Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3130806697', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs20-ps4-13', 'title': 'Abstract PS4-13: Irreversible inhibition of HER2 activating mutations with neratinib enhances the pre-clinical efficacy of trastuzumab emtansine and trastuzumab deruxtecan', 'display_name': 'Abstract PS4-13: Irreversible inhibition of HER2 activating mutations with neratinib enhances the pre-clinical efficacy of trastuzumab emtansine and trastuzumab deruxtecan', 'publication_year': 2021, 'publication_date': '2021-02-15', 'ids': {'openalex': 'https://openalex.org/W3130806697', 'doi': 'https://doi.org/10.1158/1538-7445.sabcs20-ps4-13', 'mag': '3130806697'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs20-ps4-13', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001373717', 'display_name': 'Ron Bose', 'orcid': 'https://orcid.org/0000-0003-1977-8894'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ron Bose', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034234418', 'display_name': 'Shunqiang Li', 'orcid': 'https://orcid.org/0000-0001-9508-7249'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shunqiang Li', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008339153', 'display_name': 'Tina Primeau', 'orcid': 'https://orcid.org/0009-0005-8106-4798'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tina M. Primeau', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047543960', 'display_name': 'Maureen Highkin', 'orcid': 'https://orcid.org/0009-0005-5923-7883'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maureen K. Highkin', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029112821', 'display_name': 'Ashley R. Tipton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ashley R. Tipton', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085644960', 'display_name': 'Nagalaxmi Vemalapally', 'orcid': 'https://orcid.org/0009-0001-1970-5460'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nagalaxmi Vemalapally', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006405247', 'display_name': 'Xuefeng Gao', 'orcid': 'https://orcid.org/0000-0002-1904-392X'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xuefeng Gao', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113503444', 'display_name': 'Gail Sudlow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gail Sudlow', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015397173', 'display_name': 'Irmina Diala', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154785', 'display_name': 'Puma Biotechnology (United States)', 'ror': 'https://ror.org/053kr4v45', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154785']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Irmina Diala', 'raw_affiliation_strings': ['2Puma Biotechnology Inc., Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': '2Puma Biotechnology Inc., Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4210154785']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100638906', 'display_name': 'Tao Yu', 'orcid': 'https://orcid.org/0000-0001-7909-3841'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yu Tao', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037696116', 'display_name': 'Jingqin Luo', 'orcid': 'https://orcid.org/0000-0003-2759-3072'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jingqin Luo', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004313839', 'display_name': 'Ian S. Hagemann', 'orcid': 'https://orcid.org/0000-0002-3855-9745'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ian Hagemann', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040838377', 'display_name': 'Chieh‐Yu Lin', 'orcid': 'https://orcid.org/0000-0002-4269-3234'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chieh-Yu Lin', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085464902', 'display_name': 'Richard Bryce', 'orcid': 'https://orcid.org/0000-0002-1507-9650'}, 'institutions': [{'id': 'https://openalex.org/I4210154785', 'display_name': 'Puma Biotechnology (United States)', 'ror': 'https://ror.org/053kr4v45', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154785']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard P. Bryce', 'raw_affiliation_strings': ['2Puma Biotechnology Inc., Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': '2Puma Biotechnology Inc., Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4210154785']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007997858', 'display_name': 'Alshad S. Lalani', 'orcid': 'https://orcid.org/0000-0003-4891-9983'}, 'institutions': [{'id': 'https://openalex.org/I4210154785', 'display_name': 'Puma Biotechnology (United States)', 'ror': 'https://ror.org/053kr4v45', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210154785']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alshad S. Lalani', 'raw_affiliation_strings': ['2Puma Biotechnology Inc., Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': '2Puma Biotechnology Inc., Los Angeles, CA', 'institution_ids': ['https://openalex.org/I4210154785']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086585564', 'display_name': 'Samuel Achilefu', 'orcid': 'https://orcid.org/0000-0002-3133-6717'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Samuel Achilefu', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035849162', 'display_name': 'X. Cynthia', 'orcid': 'https://orcid.org/0000-0002-8156-7492'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cynthia X. Ma', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO;'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO;', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.512, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.661911, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 76}, 'biblio': {'volume': '81', 'issue': '4_Supplement', 'first_page': 'PS4', 'last_page': '13'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9421, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9421, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9378, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9075, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neratinib', 'display_name': 'Neratinib', 'score': 0.9770862}, {'id': 'https://openalex.org/keywords/lapatinib', 'display_name': 'Lapatinib', 'score': 0.8488176}, {'id': 'https://openalex.org/keywords/trastuzumab-emtansine', 'display_name': 'Trastuzumab emtansine', 'score': 0.6785111}], 'concepts': [{'id': 'https://openalex.org/C2779413316', 'wikidata': 'https://www.wikidata.org/wiki/Q6995920', 'display_name': 'Neratinib', 'level': 5, 'score': 0.9770862}, {'id': 'https://openalex.org/C2777329042', 'wikidata': 'https://www.wikidata.org/wiki/Q420323', 'display_name': 'Lapatinib', 'level': 5, 'score': 0.8488176}, {'id': 'https://openalex.org/C2779786085', 'wikidata': 'https://www.wikidata.org/wiki/Q412616', 'display_name': 'Trastuzumab', 'level': 4, 'score': 0.7566017}, {'id': 'https://openalex.org/C2778087150', 'wikidata': 'https://www.wikidata.org/wiki/Q3997863', 'display_name': 'Trastuzumab emtansine', 'level': 5, 'score': 0.6785111}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.5763093}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.57203275}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5465325}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.5118632}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.42859632}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.30624068}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.30341446}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2936414}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.sabcs20-ps4-13', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.53, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W67104293', 'https://openalex.org/W3164150197', 'https://openalex.org/W2989981638', 'https://openalex.org/W2947545363', 'https://openalex.org/W2326908302', 'https://openalex.org/W2262572336', 'https://openalex.org/W2167587342', 'https://openalex.org/W2166148619', 'https://openalex.org/W1967506091', 'https://openalex.org/W1964808503'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'HER2': [2, 38, 75, 130, 136, 141, 156, 167, 174, 222, 239, 330, 379, 392, 399, 410, 416, 464], 'activating': [3, 137, 183, 465], 'mutations': [4, 175, 466], 'occur': [5, 235], 'in': [6, 99, 103, 107, 165, 194, 204, 246, 268, 326, 328, 378, 398], '2-5%': [7], 'of': [8, 110, 161, 172, 200, 228, 249, 292, 297, 318, 360, 389, 407, 463, 473, 482], 'metastatic': [9], 'breast': [10], 'cancer': [11], '(MBC)': [12], 'patients,': [13], 'and': [14, 55, 69, 79, 94, 102, 124, 152, 180, 191, 210, 219, 242, 262, 284, 322, 333, 364, 373, 476], 'three': [15], 'phase': [16], 'II': [17], 'or': [18, 350, 396, 401], 'basket': [19], 'clinical': [20], 'trials': [21, 43, 388], 'have': [22, 176, 313], 'shown': [23], 'that': [24, 134, 217, 301], 'the': [25, 86, 166, 211, 225, 237, 255, 289, 295, 316, 340, 358, 470, 483], 'irreversible': [26, 221], 'pan-HER': [27], 'tyrosine': [28, 168], 'kinase': [29, 169], 'inhibitor,': [30], 'neratinib,': [31], 'has': [32, 140, 154], 'good': [33], 'single': [34], 'agent': [35], 'efficacy': [36, 472], 'for': [37, 59, 387], 'mutated': [39, 380], 'MBC': [40, 78, 132], 'patients.': [41, 61], 'Current': [42], 'are': [44, 163, 181], 'combining': [45], 'neratinib': [46, 84, 201, 218, 272, 275, 308, 319, 323, 341, 390, 408, 468], 'with': [47, 74, 85, 115, 202, 236, 257, 271, 276, 310, 339, 467], 'other': [48, 220], 'targeted': [49], 'therapies': [50], 'to': [51, 82, 307, 347, 415], 'increase': [52, 224, 267], 'response': [53], 'rate': [54], 'progression': [56], 'free': [57], 'survival': [58], 'these': [60, 111, 173], 'Methods:': [62], 'We': [63, 215, 312], 'established': [64, 127, 187], 'patient': [65], 'derived': [66], 'xenografts': [67], '(PDX)': [68], 'organoids': [70], 'from': [71, 128, 188], 'two': [72], 'patients': [73, 133], 'mutated,': [76], 'non-amplified': [77, 131], 'used': [80], 'them': [81], 'test': [83], 'antibody': [87], 'drug': [88], 'conjugates': [89], '(ADC’s),': [90], 'trastuzumab': [91, 95, 361, 365, 474, 477], 'emtansine': [92, 362, 475], '(T-DM1)': [93, 363], 'deruxtecan': [96, 366, 478], '(T-DXd),': [97, 367], 'both': [98, 160, 189, 315, 329], '3D': [100, 195, 205], 'culture': [101, 206], 'vivo.': [104], 'Real': [105, 244], 'time,': [106, 245], 'vivo': [108, 247, 327], 'uptake': [109, 227, 248, 270], 'ADC’s': [112], 'was': [113, 213, 251], 'visualized': [114], 'a': [116, 155, 258], 'near': [117, 259], 'infrared': [118, 260], 'fluorophore.': [119], 'Results:': [120], 'PDX': [121], 'lines': [122], 'WHIM51': [123, 139], 'WHIM64': [125, 153], 'were': [126, 186, 192], 'ER+,': [129], 'had': [135], 'mutations.': [138, 184], 'exon': [142], '20': [143], 'insertion': [144], 'mutation': [145], 'at': [146, 280, 294], 'amino': [147], 'acid': [148], '776': [149], '(ERBB2': [150], 'A775_G776insYVMA)': [151], 'L869R': [157], 'missense': [158], 'mutation,': [159], 'which': [162], 'located': [164], 'domain.': [170], 'Both': [171], 'been': [177], 'previously': [178], 'characterized': [179], 'known': [182], 'Organoids': [185], 'PDX’s': [190, 332], 'grown': [193], 'culture.': [196], 'Drug': [197], 'combination': [198], 'testing': [199], 'T-DM1': [203, 250, 269, 277, 325, 351, 397], 'showed': [207], 'strong': [208], 'synergy': [209], 'mechanism': [212, 304, 406], 'explored.': [214], 'demonstrate': [216], 'inhibitors': [223], 'endocytic': [226], 'T-DM1,': [229], 'but': [230], 'this': [231, 302, 405], 'effect': [232], 'does': [233], 'not': [234], 'reversible': [238], 'inhibitors,': [240], 'tucatinib': [241], 'lapatinib.': [243], 'measured': [252], 'by': [253], 'labeling': [254], 'ADC': [256, 343], 'fluorophore': [261], 'we': [263, 299], 'observed': [264, 334], 'statistically': [265, 335], 'significant': [266, 336], 'pre-treatment.': [273], 'Combining': [274], 'increased': [278], 'apoptosis': [279], 'day': [281], '3': [282], 'post-treatment': [283], 'enhanced': [285], 'tumor': [286, 337, 370, 376], 'shrinkage.': [287], 'With': [288], 'FDA': [290], 'approval': [291], 'T-DXd': [293, 321, 349, 395], 'end': [296], '2019,': [298], 'hypothesized': [300], 'same': [303], 'may': [305, 412], 'apply': [306, 414], 'combined': [309], 'T-DXd.': [311], 'tested': [314], 'combinations': [317, 344], '+': [320, 324, 342], 'mutant': [331, 400], 'regression': [338, 377], 'as': [345], 'compared': [346], 'either': [348], 'on': [352], 'its': [353], 'own.': [354], 'Conclusions:': [355], 'Neratinib': [356], 'increases': [357], 'endocytosis': [359, 411], 'thereby': [368], 'increasing': [369], 'cell': [371], 'kill': [372], 'causing': [374], 'greater': [375], 'MBC.': [381, 403, 418], 'These': [382], 'data': [383], 'provide': [384], 'preclinical': [385], 'justification': [386], 'plus': [391], 'ADCs': [393], 'including': [394], 'HER2+': [402], 'Further,': [404], 'stimulated': [409], 'also': [413], 'low': [417], 'Citation': [419], 'Format:': [420], 'Ron': [421], 'Bose,': [422], 'Shunqiang': [423], 'Li,': [424], 'Tina': [425], 'M.': [426], 'Primeau,': [427], 'Maureen': [428], 'K.': [429], 'Highkin,': [430], 'Ashley': [431], 'R.': [432], 'Tipton,': [433], 'Nagalaxmi': [434], 'Vemalapally,': [435], 'Xuefeng': [436], 'Gao,': [437], 'Gail': [438], 'Sudlow,': [439], 'Irmina': [440], 'Diala,': [441], 'Yu': [442], 'Tao,': [443], 'Jingqin': [444], 'Luo,': [445], 'Ian': [446], 'Hagemann,': [447], 'Chieh-Yu': [448], 'Lin,': [449], 'Richard': [450], 'P.': [451], 'Bryce,': [452], 'Alshad': [453], 'S.': [454], 'Lalani,': [455], 'Samuel': [456], 'Achilefu,': [457], 'Cynthia': [458], 'X.': [459], 'Ma.': [460], 'Irreversible': [461], 'inhibition': [462], 'enhances': [469], 'pre-clinical': [471], '[abstract].': [479], 'In:': [480], 'Proceedings': [481], '2020': [484, 491], 'San': [485, 494], 'Antonio': [486], 'Breast': [487], 'Cancer': [488, 500], 'Virtual': [489], 'Symposium;': [490], 'Dec': [492], '8-11;': [493], 'Antonio,': [495], 'TX.': [496], 'Philadelphia': [497], '(PA):': [498], 'AACR;': [499], 'Res': [501], '2021;81(4': [502], 'Suppl):Abstract': [503], 'nr': [504], 'PS4-13.': [505]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3130806697', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-13T14:00:00.846891', 'created_date': '2021-03-01'}