Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3133887987', 'doi': 'https://doi.org/10.21203/rs.3.rs-270820/v1', 'title': 'Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants', 'display_name': 'Human Health Risk Regulation of Reproductive Toxicity, Neurotoxicity, and Endocrine Disruption in Special Populations Exposed to Organophosphorus Flame Retardants', 'publication_year': 2021, 'publication_date': '2021-03-06', 'ids': {'openalex': 'https://openalex.org/W3133887987', 'doi': 'https://doi.org/10.21203/rs.3.rs-270820/v1', 'mag': '3133887987'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-270820/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-270820/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-270820/latest.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101970887', 'display_name': 'Jiawen Yang', 'orcid': 'https://orcid.org/0000-0002-1360-655X'}, 'institutions': [{'id': 'https://openalex.org/I153473198', 'display_name': 'North China Electric Power University', 'ror': 'https://ror.org/04qr5t414', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I153473198']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiawen Yang', 'raw_affiliation_strings': ['MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China'], 'affiliations': [{'raw_affiliation_string': 'MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China', 'institution_ids': ['https://openalex.org/I153473198']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110962984', 'display_name': 'Wenjin Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I194450716', 'display_name': 'Jilin University', 'ror': 'https://ror.org/00js3aw79', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I194450716']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenjin Zhao', 'raw_affiliation_strings': ['College of New Energy and Environment, Jilin University, Changchun 130012, China'], 'affiliations': [{'raw_affiliation_string': 'College of New Energy and Environment, Jilin University, Changchun 130012, China', 'institution_ids': ['https://openalex.org/I194450716']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100345908', 'display_name': 'Yu Li', 'orcid': 'https://orcid.org/0000-0003-1430-7989'}, 'institutions': [{'id': 'https://openalex.org/I153473198', 'display_name': 'North China Electric Power University', 'ror': 'https://ror.org/04qr5t414', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I153473198']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu Li', 'raw_affiliation_strings': ['MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China'], 'affiliations': [{'raw_affiliation_string': 'MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China', 'institution_ids': ['https://openalex.org/I153473198']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.649844, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 57, 'max': 67}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10122', 'display_name': 'Toxic Organic Pollutants Impact', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10122', 'display_name': 'Toxic Organic Pollutants Impact', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10686', 'display_name': 'Effects and risks of endocrine disrupting chemicals', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2307', 'display_name': 'Health, Toxicology and Mutagenesis'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10875', 'display_name': 'Pesticide Exposure and Toxicity', 'score': 0.9802, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/reproductive-toxicity', 'display_name': 'Reproductive toxicity', 'score': 0.6286292}, {'id': 'https://openalex.org/keywords/neurotoxicity', 'display_name': 'Neurotoxicity', 'score': 0.48496032}, {'id': 'https://openalex.org/keywords/developmental-toxicity', 'display_name': 'Developmental toxicity', 'score': 0.445829}], 'concepts': [{'id': 'https://openalex.org/C99432707', 'wikidata': 'https://www.wikidata.org/wiki/Q3427345', 'display_name': 'Reproductive toxicity', 'level': 3, 'score': 0.6286292}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.62127346}, {'id': 'https://openalex.org/C2779491297', 'wikidata': 'https://www.wikidata.org/wiki/Q3338704', 'display_name': 'Neurotoxicity', 'level': 3, 'score': 0.48496032}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46784103}, {'id': 'https://openalex.org/C179335377', 'wikidata': 'https://www.wikidata.org/wiki/Q5266825', 'display_name': 'Developmental toxicity', 'level': 4, 'score': 0.445829}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40085998}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3435495}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3084034}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.15600955}, {'id': 'https://openalex.org/C172680121', 'wikidata': 'https://www.wikidata.org/wiki/Q26513', 'display_name': 'Fetus', 'level': 3, 'score': 0.12756312}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.110553235}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-270820/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-270820/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-270820/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-270820/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.61, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 84, 'referenced_works': ['https://openalex.org/W1149349272', 'https://openalex.org/W1969195287', 'https://openalex.org/W1972508603', 'https://openalex.org/W2008673871', 'https://openalex.org/W2016626255', 'https://openalex.org/W2016809140', 'https://openalex.org/W2023782921', 'https://openalex.org/W2023883958', 'https://openalex.org/W2038699706', 'https://openalex.org/W2040459007', 'https://openalex.org/W2056239863', 'https://openalex.org/W2057666902', 'https://openalex.org/W2068197014', 'https://openalex.org/W2072471721', 'https://openalex.org/W2074534173', 'https://openalex.org/W2084005746', 'https://openalex.org/W2141380411', 'https://openalex.org/W2142456684', 'https://openalex.org/W2163430576', 'https://openalex.org/W2191044230', 'https://openalex.org/W2211359496', 'https://openalex.org/W2218462132', 'https://openalex.org/W2284608228', 'https://openalex.org/W2303390650', 'https://openalex.org/W2309474928', 'https://openalex.org/W2321989633', 'https://openalex.org/W2325611439', 'https://openalex.org/W2330617220', 'https://openalex.org/W2466679691', 'https://openalex.org/W2469927308', 'https://openalex.org/W2498328254', 'https://openalex.org/W2595490461', 'https://openalex.org/W2618848228', 'https://openalex.org/W2621589167', 'https://openalex.org/W2735409693', 'https://openalex.org/W2740783841', 'https://openalex.org/W2743174978', 'https://openalex.org/W2753764553', 'https://openalex.org/W2767556821', 'https://openalex.org/W2768934062', 'https://openalex.org/W2793746406', 'https://openalex.org/W2794095048', 'https://openalex.org/W2803191813', 'https://openalex.org/W2810085336', 'https://openalex.org/W2811394070', 'https://openalex.org/W2890932733', 'https://openalex.org/W2897217139', 'https://openalex.org/W2897752192', 'https://openalex.org/W2901795281', 'https://openalex.org/W2905284071', 'https://openalex.org/W2925241694', 'https://openalex.org/W2925926548', 'https://openalex.org/W2926872467', 'https://openalex.org/W2935894102', 'https://openalex.org/W2939900361', 'https://openalex.org/W2942814173', 'https://openalex.org/W2956277876', 'https://openalex.org/W2956635169', 'https://openalex.org/W2980407404', 'https://openalex.org/W2981872219', 'https://openalex.org/W2998789838', 'https://openalex.org/W2999197824', 'https://openalex.org/W3001317133', 'https://openalex.org/W3005967738', 'https://openalex.org/W3006366170', 'https://openalex.org/W3008839596', 'https://openalex.org/W3016437102', 'https://openalex.org/W3020205162', 'https://openalex.org/W3020636734', 'https://openalex.org/W3021986733', 'https://openalex.org/W3024960612', 'https://openalex.org/W3025357246', 'https://openalex.org/W3036989660', 'https://openalex.org/W3042465897', 'https://openalex.org/W3046549302', 'https://openalex.org/W3082257837', 'https://openalex.org/W3084904909', 'https://openalex.org/W3088055753', 'https://openalex.org/W3094230217', 'https://openalex.org/W3097943650', 'https://openalex.org/W3105821009', 'https://openalex.org/W3112153955', 'https://openalex.org/W3113056266', 'https://openalex.org/W3126803434'], 'related_works': ['https://openalex.org/W3151687180', 'https://openalex.org/W3011241681', 'https://openalex.org/W2118348231', 'https://openalex.org/W2110908042', 'https://openalex.org/W2049219726', 'https://openalex.org/W2044066565', 'https://openalex.org/W2038181930', 'https://openalex.org/W2011335313', 'https://openalex.org/W1987951637', 'https://openalex.org/W1502739263'], 'abstract_inverted_index': {'Abstract': [0], 'In': [1, 187], 'this': [2], 'study,': [3], 'the': [4, 65, 68, 75, 106, 108, 129, 139, 148, 151, 158, 168, 173, 180, 185, 199, 204, 223, 233, 245, 248], 'joint': [5, 109, 130, 159], 'toxicological': [6], 'characteristics': [7], 'of': [8, 67, 111, 172, 182, 190, 226, 247], 'reproductive': [9, 122], 'toxicity,': [10], 'neurotoxicity,': [11], 'and': [12, 34, 100, 132, 154, 209], 'endocrine': [13], 'disruption': [14], '(ED)': [15], 'by': [16, 23, 119, 136], 'organophosphorus': [17], 'flame': [18], 'retardants': [19], '(OPFRs)': [20], 'were': [21, 39, 103, 116], 'regulated': [22], 'process': [24], 'control.': [25], 'Molecular': [26], 'docking': [27], 'technology,': [28], 'molecular': [29, 192], 'dynamics': [30], '(MD),': [31], '2D-QSAR': [32], 'model,': [33], 'density': [35], 'functional': [36], 'theory': [37], '(DFT)': [38], 'used': [40], 'to': [41, 56, 157, 184, 240], 'develop': [42], 'a': [43, 125, 144, 241], 'health': [44, 80], 'risk': [45], 'regulation': [46], 'scheme': [47, 72], 'for': [48, 74], 'special': [49], 'population': [50], 'such': [51], 'as': [52], 'pregnant': [53, 76, 114, 196, 214], 'women': [54, 77, 115, 197, 215], 'exposed': [55], 'OPFRs.': [57], 'It': [58], 'was': [59, 143, 216, 236], 'found': [60], 'that': [61, 203, 222], 'MD': [62], 'simulations': [63], 'confirmed': [64], 'effectiveness': [66, 246], 'recommended': [69, 140, 152, 200, 249], 'complementary': [70], 'food': [71], '(CFS)': [73], 'with': [78], 'low': [79], 'risk.': [81], 'When': [82], 'β-lactoglobulin,': [83], 'α-lactoalbumin,': [84], 'milk': [85], 'fat': [86], 'globule': [87], 'membrane': [88], '(MFGM)': [89], 'protein,': [90, 175], 'ovalbumin': [91], '(OVA),': [92], 'ovotransferrin': [93], '(OVT),': [94], 'vitamin,': [95], 'plant': [96], 'pigment,': [97], 'apple': [98], 'polyphenols,': [99], 'malic': [101], 'acid': [102], 'present': [104], 'in': [105, 113, 128, 150, 195, 213, 232], 'CFS,': [107], 'toxicity': [110, 123, 131], 'OPFRs': [112, 155, 183, 191, 208, 227], 'significantly': [117, 217, 237], 'decreased': [118, 218], '91.18%.': [120], 'The': [121, 163], 'played': [124], 'dominant': [126], 'role': [127], 'could': [133, 165], 'be': [134], 'reduced': [135, 177], '82.48%': [137], 'under': [138, 198], 'CFS.': [141, 250], 'There': [142], 'competitive': [145], 'relationship': [146], 'between': [147, 207], 'nutrients': [149], 'CFS': [153, 201], 'binding': [156, 170, 181, 205], 'toxic': [160], 'receptor': [161], '(JTR).': [162], 'former': [164], 'easily': [166], 'occupy': [167], 'target': [169], 'spot': [171], 'JTR': [174], 'which': [176, 239], 'or': [178], 'prevented': [179], 'JTR.': [186], 'addition,': [188], 'simulation': [189], 'metabolic': [193, 211], 'pathways': [194], 'showed': [202], 'affinity': [206], 'six': [210], 'kinases': [212], '(–28.85%': [219], '-–87.54%),': [220], 'indicating': [221], 'inhibition': [224], 'effect': [225], 'on': [228], 'normal': [229], 'biochemical': [230], 'reactions': [231], 'human': [234], 'body': [235], 'reduced,': [238], 'certain': [242], 'extent': [243], 'verified': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3133887987', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}], 'updated_date': '2024-12-12T08:26:03.315013', 'created_date': '2021-03-15'}