Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3138355790', 'doi': 'https://doi.org/10.1080/13543776.2021.1903432', 'title': 'TRPV4 antagonists: a patent review (2015–2020)', 'display_name': 'TRPV4 antagonists: a patent review (2015–2020)', 'publication_year': 2021, 'publication_date': '2021-03-16', 'ids': {'openalex': 'https://openalex.org/W3138355790', 'doi': 'https://doi.org/10.1080/13543776.2021.1903432', 'mag': '3138355790', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33724130'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13543776.2021.1903432', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3784663', 'display_name': 'Expert Opinion on Therapeutic Patents', 'issn_l': '1354-3776', 'issn': ['1354-3776', '1744-7674'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005138384', 'display_name': 'Brian G. Lawhorn', 'orcid': 'https://orcid.org/0000-0003-4618-5314'}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Brian G. Lawhorn', 'raw_affiliation_strings': ['Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States'], 'affiliations': [{'raw_affiliation_string': 'Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080507784', 'display_name': 'Edward J. Brnardic', 'orcid': 'https://orcid.org/0000-0001-8304-9894'}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward J. Brnardic', 'raw_affiliation_strings': ['Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States'], 'affiliations': [{'raw_affiliation_string': 'Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083223367', 'display_name': 'David J. Behm', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David J. Behm', 'raw_affiliation_strings': ['Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States'], 'affiliations': [{'raw_affiliation_string': 'Medicinal Chemistry, Medicine Design, and Early Development Leaders, GlaxoSmithKline, Collegeville, Pennsylvania, United States', 'institution_ids': ['https://openalex.org/I4210114143']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5005138384'], 'corresponding_institution_ids': ['https://openalex.org/I4210114143'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.753, 'has_fulltext': False, 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.994859, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '31', 'issue': '9', 'first_page': '773', 'last_page': '784'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11204', 'display_name': 'Ion Channels and Receptors', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10035', 'display_name': 'Phytochemicals and Antioxidant Activities', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10473', 'display_name': 'Postharvest Quality and Shelf Life Management', 'score': 0.9649, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trpv4', 'display_name': 'TRPV4', 'score': 0.5831271}], 'concepts': [{'id': 'https://openalex.org/C155164980', 'wikidata': 'https://www.wikidata.org/wiki/Q304043', 'display_name': 'Transient receptor potential channel', 'level': 3, 'score': 0.74918973}, {'id': 'https://openalex.org/C90420996', 'wikidata': 'https://www.wikidata.org/wiki/Q15324120', 'display_name': 'TRPV4', 'level': 4, 'score': 0.5831271}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.5360945}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5214421}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.45777342}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.43588698}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3625539}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.35881984}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24844232}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.15395355}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1302304}], 'mesh': [{'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000076722', 'descriptor_name': 'Drug Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013141', 'descriptor_name': 'Spiro Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D050916', 'descriptor_name': 'TRPV Cation Channels', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055808', 'descriptor_name': 'Drug Discovery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010330', 'descriptor_name': 'Patents as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013141', 'descriptor_name': 'Spiro Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050916', 'descriptor_name': 'TRPV Cation Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050916', 'descriptor_name': 'TRPV Cation Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/13543776.2021.1903432', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3784663', 'display_name': 'Expert Opinion on Therapeutic Patents', 'issn_l': '1354-3776', 'issn': ['1354-3776', '1744-7674'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33724130', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.77, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1545384325', 'https://openalex.org/W1885303834', 'https://openalex.org/W1967539333', 'https://openalex.org/W1971826341', 'https://openalex.org/W1982443960', 'https://openalex.org/W1989186239', 'https://openalex.org/W1993371332', 'https://openalex.org/W1997882821', 'https://openalex.org/W2022253437', 'https://openalex.org/W2022262895', 'https://openalex.org/W2033842010', 'https://openalex.org/W2052875174', 'https://openalex.org/W2058298068', 'https://openalex.org/W2060385673', 'https://openalex.org/W2070056663', 'https://openalex.org/W2090592412', 'https://openalex.org/W2135722864', 'https://openalex.org/W2135741627', 'https://openalex.org/W2150070295', 'https://openalex.org/W2160875760', 'https://openalex.org/W2165344509', 'https://openalex.org/W2294819950', 'https://openalex.org/W2309813068', 'https://openalex.org/W2328403892', 'https://openalex.org/W2356785084', 'https://openalex.org/W2410997457', 'https://openalex.org/W2486606959', 'https://openalex.org/W2491911250', 'https://openalex.org/W2493793689', 'https://openalex.org/W2510110914', 'https://openalex.org/W2588711175', 'https://openalex.org/W2589923909', 'https://openalex.org/W2591790016', 'https://openalex.org/W2736827087', 'https://openalex.org/W2739938272', 'https://openalex.org/W2743463442', 'https://openalex.org/W2762452123', 'https://openalex.org/W2790336955', 'https://openalex.org/W2792199596', 'https://openalex.org/W2864018304', 'https://openalex.org/W2895532793', 'https://openalex.org/W2896397022', 'https://openalex.org/W2902348349', 'https://openalex.org/W2908883259', 'https://openalex.org/W2910252376', 'https://openalex.org/W2917689967', 'https://openalex.org/W2946960869', 'https://openalex.org/W2950316503', 'https://openalex.org/W2950863198', 'https://openalex.org/W2951809217', 'https://openalex.org/W2959340878', 'https://openalex.org/W2962665805', 'https://openalex.org/W2974815587', 'https://openalex.org/W2975356727', 'https://openalex.org/W2980339319', 'https://openalex.org/W2999744331', 'https://openalex.org/W3001039549', 'https://openalex.org/W3002301686', 'https://openalex.org/W3004721196', 'https://openalex.org/W3013962574', 'https://openalex.org/W3024695741', 'https://openalex.org/W3032806002', 'https://openalex.org/W3037412443', 'https://openalex.org/W3043919926', 'https://openalex.org/W3080716835', 'https://openalex.org/W3083285711', 'https://openalex.org/W3087402864', 'https://openalex.org/W3087528850', 'https://openalex.org/W3088112371', 'https://openalex.org/W3100040381', 'https://openalex.org/W3104358093', 'https://openalex.org/W4233595534'], 'related_works': ['https://openalex.org/W3181620686', 'https://openalex.org/W3119502049', 'https://openalex.org/W2592141234', 'https://openalex.org/W2529776329', 'https://openalex.org/W2180401043', 'https://openalex.org/W2146252487', 'https://openalex.org/W2085703491', 'https://openalex.org/W2067433745', 'https://openalex.org/W2036179916', 'https://openalex.org/W2022359639'], 'abstract_inverted_index': {'Introduction:': [0], 'Transient': [1], 'receptor': [2], 'potential': [3, 143], 'vanilloid': [4], '4': [5], '(TRPV4)': [6], 'is': [7, 12, 16, 41, 178], 'an': [8], 'ion': [9], 'channel': [10, 134], 'that': [11, 140], 'widely': [13], 'expressed': [14], 'and': [15, 22, 40, 61, 73, 93, 98, 111, 135, 186], 'activated': [17], 'by': [18], 'numerous': [19], 'chemical,': [20], 'osmotic': [21], 'mechanical': [23], 'stimuli.': [24], 'By': [25], 'modulating': [26], 'Ca2+': [27], 'entry,': [28], 'TRPV4': [29, 71, 95, 103, 117, 170], 'regulates': [30], 'cellular': [31], 'signaling': [32], 'associated': [33], 'with': [34, 129, 166], 'a': [35, 42, 108, 147], 'variety': [36, 148], 'of': [37, 44, 48, 116, 146, 149, 169, 183, 189], '(patho)physiological': [38], 'processes': [39], 'target': [43, 110], 'interest': [45], 'for': [46, 144], 'treatment': [47, 145], 'human': [49], 'diseases': [50], 'including': [51, 87], 'heart': [52], 'failure,': [53], 'respiratory': [54], 'diseases,': [55], 'gastrointestinal': [56], 'disorders,': [57], 'dermatological': [58], 'conditions,': [59], 'pain': [60], 'cancer,': [62], 'among': [63], 'others.Areas': [64], 'covered:': [65], 'This': [66], 'article': [67], 'reviews': [68], 'small': [69], 'molecule': [70], 'antagonists': [72, 118, 171], 'new': [74], 'therapeutic': [75, 190], 'use': [76], 'claims': [77], 'disclosed': [78], 'in': [79, 114, 122, 138, 160, 172], 'the': [80, 90, 133, 161, 181, 187], 'patent': [81], 'literature': [82], 'from': [83], '2015': [84], 'to': [85, 106], '2020,': [86], 'applications': [88], 'covering': [89], 'first': [91], 'potent': [92], 'selective': [94], 'clinical': [96, 153], 'candidate': [97], 'other': [99], 'advanced': [100], 'chemotypes.Expert': [101], 'opinion:': [102], 'has': [104, 119, 155], 'proven': [105], 'be': [107], 'tractable': [109], 'significant': [112], 'progress': [113], 'discovery': [115], 'been': [120, 158], 'realized': [121], 'recent': [123], 'years.': [124], 'Several': [125], 'unique': [126], 'chemical': [127], 'templates': [128], 'drug-like': [130], 'properties': [131], 'inhibit': [132], 'show': [136], 'efficacy': [137, 154], 'models': [139], 'suggest': [141], 'their': [142], 'diseases.': [150], 'While': [151], 'compelling': [152], 'not': [156], 'yet': [157], 'seen': [159], 'limited': [162], 'early': [163], 'studies': [164], 'conducted': [165], 'GSK2798745,': [167], 'evaluation': [168], 'larger': [173], 'trials': [174], 'across': [175], 'several': [176], 'indications': [177], 'warranted': [179], 'given': [180], 'availability': [182], 'high-quality': [184], 'candidates': [185], 'promise': [188], 'benefit': [191], 'based': [192], 'on': [193], 'pre-clinical': [194], 'evidence.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3138355790', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-15T14:53:40.618454', 'created_date': '2021-03-29'}