MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells

Name: Work Video:
Duration: 3 min 30 s
Yingchun Han; Jichao Zhang; Shan Huang; Naixuan Cheng; Congcong Zhang; Yulin Li; Xiaonan Wang; Jinghua Liu; Bin You; Jie Du
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3426, 3459, 3481, 3521, 3621, 3703, 4026, 4043, 4139, 4165, 4185], 'ectopic': [4, 190], 'deposition': [5, 191, 2143, 3483], 'of': [6, 17, 47, 107, 119, 128, 150, 155, 160, 170, 192, 203, 233, 293, 305, 314, 336, 341, 346, 356, 480, 493, 522, 534, 541, 555, 625, 851, 925, 934, 954, 991, 1025, 1074, 1121, 1140, 1143, 1156, 1314, 1332, 1345, 1358, 1373, 1397, 1403, 1405, 1484, 1542, 1722, 1765, 1869, 1912, 1933, 1948, 2027, 2099, 2107, 2169, 2278, 2299, 2328, 2350, 2406, 2420, 2431, 2696, 2720, 2730, 2787, 2983, 3038, 3069, 3076, 3120, 3134, 3167, 3197, 3221, 3231, 3277, 3340, 3390, 3429, 3446, 3516, 3523, 3554, 3656, 3811, 3874, 3951, 3973, 4001, 4028, 4045, 4177, 4187], 'calcium': [7, 193, 654, 1075, 1628, 2142, 2159, 3482, 3486, 3505], 'hydroxyapatite': [8, 194], 'minerals': [9, 195], 'in': [10, 50, 62, 70, 90, 99, 130, 196, 236, 248, 256, 276, 285, 316, 379, 393, 436, 487, 573, 617, 647, 682, 753, 916, 963, 968, 1130, 1145, 1176, 1214, 1297, 1316, 1329, 1385, 1435, 1492, 1551, 1603, 1644, 1685, 1866, 1916, 1935, 1945, 1979, 2024, 2041, 2069, 2090, 2171, 2215, 2252, 2265, 2323, 2347, 2417, 2444, 2468, 2546, 2597, 2745, 2750, 2762, 2783, 2798, 2821, 2856, 2912, 2927, 2938, 2957, 2995, 3005, 3013, 3041, 3072, 3138, 3171, 3246, 3267, 3298, 3317, 3348, 3354, 3369, 3392, 3413, 3441, 3448, 3469, 3490, 3507, 3577, 3598, 3762, 3813, 3833, 3876, 3900, 3914, 3953, 4003, 4006, 4025, 4071, 4147, 4184], 'arterial': [11, 197, 574, 679], 'wall,': [12, 198], 'which': [13, 199, 435, 576, 1367, 1953, 2036, 2102, 2741, 3437], 'involves': [14, 200], 'transdifferentiation': [16, 202], 'vascular': [18, 51, 75, 131, 178, 204, 237, 261, 317, 364, 460, 494, 507, 523, 546, 593, 626, 793, 838, 926, 969, 992, 1026, 1097, 1146, 1317, 1337, 1378, 1386, 1543, 1549, 1618, 1640, 1686, 1734, 1971, 2028, 2486, 2493, 2520, 2544, 2591, 2598, 2751, 2809, 2986, 2996, 3015, 3260, 3351, 3395, 3579, 3806, 3869, 3946, 4004, 4076, 4115, 4124], 'smooth': [19, 205, 627, 675, 896, 993, 1027, 1544, 1735, 2599, 3016, 3321, 3807, 3814, 3870, 3877, 3947, 3954, 4116], 'muscle': [20, 206, 628, 676, 788, 833, 897, 994, 1028, 1490, 1545, 1736, 2064, 2600, 2827, 2851, 3017, 3322, 3808, 3815, 3871, 3878, 3948, 3955, 4117], 'cells': [21, 207, 629, 677, 862, 1539, 1546, 2701, 2725, 3018, 3048, 3137, 3170, 3202, 3226, 3606, 3723, 3727, 3804, 3867, 3944], '(VSMCs)': [22, 208, 630], 'toward': [23, 209], 'an': [24, 210, 386, 3574], 'osteogenic': [25, 35, 146, 211, 221, 332, 571, 623, 935, 1236, 3453, 4068], 'phenotype.': [26, 212], 'However,': [27, 213, 928, 1137, 1309, 2237, 2935], 'underlying': [29, 215, 2625, 2674], 'molecular': [30, 216, 543], 'mechanisms': [31, 217, 544, 614], 'regulating': [32, 181, 218, 367, 545, 931, 1126, 2067, 2854, 3578], 'VSMC': [34, 184, 220, 370, 852, 1374, 3526, 3540, 3563], 'switch': [36, 147, 222, 333, 850, 936, 4069], 'remain': [37, 223], 'incompletely': [38, 224], 'understood.': [39, 225], 'In': [40, 133, 152, 226, 319, 338, 696, 1150, 2030, 2775, 3187, 4164], 'this': [41, 227, 1151, 2031, 3472], 'study,': [42, 228, 1152, 2032], 'we': [43, 113, 229, 299, 504, 1340, 2174, 2394, 2923, 3254, 3406], 'examined': [44, 230], 'roles': [46, 232, 652, 1142, 4183], 'microRNAs': [48, 234, 1123, 1907, 4002], '(miRNAs)': [49, 235, 942], 'calcification.': [52, 132, 238, 318, 1338, 1379, 1641, 1972, 2029, 2209, 2290, 2407, 2487, 2997, 3396, 3580, 3588, 4152], 'miRNA-seq': [53, 239], 'transcriptome': [54, 80, 240, 266, 1154], 'analysis': [55, 81, 241, 267, 1155, 1929, 2098, 2161, 2437, 4136], 'identified': [56, 114, 242, 300, 2619], 'miR-223-3p': [57, 108, 129, 138, 171, 243, 294, 315, 324, 357, 1040, 1163, 1173, 1234, 1315, 1346, 1819, 1856, 1934, 1941, 1968, 2020, 2033, 2091, 2108, 2170, 2181, 2279, 2386, 2397, 2746, 2817, 2984, 2993, 3022, 3052, 3121, 3128, 3258, 3272, 3302, 3311, 3391, 3400, 3447, 3476, 3524, 3537, 3555, 3572, 3590, 3897, 3912], 'as': [58, 123, 244, 309, 426, 972, 1689, 1860, 2220, 2365, 2620, 2669, 3091, 3654, 3725, 3837], 'a': [59, 124, 167, 245, 310, 353, 375, 532, 569, 632, 1392, 1442, 1723, 1965, 2022, 2197, 2399, 2612, 2621, 2991, 3024, 3054, 3337, 3387], 'candidate': [60, 246], 'miRNA': [61, 111, 247, 297, 1153, 1659, 1978, 1988, 2011], 'calcified': [63, 95, 249, 281, 1158, 1645, 3904], 'mouse': [64, 250, 1159, 1330], 'aortas.': [65, 96, 251, 282, 3905], 'MiR-223-3p': [66, 252, 1362, 2088, 2222, 2999, 3581, 3600, 3716], 'knockout': [67, 253, 1325, 2034, 2188], 'aggravated': [68, 254, 2241, 2388, 3350], 'both': [71, 91, 174, 257, 277, 360, 1333, 2150, 2281, 2389, 2404, 3584, 4072, 4148, 4161], 'medial': [72, 92, 175, 258, 278, 361, 618, 1334, 1617, 1936, 1980, 2003, 2282, 2390, 2469, 3557, 3585, 3901, 4073, 4149], 'and': [73, 84, 93, 117, 148, 176, 259, 270, 279, 303, 334, 362, 383, 406, 432, 464, 485, 529, 563, 595, 619, 655, 678, 685, 751, 804, 810, 855, 860, 1022, 1072, 1076, 1091, 1182, 1212, 1221, 1233, 1269, 1301, 1312, 1335, 1356, 1377, 1429, 1489, 1547, 1593, 1626, 1650, 1725, 1818, 1960, 1970, 1982, 1996, 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2195, 2218, 2464, 2781, 2942, 3367, 3467, 3488], 'upregulated': [89, 275, 1168, 1673, 1944, 2441, 2465, 2759, 3552], 'Overlapping': [97, 283], 'genes': [98, 106, 284, 292, 1125, 2673, 2760, 3440], 'these': [100, 286, 2969, 3381, 4157], 'with': [103, 289, 1178, 1216, 1437, 1494, 1727, 1871, 1909, 2145, 2180, 2258, 2455, 3021, 3051, 3271, 3280, 3283, 3301, 3304, 3307, 3362, 3416, 3421], 'predicted': [104, 290, 2782], 'target': [105, 126, 291, 312, 956, 1351, 2981, 2994, 3000, 3118, 3388], 'derived': [109, 295, 3603], 'from': [110, 296, 1647, 1653, 3371, 3604], 'databases,': [112, 298], 'signal': [115, 301, 1354, 3801, 3864, 3941], 'transducer': [116, 302], 'activator': [118, 304, 1357], 'transcription': [120, 306, 709, 1359], '3': [121, 307, 1360, 2670, 3029, 3059], '(STAT3)': [122, 308], 'potential': [125, 311, 2992], 'gene': [127, 313, 1353, 2624, 2797, 2982, 3119, 3389, 3454], 'vitro': [134, 320], 'experiments': [135, 321], 'showed': [136, 322, 1323, 1991, 2954, 3274], 'that': [137, 172, 323, 358, 949, 1162, 1172, 1342, 1678, 2275, 2396, 2614, 2816, 2975, 3257, 3294, 3384, 3536, 3551, 3571, 3896, 4138, 4155], 'blocked': [139, 325, 3474], 'interleukin-6': [140, 326, 1364], '(IL-6)/STAT3': [141, 327, 1365], 'signaling,': [142, 328, 1366, 2617], 'thereby': [143, 329], 'preventing': [144, 330], 'VSMCs.': [151, 337, 3268, 3599], 'contrast,': [153, 339], 'overexpression': [154, 340, 3515], 'STAT3': [156, 342, 2790, 3007, 3011, 3039, 3070, 3265, 3278, 3295, 3315, 3345, 3366, 3385, 3411, 3460, 3499, 3517, 3544, 4170], 'diminished': [157, 343], 'effect': [159, 345, 2749, 3522], 'miR-223-3p.': [161, 347, 3341, 4178], 'Taken': [162, 348, 3379, 3546], 'together,': [163, 349, 3380, 3547], 'results': [165, 351, 1963, 2273, 2973, 3382, 3534], 'indicate': [166, 352, 2274], 'protective': [168, 354], 'role': [169, 355, 1311, 2023, 2168, 3576], 'inhibits': [173, 359, 792, 837, 1835, 2818, 3538], 'by': [180, 366, 902, 1059, 1256, 1290, 1598, 1658, 1730, 1837, 2066, 2096, 2149, 2372, 2548, 2593, 2828, 2853, 2906, 2933, 3098, 3262, 3403, 3475, 3542, 3565, 3594, 3701, 3719], 'IL-6/STAT3': [182, 368, 3596, 4179], 'signaling-mediated': [183, 369], 'transdifferentiation.': [185, 371], 'characteristic': [376, 634], 'pathological': [377, 520, 635], 'change': [378, 1667], 'atherosclerosis,': [380], 'hypertension,': [381], 'diabetes': [382, 756], 'also': [385, 1863, 1943, 2953, 3502], 'independent': [387], 'risk': [388], 'factor': [389, 746], 'for': [390, 559, 653, 1370, 2200], 'all-cause': [391], 'mortality': [392], 'chronic': [394, 648, 1217, 1298, 1438, 1495, 1552, 1604, 4008, 4046], 'kidney': [395, 649, 1218, 1299, 1407, 1439, 1496, 1553, 4009, 4047], 'disease': [396, 1219, 1440], '(CKD)': [397], '(1Rogers': [398], 'M.A.': [399], 'Aikawa': [400, 1533, 1572], 'E.': [401, 719, 1465, 1534, 1571, 1821, 2553, 2572, 2660, 3981], 'Cardiovascular': [402], 'calcification:': [403], 'Artificial': [404], 'intelligence': [405], 'big': [407], 'data': [408, 2001, 3549, 3569, 3894], 'accelerate': [409], 'mechanistic': [410], 'discovery.Nat.': [411], 'Rev.': [412, 687, 4049], 'Cardiol.': [413, 1770, 3821, 3884, 3961], '2019;': [414, 2682, 2732, 3233], '16:': [415, 4052], '261-274Crossref': [416], 'PubMed': [417, 471, 513, 607, 661, 691, 762, 799, 844, 910, 1006, 1035, 1067, 1104, 1228, 1264, 1455, 1502, 1565, 1610, 1744, 1779, 1813, 1845, 1923, 2081, 2536, 2606, 2735, 2868, 2917, 3182, 3236, 3629, 3664, 3711, 3769, 3825, 3888, 3965, 4016, 4054, 4130], 'Scopus': [418, 472, 514, 608, 662, 692, 763, 800, 845, 911, 1007, 1036, 1068, 1105, 1229, 1265, 1456, 1503, 1566, 1611, 1745, 1780, 1814, 1846, 1924, 2082, 2537, 2607, 2685, 2736, 2869, 2918, 3183, 3237, 3630, 3665, 3712, 3770, 3826, 3889, 3966, 4017, 4055, 4131], '(41)': [419], 'Google': [420, 474, 516, 610, 664, 694, 765, 802, 847, 913, 1009, 1038, 1070, 1107, 1231, 1267, 1307, 1458, 1505, 1568, 1613, 1747, 1782, 1816, 1848, 1926, 2084, 2539, 2609, 2687, 2738, 2871, 2920, 3185, 3239, 3632, 3667, 3714, 3772, 3828, 3891, 3968, 4019, 4057, 4133], 'Scholar).': [421, 475, 517, 611, 695, 848, 1308, 1927, 2610, 2688, 2739, 2921, 3186, 3240, 3715, 3892, 4020, 4134], 'mainly': [424, 3602], 'manifests': [425], 'increased': [427, 1865, 1985, 2141, 3464, 3911, 4059], 'blood': [428, 2112, 3803, 3866, 3943], 'vessel': [429], 'wall': [430], 'stiffness': [431, 752], 'decreased': [433, 1989, 3275, 3504], 'compliance,': [434], 'turn': [437], 'lead': [438], 'to': [439, 579, 598, 698, 922, 938, 1095, 1293, 1349, 1391, 1615, 1682, 2017, 2165, 2184, 2202, 2205, 2403, 2411, 2485, 3409, 3721, 4063, 4173], 'cardiovascular': [440, 3622, 3834], 'events': [441], '(2Lanzer': [442], 'P.': [443, 667, 671, 878, 1087, 1575, 1890, 2896, 3750], 'Boehm': [444], 'M.': [445, 449, 737, 876, 893, 979, 1017, 1185, 1418, 1522, 1573, 1710, 1904, 2505, 2557, 2650, 2874, 2892, 3787, 3927, 4033, 4079, 4081], 'Sorribas': [446], 'V.': [447, 669, 1113, 1207, 1463, 1826, 2561, 3611, 3647, 3979], 'Thiriet': [448], 'Janzen': [450], 'J.': [451, 467, 774, 819, 996, 1193, 1272, 1278, 1479, 1498, 1512, 1798, 1892, 2058, 2507, 2555, 2845, 3685, 3785, 3925], 'Zeller': [452], 'T.': [453, 1111, 1704, 1761, 1882, 2880], 'St': [454], 'Hilaire': [455], 'C.': [456, 458, 721, 977, 1052, 1249, 1282, 1510, 1518, 1694, 2048, 2060, 2578, 2583, 2633, 2835, 2847, 3142, 3742, 3797, 3850, 3937, 4109], 'Shanahan': [457, 4106], 'Medial': [459], 'revisited:': [462], 'Review': [463], 'perspectives.Eur.': [465], 'Heart': [466], '2014;': [468, 1032, 1101, 1134, 3626, 3766, 4013], '35:': [469], '1515-1525Crossref': [470], '(362)': [473], 'With': [476], 'increasing': [478], 'prevalence': [479], 'coronary': [481, 1872, 1913], 'heart': [482], 'disease,': [483], 'diabetes,': [484], 'CKD': [486, 1179, 1648, 2120, 2445, 3974, 4031], 'aging': [489], 'population,': [490], 'harmfulness': [492], 'has': [496], 'become': [497], 'increasingly': [498], 'obvious': [499], '(3Bostrom': [500], 'K.I.': [501], 'Where': [502], 'do': [503], 'stand': [505], 'on': [506, 592, 1664, 3114], 'calcification?.Vasc.': [508], 'Pharmacol.': [509], '2016;': [510, 1557], '84:': [511], '8-14Crossref': [512], '(33)': [515], 'Unfortunately,': [518], 'mechanism': [521, 930, 1313], 'currently': [526], 'poorly': [527], 'understood,': [528], 'there': [530, 2123, 3242], 'lack': [533], 'effective': [535, 560], 'clinical': [536, 561], 'treatments.': [537], 'Therefore,': [538], 'further': [539, 1974], 'investigation': [540], 'could': [548], 'have': [549, 1679, 2009, 2037, 2481, 2814, 3909], 'great': [550], 'significance,': [551], 'enabling': [552], 'discovery': [554], 'novel': [556, 1382], 'therapeutic': [557], 'targets': [558, 4176], 'prevention': [562], 'treatment': [564], 'strategies.': [565], 'regulated': [570, 903, 2414], 'process': [572, 636, 933], 'tissue,': [575, 2101], 'similar': [578], 'bone': [580, 599, 1302], 'development': [581, 2026], '(4Chen': [582], 'Y.': [583, 723, 768, 786, 813, 831, 870, 1044, 1241, 1280, 1473, 1581, 1692, 1706, 1714, 1794, 1884, 2050, 2515, 2709, 2713, 2837, 2876, 2882, 2884, 2890, 3210, 3214, 3791, 3848, 3931], 'Zhao': [584, 1791, 1795, 1887], 'X.': [585, 776, 821, 887, 1048, 1245, 1286, 1471, 1477, 1708, 1718, 1894, 2056, 2843, 3639, 3789, 3929], 'Wu': [586, 3157, 3678, 3782, 3922], 'H.': [587, 1203, 1475, 1514, 1786, 1898, 2888, 3651, 3691, 3854], 'Arterial': [588, 645, 1592], 'stiffness:': [589], 'A': [590], 'Focus': [591], 'its': [596, 1350], 'Link': [597], 'Mineralization.Arterioscler.': [600], 'Thromb.': [601, 1738], 'Vasc.': [602, 1739], 'Biol.': [603, 1740, 1809, 2071, 2858, 3660], '2020;': [604, 1771, 2073, 2860, 4051, 4127], '40:': [605], '1078-1093Crossref': [606], '(20)': [609, 3713], 'Although': [612], 'different': [613, 2010], 'are': [615, 943, 1319, 1540, 2363, 3089, 3438, 4145, 4171], 'involved': [616, 967, 1384, 1684, 2744, 2761, 3347, 4146], 'calcification,': [621, 970, 1387, 1687, 1981, 2173, 2393, 2810], 'transformation': [624], 'common': [633, 2402], '(5Shanahan': [637], 'C.M.': [638, 644, 1422, 4107], 'Crouthamel': [639], 'M.H.': [640], 'Kapustin': [641], 'A.': [642, 739, 780, 825, 1119, 2574, 2581, 2703, 3204, 3992, 4039, 4086], 'Giachelli': [643, 1421], 'disease:': [650], 'Key': [651], 'phosphate.Circ.': [656], 'Res.': [657, 758, 795, 840, 906, 2532, 4126], '2011;': [658, 998, 1499], '109:': [659], '697-711Crossref': [660], '(566)': [663], 'Scholar,': [665, 766, 1459, 1506, 1569, 2872], '6Lacolley': [666], 'Regnault': [668], 'Segers': [670], 'Laurent': [672], 'S.': [673, 731, 1042, 1191, 1239, 1526, 1532, 1753, 1755, 1792, 1878, 1902, 2052, 2565, 2631, 2638, 2644, 2658, 2711, 2839, 2898, 3212, 3748, 3779, 3795, 3840, 3919, 3935, 3990, 4035, 4037], 'stiffening:': [680], 'Relevance': [681], 'development,': [683], 'aging,': [684], 'disease.Physiol.': [686], '2017;': [688, 1225, 1304, 1810, 2914, 3179], '97:': [689], '1555-1617Crossref': [690], '(229)': [693], 'response': [697], 'cytokines,': [699], 'oxidized': [700], 'lipids,': [701], 'or': [702, 1990, 2232, 2267, 2961, 3023, 3053, 3324], 'high': [703, 1443, 2105], 'phosphorus': [704], 'levels,': [705], 'VSMCs': [706, 2547, 2698, 2722, 3199, 3223, 3269, 3281, 3299, 3393, 3414, 3442, 3449, 3466, 3492, 3775], 'express': [707], 'osteoblast-specific': [708, 3439], 'factors': [710], '(e.g.,': [711, 807], 'Runx2,': [712, 3436], 'Osterix)': [713], '(7Raaz': [714], 'U.': [715, 983, 4101], 'Schellinger': [716], 'I.N.': [717], 'Chernogubova': [718], 'Warnecke': [720], 'Kayama': [722], 'Penov': [724], 'K.': [725, 772, 782, 817, 827, 889, 1054, 1205, 1251, 1528, 2705, 2707, 3206, 3208], 'Hennigs': [726], 'J.K.': [727], 'Salomons': [728], 'F.': [729, 741, 1284, 1702, 2563, 2648, 3144, 3608, 3729, 3976], 'Eken': [730], 'Emrich': [732], 'F.C.': [733], 'Zheng': [734, 869, 1045, 1242], 'W.H.': [735], 'Adam': [736], 'Jagger': [738], 'Nakagami': [740], 'Toh': [742], 'R.': [743, 885, 1508, 1591, 1796, 2640], 'et': [744, 894, 1905, 2584, 2661, 4110], 'al.Transcription': [745], 'Runx2': [747], 'promotes': [748, 1288, 2062, 2288, 2849], 'aortic': [749, 1433, 1594, 1627, 2158, 2627, 2676, 3320], 'Fibrosis': [750], 'type': [754], '2': [755], 'Mellitus.Circ.': [757], '2015;': [759, 907, 1842, 1920, 3822, 3885, 3962], '117:': [760], '513-524Crossref': [761], '(57)': [764], '8Sun': [767], 'Byon': [769, 814], 'C.H.': [770, 815], 'Yuan': [771, 816], 'Chen': [773, 785, 818, 830, 1014, 3686, 3692], 'Mao': [775, 820], 'Heath': [777, 822], 'J.M.': [778, 823], 'Javed': [779, 824], 'Zhang': [781, 826, 1016, 1275, 1703, 1889, 2059, 2846, 2895, 3676, 3680, 3684, 3796, 3936], 'Anderson': [783, 828], 'P.G.': [784, 829], 'Smooth': [787, 832], 'cell-specific': [789, 834], 'runx2': [790, 835], 'deficiency': [791, 836, 1602, 2089, 2223, 2387, 3582], 'calcification.Circ.': [794, 839, 4125], '2012;': [796, 841, 1447, 1741, 2603], '111:': [797, 842], '543-552Crossref': [798, 843], '(181)': [801, 846], 'Scholar),': [803, 1010, 1039, 1108, 1232, 1614, 1748, 1783, 1817, 2540, 3668, 3829, 4058], 'differentiation': [805, 974, 1024, 1058, 1237, 1255, 1376, 2695, 2719, 3196, 3220, 3637, 3673, 3700], 'markers': [806], 'Osteopontin,': [808], 'Osteocalcin': [809], 'Alp)': [811], '(8Sun': [812], 'Osteogenic': [849], 'accelerates': [853], 'calcium-': [854], 'phosphorus-rich': [856], 'matrix': [857], 'vesicles': [858], 'releasing': [859], 'apoptotic': [861], '(9Kapustin': [863], 'A.N.': [864], 'Chatrou': [865, 4080], 'M.L.L.': [866], 'Drozdov': [867], 'I.': [868], 'Davidson': [871], 'S.M.': [872], 'Soong': [873], 'D.': [874, 883, 1050, 1085, 1197, 1247, 1583, 1888, 2511, 2576, 2635, 2894, 4097], 'Furmanik': [875], 'Sanchis': [877], 'De': [879], 'Rosales': [880], 'R.T.M.': [881], 'Alvarez-Hernandez': [882], 'Shroff': [884], 'Yin': [886], 'Muller': [888], 'Skepper': [890], 'J.N.': [891], 'Mayr': [892], 'al.Vascular': [895], 'cell': [898, 3672, 3699, 4118], 'mediated': [901, 2747], 'exosome': [904], 'secretion.Circ.': [905], '116:': [908], '1312-1323Crossref': [909], '(270)': [912], 'Scholar)': [914, 1268, 1849, 2085, 3633, 3773, 3969], 'depositing': [915], 'remodeled': [918], 'extracellular': [919, 4122], 'matrix,': [920], 'leading': [921], 'formation': [924], 'calcifications.': [927], 'remains': [937, 1148], 'be': [939, 1683, 4174], 'elucidated.': [940], 'MicroRNAs': [941, 1210], 'short': [944], '(20–25': [945], 'nucleotides)': [946], 'single-stranded': [947], 'RNAs': [948], 'regulate': [950, 959], 'translational': [952], 'processing': [953], 'their': [955, 1665], 'mRNAs.': [957], 'MiRNAs': [958], 'several': [960, 1676], 'key': [961], 'checkpoints': [962], 'cellular': [965, 3338, 3485], 'processes': [966], 'such': [971, 1688, 3724, 3836], 'osteoblast': [973, 1057, 1254], '(miR-125b': [975], '(10Goettsch': [976], 'Rauner': [978], 'Pacyna': [980], 'N.': [981, 1195, 1520, 2046, 2642, 2833, 3641, 3649], 'Hempel': [982], 'Bornstein': [984], 'S.R.': [985], 'Hofbauer': [986], 'L.C.': [987], 'miR-125b': [988], 'regulates': [989, 1019, 1235, 3129, 3162, 3562, 3592, 3635, 3695, 3759], 'cells.Am.': [995], 'Pathol.': [997], '179:': [999], '1594-1600Abstract': [1000], 'Full': [1001, 1003, 1450, 1452, 1560, 1562, 1774, 1776, 2076, 2078, 2863, 2865], 'Text': [1002, 1004, 1451, 1453, 1561, 1563, 1775, 1777, 2077, 2079, 2864, 2866], 'PDF': [1005, 1454, 1564, 1778, 2080, 2867], '(124)': [1008], 'miR-205': [1011], '(11Qiao': [1012], 'W.': [1013, 1720, 1876, 1880, 3781, 3783, 3846, 3858, 3921, 3923], 'L.': [1015, 1276, 1461, 1698, 1790, 1823, 1830, 3146, 3160, 3615, 3677, 3744, 3844, 3852, 3986, 3998, 4103], 'MicroRNA-205': [1018], 'osteoblastic': [1023, 1375], 'cells.Cell': [1029], 'Physiol.': [1030, 1062, 1259], 'Biochem.': [1031, 1063, 1099, 1260], '33:': [1033], '1945-1953Crossref': [1034], '(51)': [1037], '(12Zhang': [1041, 1238], 'Liu': [1043, 1049, 1240, 1246, 1695, 1699, 1881, 1901, 2047, 2834], 'Z.': [1046, 1243, 1467, 1696, 1896, 2568, 2646, 2878, 3681, 3777, 3860, 3917], 'Zeng': [1047, 1244, 3690], 'Wang': [1051, 1248, 1476, 1697, 1705, 1707, 1717, 2055, 2842, 3794, 3934], 'Ting': [1053, 1250], 'MicroRNA-223': [1055, 1252, 2901, 3812, 3875, 3952], 'suppresses': [1056, 1253, 1486], 'inhibiting': [1060, 1257, 2549, 2594, 2907], 'DHRS3.Cell': [1061, 1258], '2018;': [1064, 1261, 3661], '47:': [1065, 1262], '667-679Crossref': [1066, 1263], '(23)': [1069, 1266], 'Scholar))': [1071], 'regulation': [1073, 4186], 'phosphate': [1077, 1444, 1833], 'homeostasis': [1078], '(miR-221': [1079], '(13Mackenzie': [1080], 'N.C.W.': [1081], 'Staines': [1082], 'K.A.': [1083], 'Zhu': [1084, 1713, 1793, 1797], 'Genever': [1086], 'Macrae': [1088], 'V.E.': [1089], 'miRNA-221': [1090], 'miRNA-222': [1092], 'synergistically': [1093], 'function': [1094, 3133, 3166, 3816, 3879, 3956], 'promote': [1096], 'calcification.Cell': [1098], 'Funct.': [1100], '32:': [1102, 1742], '209-216Crossref': [1103], '(56)': [1106], 'miR-9': [1109], '(14Clement': [1110], 'Salone': [1112], 'Charpentier': [1114], 'B.': [1115, 1189, 1209, 1700, 1788, 2900, 3148, 3150, 4088, 4105], 'Jouzeau': [1116], 'J.Y.': [1117], 'Bianchi': [1118], 'Identification': [1120], 'new': [1122, 2622, 2671], 'targeting': [1124, 1804, 2830, 3126, 3404, 3566, 3595, 3702, 4156], 'Pi/PPi': [1128], 'balance': [1129], 'chondrocytes.Biomed.': [1131], 'Mater.': [1132], 'Eng.': [1133], '24Google': [1135], 'Scholar)).': [1136], 'our': [1138, 1858, 2042, 3548], 'understanding': [1139], 'miRNAs': [1144, 1383, 1674, 1677], 'incomplete.': [1149], 'CKD-induced': [1157], 'aortas': [1160, 1646, 1652, 1947, 2419], 'revealed': [1161, 4137], 'among': [1165], 'most': [1167], 'microRNAs.': [1169], "It's": [1170], 'reported': [1171, 1681, 2483, 2815, 3910, 4172], 'downregulated': [1175, 3297], 'patients': [1177, 1215, 1870], 'stage': [1180], '4': [1181], '5': [1183], '(15Ulbing': [1184], 'Kirsch': [1186], 'A.H.': [1187], 'Leber': [1188], 'Lemesch': [1190], 'Münzker': [1192], 'Schweighofer': [1194], 'Hofer': [1196], 'Trummer': [1198], 'O.': [1199], 'Rosenkranz': [1200], 'A.R.': [1201, 3154], 'Müller': [1202], 'Eller': [1204], 'Stadlbauer': [1206], 'Obermayer-Pietsch': [1208], '223-3p': [1211], '93-5p': [1213], 'before': [1220, 2040], 'after': [1222, 1636, 2119, 2136], 'renal': [1223, 1605], 'transplantation.Bone.': [1224], '95:': [1226], '115-123Crossref': [1227], '(42)': [1230], 'osteoclastogenesis': [1270, 1289, 1836], '(16Li': [1271], 'Xing': [1273], 'G.': [1274, 1579, 1886, 3740, 4093], 'Shang': [1277], 'Li': [1279, 1281, 1883, 1899, 2049, 2645, 2836, 3780, 3788, 3920, 3928], 'Tian': [1283], 'Yang': [1285, 3784, 3924], 'Satb1': [1287], 'recruiting': [1291], 'CBP': [1292], 'upregulate': [1294], 'miR-223': [1295, 2212, 3653, 4060], 'expression': [1296, 1969, 2012, 2967, 3012, 3040, 3248, 3316, 3412, 3428, 3455, 3553, 3761, 3898], 'disease-mineral': [1300], 'disorder.Pharmazie.': [1303], '72:': [1305], '680-686PubMed': [1306], 'unknown.': [1320, 2754], 'Our': [1321, 3568, 3893], 'study': [1322], 'thatmiR-223-3p': [1324], '(KO)': [1326], 'accelerated': [1327], 'models': [1331], 'endothelial': [1336, 3726, 3763], 'Mechanistically,': [1339, 3589], 'found': [1341, 1983], 'effects': [1344], 'linked': [1348], 'gene,': [1352], 'transducer,': [1355], '(STAT3).': [1361], 'inhibited': [1363, 3259, 3401, 3450], 'required': [1369], 'induction': [1372], 'To': [1380, 3342, 3397], 'identify': [1381, 2412, 3398], 'mice': [1388, 1436, 1493, 2035, 2093, 2131, 2139, 2179, 2183, 2189, 2194, 2214, 2239, 2269, 2308, 2356, 2453, 2932, 2949, 3082], 'subjected': [1390], 'modified': [1393], 'two-step': [1394], 'surgical': [1395], 'model': [1396], 'subtotal': [1398], 'nephrectomy,': [1399, 1637, 2137], 'involving': [1400], 'removal': [1402], '5/6': [1404], 'tissue': [1408], '(17Lau': [1409], 'W.L.': [1410], 'Leaf': [1411], 'E.M.': [1412], 'Hu': [1413, 1466], 'M.C.': [1414], 'Takeno': [1415], 'M.M.': [1416, 3152], 'Kuro-o': [1417], 'Moe': [1419], 'O.W.': [1420], 'Vitamin': [1423], 'D': [1424, 2249, 2333, 3495], 'receptor': [1425, 2588, 2963], 'agonists': [1426], 'increase': [1427], 'klotho': [1428], 'osteopontin': [1430], 'while': [1431, 1986, 2122, 3310], 'decreasing': [1432], 'fed': [1441, 2196], 'diet.Kidney': [1445], 'Int.': [1446], '82:': [1448], '1261-1270Abstract': [1449], '(172)': [1457], '18Zhang': [1460], 'Rajan': [1462], 'Lin': [1464], 'Han': [1468, 2053, 2840], 'H.Q.': [1469], 'Zhou': [1470, 2877], 'Song': [1472, 1891, 1897], 'Min': [1474], 'Du': [1478, 2057, 2844], 'Mitch': [1480], 'W.E.': [1481], 'Pharmacological': [1482], 'inhibition': [1483], 'myostatin': [1485], 'systemic': [1487], 'inflammation': [1488, 2068, 2805, 2855, 4022], 'atrophy': [1491], 'disease.FASEB': [1497], '25:': [1500], '1653-1663Crossref': [1501], '(200)': [1504], '19Kramann': [1507], 'Goettsch': [1509], 'Wongboonsin': [1511], 'Iwata': [1513], 'Schneider': [1515], 'R.K.': [1516], 'Kuppe': [1517], 'Kaesler': [1519], 'Chang-Panesso': [1521], 'Machado': [1523], 'F.G.': [1524], 'Gratwohl': [1525], 'Madhurima': [1527], 'Hutcheson': [1529], 'J.D.': [1530], 'Jain': [1531], 'Humphreys': [1535], 'B.D.': [1536], 'Adventitial': [1537], 'MSC-like': [1538], 'Progenitors': [1541], 'drive': [1548], 'disease.Cell': [1554], 'Stem': [1555], 'Cell.': [1556, 1769], '19:': [1558], '628-642Abstract': [1559], '(171)': [1567], '20Aikawa': [1570], 'Libby': [1574], 'Figueiredo': [1576], 'J.L.': [1577], 'Rusanescu': [1578], 'Iwamoto': [1580], 'Fukuda': [1582], 'Kohler': [1584], 'R.H.': [1585, 4084], 'Shi': [1586], 'G.P.': [1587], 'Jaffer': [1588], 'F.A.': [1589], 'Weissleder': [1590], 'valve': [1595, 2628, 2677], 'abolished': [1597], 'elastolytic': [1599], 'cathepsin': [1600], 'S': [1601, 2153, 2318, 2339], 'disease.Circulation.': [1606], '2009;': [1607], '119:': [1608], '1785-1794Crossref': [1609], '(217)': [1612], 'induce': [1616, 3193, 3410], '(Fig.': [1620, 1624, 1630, 1850, 1938, 2109, 2132, 2155, 2162, 2230, 2234, 2243, 2247, 2270, 2446, 2451, 2473, 2950, 2959, 3122, 3374, 3443, 3456, 3478, 3493, 3512, 3518, 3528], '1A).': [1621], 'Aortic': [1622], '1B)': [1625], 'levels': [1629, 1643, 2106, 2941, 3913], '1C)': [1631], 'detected': [1633, 2118, 2264, 2924, 2943, 3368], '6': [1634, 3085], 'weeks': [1635, 2135], 'confirming': [1638], 'formed': [1639], 'MiRNA': [1642], 'group': [1649, 1655, 2044, 3373], 'control': [1651, 2425, 2456, 3025, 3055, 3285, 3308], 'sham': [1654], 'analyzed': [1657, 1975], 'sequencing.': [1660], 'When': [1661], 'sorted': [1662], 'based': [1663], 'fold': [1666], '(FC)': [1668], 'values,': [1669], 'top': [1671], 'ten': [1672], 'include': [1675], 'been': [1680, 2038, 2482], 'miR-29a/b': [1690], '(21Du': [1691], 'Gao': [1693, 2051, 2838, 2881, 2883, 2899], 'He': [1701, 2875], 'Xu': [1709, 1715, 1895, 2891], 'Luo': [1711], 'G.-Z.': [1712], 'Q.': [1716, 1900, 3842], 'Kong': [1719], 'Upregulation': [1721], 'disintegrin': [1724], 'metalloproteinase': [1726], 'thrombospondin': [1728], 'motifs-7': [1729], 'miR-29': [1731], 'repression': [1732], 'mediates': [1733], 'calcification.Arterioscler.': [1737], '2580-2588Crossref': [1743], '(99)': [1746], 'miR-214': [1749], '(22Gupta': [1750], 'S.K.': [1751, 1759], 'Kumari': [1752], 'Singh': [1754, 1758], 'Barthwal': [1756], 'M.K.': [1757], 'Thum': [1760], 'Non-coding': [1762], 'RNAs:': [1763], 'Regulators': [1764], 'valvular': [1766], 'calcification.J.': [1767], 'Mol.': [1768], '142:': [1772], '14-23Abstract': [1773], '(4)': [1781], 'miR-139': [1784], '(23Long': [1785], 'Sun': [1787, 1879], 'Cheng': [1789], 'miR-139-5p': [1799], 'Represses': [1800], 'BMSC': [1801], 'Osteogenesis': [1802], 'via': [1803, 2495, 2522], 'Wnt/β-Catenin': [1805], 'pathway.DNA': [1807], 'Cell': [1808], '36:': [1811], '715-724Crossref': [1812], '(53)': [1815], "(24M'Baya-Moutoula": [1820], 'Louvet': [1822, 3985], 'Metzinger-Le': [1824, 3609, 3977], 'Meuth': [1825, 3610, 3978], 'Massy': [1827, 3612, 3995], 'Z.A.': [1828, 3613, 3996], 'Metzinger': [1829, 3614, 3997], 'High': [1831], 'inorganic': [1832], 'concentration': [1834, 2116], 'modulating': [1838], 'miR-223.Biochim.': [1839], 'Biophys.': [1840, 3624, 4011], 'Acta.': [1841, 3625, 4012], '1852:': [1843], '2202-2212Crossref': [1844], '(39)': [1847], '1D,': [1851], 'Table': [1852], 'S1).': [1853, 1961], 'Among': [1854], 'them,': [1855], 'drew': [1857], 'attention,': [1859], 'it': [1861, 3831], 'significantly': [1864, 3463, 3503], 'plasma': [1868, 2228, 2292, 2925, 2939], 'artery': [1873, 1914, 2255, 2326], 'calcifications': [1874], '(25Liu': [1875], 'Ling': [1877], 'Zhong': [1885], 'Jin': [1893], 'Chai': [1903], 'al.Circulating': [1906], 'correlated': [1908], 'level': [1911, 3276, 3462], 'symptomatic': [1917], 'patients.Sci.': [1918], 'Rep.': [1919], '5:': [1921, 3767], '16099Crossref': [1922], '(43)': [1925], 'RT-PCR': [1928, 2097, 2952], 'confirmed': [1930, 2095, 3293], 'upregulation': [1932], '1E).': [1939], 'Meanwhile,': [1940], 'was': [1942, 2094, 2117, 2124, 2263, 2409, 2802, 3243, 3296, 3346, 3359, 3473], 'aged': [1949, 1997, 2302, 2306, 2351, 2422, 2449, 2928, 2945, 3077], 'ApoE': [1950, 2176, 2303, 2352, 3078], 'KO': [1951, 2092, 2130, 2138, 2177, 2182, 2213, 2268, 2287, 2304, 2331, 2353, 3079], 'mice,': [1952, 2147, 3253, 3356], 'displayed': [1954, 2240], 'significant': [1955], '(Figs.': [1958, 2791, 3287, 3327], '1E': [1959], 'These': [1962, 2000, 2272, 2972, 3533], 'suggest': [1964, 2002, 2974, 3383, 3550], 'correlation': [1966], 'between': [1967, 1994, 2127, 2944, 2968, 3249, 3802, 3865, 3942], 'We': [1973, 2014, 2427, 2755, 3111], 'other': [1976, 1987], 'up-regulated': [1977], 'miR-21a-5p': [1984], 'no': [1992, 2125, 2796, 2936, 2955, 3244], 'difference': [1993, 2126, 3245], 'WT': [1995, 2128, 2146, 2210, 2266, 2329], 'ApoE−/−': [1998, 2191, 2259, 2450, 2929, 2946, 3250, 3363], 'mice.': [1999, 2260, 2426, 2457], 'may': [2008, 4061, 4159], 'profile.': [2013], 'next': [2015, 2756, 3112, 3255], 'sought': [2016], 'determine': [2018, 3343], 'whether': [2019, 3344, 3399], 'plays': [2021, 3573, 4181], 'published': [2039], 'research': [2043], '(26Cheng': [2045, 2832], 'Y.-C.': [2054, 2841], 'MicroRNA-223-3p': [2061, 2848], 'skeletal': [2063, 2826, 2850], 'regeneration': [2065, 2852], 'mice.J.': [2070, 2857], 'Chem.': [2072, 2859], '295:': [2074, 2861], '10212-10223Abstract': [2075, 2862], '(9)': [2083, 2870], 'used.': [2087], 'spleen': [2100], 'should': [2103], 'contain': [2104], '2A).': [2110], 'Increased': [2111], 'urea': [2113], 'nitrogen': [2114], '(BUN)': [2115], 'surgery,': [2121], '2B).': [2133], 'Six': [2134], 'had': [2140], 'compared': [2144, 2257, 2454, 3279, 3303], 'shown': [2148], 'Alizarin': [2151, 2316, 2337], 'Red': [2152, 2317, 2338], 'staining': [2154, 2319, 2322, 2342], '2C)': [2156], 'content': [2160, 3487], '2D).': [2163], 'Next,': [2164], 'clarify': [2166], 'crossbred': [2175], '(ApoE−/−)': [2178], 'generate': [2185, 2206], 'miR-223-3p/ApoE': [2186], 'double': [2187], '(DKO).': [2190], 'DKO': [2193, 2238, 2307, 2355, 2931, 2948, 3081, 3252, 3355, 3372], 'chow': [2198, 2216], 'diet': [2199, 2217], 'up': [2201], '16': [2203], 'months': [2204], 'aging-induced': [2207], 'used': [2219, 3407], 'control.': [2221], 'did': [2224, 3312], 'not': [2225, 2979, 3313], 'affect': [2226, 3314], 'triglyceride': [2229, 2293], '3A)': [2231], 'cholesterol': [2233, 2297], '3B)': [2235], 'levels.': [2236], 'atherosclerosis': [2242, 3838, 3915, 4029], 'S2)': [2244], '3,': [2248], 'E)': [2251], 'brachiocephalic': [2254, 2325, 3074], '(BCA)': [2256, 2327], 'No': [2261], '3C).': [2271], 'loss': [2277], 'increases': [2280, 2808, 3899], 'calcification.Figure': [2285], '3MiR-223-3p': [2286], 'A,': [2291, 2998], 'B,': [2295, 3010], 'total': [2296], 'concentrations': [2298], 'WT,': [2300], 'KO,': [2301], '(n': [2309, 2357, 3027, 3057, 3083], '=': [2310, 2358, 3028, 3058, 3084], '6–7': [2311, 2359], 'per': [2312, 2360, 3030, 3060, 3086], 'group).': [2313, 2361, 3031, 3061, 3087], 'C,': [2314], 'representative': [2315, 2336, 3033], 'HE': [2321, 2341], 'groups.': [2332, 2971], 'E,': [2335], 'staining,': [2340], '(D)': [2343], 'quantification': [2345, 3037, 3067], '(E)': [2346, 3049, 3065], 'BCA': [2349], 'Data': [2362, 3088], 'expressed': [2364, 3090], 'mean': [2367, 3093], '±': [2368, 3094], 'SD.': [2369, 3095], '∗p': [2370, 3096], '<0.05': [2371, 3097], 'unpaired': [2373, 3099], 'two-tailed': [2374, 3100], "Student's": [2375, 3101], 't-test.View': [2376, 3102], 'Large': [2377, 3103], 'Image': [2378, 3104], 'Figure': [2379, 3105], 'ViewerDownload': [2380, 3106], 'Hi-res': [2381, 3107], 'image': [2382, 3108], 'Download': [2383, 3109], '(PPT)': [2384, 3110], 'As': [2385, 3241], 'hypothesized': [2395, 3256], 'interrupts': [2398], 'pathway': [2401, 2436, 2801, 2911], 'forms': [2405], 'RNA-Seq': [2408, 4135], 'applied': [2410], 'differentially': [2413], 'CKD,': [2421], 'ApoE−/−,': [2423], 'performed': [2428], 'Kyoto': [2429], 'Encyclopedia': [2430], 'Genes': [2432], 'Genomes': [2434], '(KEGG)': [2435], 'ranked': [2439], '4A)': [2447], '4B)': [2452], 'The': [2458], 'JAK/STAT': [2459, 2616, 2766, 2777, 4140, 4166], 'overlapped': [2467], '4,': [2474], 'C': [2475, 3329], 'D).': [2477], 'Both': [2478], 'relating': [2484], 'N-3': [2488, 2516], 'fatty': [2489, 2517], 'acids': [2490, 2518], 'directly': [2491, 2829, 3125], 'inhibit': [2492, 2519, 4160], 'p38': [2497], 'mitogen-activated': [2498], 'protein': [2499, 2525, 3461], 'kinase': [2500, 2526], 'PPARγ': [2502, 2542, 2589], '(27Abedin': [2504], 'Lim': [2506], 'Tang': [2508], 'T.B.': [2509], 'Park': [2510], 'Demer': [2512], 'L.L.': [2513], 'Tintut': [2514], 'p38-mitogen-activated': [2524], 'peroxisome': [2528], 'proliferator-activated': [2529], 'receptor-gamma': [2530], 'pathways.Circ.': [2531], '2006;': [2533], '98:': [2534], '727-729Crossref': [2535], '(75)': [2538, 3666, 3890], 'counteracts': [2543, 2590], 'Wnt5a': [2550, 2595], '(28Woldt': [2552], 'Terrand': [2554], 'Mlih': [2556], 'Matz': [2558], 'R.L.': [2559], 'Bruban': [2560], 'Coudane': [2562], 'Foppolo': [2564], 'El': [2566], 'Asmar': [2567], 'Chollet': [2569], 'M.E.': [2570], 'Ninio': [2571], 'Bednarczyk': [2573], 'Thiersé': [2575], 'Schaeffer': [2577], 'Van': [2579], 'Dorsselaer': [2580], 'Boudier': [2582], 'al.The': [2585], 'nuclear': [2586], 'hormone': [2587], 'signalling': [2596], 'cells.Nat.': [2601, 3764], 'Commun.': [2602, 3765], '3:': [2604], '1077Crossref': [2605], '(60)': [2608], 'IL-6,': [2611], 'cytokine': [2613], 'activates': [2615], 'susceptibility': [2623, 2672], 'calcific': [2626, 2675], 'stenosis': [2629], '(29Thériault': [2630], 'Dina': [2632], 'Messika-Zeitoun': [2634], 'Le': [2636, 3644], 'Scouarnec': [2637], 'Capoulade': [2639], 'Gaudreault': [2641], 'Rigade': [2643], 'Simonet': [2647], 'Lamontagne': [2649], 'Clavel': [2651], 'M.-A.': [2652], 'Arsenault': [2653], 'B.J.': [2654], 'Boureau': [2655], 'A.-S.': [2656], 'Lecointe': [2657], 'Baron': [2659], 'al.Genetic': [2662], 'Association': [2663], 'Analyses': [2664], 'Highlight': [2665], ',': [2666, 2667], 'stenosis.Circ.': [2678], 'Genomic': [2679], 'Precision': [2680], 'Med.': [2681], '12:': [2683], 'e002617Crossref': [2684], '(12)': [2686], "What's": [2689], 'more,': [2690], 'IL-6': [2691, 2714, 2788, 2831, 2926, 2940, 2958, 2962, 2976, 3189, 3215, 3247, 4168], 'induces': [2692, 2717, 3218], 'STAT3-dependent': [2694, 2718, 3195, 3219], 'human': [2697, 2721, 3198, 3222, 3669, 3696], 'into': [2699, 2723, 3200, 3224], 'osteoblast-like': [2700, 2724, 3201, 3225], '(30Kurozumi': [2702, 3203], 'Nakano': [2704, 3205], 'Yamagata': [2706, 3207], 'Okada': [2708, 3209], 'Nakayamada': [2710, 3211], 'Tanaka': [2712, 3213], 'sIL-6R': [2716, 3217], 'through': [2726, 3227], 'JMJD2B-mediated': [2727, 3228], 'histone': [2728, 3229], 'demethylation': [2729, 3230], 'RUNX2.Bone.': [2731, 3232], '124:': [2733, 3234], '53-61Crossref': [2734, 3235], '(26)': [2737, 3238], 'While': [2740, 3514], 'protection': [2748], 'screened': [2757], 'all': [2758], 'using': [2769, 3500], 'MiRTarBase': [2771], 'TargetScan': [2773], 'databases.': [2774], 'pathway,': [2778, 4167], 'miR-223-3p-binding': [2779], 'sites': [2780, 3001], '3′': [2785, 3008], 'UTRs': [2786], '5A': [2792], '6A),': [2794], 'predicted.': [2803], 'IL-6-induced': [2804, 3264], 'initiates': [2806], 'previous': [2812, 3422, 3907], 'studies': [2813, 3908], 'proinflammatory': [2819], 'responses': [2820], 'liver': [2823, 2904], 'injured': [2825], '31Li': [2873], 'Ramirez': [2879], 'Ross': [2885], 'R.A.': [2886], 'Cao': [2887], 'Cai': [2889], 'Feng': [2893], 'Liangpunsakul': [2897], 'ameliorates': [2902], 'alcoholic': [2903], 'injury': [2905], 'IL-6-p47-oxidative': [2909], 'stress': [2910], 'neutrophils.Gut.': [2913], '66:': [2915], '705-715Crossref': [2916], '(120)': [2919], 'So': [2922], 'ELISA.': [2934], 'differences': [2937, 2956], '5B).': [2951], '5C)': [2960], '(IL-6R;': [2964], 'Fig.': [2965], '5D)': [2966], 'two': [2970], 'probably': [2978], 'during': [2985, 3394, 3525, 3556], 'progression.Figure': [2988], '6STAT3': [2989], '(in': [3002], 'red': [3003], 'letters)': [3004], 'UTRs.': [3009], 'primary': [3014], '(mVSMCs)': [3019], 'transfected': [3020, 3050, 3270, 3282, 3300, 3306], 'mimic': [3026, 3056], 'C–E,': [3032], 'western': [3034], 'blot': [3035], 'mVSMCs': [3042], '(C),': [3043], 'MOVAS': [3044, 3318], '(D),': [3045], '3T3': [3047, 3325], 'F–G,': [3062], 'Representative': [3063], 'images': [3064], '(F)': [3068], 'IHC': [3071], 'trunks': [3075], 'focused': [3113], 'STAT3,': [3115, 3127, 3405], 'another': [3116], 'known': [3117], '6A).': [3123], 'By': [3124], 'number': [3131, 3164], 'myeloid-derived': [3135, 3168], 'suppressor': [3136, 3169], 'multiple': [3139, 3172], 'sclerosis': [3140, 3173], '(32Cantoni': [3141], 'Cignarella': [3143], 'Ghezzi': [3145], 'Mikesell': [3147], 'Bollman': [3149], 'Berrien-Elliott': [3151], 'Ireland': [3153], 'Fehniger': [3155], 'T.A.': [3156], 'G.F.': [3158], 'Piccio': [3159], 'Mir-223': [3161], 'experimental': [3175, 4007], 'autoimmune': [3176], 'encephalomyelitis.Acta': [3177], 'Neuropathol.': [3178], '133:': [3180], '61-77Crossref': [3181], '(50)': [3184], 'addition,': [3188], 'soluble': [3191], '(s)IL-6R': [3192], 'blocking': [3263, 3543], 'mimics': [3273, 3286, 3477], 'negative': [3284], '6B,': [3288], 'S3A).': [3290], 'Western': [3291], 'blotting': [3292], 'those': [3305], 'mimics;': [3309], '(mouse': [3319], 'cells)': [3323], 'fibroblasts': [3326], '6,': [3328, 3375], 'D,': [3331], 'S3,': [3332], 'B': [3333], 'C),': [3335], 'suggesting': [3336], 'specificity': [3339], 'observed': [3353], 'immunohistochemistry': [3357], '(IHC)': [3358], 'performed.': [3360], 'Compared': [3361], 'group,': [3364], 'more': [3365], 'BCAs': [3370], 'F': [3376], 'G).': [3378], 'IL-6/sIL-6R': [3408, 3424, 3451], 'cultured': [3415, 3468], 'osteoblast-induced': [3417], 'medium': [3418], '(OIM).': [3419], 'Consistent': [3420], 'studies,': [3423], 'enhanced': [3425], 'mRNA': [3427], 'alkaline': [3430], 'phosphatase': [3431], '(Alp),': [3432], 'osteocalcin': [3433], '(Ocn),': [3434], '7A).': [3444], 'Overexpression': [3445], 'complex-induced': [3452], '7B).': [3457], 'Accordingly,': [3458, 3480], 'when': [3465], 'OIM,': [3470], '7C).': [3479], 'reduced': [3489], 'miR-223-3p-transfected': [3491], '7,': [3494, 3529], 'E).': [3497], 'Knockdown': [3498], 'siRNA': [3501], 'accumulation': [3506], 'IL-6/s': [3508], 'IL6R-induced': [3509], 'VSCM': [3510], 'S4).': [3513], '7F)': [3519], 'eliminated': [3520], 'G': [3530], 'H).': [3532], 'show': [3535, 3895], 'IL-6/STAT3-induced': [3539], 'expression.': [3545], 'negatively': [3561, 3591], 'STAT3.': [3567], 'demonstrate': [3570], 'important': [3575, 4182], 'aggravates': [3583], 'myeloid': [3605], '(33Taibi': [3607], 'miR-223:': [3616], 'An': [3617, 3798, 3861, 3938], 'inflammatory': [3618], 'oncomiR': [3619], 'enters': [3620], 'field.Biochim.': [3623], '1842:': [3627, 4014], '1001-1009Crossref': [3628], '(123)': [3631], 'hematopoietic': [3636], '(34Yuan': [3638], 'Berg': [3640], 'Lee': [3642], 'J.W.': [3643], 'T.-T.': [3645], 'Neudecker': [3646], 'Jing': [3648], 'Eltzschig': [3650], 'MicroRNA': [3652], 'regulator': [3655], 'innate': [3657], 'immunity.J.': [3658], 'Leukoc.': [3659], '104:': [3662], '515-524Crossref': [3663], 'embryonic': [3670, 3697], 'stem': [3671, 3698], '(35Yu': [3674], 'Y.-H.': [3675], 'D.-S.': [3679, 3689], 'Huang': [3682], 'F.-F.': [3683], 'X.-P.': [3687], 'Liang': [3688], 'F.-P.': [3693], 'MiR-223': [3694], 'IGF-1R/Akt': [3704], 'pathway.PLoS': [3706], 'ONE.': [3707], '2013;': [3708], '8:': [3709], 'e78769Crossref': [3710], 'delivered': [3718], 'exosomes': [3720], 'recipient': [3722], '(36Tabet': [3728], 'Vickers': [3730], 'K.C.': [3731], 'Cuesta': [3732], 'Torres': [3733], 'L.F.': [3734], 'Wiese': [3735], 'C.B.': [3736], 'Shoucri': [3737], 'B.M.': [3738], 'Lambert': [3739], 'Catherinet': [3741], 'Prado-Lourenco': [3743], 'Levin': [3745], 'M.G.': [3746], 'Thacker': [3747], 'Sethupathy': [3749], 'Barter': [3751], 'P.J.': [3752], 'Remaley': [3753], 'A.T.': [3754], 'Rye': [3755], 'K.-A.': [3756], 'HDL-transferred': [3757], 'microRNA-223': [3758], 'ICAM-1': [3760], '3292Crossref': [3768], '(257)': [3771], '(37Shan': [3776, 3916], 'Qin': [3778, 3918], 'Chu': [3786, 3926], 'Huo': [3790, 3930], 'Schaer': [3792, 3932], 'G.L.': [3793, 3933], 'Endocrine': [3799, 3862, 3939], 'Genetic': [3800, 3863, 3940], 'cells:': [3809, 3872, 3949], 'Role': [3810, 3873, 3950], 'Atherogenesis.J.': [3818, 3881, 3958], 'Am.': [3819, 3882, 3959], 'Coll.': [3820, 3883, 3960], '65:': [3823, 3886, 3963], '2526-2537Crossref': [3824, 3887, 3964], '(72)': [3827, 3967], 'where': [3830], 'participates': [3832], 'diseases': [3835], '(38Zhen': [3839], 'Shanshan': [3841], 'Wen': [3843], 'Weibin': [3845], 'Jian': [3847], 'Maoping': [3849], 'Xiaokun': [3851], 'Yuqing': [3853], 'Gary': [3855], 'L.S.': [3856], 'Shenming': [3857], 'Chunxiang': [3859], 'Consistently,': [3906], 'advanced': [3971], 'stages': [3972], '(39Taïbi': [3975], "M'Baya-Moutoula": [3980], 'Djelouat': [3982], 'M.s.': [3983], 'e.I.': [3984], 'Bugnicourt': [3987], 'J.-M.': [3988, 3994], 'Poirot': [3989], 'Bengrine': [3991], 'Chillon': [3993], 'Possible': [3999], 'involvement': [4000], 'damage': [4005], 'disease.Biochim.': [4010], '88-98Crossref': [4015], '(52)': [4018], 'Since': [4021], 'prevalent': [4024], 'pathophysiology': [4027], '(40Ruiz-Ortega': [4032], 'Rayego-Mateos': [4034], 'Lamas': [4036], 'Ortiz': [4038], 'Rodrigues-Diez': [4040], 'R.R.': [4041], 'Targeting': [4042], 'progression': [4044], 'disease.Nat.': [4048], 'Nephrol.': [4050], '269-288Crossref': [4053], '(111)': [4056], 'due': [4062], 'accumulated': [4064], 'immune': [4065], 'cells.': [4066], 'VMSC': [4067], 'occurs': [4070], '(41Furmanik': [4078], 'van': [4082, 4091], 'Gorp': [4083], 'Akbulut': [4085], 'Willems': [4087], 'Schmidt': [4089], 'H.H.': [4090], 'Eys': [4092], 'Bochaton-Piallat': [4094], 'M.-L.': [4095], 'Proudfoot': [4096], 'Biessen': [4098], 'E.A.': [4099], 'Hedin': [4100], 'Matic': [4102], 'Mees': [4104], 'Reutelingsperger': [4108], 'al.Reactive': [4111], 'Oxygen-Forming': [4112], 'Nox5': [4113], 'Links': [4114], 'phenotypic': [4119], 'switching': [4120], 'Vesicle-mediated': [4123], '127:': [4128], '911-927Crossref': [4129], '(24)': [4132], 'This': [4153], 'suggests': [4154], 'types.': [4163], 'direct': [4175], 'inflammation,': [4188], 'differentiation,': [4189], 'immunity': [4191], '(4': [4192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3134733017', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-12-19T14:07:48.165994', 'created_date': '2021-03-15'}
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