Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3143116703', 'doi': 'https://doi.org/10.3389/fendo.2021.599149', 'title': 'Androgen and Luteinizing Hormone Stimulate the Function of Rat Immature Leydig Cells Through Different Transcription Signals', 'display_name': 'Androgen and Luteinizing Hormone Stimulate the Function of Rat Immature Leydig Cells Through Different Transcription Signals', 'publication_year': 2021, 'publication_date': '2021-03-17', 'ids': {'openalex': 'https://openalex.org/W3143116703', 'doi': 'https://doi.org/10.3389/fendo.2021.599149', 'mag': '3143116703', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33815270', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8011569'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2021.599149', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2021.599149/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2021.599149/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103127180', 'display_name': 'Xiaoheng Li', 'orcid': 'https://orcid.org/0000-0003-2943-119X'}, 'institutions': [{'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoheng Li', 'raw_affiliation_strings': ["Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}, {'raw_affiliation_string': "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I27781120', 'https://openalex.org/I4210099512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068517442', 'display_name': 'Qiqi Zhu', 'orcid': 'https://orcid.org/0000-0001-8010-5707'}, 'institutions': [{'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiqi Zhu', 'raw_affiliation_strings': ["Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}, {'raw_affiliation_string': "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I27781120', 'https://openalex.org/I4210099512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101091186', 'display_name': 'Zina Wen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zina Wen', 'raw_affiliation_strings': ["Department of Andrology, Chengdu Xi'nan Gynecological Hospital, Sichuan, China", "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Andrology, Chengdu Xi'nan Gynecological Hospital, Sichuan, China", 'institution_ids': []}, {'raw_affiliation_string': "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059334149', 'display_name': 'Kaimin Yuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kaimin Yuan', 'raw_affiliation_strings': ["Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078794426', 'display_name': 'Zhijian Su', 'orcid': 'https://orcid.org/0009-0008-6946-0554'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhijian Su', 'raw_affiliation_strings': ['Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology & Guangdong Provincial Key Laboratory of Bioengineering Medicine, Jinan University, Guangzhou, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100322864', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0001-8599-7249'}, 'institutions': [{'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yiyan Wang', 'raw_affiliation_strings': ["Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101653509', 'display_name': 'Ying Zhong', 'orcid': 'https://orcid.org/0000-0002-8161-7429'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Ying Zhong', 'raw_affiliation_strings': ["Department of Andrology, Chengdu Xi'nan Gynecological Hospital, Sichuan, China"], 'affiliations': [{'raw_affiliation_string': "Department of Andrology, Chengdu Xi'nan Gynecological Hospital, Sichuan, China", 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091243949', 'display_name': 'Ren‐Shan Ge', 'orcid': 'https://orcid.org/0000-0002-3448-9823'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}, {'id': 'https://openalex.org/I4210099512', 'display_name': "Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University", 'ror': 'https://ror.org/0156rhd17', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099512']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Ren-Shan Ge', 'raw_affiliation_strings': ["Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China"], 'affiliations': [{'raw_affiliation_string': "Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I27781120', 'https://openalex.org/I4210099512']}, {'raw_affiliation_string': "Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China", 'institution_ids': ['https://openalex.org/I4210099512', 'https://openalex.org/I27781120']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5101653509', 'https://openalex.org/A5091243949'], 'corresponding_institution_ids': ['https://openalex.org/I27781120', 'https://openalex.org/I4210099512'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 3.295, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.813479, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '12', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10116', 'display_name': 'Male Reproductive Health', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10116', 'display_name': 'Male Reproductive Health', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10584', 'display_name': 'Reproductive Health in Dairy Cattle', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10364', 'display_name': 'Fertility Preservation in Cancer Patients', 'score': 0.9885, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyp17a1', 'display_name': 'CYP17A1', 'score': 0.87171245}, {'id': 'https://openalex.org/keywords/reproductive-hormones', 'display_name': 'Reproductive Hormones', 'score': 0.474983}], 'concepts': [{'id': 'https://openalex.org/C142716871', 'wikidata': 'https://www.wikidata.org/wiki/Q408305', 'display_name': 'CYP17A1', 'level': 3, 'score': 0.87171245}, {'id': 'https://openalex.org/C2777736315', 'wikidata': 'https://www.wikidata.org/wiki/Q636846', 'display_name': 'Leydig cell', 'level': 4, 'score': 0.8596375}, {'id': 'https://openalex.org/C2778575703', 'wikidata': 'https://www.wikidata.org/wiki/Q50265477', 'display_name': 'Luteinizing hormone', 'level': 3, 'score': 0.8039328}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7914308}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.78233767}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.69491076}, {'id': 'https://openalex.org/C80446465', 'wikidata': 'https://www.wikidata.org/wiki/Q412483', 'display_name': 'Cholesterol side-chain cleavage enzyme', 'level': 4, 'score': 0.58590543}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.5449246}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.51055706}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5057626}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19164574}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08594197}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.07361543}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009277', 'descriptor_name': 'Nandrolone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002786', 'descriptor_name': 'Cholesterol Side-Chain Cleavage Enzyme', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002786', 'descriptor_name': 'Cholesterol Side-Chain Cleavage Enzyme', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002786', 'descriptor_name': 'Cholesterol Side-Chain Cleavage Enzyme', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007985', 'descriptor_name': 'Leydig Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009277', 'descriptor_name': 'Nandrolone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009277', 'descriptor_name': 'Nandrolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051122', 'descriptor_name': 'Scavenger Receptors, Class B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051122', 'descriptor_name': 'Scavenger Receptors, Class B', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051122', 'descriptor_name': 'Scavenger Receptors, Class B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013254', 'descriptor_name': 'Steroid 17-alpha-Hydroxylase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2021.599149', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2021.599149/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/dcb8df07b30f4a4296773182c58845c8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8011569', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33815270', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fendo.2021.599149', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fendo.2021.599149/pdf', 'source': {'id': 'https://openalex.org/S2597401208', 'display_name': 'Frontiers in Endocrinology', 'issn_l': '1664-2392', 'issn': ['1664-2392'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': None}, {'funder': 'https://openalex.org/F4320324224', 'funder_display_name': 'Wenzhou Municipal Science and Technology Bureau', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1533422392', 'https://openalex.org/W1549886276', 'https://openalex.org/W1895530899', 'https://openalex.org/W1967203069', 'https://openalex.org/W1977053579', 'https://openalex.org/W1978013981', 'https://openalex.org/W1999100420', 'https://openalex.org/W1999976336', 'https://openalex.org/W2000024512', 'https://openalex.org/W2012490265', 'https://openalex.org/W2019006998', 'https://openalex.org/W2021334674', 'https://openalex.org/W2027215921', 'https://openalex.org/W2028728873', 'https://openalex.org/W2033527028', 'https://openalex.org/W2040081565', 'https://openalex.org/W2046375748', 'https://openalex.org/W2050765869', 'https://openalex.org/W2056604122', 'https://openalex.org/W2060146933', 'https://openalex.org/W2076978846', 'https://openalex.org/W2088323170', 'https://openalex.org/W2092653631', 'https://openalex.org/W2104801079', 'https://openalex.org/W2110378444', 'https://openalex.org/W2111329073', 'https://openalex.org/W2112555925', 'https://openalex.org/W2112819219', 'https://openalex.org/W2131727903', 'https://openalex.org/W2132987101', 'https://openalex.org/W2141337056', 'https://openalex.org/W2145820822', 'https://openalex.org/W2148120442', 'https://openalex.org/W2148733715', 'https://openalex.org/W2149618004', 'https://openalex.org/W2154927168', 'https://openalex.org/W2158202485', 'https://openalex.org/W2171630591', 'https://openalex.org/W2732818952', 'https://openalex.org/W2788859782', 'https://openalex.org/W2983892432', 'https://openalex.org/W6926059'], 'related_works': ['https://openalex.org/W799934498', 'https://openalex.org/W3153048880', 'https://openalex.org/W3111280104', 'https://openalex.org/W2997919677', 'https://openalex.org/W2899762906', 'https://openalex.org/W2612177456', 'https://openalex.org/W2292621705', 'https://openalex.org/W2090402776', 'https://openalex.org/W2023266329', 'https://openalex.org/W2004411045'], 'abstract_inverted_index': {'The': [0, 26], 'function': [1, 133, 155], 'of': [2, 20, 28, 98, 111, 121, 137, 150], 'immature': [3, 81, 152], 'Leydig': [4, 45, 82, 131, 153], 'cells': [5, 46, 83], 'is': [6, 23], 'regulated': [7], 'by': [8, 80, 125], 'hormones,': [9], 'such': [10], 'as': [11], 'androgen': [12, 62], 'and': [13, 55, 87, 89, 105, 113, 128, 144], 'luteinizing': [14, 35], 'hormone': [15, 36], '(LH).': [16], 'However,': [17], 'the': [18, 77, 96, 109, 117, 119, 148], 'regulation': [19, 149], 'this': [21, 29, 42], 'process': [22], 'still': [24], 'unclear.': [25], 'objective': [27], 'study': [30], 'was': [31, 123], 'to': [32, 41], 'determine': [33], 'whether': [34], '(LH)': [37], 'or': [38, 61, 72], 'androgens': [39, 78, 145], 'contribute': [40], 'process.': [43], 'Immature': [44], 'were': [47], 'purified': [48], 'from': [49], '35-day-old': [50], 'male': [51], 'Sprague': [52], 'Dawley': [53], 'rats': [54], 'cultured': [56], 'with': [57], 'LH': [58, 71, 94, 127, 143], '(1': [59], 'ng/ml)': [60], '(7α-methyl-19-': [63], 'nortestosterone,': [64], 'MENT,': [65], '100': [66], 'nM)': [67], 'for': [68], '2': [69], 'days.': [70], 'MENT': [73, 129], 'treatment': [74], 'significantly': [75], 'increased': [76], 'produced': [79], 'in': [84, 147], 'rats.': [85], 'Microarray': [86], 'qPCR': [88], 'enzymatic': [90], 'tests': [91], 'showed': [92], 'that': [93, 142], 'up-regulated': [95, 124], 'expression': [97, 110, 120], 'Scarb1': [99], ',': [100, 102, 104], 'Cyp11a1': [101], 'Cyp17a1': [103, 122], 'Srd5a1': [106], 'while': [107], 'down-regulated': [108], 'Sult2a1': [112], 'Akr1c14': [114], '.': [115], 'On': [116], 'contrary,': [118], 'MENT.': [126], 'regulate': [130], 'cell': [132, 154], 'through': [134, 156], 'different': [135, 157], 'sets': [136], 'transcription': [138], 'factors.': [139], 'We': [140], 'conclude': [141], 'participate': [146], 'rat': [151], 'transcriptional': [158], 'pathways.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3143116703', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 9}], 'updated_date': '2024-09-13T23:36:47.616929', 'created_date': '2021-04-13'}