Publication Information

{'id': 'https://openalex.org/W3143540573', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-1416.2016.07.011', 'title': 'Role of Akt/GSK-3β signaling pathway in isoflurane preconditioning-induced inhibition of mPTP opening during myocardial ischemia-reperfusion in rats', 'display_name': 'Role of Akt/GSK-3β signaling pathway in isoflurane preconditioning-induced inhibition of mPTP opening during myocardial ischemia-reperfusion in rats', 'publication_year': 2016, 'publication_date': '2016-07-20', 'ids': {'openalex': 'https://openalex.org/W3143540573', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-1416.2016.07.011', 'mag': '3143540573'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN131073201607/907643.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764665209', 'display_name': 'Zhonghua mazuixue zazhi', 'issn_l': '0254-1416', 'issn': ['0254-1416'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 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'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liuhui Chang', 'raw_affiliation_strings': ['Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China', 'institution_ids': ['https://openalex.org/I4210124971', 'https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100405587', 'display_name': 'Hong Xie', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}, 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'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoxiao Zhang', 'raw_affiliation_strings': ['Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China', 'institution_ids': ['https://openalex.org/I4210124971', 'https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075088719', 'display_name': 'Xiaoming Chai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoming Chai', 'raw_affiliation_strings': ['Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China', 'institution_ids': ['https://openalex.org/I4210124971', 'https://openalex.org/I3923682']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101892567', 'display_name': 'Jiang Zhu', 'orcid': 'https://orcid.org/0000-0003-0259-7157'}, 'institutions': [{'id': 'https://openalex.org/I4210124971', 'display_name': 'Second Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/02xjrkt08', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210124971']}, {'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiang Zhu', 'raw_affiliation_strings': ['Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Second Affiliated Hospital of Soochow University, Suzhou 215004, China', 'institution_ids': ['https://openalex.org/I4210124971', 'https://openalex.org/I3923682']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 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'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12055', 'display_name': 'Boron Compounds in Chemistry', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mptp', 'display_name': 'MPTP', 'score': 0.5630868}, {'id': 'https://openalex.org/keywords/ischemic-preconditioning', 'display_name': 'Ischemic Preconditioning', 'score': 0.49551737}], 'concepts': [{'id': 'https://openalex.org/C2776359302', 'wikidata': 'https://www.wikidata.org/wiki/Q413918', 'display_name': 'Isoflurane', 'level': 2, 'score': 0.74197114}, {'id': 'https://openalex.org/C13591479', 'wikidata': 'https://www.wikidata.org/wiki/Q6881880', 'display_name': 'Mitochondrial permeability transition pore', 'level': 4, 'score': 0.6934117}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.57051104}, {'id': 'https://openalex.org/C2778674702', 'wikidata': 'https://www.wikidata.org/wiki/Q239816', 'display_name': 'MPTP', 'level': 4, 'score': 0.5630868}, {'id': 'https://openalex.org/C2779311647', 'wikidata': 'https://www.wikidata.org/wiki/Q17148404', 'display_name': 'Ischemic preconditioning', 'level': 3, 'score': 0.49551737}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49220458}, {'id': 'https://openalex.org/C115725540', 'wikidata': 'https://www.wikidata.org/wiki/Q7846263', 'display_name': 'Troponin I', 'level': 3, 'score': 0.44670683}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4270105}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4210673}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.40743265}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.4028729}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4015535}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.38075358}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.34460175}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.2335737}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.18445814}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16485584}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN131073201607/907643.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764665209', 'display_name': 'Zhonghua mazuixue zazhi', 'issn_l': '0254-1416', 'issn': ['0254-1416'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032854751', 'https://openalex.org/W3032790828', 'https://openalex.org/W3032693003', 'https://openalex.org/W3032559922', 'https://openalex.org/W3032553919', 'https://openalex.org/W3032121034', 'https://openalex.org/W3032109628', 'https://openalex.org/W3031769436', 'https://openalex.org/W3030926098', 'https://openalex.org/W3030746861', 'https://openalex.org/W3030295302', 'https://openalex.org/W3029890259', 'https://openalex.org/W3029863729', 'https://openalex.org/W3029051187', 'https://openalex.org/W3028778539', 'https://openalex.org/W3028650351', 'https://openalex.org/W3028617000', 'https://openalex.org/W2752275381', 'https://openalex.org/W2388291660', 'https://openalex.org/W2071765466'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'evaluate': [1], 'the': [2, 66, 71, 100, 134, 158, 183, 226, 242, 254, 269, 279, 290, 300, 315, 326, 336, 346], 'role': [3], 'of': [4, 15, 65, 70, 82, 102, 125, 140, 146, 165, 182, 185, 194, 213, 229, 256, 271, 282, 292, 303, 328, 338, 349, 358, 388], 'serine-threonine': [5], 'kinase(Akt)/glycogen': [6], 'synthase': [7, 403], 'kinase-3': [8], 'beta(GSK-3β)signaling': [9], 'pathway': [10, 391], 'in': [11, 206, 258, 264, 286, 307, 330, 353, 369, 392], 'isoflurane': [12, 50, 87, 121, 375], 'preconditioning-induced': [13], 'inhibition': [14], 'mitochondrial': [16], 'permeability': [17], 'transition': [18], 'pore': [19], 'protein(mPTP)opening': [20], 'during': [21, 380], 'myocardial': [22, 103, 141, 176, 207, 221, 243, 316, 370, 381], 'ischemia-reperfusion(I/R)in': [23], 'rats.\r\n\r\n\r\nMethods\r\nNinety-six': [24], 'male': [25], 'Sprague-Dawley': [26], 'rats,': [27], 'aged': [28], '3-4': [29], 'months,': [30], 'weighing': [31], '200-250': [32], 'g,': [33], 'were': [34, 129, 136, 150, 155, 172, 178, 217, 223, 250, 323], 'randomly': [35], 'divided': [36], 'into': [37], '4': [38], 'groups(n=24': [39], 'each)using': [40], 'a': [41, 234], 'random': [42], 'number': [43], 'table:': [44], 'control': [45], 'group(group': [46, 52, 57], 'C);': [47], 'I/R': [48, 60, 104, 265], 'group;': [49], 'preconditioning': [51, 376], 'IPC);': [53], 'Akt': [54], 'inhibitor': [55], 'MK-2206': [56, 110], 'MK).': [58], 'Myocardial': [59], 'was': [61, 88, 106, 231, 262, 275, 284, 296, 305, 334, 342, 351, 367], 'induced': [62], 'by': [63, 79, 94, 373], 'occlusion': [64], 'anterior': [67], 'descending': [68], 'branch': [69], 'left': [72], 'coronary': [73], 'artery': [74], 'for': [75, 90, 138, 163, 180], '30': [76, 91, 118], 'min': [77, 92, 96, 119], 'followed': [78, 93], '2': [80, 123, 144, 211], 'h': [81, 124, 145, 212], 'reperfusion.In': [83], 'group': [84, 108, 240, 287, 308, 313, 354], 'IPC,': [85, 314], '1.5%': [86], 'inhaled': [89], '45': [95], 'washout,': [97], 'and': [98, 131, 133, 152, 175, 189, 219, 225, 246, 253, 260, 266, 278, 289, 299, 319, 332, 345], 'then': [99, 173], 'model': [101], 'injury': [105], 'established.In': [107], 'MK,': [109], '300': [111], 'μg/kg(in': [112], 'dimethyl': [113], 'sulfoxide)was': [114], 'injected': [115], 'intraperitoneally': [116], 'at': [117], 'before': [120], 'inhalation.At': [122], 'reperfusion,': [126, 147, 214], '8': [127, 148, 215], 'rats': [128, 149, 171, 216], 'selected': [130, 218], 'sacrificed,': [132, 174, 220], 'hearts': [135], 'removed': [137], 'determination': [139, 164, 181], 'infarct': [142, 244, 317], 'size.At': [143], 'selected,': [151], 'blood': [153], 'samples': [154], 'collected': [156], 'from': [157], 'right': [159], 'internal': [160], 'jugular': [161], 'vein': [162], 'serum': [166, 247, 320], 'cardiac': [167], 'troponin': [168], 'I(cTnI)': [169], 'concentrations.The': [170], 'specimens': [177], 'obtained': [179], 'expression': [184, 255, 327], 'phosphorylated': [186], 'GSK-3β(p-GSK-3β)in': [187], 'cytoplasm': [188, 259, 331], 'mitochondria(by': [190], 'Western': [191], 'blot)and': [192], 'co-expression': [193, 270, 291, 337, 357], 'p-GSK-3β': [195, 257, 272, 293, 329, 339, 359], 'with': [196, 233, 239, 273, 294, 312, 340, 360], 'adenine': [197], 'nucleotide': [198], 'translocator(ANT),': [199], 'voltage-dependent': [200, 361], 'anion': [201, 362], 'channel': [202, 363], 'or': [203, 364], 'cyclophilin': [204, 365], 'D': [205, 366], 'tissues(using': [208], 'co-immunoprecipitation).': [209], 'At': [210], 'cells': [222], 'obtained,': [224], 'opening': [227, 280, 301, 347, 379], 'time': [228, 281, 302, 348], 'mPTP': [230, 283, 304, 350, 378], 'determined': [232], 'laser': [235], 'scanning': [236], 'confocal': [237], 'microscope.\r\n\r\n\r\nResults\r\nCompared': [238], 'C,': [241], 'size': [245, 318], 'cTnI': [248, 321], 'concentrations': [249, 322], 'significantly': [251, 276, 297, 324, 343], 'increased,': [252, 325], 'mitochondria': [261, 333], 'up-regulated': [263], 'IPC': [267], 'groups,': [268], 'ANT': [274, 295, 341], 'down-regulated,': [277, 344], 'shortened': [285, 352], 'I/R,': [288], 'up-regulated,': [298, 335], 'prolonged': [306], 'IPC(P': [309], '0.05).': [310], 'Compared': [311], 'MK(P<0.05).': [355], 'No': [356], 'found': [368], 'tissues.\r\n\r\n\r\nConclusion\r\nThe': [371], 'mechanism': [372], 'which': [374], 'inhibits': [377], 'ischemia-reperfusion': [382], 'is': [383], 'partially': [384], 'related': [385], 'to': [386], 'activation': [387], 'Akt/GSK-3β': [389], 'signaling': [390], 'rats.\r\n\r\n\r\nKey': [393], 'words:': [394], '\r\nIsoflurane;\xa0Ischemic': [395], 'preconditioning;\xa0Myocardial': [396], 'reperfusion': [397], 'injury;\xa0Mitochondrial': [398], 'membrane': [399], 'transport': [400], 'proteins;\xa0Protein-serine-threonine': [401], 'kinases;\xa0Glycogen': [402], 'kinase': [404], '3': [405]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3143540573', 'counts_by_year': [], 'updated_date': '2024-12-24T06:03:47.262136', 'created_date': '2021-04-13'}