Title: Clinical and Experimental Study on Sustained Release Tablet of Tripterygium Wilfordii in Treating Rheumatoid Arthritis
Abstract: Adopt to the prospective, multi-center, random, single-blind, equal rank-control methods, 226 patients of rheumatoid arthritis diagnosed according to the ARA criteria, were divided into 2 groups. One hundred and fourteen patients of test group were treated with sustained release tablets of Triptergium wilfordii (TW-SR) orally, 2 tablets, twice a day for 4 weeks, 112 patients of control group received tablets of Tripterygium wilfordii (TW) orally, 2 tablets 3 times per day for 4 weeks.Results showed that the total effective rate of the two groups were 92. 11 % and 90. 65%, respectively (P >0. 05).The adverse reaction rate of TW-SR group was 20. 18%, which was lowered than that of TW group (70 . 54%,P < 0 . 01 ) . Results of pre-clinical pharmacologic experimental study showed that the TW-SR has obvious anti-inflammatory,analgesia and immunosuppress'ive action as the TW has, while its toxicity was less than the latter significantly.
Publication Year: 1996
Publication Date: 1996-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot