Publication Information

{'id': 'https://openalex.org/W3142564810', 'doi': None, 'title': 'Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase', 'display_name': 'Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W3142564810', 'mag': '3142564810'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://www.cqvip.com/QK/85656X/201112/38613808.html', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306541197', 'display_name': '中华医学杂志：英文版', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 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'https://openalex.org/W2348764006', 'https://openalex.org/W2329198530', 'https://openalex.org/W2151948477', 'https://openalex.org/W2121254343', 'https://openalex.org/W2108740204', 'https://openalex.org/W2052410694', 'https://openalex.org/W1974757348', 'https://openalex.org/W1562836248', 'https://openalex.org/W1503890822'], 'abstract_inverted_index': {'背景': [0], 'Metformin': [1, 68, 84], '与': [2], 'type-2': [3], '糖尿病在病人的治疗成为了一块奠基石。积累的证据建议': [4], 'metformin': [5, 7, 31], '支持指导心血管的效果。如果': [6], '在主要': [8], 'cardiomyocytes': [9, 86], '上有有益的效果，试图调查的现在的学习由': [10], 'H2O2': [11, 39, 72], '损坏了，并且表明': [12], 'metformin.Methods': [13], 'Cardiomyocytes': [14], '的行动的潜在的机制面对': [15], '100': [16], 'umol/L': [17, 28, 52], '被孵化。为': [18], '12': [19], '个小时的': [20], 'H2O2。Cardiomyocytes': [21], '是有在不同集中和时间并且与': [22], 'aminoimidazole': [23], 'carboxamide': [24], 'ribonucleotide': [25], '(AICAR': [26], ')(500': [27], ')': [29, 43, 53, 63, 81], '的': [30, 32, 46, 78], 'pretreated，腺苷': [33], 'monophophate': [34], '(安培)': [35], '激活为': [36], '60': [37], '的收缩筋在': [38], '的增加前纪录的蛋白质': [40], 'kinase': [41], '(AMPK': [42], '。另外的房间是有复合': [44], 'C': [45], 'preincubated': [47], '(一个': [48], 'AMPK': [49, 75], '对手，': [50], '20': [51], '为': [54], '4': [55], '个小时。房间的生存能力和': [56], 'apoptosis': [57, 70], '被分析。AMPK，': [58], 'endothelial': [59], '氮的氧化物': [60], 'synthase': [61], '(eNOS': [62], '，和转变生长因素(TGF': [64], ')-1': [65], '用': [66], 'immunblotting.Results': [67], '被分析细胞生存能力和稀释氧化导致压力的': [69], '上的': [71], '的影响上的有的对抗效果。Metformin': [73], '也增加了': [74], '和': [76], 'eNOS': [77], 'phosphorylation，并且减少了': [79], 'TGF-1，基本成纤维细胞生长因素(bFGF': [80], '，和肿瘤坏死因素(TNF': [82], ')-.Conclusions': [83], '的表示在': [85], '上有有益的效果，并且这效果包含': [87], 'AMPK-eNOS': [88], '小径的激活。Metformin': [89], '可能为心疾病的处理是潜在地有益的。': [90]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3142564810', 'counts_by_year': [], 'updated_date': '2024-12-06T05:18:50.898221', 'created_date': '2021-04-13'}