Publication Information

{'id': 'https://openalex.org/W3129141008', 'doi': 'https://doi.org/10.1158/1557-3265.endomet20-pr004', 'title': 'Abstract PR004: Multi-dimensional biomarker analyses identify pembrolizumab responders in advanced stage, high grade endometrial cancer', 'display_name': 'Abstract PR004: Multi-dimensional biomarker analyses identify pembrolizumab responders in advanced stage, high grade endometrial cancer', 'publication_year': 2021, 'publication_date': '2021-02-01', 'ids': {'openalex': 'https://openalex.org/W3129141008', 'doi': 'https://doi.org/10.1158/1557-3265.endomet20-pr004', 'mag': '3129141008'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1557-3265.endomet20-pr004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002033312', 'display_name': 'Katherine C. Fuh', 'orcid': 'https://orcid.org/0000-0002-7693-2694'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katherine Fuh', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063063176', 'display_name': 'Elena Lomonosova', 'orcid': 'https://orcid.org/0000-0003-3739-4261'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elena Lomonosova', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083027775', 'display_name': 'Russell K. Pachynski', 'orcid': 'https://orcid.org/0000-0002-8966-7631'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Russell Pachynski', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039394193', 'display_name': 'Olga Malkova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Olga Malkova', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002632381', 'display_name': 'Stephen T. Oh', 'orcid': 'https://orcid.org/0000-0002-8564-5400'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen Oh', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030433779', 'display_name': 'Andrea R. Hagemann', 'orcid': 'https://orcid.org/0000-0002-3484-0046'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrea Hagemann', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068335479', 'display_name': 'Carolyn K. McCourt', 'orcid': 'https://orcid.org/0000-0003-2229-8971'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carolyn McCourt', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003854163', 'display_name': 'Matthew A. Powell', 'orcid': 'https://orcid.org/0000-0002-9001-3862'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Powell', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071972147', 'display_name': 'Wendy J. Fantl', 'orcid': 'https://orcid.org/0000-0003-3452-7292'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wendy Fantl', 'raw_affiliation_strings': ['2Stanford University, Stanford, CA.'], 'affiliations': [{'raw_affiliation_string': '2Stanford University, Stanford, CA.', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024497385', 'display_name': 'Premal H. Thaker', 'orcid': 'https://orcid.org/0000-0002-0568-6959'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Premal Thaker', 'raw_affiliation_strings': ['1Washington University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': '1Washington University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I204465549']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': '27', 'issue': '3_Supplement', 'first_page': 'PR004', 'last_page': 'PR004'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10668', 'display_name': 'Endometrial and Cervical Cancer Treatments', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2729', 'display_name': 'Obstetrics and Gynecology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microsatellite-instability', 'display_name': 'Microsatellite Instability', 'score': 0.5051554}], 'concepts': [{'id': 'https://openalex.org/C2780057760', 'wikidata': 'https://www.wikidata.org/wiki/Q13896859', 'display_name': 'Pembrolizumab', 'level': 4, 'score': 0.95923615}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8323358}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.599408}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5501767}, {'id': 'https://openalex.org/C2777088508', 'wikidata': 'https://www.wikidata.org/wiki/Q944777', 'display_name': 'Endometrial cancer', 'level': 3, 'score': 0.5321853}, {'id': 'https://openalex.org/C2779767149', 'wikidata': 'https://www.wikidata.org/wiki/Q488212', 'display_name': 'Microsatellite instability', 'level': 5, 'score': 0.5051554}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.43997338}, {'id': 'https://openalex.org/C2780380082', 'wikidata': 'https://www.wikidata.org/wiki/Q12646460', 'display_name': 'Granzyme B', 'level': 4, 'score': 0.4293142}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.3962767}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39617494}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.36038506}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.35317743}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24184737}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C61320498', 'wikidata': 'https://www.wikidata.org/wiki/Q265193', 'display_name': 'Microsatellite', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1557-3265.endomet20-pr004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183149254', 'display_name': 'Clinical Cancer Research', 'issn_l': '1078-0432', 'issn': ['1078-0432', '1557-3265'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.6, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4367854425', 'https://openalex.org/W4200023723', 'https://openalex.org/W3037068108', 'https://openalex.org/W2891524425', 'https://openalex.org/W2585407512', 'https://openalex.org/W2417654518', 'https://openalex.org/W2415923527', 'https://openalex.org/W2391826283', 'https://openalex.org/W2059423835', 'https://openalex.org/W2016963217'], 'abstract_inverted_index': {'Abstract': [0], 'Objectives:': [1], 'The': [2, 69], 'recent': [3], 'FDA': [4], 'approval': [5], 'of': [6, 11, 30, 34, 50, 64, 77, 120, 135, 157, 193, 202, 218, 220, 258, 268, 356], 'pembrolizumab': [7, 51, 80, 122, 136, 158, 246, 292, 344], 'for': [8, 56, 171], 'the': [9, 28, 53, 75, 97, 208, 211, 280, 357], 'treatment': [10, 29, 78, 152, 209, 247, 293], 'recurrent,': [12], 'tissue': [13], 'agnostic': [14], 'cancers': [15, 62], 'with': [16, 79, 117, 315], 'Microsatellite': [17], 'Instability-High': [18], '(MSI-H)': [19], 'or': [20, 66], 'Mismatch': [21], 'Repair': [22], 'Deficient': [23], '(dMMR)': [24], 'has': [25], 'led': [26], 'to': [27, 44, 73, 85, 95, 125, 188, 310], 'a': [31, 42], 'selected': [32], 'cohort': [33], 'endometrial': [35, 61, 316, 351], 'cancer': [36, 352], '(EC)': [37], 'patients.': [38], 'Methods:': [39], 'We': [40, 214], 'designed': [41], 'study': [43], 'ascertain': [45], 'tumor': [46], 'immune': [47, 98], 'modulatory': [48], 'effects': [49], 'in': [52, 230, 234, 248, 253, 275, 279, 294, 313, 346], 'front-line': [54], 'setting': [55], 'advanced': [57, 347], 'stage': [58], 'III/IV': [59], 'surgically-resectable': [60], 'regardless': [63], 'MSI-H': [65], 'dMMR': [67], 'status.': [68], 'primary': [70], 'objectives': [71], 'were': [72, 115, 169, 243, 251, 273, 289], 'determine': [74, 86], 'safety': [76], 'by': [81, 128], 'radiographic': [82], 'imaging': [83], 'and': [84, 101, 130, 132, 153, 181, 222, 238, 265, 368], 'progression-free': [87], 'survival': [88], 'at': [89, 148, 263], '6': [90], 'months.': [91], 'Exploratory': [92], 'objective': [93], 'was': [94, 143, 165], 'compare': [96], 'response': [99], 'before': [100, 151], 'after': [102, 207, 245, 291], 'treatment.': [103, 159], 'In': [104], 'an': [105, 178], 'open': [106], 'label,': [107], 'single-arm': [108], 'Phase': [109], 'I': [110], 'trial,': [111], '8': [112], 'EC': [113, 146], 'patients': [114, 147, 314], 'treated': [116], '2': [118, 155], 'doses': [119, 134, 156], 'preoperative': [121], 'IV': [123], 'prior': [124], 'surgery': [126], 'followed': [127], 'carboplatin': [129], 'paclitaxel': [131], '4': [133], '200mg/kg': [137], 'q3': [138], 'weeks': [139], 'IV.': [140], 'Peripheral': [141], 'blood': [142, 302], 'collected': [144], 'from': [145, 161], 'baseline': [149, 264], 'level': [150], 'post': [154], 'Blood': [160], 'healthy': [162], 'controls': [163], '(HC)': [164], 'also': [166], 'collected.': [167], 'Both': [168], 'processed': [170], 'high-dimensional': [172], 'single-cell': [173], 'mass': [174], 'cytometry': [175], '(CyTOF)': [176], 'using': [177], 'optimized': [179], 'lymphoid': [180], 'myeloid': [182], 'panel.': [183], 'Results:': [184], 'Patients': [185], 'who': [186], 'responded': [187], 'therapy': [189], 'showed': [190], 'lower': [191], 'frequency': [192, 201, 257, 267], 'circulating': [194, 287], 'CD8+': [195, 203, 221], 'naïve': [196], 'T': [197, 205, 224, 240, 261, 270], 'cells': [198, 206, 225, 262, 271], 'but': [199, 232, 250, 277], 'higher': [200], 'effector': [204], 'than': [210], 'poor': [212, 235, 254, 281], 'responders.': [213, 236, 255, 282, 295], 'observed': [215, 274], 'post-therapy': [216], 'expansion': [217], 'populations': [219, 242], 'CD4+': [223, 260], 'expressing': [226], 'co-stimulatory': [227], 'receptor': [228], 'ICOS': [229], 'responders': [231, 249, 276, 345], 'not': [233, 278], 'Granzyme+CD8+': [237], 'Granzyme+CD4+': [239], 'cell': [241], 'expanded': [244], 'decreased': [252], 'Higher': [256], 'CD27+Fas-': [259], 'increased': [266], 'CD27-Fas+CD4+': [269], 'post-treatment': [272], 'Furthermore,': [283], 'we': [284], 'identified': [285], 'that': [286, 300], 'MDSCs': [288], 'reduced': [290], 'Conclusions:': [296], 'Our': [297], 'results': [298], 'suggest': [299], 'peripheral': [301], 'analysis': [303], 'may': [304], 'provide': [305], 'valuable': [306], 'insights': [307], 'into': [308], 'responses': [309], 'anti-PD-1-targeted': [311], 'therapies': [312], 'cancers.': [317], 'Citation': [318], 'Format:': [319], 'Katherine': [320], 'Fuh,': [321], 'Elena': [322], 'Lomonosova,': [323], 'Russell': [324], 'Pachynski,': [325], 'Olga': [326], 'Malkova,': [327], 'Stephen': [328], 'Oh,': [329], 'Andrea': [330], 'Hagemann,': [331], 'Carolyn': [332], 'McCourt,': [333], 'Matthew': [334], 'Powell,': [335], 'Wendy': [336], 'Fantl,': [337], 'Premal': [338], 'Thaker.': [339], 'Multi-dimensional': [340], 'biomarker': [341], 'analyses': [342], 'identify': [343], 'stage,': [348], 'high': [349], 'grade': [350], '[abstract].': [353], 'In:': [354], 'Proceedings': [355], 'AACR': [358], 'Virtual': [359], 'Special': [360], 'Conference:': [361], 'Endometrial': [362], 'Cancer:': [363], 'New': [364], 'Biology': [365], 'Driving': [366], 'Research': [367], 'Treatment;': [369], '2020': [370], 'Nov': [371], '9-10.': [372], 'Philadelphia': [373], '(PA):': [374], 'AACR;': [375], 'Clin': [376], 'Cancer': [377], 'Res': [378], '2021;27(3_Suppl):Abstract': [379], 'nr': [380], 'PR004.': [381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3129141008', 'counts_by_year': [], 'updated_date': '2024-12-14T18:38:01.450723', 'created_date': '2021-02-15'}