial cardiomyectomy is a more effective way to establish a reflux esophagitis model,but with higher mortality.Balloon dilatation is a safe and effective to establish a reflux esophagitis model,which is also more consistent with anatomical structure and suitable for research of endoscopic or other new surgeries.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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