Publication Information

{'id': 'https://openalex.org/W3130776464', 'doi': 'https://doi.org/10.1016/j.jid.2021.01.017', 'title': 'Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany', 'display_name': 'Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany', 'publication_year': 2021, 'publication_date': '2021-02-17', 'ids': {'openalex': 'https://openalex.org/W3130776464', 'doi': 'https://doi.org/10.1016/j.jid.2021.01.017', 'mag': '3130776464', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33609556'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jid.2021.01.017', 'pdf_url': 'http://www.jidonline.org/article/S0022202X21001469/pdf', 'source': {'id': 'https://openalex.org/S28607811', 'display_name': 'Journal of Investigative Dermatology', 'issn_l': '0022-202X', 'issn': ['0022-202X', '1523-1747'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 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'raw_affiliation_strings': ['Department of Dermatology, University of Berlin, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University of Berlin, Berlin, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027479980', 'display_name': 'Michael Sticherling', 'orcid': 'https://orcid.org/0000-0001-9396-3938'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}, {'id': 'https://openalex.org/I4210088053', 'display_name': 'Universitätsklinikum Erlangen', 'ror': 'https://ror.org/0030f2a11', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088053']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Sticherling', 'raw_affiliation_strings': ['Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854', 'https://openalex.org/I4210088053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082049025', 'display_name': 'Knut Schäkel', 'orcid': 'https://orcid.org/0000-0001-6344-7799'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Knut Schäkel', 'raw_affiliation_strings': ['Department of Dermatology, University of Heidelberg, Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University of Heidelberg, Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005979782', 'display_name': 'Sarah Schuhmann', 'orcid': 'https://orcid.org/0000-0002-6775-3547'}, 'institutions': [{'id': 'https://openalex.org/I4210088053', 'display_name': 'Universitätsklinikum Erlangen', 'ror': 'https://ror.org/0030f2a11', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088053']}, {'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Sarah Schuhmann', 'raw_affiliation_strings': ['Institute of Human Genetics, University 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Prinz', 'orcid': 'https://orcid.org/0000-0002-8857-5495'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jörg C. Prinz', 'raw_affiliation_strings': ['Department of Dermatology and Allergology, Ludwig-Maximilian University Munich, Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology and Allergology, Ludwig-Maximilian University Munich, Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032343417', 'display_name': 'Harald Burkhardt', 'orcid': 'https://orcid.org/0000-0002-6261-3131'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}, {'id': 'https://openalex.org/I4210107844', 'display_name': 'Fraunhofer Institute for Translational Medicine and Pharmacology', 'ror': 'https://ror.org/01s1h3j07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210107844', 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'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114090438']}, {'id': 'https://openalex.org/I4210107844', 'display_name': 'Fraunhofer Institute for Translational Medicine and Pharmacology', 'ror': 'https://ror.org/01s1h3j07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210107844', 'https://openalex.org/I4923324']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank Behrens', 'raw_affiliation_strings': ['Division of Rheumatology, Goethe University, Frankfurt am Main, Germany', 'Fraunhofer Project Group Translational Medicine and Pharmacology, IME, Goethe University, Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Fraunhofer Project Group Translational Medicine and Pharmacology, IME, Goethe University, Frankfurt am Main, Germany', 'institution_ids': ['https://openalex.org/I114090438', 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['Division of Rheumatology, Goethe University, Frankfurt am Main, Germany', 'Fraunhofer Project Group Translational Medicine and Pharmacology, IME, Goethe University, Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Fraunhofer Project Group Translational Medicine and Pharmacology, IME, Goethe University, Frankfurt am Main, Germany', 'institution_ids': ['https://openalex.org/I114090438', 'https://openalex.org/I4210107844']}, {'raw_affiliation_string': 'Division of Rheumatology, Goethe University, Frankfurt am Main, Germany', 'institution_ids': ['https://openalex.org/I114090438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029412055', 'display_name': 'Michaela Köhm', 'orcid': 'https://orcid.org/0000-0002-3579-5574'}, 'institutions': [{'id': 'https://openalex.org/I114090438', 'display_name': 'Goethe University Frankfurt', 'ror': 'https://ror.org/04cvxnb49', 'country_code': 'DE', 'type': 'education', 'lineage': 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[{'raw_affiliation_string': 'Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany', 'institution_ids': ['https://openalex.org/I4210088053', 'https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040409271', 'display_name': 'David Simón', 'orcid': 'https://orcid.org/0000-0001-8310-7820'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}, {'id': 'https://openalex.org/I4210088053', 'display_name': 'Universitätsklinikum Erlangen', 'ror': 'https://ror.org/0030f2a11', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088053']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'David Simon', 'raw_affiliation_strings': ['Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854', 'https://openalex.org/I4210088053']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075261558', 'display_name': 'Georg Schett', 'orcid': 'https://orcid.org/0000-0001-8740-9615'}, 'institutions': [{'id': 'https://openalex.org/I4210088053', 'display_name': 'Universitätsklinikum Erlangen', 'ror': 'https://ror.org/0030f2a11', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210088053']}, {'id': 'https://openalex.org/I181369854', 'display_name': 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559, 655, 657, 736, 858, 863, 912, 962, 964, 968, 995, 1030, 1077, 1084, 1087, 1090, 1093, 1191, 1197, 1205, 1226, 1318, 1339, 1362, 1366, 1370, 1374, 1525, 1641, 1841, 1843, 1850, 1895, 1908, 1934, 1959, 1963, 1991, 2096, 2098, 2465], 'strong': [9], 'impact': [10], 'on': [11, 935, 1045, 2064, 2265], "patients'": [12], 'QOL.': [13], 'The': [14, 231, 583, 2278], 'most': [15, 322, 419, 1109, 1977], 'psoriasis': [17, 19, 73, 178, 200, 208, 278, 515, 629, 674, 702, 771, 1140, 1258, 1492, 1606, 1751, 1842, 2015, 2048, 2097, 2131, 2147, 2271], 'form,': [18], 'vulgaris': [20], '(PsV),': [21], 'characterized': [23, 213], 'by': [24, 214, 809, 889, 894, 902, 2275, 2332, 2345, 2355], 'demarcated,': [25], 'erythematous,': [26], 'raised': [27], 'plaques': [28], 'along': [29], 'silvery': [31], 'scales.': [32], 'Up': [33], 'to': [34, 192, 241, 389, 663, 794, 870, 947, 981, 1000, 1065, 1331, 1816, 1823, 1856, 1937, 1980, 2000, 2089, 2118, 2128, 2289, 2334, 2348, 2357, 2374], '30%': [35], 'of': [36, 66, 110, 120, 234, 392, 441, 450, 468, 470, 585, 591, 598, 673, 729, 745, 798, 813, 823, 845, 855, 879, 883, 906, 917, 938, 942, 960, 975, 989, 1049, 1060, 1075, 1095, 1107, 1221, 1286, 1303, 1316, 1335, 1355, 1385, 1475, 1496, 1509, 1532, 1589, 1610, 1625, 1648, 1703, 1722, 1789, 1820, 1839, 1852, 1880, 1905, 1911, 1918, 1944, 1956, 1983, 2003, 2009, 2075, 2094, 2140, 2144, 2253, 2284, 2318, 2365], 'patients': [37, 71, 122, 255, 301, 323, 420, 654, 735, 857, 961, 1076, 1225, 1725, 1840, 2074, 2095, 2291], 'PsV': [39, 136, 193, 737, 913, 963, 1031, 1035, 1860, 1993], 'develop': [40], 'an': [41, 486, 725], 'joint': [43, 896], 'disease': [44, 327, 424, 1919, 1945], 'named': [45], 'psoriatic': [46, 68, 111, 152, 197, 460, 750, 768, 773, 803, 1227, 1489, 1535, 1603, 1651], 'arthritis': [47, 69, 112, 769, 774], '(PsA)': [48], '(Mease': [49], 'et': [50, 64, 96, 155, 169, 257, 271, 303, 317, 352, 366, 400, 414, 494, 508, 539, 553, 608, 622, 681, 695, 753, 1119, 1133, 1237, 1251, 1539, 1553, 1656, 1670, 1730, 1744, 1775, 1804, 2025, 2039], 'al.,': [51, 97, 156, 258, 304, 353, 401, 495, 540, 609, 682, 754, 1120, 1238, 1540, 1657, 1731, 1776, 1805, 2026], '2013Mease': [52], 'P.J.': [53], 'Gladman': [54], 'D.D.': [55], 'Papp': [56], 'K.A.': [57], 'Khraishi': [58], 'M.M.': [59], 'Thaçi': [60], 'D.': [61, 308, 405, 756], 'Behrens': [62], 'F.': [63], 'al.Prevalence': [65], 'rheumatologist-diagnosed': [67], 'in': [70, 74, 113, 148, 223, 253, 297, 491, 512, 605, 626, 699, 734, 748, 801, 851, 951, 984, 998, 1003, 1063, 1071, 1137, 1203, 1224, 1230, 1255, 1298, 1343, 1359, 1514, 1561, 1567, 1580, 1630, 1678, 1684, 1712, 1719, 1724, 1748, 1792, 1859, 1876, 2014, 2073, 2109, 2156, 2249, 2262, 2268, 2296], 'European/North': [75], 'American': [76], 'dermatology': [77], 'clinics.J': [78], 'Am': [79], 'Acad': [80], 'Dermatol.': [81, 127, 331, 428], '2013;': [82], '69:': [83], '729-735Abstract': [84], 'Full': [85, 87, 286, 288, 528, 530, 573, 575, 642, 644, 715, 717, 1153, 1155, 1271, 1273, 1764, 1766, 1830], 'Text': [86, 88, 287, 289, 529, 531, 574, 576, 643, 645, 716, 718, 1154, 1156, 1272, 1274, 1765, 1767, 1831], 'PDF': [89, 290, 532, 577, 646, 719, 1157, 1275, 1768, 1832], 'PubMed': [90, 131, 185, 291, 335, 380, 432, 533, 578, 647, 720, 785, 1158, 1276, 1573, 1690, 1769, 1798, 1833, 2055], 'Scopus': [91, 132, 186, 292, 336, 381, 433, 534, 579, 648, 721, 786, 1159, 1277, 1574, 1691, 1770, 1799, 2056], '(272)': [92], 'Google': [93, 134, 188, 294, 338, 383, 435, 536, 581, 650, 723, 788, 1161, 1279, 1576, 1693, 1772, 1801, 1834, 2058], 'Scholar;': [94, 537, 1773, 1802], 'Reich': [95], '2009Reich': [98], 'K.': [99, 101, 268, 550, 760], 'Krüger': [100], 'Mössner': [102], 'R.': [103, 270, 306, 403], 'Augustin': [104], 'M.': [105, 168, 501, 503, 542, 544, 548, 615, 617, 688, 690, 1126, 1128, 1244, 1246, 1737, 1739, 1786, 1811, 2038], 'Epidemiology': [106], 'and': [107, 137, 194, 205, 273, 299, 370, 394, 453, 462, 481, 516, 563, 594, 630, 668, 703, 738, 819, 836, 848, 860, 898, 915, 1007, 1036, 1051, 1101, 1141, 1167, 1174, 1183, 1200, 1208, 1214, 1229, 1259, 1296, 1301, 1353, 1381, 1389, 1516, 1632, 1716, 1752, 1861, 1864, 1923, 1994, 2102, 2159, 2272, 2292, 2305, 2354, 2359, 2367, 2371, 2431], 'clinical': [108, 2263], 'pattern': [109], 'Germany:': [114], 'prospective': [116], 'interdisciplinary': [117], 'epidemiological': [118], 'study': [119, 806, 1073, 1950], '1511': [121], 'plaque-type': [124], 'psoriasis.Br': [125], 'J': [126, 330, 375, 427, 522, 567, 636, 709, 1147, 1265, 1758], '2009;': [128], '160:': [129], '1040-1047Crossref': [130], '(273)': [133], 'Scholar).': [135, 189, 339, 436, 582, 651, 789, 1835, 2059], 'PsA': [138], 'are': [139, 227, 557, 660, 2154, 2287], 'genetically': [140], 'complex': [141], 'diseases': [142, 455], '>65': [144], 'susceptibility': [145, 489, 1064, 2022, 2127], 'loci': [146], 'identified': [147, 483, 869], 'one': [149, 861, 983], 'or': [150, 201, 1023, 1034, 1511, 1627], 'both': [151, 1992], 'subtypes': [153, 461, 1228], '(Tsoi': [154, 2024], '2017Tsoi': [157, 2027], 'L.C.': [158, 1544, 1661, 2028], 'Stuart': [159, 2029], 'P.E.': [160, 2030], 'Tian': [161, 2031], 'C.': [162, 1778, 2032, 2186], 'Gudjonsson': [163, 2033], 'J.E.': [164, 2034], 'Das': [165, 2035], 'S.': [166, 260, 314, 355, 365, 411, 497, 507, 611, 621, 684, 694, 1122, 1132, 1240, 1250, 1733, 1743, 1809, 2036], 'Zawistowski': [167, 2037], 'al.Large': [170, 2040], 'scale': [171, 2041], 'meta-analysis': [172, 2042], 'characterizes': [173, 2043], 'genetic': [174, 232, 274, 319, 416, 466, 2044, 2123, 2138], 'architecture': [175, 2045], 'for': [176, 229, 321, 349, 418, 1027, 1105, 1312, 1529, 1645, 1974, 2046, 2308, 2324, 2380], 'associated': [179, 558, 939, 967, 1338, 2049], 'variants.Nat': [180, 2050], 'Commun.': [181, 2051], '2017;': [182, 2052], '8:': [183, 2053], '15382Crossref': [184, 2054], '(125)': [187, 2057], 'In': [190, 652, 992], 'contrast': [191], 'PsA,': [195, 739, 1367, 1488, 1602], 'pustular': [196, 199, 207, 277, 325, 372, 422, 463, 514, 519, 564, 628, 633, 701, 706, 1139, 1144, 1257, 1262, 1750, 1755, 2270], 'subtypes—palmoplantar': [198], 'palmoplantar': [202, 1486, 1600, 2273], 'pustulosis': [203, 2274], '(PPP)': [204], 'generalized': [206, 221, 371, 513, 627, 700, 865, 1138, 1256, 1749, 2269], '(GPP)—are': [209], 'rarer.': [210], 'PPP': [211, 235, 1037, 1317, 1344, 1862], 'localized': [215], 'epidermal': [216], 'neutrophil': [217, 561], 'pustules,': [218], 'whereas': [219, 1016], 'more': [220, 661, 2087], 'pustules': [222, 606], 'severe': [224], 'multisystemic': [225], 'inflammation': [226, 511, 604, 625, 698, 1136, 1254, 1747], 'typical': [228], 'GPP.': [230], 'etiology': [233, 2139], 'unsolved;': [237], 'discrepant': [238], 'results': [239, 1887], 'related': [240], 'association': [242, 1315, 1955, 1969, 1990], 'IL36RN': [244, 341, 996, 1028, 1896], '(encoding': [245], 'the': [246, 390, 465, 596, 796, 810, 814, 820, 824, 843, 877, 907, 918, 931, 936, 952, 958, 982, 1001, 1017, 1108, 1188, 1218, 1284, 1326, 1530, 1646, 1696, 1701, 1837, 1877, 1903, 1909, 1916, 1942, 1966, 1981, 2001, 2007, 2092, 2129, 2137, 2145, 2250, 2290, 2337, 2351, 2362, 2377], 'IL-36': [247, 599], 'receptor': [248], 'antagonist)': [249], 'variants': [250, 659, 679, 747, 800, 850, 873, 966, 997, 1062, 1070, 1114, 1207, 1223, 1289, 1320, 1513, 1629, 1845, 1882, 1897, 1907, 1958, 2084, 2100], 'were': [251, 887, 892, 933, 1014, 1021, 1043, 1290, 1519, 1635, 1888], 'reported': [252], 'British': [254], '(Twelves': [256], '2019Twelves': [259], 'Mostafa': [261], 'A.': [262, 361, 505, 619, 692, 762, 1130, 1248, 1741], 'Dand': [263], 'N.': [264, 546], 'Burri': [265], 'E.': [266], 'Farkas': [267], 'Wilson': [269], 'al.Clinical': [272], 'differences': [275], 'between': [276, 1292], 'subtypes.J': [279], 'Allergy': [280], 'Clin': [281], 'Immunol.': [282], '2019;': [283], '143:': [284], '1021-1026Abstract': [285], '(63)': [293], 'Scholar)': [295, 1162, 1280], 'versus': [296], 'German': [298, 1378, 2065], 'Estonian': [300], '(Mössner': [302, 399], '2018Mössner': [305, 402], 'Wilsmann-Theis': [307, 404], 'Oji': [309, 406], 'V.': [310, 407, 766], 'Gkogkolou': [311, 408], 'P.': [312, 316, 357, 409, 413, 1780], 'Löhr': [313, 410, 506, 620, 693, 1131, 1249, 1742], 'Schulz': [315, 412], 'al.The': [318, 415, 1554, 1671], 'basis': [320, 417, 467, 878, 937], 'remains': [328, 425], 'elusive.Br': [329, 426], '2018;': [332, 429, 782], '178:': [333, 430], '740-748Crossref': [334, 431], '(43)': [337, 434], 'Conversely,': [340], 'has': [342, 731], 'been': [343, 732], 'acknowledged': [344], 'as': [345, 485, 1233, 2020], 'major': [347, 488], 'gene': [348, 490], 'GPP': [350, 492, 656, 859, 2141], '(Marrakchi': [351], '2011Marrakchi': [354], 'Guigue': [356], 'Renshaw': [358], 'B.R.': [359], 'Puel': [360], 'Pei': [362], 'X.Y.': [363], 'Fraitag': [364], 'al.Interleukin-36-receptor': [367], 'antagonist': [368], 'deficiency': [369, 584, 950, 970, 1715, 1791, 1814], 'psoriasis.N': [373], 'Engl': [374], 'Med.': [376], '2011;': [377], '365:': [378], '620-628Crossref': [379], '(623)': [382], 'Scholar),': [384], 'although': [385, 1965], 'further': [386, 825], 'factors': [387, 2124], 'contribute': [388], 'pathogenesis': [391], 'GPP,': [393], 'oligogenic': [395], 'inheritance': [396], 'discussed': [398], 'Patients': [437, 1361, 1365, 1369, 1373], 'diagnosed': [438], 'syndrome': [440, 469, 1094, 1302, 1495, 1609], 'synovitis,': [442, 471, 1096, 1304, 1497, 1611], 'acne,': [443, 472, 1097, 1305, 1498, 1612], 'pustulosis,': [444, 473, 867, 1098, 1306, 1499, 1613], 'hyperostosis,': [445, 474, 1099, 1307, 1500, 1614], 'osteitis': [446, 475], 'exhibit': [447], 'different': [448, 1198], 'combinations': [449, 1710], 'bone': [454], 'considerably': [456], 'overlapping': [457], 'psoriasis;': [464], 'largely': [477, 2125], 'unknown.': [478], 'Recently,': [479], 'we': [480, 1052, 1067, 1309, 1707, 1869, 1930, 2067], 'others': [482], 'MPO': [484, 588, 658, 678, 730, 746, 799, 872, 928, 943, 949, 965, 1004, 1061, 1069, 1113, 1206, 1288, 1319, 1341, 1357, 1705, 1714, 1881, 1892, 1906, 1957, 2019, 2083], 'additional': [487, 517, 631, 704, 1142, 1260, 1753], '(Haskamp': [493, 607, 680, 1118, 1236, 1729], '2020Haskamp': [496, 610, 683, 1121, 1239, 1732], 'Bruns': [498, 612, 685, 1123, 1241, 1734], 'H.': [499, 613, 686, 1124, 1242, 1735], 'Hahn': [500, 614, 687, 1125, 1243, 1736], 'Hoffmann': [502, 616, 689, 1127, 1245, 1738], 'Gregor': [504, 618, 691, 1129, 1247, 1740], 'al.Myeloperoxidase': [509, 623, 696, 1134, 1252, 1745], 'modulates': [510, 624, 697, 1135, 1253, 1746], 'rare': [518, 632, 705, 1143, 1261, 1754], 'diseases.Am': [521, 635, 708, 1146, 1264, 1757], 'Hum': [523, 568, 637, 710, 1148, 1266, 1759], 'Genet.': [524, 569, 638, 711, 1149, 1267, 1760], '2020;': [525, 570, 639, 712, 1150, 1268, 1570, 1687, 1761], '107:': [526, 571, 640, 713, 1151, 1269, 1762], '527-538Abstract': [527, 641, 714, 1152, 1270, 1763], '(14)': [535, 649, 722, 1160, 1278, 1771], 'Vergnano': [538], '2020Vergnano': [541], 'Mockenhaupt': [543], 'Benzian-Olsson': [545], 'Paulmann': [547], 'Grys': [549], 'Mahil': [551], 'S.K.': [552], 'al.Loss-of-function': [554], 'myeloperoxidase': [555, 1790, 1813], 'mutations': [556], 'increased': [560, 726, 1847], 'counts': [562], 'disease.Am': [566], '539-543Abstract': [572], '(11)': [580], 'neutrophilic': [586], 'enzyme': [587, 940, 1720], 'impairs': [589], 'phagocytosis': [590], 'dying': [592], 'neutrophils': [593], 'increases': [595], 'activity': [597, 941, 1721], 'activating': [600], 'proteases,': [601], 'thereby': [602], 'driving': [603], 'addition,': [653], 'likely': [662], 'have': [664], 'PPP,': [665, 1371, 1485, 1599, 1964], 'tongue': [666], 'manifestations,': [667], 'positive': [670, 1924], 'family': [671, 853, 885, 910, 922, 986, 1925], 'history': [672, 1926], 'than': [675, 2107], 'those': [676, 884, 2143], 'without': [677, 772], 'Scholar);': [724], 'serum': [727, 777], 'amount': [728], 'detected': [733], 'suggesting': [740], 'potentially': [742], 'protective': [743], 'role': [744, 797, 1059, 2072], 'manifestations': [751], '(Cretu': [752], '2018Cretu': [755], 'Gao': [757], 'L.': [758], 'Liang': [759], 'Soosaipillai': [761], 'Diamandis': [763], 'E.P.': [764], 'Chandran': [765], 'Differentiating': [767], 'from': [770, 833, 945, 1537, 1559, 1654, 1676, 2142, 2336, 2350, 2361, 2376], 'using': [775, 1163, 1521, 1637], 'novel': [776], 'biomarkers.Arthritis': [778], 'Care': [779], 'Res': [780], '(Hoboken).': [781], '70:': [783], '454-461Crossref': [784], '(26)': [787], 'These': [790, 2111], 'findings': [791, 1042, 2112, 2135], 'prompted': [792], 'us': [793], 'investigate': [795], 'other': [802, 2076, 2122, 2146], 'subtypes.': [804, 2132, 2148], 'This': [805, 1996, 2328], 'was': [807, 831, 900, 971, 979, 1846, 2104, 2330], 'approved': [808], 'ethical': [811, 821], 'committee': [812], 'Friedrich-Alexander-Universität': [815], 'Erlangen-Nürnberg': [816], '(Erlangen,': [817], 'Germany)': [818], 'committees': [822], 'involved': [826, 2261], 'universities.': [827], 'Written': [828], 'informed': [829], 'consent': [830], 'obtained': [832, 1931], 'each': [834], 'affected': [835, 888, 893, 901], 'control': [837, 1103, 1231, 1294, 1517, 1633, 1853], 'individual': [838], 'before': [839, 1235], 'enrolment.': [840], 'We': [841, 1079, 1185, 1216, 1987, 2286, 2299, 2312], 'analyzed': [842, 909, 920, 934, 2153], 'segregation': [844], 'MPO,': [846], 'IL36RN,': [847], 'CARD14': [849], 'available': [852, 2155], 'members': [854, 886, 911, 923, 987], 'seven': [856, 1106], 'patient': [862, 1515, 1631, 1985], 'acute': [864], 'exanthematous': [866], 'previously': [868], 'carry': [871], '(Figure': [874], '1).': [875, 1282], 'On': [876], 'self-reported': [880], 'diagnoses,': [881], '14': [882], 'PsV,': [890, 1066, 1363, 1491, 1605], '2': [891], 'disease,': [897], '1': [899], 'PPP.': [903], 'Overall,': [904, 2133], '6': [905], '12': [908], '(50%)': [914], '8': [916], '13': [919], 'healthy': [921, 985], '(62%)': [924], 'carried': [925], 'heterozygous': [927, 1012, 1022, 1025], 'variant.': [929], 'When': [930], 'families': [932, 994], 'variants,': [944, 1706], 'complete': [946, 969], 'partial': [948, 1340, 1713], 'homozygous': [953], 'state': [954, 2281], '(Supplementary': [955, 1115, 1172, 1212, 1726, 1883, 1898, 1913, 1920, 1927], 'Table': [956, 1116, 1349, 1727, 1884, 1899, 1921, 1928], 'S1),': [957, 1915], 'proportion': [959, 2093], 'slightly': [972], 'higher': [973, 1857, 2106], '(6': [974], '10,': [976], '60%)': [977], 'but': [978, 2116], 'similar': [980, 1291], '(7': [988], '11,': [990], '64%).': [991], 'two': [993, 1018, 1293, 1704, 1844, 2082, 2099], 'addition': [999], 'ones': [1002], '(pedigrees': [1005], 'VI': [1006], 'VII,': [1008], 'Figure': [1009, 1178, 1914], '1),': [1010], 'double': [1011], 'individuals': [1013, 1019, 1050, 1082, 1204, 1232, 1854, 2080], 'healthy,': [1015], 'who': [1020, 2294], 'compound': [1024], 'only': [1026], 'presented': [1029], '(family': [1032], 'VI)': [1033], '(pedigree': [1038], 'VII).': [1039], 'Because': [1040, 2060], 'these': [1041, 2004], 'based': [1044], 'limited': [1047], 'number': [1048, 1474, 1588], 'could': [1053], 'neither': [1054], 'establish': [1055], 'nor': [1056], 'exclude': [1057, 2069], 'investigated': [1068], 'larger': [1072], 'groups': [1074, 1295, 1518, 1634], 'psoriasis.': [1078], 'genotyped': [1080], '3,663': [1081], '(1,105': [1083], 'PsV;': [1085, 1299], '1,313': [1086, 1364], 'PsA;': [1088, 1300], '271': [1089, 1368], 'PPP;': [1091], '52': [1092, 1372], 'osteitis;': [1100, 1501, 1615], '922': [1102, 1377], 'individuals)': [1104], 'functionally': [1111], 'relevant': [1112], 'S1)': [1117], 'global': [1164], 'screening': [1165], 'array': [1166], 'single': [1168, 1327], 'SNP': [1169], 'genotyping': [1170, 1189, 1196], 'assays': [1171, 1199], 'Materials': [1173, 1213], 'Methods': [1175], 'including': [1176, 1194], 'Supplementary': [1177, 1180, 1348, 2468], 'S2,': [1179], 'Tables': [1181], 'S7': [1182], 'S8).': [1184], 'extensively': [1186], 'validated': [1187], 'quality': [1190], 'several': [1192], 'approaches,': [1193], 'repeated': [1195], 'Sanger': [1201], 'sequencing': [1202], 'randomly': [1209], 'selected': [1210], 'genotypes': [1211], 'Methods).': [1215], 'determined': [1217], 'cumulative': [1219], 'frequency': [1220, 1507, 1623], 'all': [1222, 1287], 'described': [1234], '(Table': [1281], 'Whereas': [1283], 'frequencies': [1285], 'comparable': [1297], 'osteitis,': [1308], 'observed': [1310, 1708], 'evidence': [1311], 'marginal': [1313], 'significant': [1314, 1874, 1954], '(P': [1321, 1345, 1946], '=': [1322, 1346, 1947], '0.015).': [1323], 'Analyses': [1324], 'at': [1325, 1387], 'variant': [1328, 1336], 'level': [1329, 1698], 'pointed': [1330], 'prominent': [1333], 'contribution': [1334], 'c.995C>T/p.(Ala332Val),': [1337], 'deficiency,': [1342], '0.008;': [1347], 'S1).Table': [1350], '1Allele': [1351], 'Numbers': [1352], 'Frequencies': [1354], 'Rare': [1356], 'Variants': [1358], '1,105': [1360], 'SAPHO': [1375], 'Syndrome,': [1376, 1400], 'Control': [1379], 'Indivs.,': [1380, 1403, 1406], '64,591': [1382], 'NFE': [1383], 'Indivs.': [1384], 'gnomADVariant': [1386], 'Nucleotide': [1388], 'Protein': [1390], 'LevelPsoriasis': [1391], 'SubtypesControl': [1392], 'Indivs.PsV,': [1393], 'n': [1394, 1396, 1398, 1401, 1404, 1407], '(%)PsA,': [1395], '(%)PPP,': [1397], '(%)SAPHO': [1399], '(%)Control': [1402], '(%)NFE': [1405], '(%)c.752T>C/p.(Met251Thr)27': [1408], '(1.22)38': [1409], '(1.45)8': [1410], '(1.48)2': [1411], '(1.92)25': [1412], '(1.36)1,735': [1413], '(1.34)c.995C>T/p.(Ala332Val)33': [1414], '(1.49)38': [1415], '(1.45)19': [1416], '(3.51)1': [1417], '(0.96)34': [1418], '(1.84)2,314': [1419], '(1.79)c.1555_1568del/': [1420], 'p.(Met519Profs∗21)6': [1421], '(0.27)6': [1422, 1434], '(0.23)2': [1423], '(0.37)1': [1424], '(0.96)2': [1425], '(0.11)0': [1426], '(.15)c.1642C>T/p.(Arg548Trp)0': [1427], '(0)0': [1428, 1429, 1430, 1440, 1441], '(0)1': [1431], '(0.05)67': [1432], '(0.05)c.1705C>T/p.(Arg569Trp)6': [1433], '(0.23)3': [1435], '(0.55)1': [1436], '(0.96)3': [1437], '(0.16)370': [1438], '(0.29)c.1768C>T/p.(Arg590Cys)0': [1439], '(0.00)0': [1442, 1443], '(0)9': [1444], '(0.01)c.2031-2A>C15': [1445], '(0.68)15': [1446], '(0.57)4': [1447], '(0.74)1': [1448], '(0.96)11': [1449], '(0.6)936': [1450], '(0.72)Σ': [1451], 'mutant': [1452], 'alleles87': [1453], '(3.94)103': [1454], '(3.92)36': [1455], '(6.64)6': [1456], '(5.77)Σ': [1457], '5,696': [1458], '(4.35)Σ': [1459], 'WT': [1460], 'alleles2,123': [1461], '(96.06)2,523': [1462], '(96.08)506': [1463], '(93.36)98': [1464], '(94.23)Σ': [1465], '125,330': [1466], '(95.65)P-valuen.s.': [1467], '(0.399)n.s.': [1468], '(0.333)0.015n.s.': [1469], '(0.464)——Abbreviations:': [1470], 'indivs.,': [1471, 1585], 'individuals;': [1472, 1586], 'n,': [1473, 1587], 'patients;': [1476, 1590], 'NFE,': [1477, 1591], 'non-Finnish': [1478, 1592], 'European;': [1479, 1593], 'no.,': [1480, 1594], 'number;': [1481, 1595], 'n.s.,': [1482, 1596], 'not': [1483, 1527, 1597, 1643, 1871, 1971, 2017], 'significant;': [1484, 1598], 'pustulosis;': [1487, 1601], 'arthritis;': [1490, 1604], 'vulgaris;': [1493, 1607], 'SAPHO,': [1494, 1608], 'WT,': [1502, 1616], 'wild': [1503, 1617], 'type.Σ': [1504], 'indicates': [1505, 1620], 'sum.Cumulative': [1506], 'distributions': [1508, 1624], 'missense': [1510, 1626, 1818], 'splice': [1512, 1628], 'compared': [1520, 1636, 1849], "Fisher's": [1522, 1638], 'exact': [1523, 1639], 'test': [1524, 1640], 'P-values': [1526, 1642], 'adjusted': [1528, 1644], 'no.': [1531, 1647], 'tests': [1533, 1649], '(four': [1534, 1650], 'subtypes).Source': [1536], 'Karczewski': [1538, 1655], '2020Karczewski': [1541, 1658], 'K.J.': [1542, 1659], 'Francioli': [1543, 1660], 'Tiao': [1545, 1662], 'G.': [1546, 1663], 'Cummings': [1547, 1664], 'B.B.': [1548, 1665], 'Alföldi': [1549, 1666], 'J.': [1550, 1667], 'Wang': [1551, 1668], 'Q.': [1552, 1669], 'mutational': [1555, 1672], 'constraint': [1556, 1673], 'spectrum': [1557, 1674], 'quantified': [1558, 1675], 'variation': [1560, 1677], '141,456': [1562, 1679], 'humans': [1563, 1680], '[published': [1564, 1681], 'correction': [1565, 1682, 1973], 'appears': [1566, 1683], 'Nature': [1568, 1685], '2021;590:E53].Nature.': [1569, 1686], '581:': [1571, 1688], '434-443Crossref': [1572, 1689], '(1605)': [1575, 1692], 'Scholar.': [1577, 1694], 'Open': [1578], 'table': [1579], 'new': [1582], 'tab': [1583], 'Abbreviations:': [1584], 'type.': [1618], 'Σ': [1619], 'sum.': [1621], 'Cumulative': [1622], 'subtypes).': [1652], 'Source': [1653], 'At': [1695], 'genotype': [1697, 1893], 'when': [1699, 1890], 'considering': [1700], 'combination': [1702], 'mainly': [1709], 'resulting': [1711], 'estimated': [1717], 'loss': [1718], '65‒90%': [1723], 'S2)': [1728], 'Marchetti': [1774], '2004Marchetti': [1777], 'Patriarca': [1779], 'Solero': [1781], 'G.P.': [1782], 'Baralle': [1783], 'F.E.': [1784], 'Romano': [1785], 'Genetic': [1787], 'characterization': [1788], 'Italy.Hum': [1793], 'Mutat.': [1794], '2004;': [1795], '23:': [1796], '496-505Crossref': [1797], '(23)': [1800], 'Nauseef': [1803], '1994Nauseef': [1806], 'W.M.': [1807], 'Brigham': [1808], 'Cogley': [1810], 'Hereditary': [1812], 'due': [1815, 1999], 'mutation': [1819], 'arginine': [1821], '569': [1822], 'tryptophan.J': [1824], 'Biol': [1825], 'Chem.': [1826], '1994;': [1827], '269:': [1828], '1212-1216Abstract': [1829], 'Although': [1836], 'percentage': [1838], '1.5-fold': [1848], 'that': [1851, 2108], 'owing': [1855, 1979], 'percentages': [1858], '(0.54%': [1863], '0.74%,': [1865], 'respectively,': [1866], 'vs.': [1867], '0.27%),': [1868], 'did': [1870, 1970, 2016], 'observe': [1872], 'difference': [1875], 'overall': [1878], 'numbers': [1879], 'S3).': [1885], 'Similar': [1886], 'found': [1889, 1951, 1988], 'combining': [1891], 'data': [1894, 2150], 'S4).': [1900], 'By': [1901], 'investigating': [1902], 'relationships': [1904], 'age': [1910], 'onset': [1912], 'severity': [1917, 1943], 'S5),': [1922], 'S6),': [1929], 'negative': [1932, 1939], 'findings,': [1933], 'tendency': [1936], 'correlation': [1940], 'regarding': [1941], '0.09).': [1948], 'Our': [1949], 'marginally': [1953], 'intermediate': [1960], 'effect': [1961], 'size': [1962, 1982], 'P-value': [1967], 'indicating': [1968], 'withstand': [1972], 'multiple': [1975], 'testing': [1976], 'probably': [1978], 'our': [1984, 2010, 2061, 2134], 'cohort.': [1986], 'no': [1989, 2282], 'PsA.': [1995], 'might': [1997], 'be': [1998, 2086], 'rarity': [2002], 'alleles,': [2005], 'limiting': [2006], 'power': [2008], 'study.': [2011, 2298], 'Previous': [2012], 'GWASs': [2013], 'describe': [2018], 'locus': [2023], 'analyses': [2062], 'focused': [2063], 'patients,': [2066], 'cannot': [2068], 'potential': [2071], 'ethnic': [2077], 'backgrounds.': [2078], 'Nevertheless,': [2079], 'carrying': [2081], 'may': [2085], 'susceptible': [2088], 'psoriasis,': [2090], 'because': [2091], '(PPP': [2101], 'PsV)': [2103], 'nominally': [2105], 'controls.': [2110], 'require': [2113], 'independent': [2114], 'replication': [2115], 'point': [2117], 'situation': [2120], 'where': [2121], 'increase': [2126], 'four': [2130], 'differentiate': [2136], 'Relevant': [2149], 'generated': [2151], 'and/or': [2152], 'this': [2157, 2297, 2326], 'manuscript': [2158], 'its': [2160], 'supplementary': [2161], 'file.': [2162], 'Stefan': [2163], 'Haskamp:': [2164], 'http://orcid.org/0000-0003-3760-9074': [2165], 'Joseph': [2166], 'Simon': [2167], 'Horowitz:': [2168], 'http://orcid.org/0000-0002-4456-6984': [2169], 'Vinzenz': [2170], 'Oji:': [2171], 'http://orcid.org/0000-0003-1380-4828': [2172], 'Sandra': [2173], 'Philipp:': [2174], 'http://orcid.org/0000-0002-9421-5461': [2175], 'Michael': [2176], 'Sticherling:': [2177], 'http://orcid.org/0000-0001-9396-3938': [2178], 'Knut': [2179], 'Schäkel:': [2180], 'http://orcid.org/0000-0001-6344-7799': [2181], 'Sarah': [2182], 'Schuhmann:': [2183], 'http://orcid.org/0000-0002-6775-3547': [2184], 'Jörg': [2185], 'Prinz:': [2187], 'http://orcid.org/0000-0002-8857-5495': [2188], 'Harald': [2189], 'Burkhardt:': [2190], 'http://orcid.org/0000-0002-6261-3131': [2191], 'Frank': [2192], 'Behrens:': [2193], 'http://orcid.org/0000-0001-8750-7186': [2194], 'Beate': [2195], 'Böhm:': [2196], 'http://orcid.org/0000-0001-5823-1184': [2197], 'Michaela': [2198], 'Köhm:': [2199], 'http://orcid.org/0000-0002-3579-5574': [2200], 'Jürgen': [2201], 'Rech:': [2202], 'http://orcid.org/0000-0002-2569-2029': [2203], 'David': [2204], 'Simon:': [2205], 'http://orcid.org/0000-0001-8310-7820': [2206], 'Georg': [2207], 'Schett:': [2208], 'http://orcid.org/0000-0001-8740-9615': [2209], 'Kirsten': [2210], 'Morrison:': [2211], 'http://orcid.org/0000-0002-5308-0249': [2212], 'Sascha': [2213], 'Gerdes:': [2214], 'http://orcid.org/0000-0002-6667-7757': [2215], 'Gunter': [2216], 'Assmann:': [2217], 'http://orcid.org/0000-0002-3216-9340': [2218], 'Ali': [2219], 'Nimeh:': [2220], 'http://orcid.org/0000-0003-0912-4758': [2221], 'Volker': [2222], 'Schuster:': [2223], 'http://orcid.org/0000-0001-5735-1838': [2224], 'Arnd': [2225], 'Jacobi:': [2226], 'http://orcid.org/0000-0002-0684-3426': [2227], 'Ansgar': [2228], 'Weyergraf:': [2229], 'http://orcid.org/0000-0001-5221-2492': [2230], 'André': [2231], 'Reis:': [2232], 'http://orcid.org/0000-0002-6301-6363': [2233], 'Steffen': [2234], 'Uebe:': [2235], 'http://orcid.org/0000-0002-4819-7637': [2236], 'Dagmar': [2237], 'Wilsmann-Theis:': [2238], 'http://orcid.org/0000-0002-5594-7192': [2239], 'Rotraut': [2240], 'Mößner:': [2241], 'http://orcid.org/0000-0003-2476-7647': [2242], 'Ulrike': [2243], 'Hüffmeier:': [2244], 'http://orcid.org/0000-0001-6448-4671': [2245], 'JSH': [2246], 'employed': [2248], 'psychiatric': [2251], 'department': [2252], 'Klinik': [2254], 'am': [2255], 'Europakanal,': [2256], 'Erlangen,': [2257], 'Germany.': [2258], 'MS': [2259], 'studies': [2264], 'anti‒IL-36': [2266], 'antibody': [2267], 'Boehringer': [2276], 'Mannheim.': [2277], 'remaining': [2279], 'authors': [2280], 'conflict': [2283], 'interest.': [2285], 'grateful': [2288], 'controls': [2293], 'participated': [2295], 'thank': [2300, 2313], 'Anne': [2301], 'Gerschütz,': [2302], 'Valentina': [2303], 'Rabinovich,': [2304], 'Iris': [2306], 'Kerker': [2307], 'excellent': [2309], 'technical': [2310], 'assistance.': [2311], 'Peter': [2314], 'Morrison,': [2315], 'PhD': [2316], '(Department': [2317], 'Dermatology,': [2319], 'Førde': [2320], 'Sentralsjukehus,': [2321], 'Førde,': [2322], 'Norway)': [2323], 'proofreading': [2325], 'manuscript.': [2327], 'project': [2329, 2341], 'funded': [2331], 'grants': [2333, 2356], 'UH': [2335, 2349, 2360, 2375, 2459], 'Deutsche': [2338], 'Forschungsgemeinschaft': [2339], '(CRC1181,': [2340], 'A05;': [2342], 'HU': [2343], '2163/1-1),': [2344], 'grant': [2347, 2373], 'Dr.': [2352], 'Pfleger-Stiftung,': [2353], 'AR': [2358], 'Federal': [2363], 'Ministry': [2364], 'Education': [2366], 'Research': [2368, 2382], '(Metarthros': [2369], '01EC1407A)': [2370], 'Interdisciplinary': [2378], 'Centre': [2379], 'Clinical': [2381], 'Erlangen': [2383], '(Project': [2384], 'A85).': [2385], 'Conceptualization:': [2386], 'UH;': [2387, 2390, 2396, 2420, 2427], 'Investigation:': [2388], 'JSH,': [2389, 2394, 2434], 'Formal': [2391], 'Analysis:': [2392], 'SH,': [2393, 2426, 2433], 'SU,': [2395, 2456], 'Resources:': [2397], 'VO,': [2398, 2435], 'SP,': [2399, 2436], 'MS,': [2400, 2437], 'KS,': [2401, 2438], 'SS,': [2402, 2439], 'JCP,': [2403, 2440], 'HB,': [2404, 2441], 'FB,': [2405, 2442], 'BB,': [2406, 2443], 'MK,': [2407, 2444], 'JR,': [2408, 2445], 'DS,': [2409, 2446], 'GS,': [2410, 2447], 'KM,': [2411, 2448], 'SG,': [2412, 2449], 'GA,': [2413, 2450], 'AN,': [2414, 2451], 'VS,': [2415, 2452], 'AJ,': [2416, 2453], 'AW,': [2417, 2454], 'DWT,': [2418, 2457], 'RM,': [2419, 2458], 'Writing': [2421, 2428], '-': [2422, 2429], 'Original': [2423], 'Draft': [2424], 'Preparation:': [2425], 'Review': [2430], 'Editing:': [2432], 'AR,': [2455], 'Download': [2460], '.pdf': [2461], '(.62': [2462], 'MB)': [2463], 'Help': [2464], 'pdf': [2466], 'files': [2467], 'File': [2469]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3130776464', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-24T06:13:51.029814', 'created_date': '2021-03-01'}