Title: Cellular and molecular mechanisms underlying radiation carcinogenesis
Abstract: When considering and analyzing experimental material concerning cellular aspects of the problem of radiation carcinogenesis, the following conclusions can be made: neoplastic transformation of cells in a culture is caused already by small radiation doses, under the effect of which the level of DNA injury is quite insignificant; the frequency of cell transformation depends on the type of radiation, it is particularly pronounced under the effect of radiations with a high linear energy transfer; a correlation between the processes of postradiation recovery and radiogenic transformation of cells is detected, nonrepairable injures of DNA playing the most important role in radiation carcinogenesis; tumour promoters and anticarcinogenic agens produce a modifying effect on the transformation of irradiated cells. Molecular mechanisms of oncogene activation are thoroughly studied using the model of virus carcinogenesis, the problem of the nature of chemical and, in particular, radiation cell transformation remains scantily investigated.
Publication Year: 1986
Publication Date: 1986-01-01
Language: en
Type: article
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