Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3128069535', 'doi': 'https://doi.org/10.3892/or.2021.7969', 'title': 'Inhibitor of apoptosis protein Livin promotes tumor progression and chemoradioresistance in human anaplastic thyroid cancer', 'display_name': 'Inhibitor of apoptosis protein Livin promotes tumor progression and chemoradioresistance in human anaplastic thyroid cancer', 'publication_year': 2021, 'publication_date': '2021-02-05', 'ids': {'openalex': 'https://openalex.org/W3128069535', 'doi': 'https://doi.org/10.3892/or.2021.7969', 'mag': '3128069535', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33649820'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2021.7969', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2021.7969/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.spandidos-publications.com/10.3892/or.2021.7969/download', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055261519', 'display_name': 'Hee Seung Kim', 'orcid': 'https://orcid.org/0000-0001-6876-8671'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hee Kim', 'raw_affiliation_strings': ['Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076282786', 'display_name': 'Sun‐Ae Kim', 'orcid': 'https://orcid.org/0000-0002-6896-7459'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sun-Ae Kim', 'raw_affiliation_strings': ['Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053600900', 'display_name': 'Eun Sun Jung', 'orcid': 'https://orcid.org/0000-0002-3887-987X'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun Jung', 'raw_affiliation_strings': ['Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101834577', 'display_name': 'Kyung‐Hwa Lee', 'orcid': 'https://orcid.org/0000-0002-3935-0361'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kyung-Hwa Lee', 'raw_affiliation_strings': ['Department of Pathology, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100610130', 'display_name': 'Joon Lee', 'orcid': 'https://orcid.org/0000-0001-8593-9321'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Joon Lee', 'raw_affiliation_strings': ['Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064371755', 'display_name': 'Ho‐Cheol Kang', 'orcid': 'https://orcid.org/0000-0002-0448-1345'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ho-Cheol Kang', 'raw_affiliation_strings': ['Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026872254', 'display_name': 'Young‐Eun Joo', 'orcid': 'https://orcid.org/0000-0003-0422-2439'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Eun Joo', 'raw_affiliation_strings': ['Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Chonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089633864', 'display_name': 'Sang Chul Lim', 'orcid': 'https://orcid.org/0000-0001-5610-1554'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sang Lim', 'raw_affiliation_strings': ['Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062473163', 'display_name': 'Tae Hyun Yoon', 'orcid': 'https://orcid.org/0000-0002-2743-6360'}, 'institutions': [{'id': 'https://openalex.org/I4210148121', 'display_name': 'Chonnam National University Hwasun Hospital', 'ror': 'https://ror.org/054gh2b75', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210148121']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Tae Yoon', 'raw_affiliation_strings': ['Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Otorhinolaryngology‑Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Hwasun, Jeonnam 58128, Republic of Korea', 'institution_ids': ['https://openalex.org/I4210148121']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.909, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '45', 'issue': '4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Molecular Mechanisms of Apoptosis and Cell Death', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10329', 'display_name': 'Management and Diagnosis of Thyroid Cancer', 'score': 0.9529, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/anaplastic-thyroid-cancer', 'display_name': 'Anaplastic thyroid cancer', 'score': 0.7561357}, {'id': 'https://openalex.org/keywords/inhibitor-of-apoptosis', 'display_name': 'Inhibitor of apoptosis', 'score': 0.53118944}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.517248}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.5086842}], 'concepts': [{'id': 'https://openalex.org/C2780256643', 'wikidata': 'https://www.wikidata.org/wiki/Q3658382', 'display_name': 'Anaplastic thyroid cancer', 'level': 4, 'score': 0.7561357}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.64428586}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6074458}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.5537164}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.53642887}, {'id': 'https://openalex.org/C2777408456', 'wikidata': 'https://www.wikidata.org/wiki/Q174299', 'display_name': 'Inhibitor of apoptosis', 'level': 4, 'score': 0.53118944}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.51255274}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.5086842}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.48663172}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.4850425}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.44278732}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.42988485}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3776859}, {'id': 'https://openalex.org/C2779761222', 'wikidata': 'https://www.wikidata.org/wiki/Q826522', 'display_name': 'Thyroid cancer', 'level': 3, 'score': 0.32922617}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.3219226}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28810984}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.24164033}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.15373081}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.0577434}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D065646', 'descriptor_name': 'Thyroid Carcinoma, Anaplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D065646', 'descriptor_name': 'Thyroid Carcinoma, Anaplastic', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D048868', 'descriptor_name': 'Adaptor Proteins, Signal Transducing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010671', 'descriptor_name': 'Phenylurea Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011804', 'descriptor_name': 'Quinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011836', 'descriptor_name': 'Radiation Tolerance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065646', 'descriptor_name': 'Thyroid Carcinoma, Anaplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065646', 'descriptor_name': 'Thyroid Carcinoma, Anaplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013964', 'descriptor_name': 'Thyroid Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2021.7969', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2021.7969/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33649820', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2021.7969', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2021.7969/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.87}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3160097740', 'https://openalex.org/W2801385654', 'https://openalex.org/W2758931657', 'https://openalex.org/W2619229173', 'https://openalex.org/W2409558739', 'https://openalex.org/W2347996910', 'https://openalex.org/W2225849677', 'https://openalex.org/W2118986295', 'https://openalex.org/W2046943712', 'https://openalex.org/W1974988242'], 'abstract_inverted_index': {'Anaplastic': [0], 'thyroid': [1], 'cancer': [2, 84, 123], '(ATC)': [3], 'is': [4, 28], 'characterized': [5], 'by': [6, 111], 'a': [7, 44, 96, 241], 'rapid': [8], 'and': [9, 20, 63, 86, 90, 138, 150, 163, 185, 199, 212, 214, 246, 262], 'aggressive': [10], 'course': [11], 'of': [12, 46, 50, 72, 81, 88, 120, 148, 153, 209, 257], 'progression.': [13], 'Despite': [14], 'significant': [15], 'advances': [16], 'in': [17, 66, 83, 102, 126, 176, 190, 264], 'surgery,': [18], 'radiotherapy': [19], 'chemotherapy,': [21], 'the': [22, 47, 73, 79, 103, 118, 146, 151, 255], 'disease‑specific': [23], 'mortality': [24], 'due': [25], 'to': [26, 57, 77, 91, 171, 259], 'ATC': [27, 89, 106, 128, 178, 192, 235], 'approximately': [29], '100%.': [30], 'New': [31], 'strategies,': [32], 'such': [33, 132], 'as': [34, 95, 133, 227, 229], 'molecular': [35], 'targeted': [36], 'therapies,': [37], 'are': [38], 'imperative': [39], 'for': [40], 'improving': [41], 'survival.': [42], 'Livin,': [43], 'member': [45], 'human': [48, 68, 104, 127, 177, 191, 234], 'inhibitor': [49], 'apoptosis': [51, 140], 'protein': [52, 174], 'family,': [53], 'has': [54], 'been': [55], 'found': [56], 'be': [58], 'associated': [59, 156], 'with': [60, 157, 205, 237], 'tumor': [61, 196, 260], 'progression': [62, 85, 261], 'poor': [64], 'prognosis': [65], 'various': [67, 130], 'cancers.': [69], 'The': [70, 180], 'aim': [71], 'present': [74], 'study': [75], 'was': [76, 109, 169, 188], 'evaluate': [78], 'role': [80], 'Livin': [82, 100, 121, 149, 158, 173, 183, 258], 'chemoradioresistance': [87, 263], 'investigate': [92], 'its': [93], 'potential': [94], 'therapeutic': [97], 'target.': [98], 'Endogenous': [99], 'expression': [101, 147, 175, 184, 207], 'BHT101': [105], 'cell': [107, 124, 134, 136, 139, 197, 203, 223], 'line': [108], 'silenced': [110], 'Livin‑specific': [112], 'small': [113], 'interfering': [114], 'RNA.': [115], 'To': [116, 144], 'assess': [117, 145], 'impact': [119], 'on': [122], 'behavior': [125], 'cells,': [129], 'methods': [131], 'invasion,': [135], 'viability': [137, 224], 'assays': [141], 'were': [142, 166], 'applied.': [143], 'change': [152], 'apoptosis‑related': [154], 'proteins': [155], 'expression,': [159], 'reverse': [160], 'transcription‑quantitative': [161], 'PCR': [162], 'western': [164], 'blotting': [165], 'performed.': [167], 'Immunohistochemistry': [168], 'performed': [170], 'detect': [172], 'tissues.': [179], 'association': [181], 'between': [182], 'apoptotic/proliferation': [186], 'index': [187, 245], 'analyzed': [189], 'cells.': [193], 'Livin‑knockdown': [194, 217], 'suppressed': [195], 'invasion;': [198], 'conversely,': [200], 'it': [201], 'enhanced': [202, 218], 'apoptosis,': [204, 220], 'elevated': [206], 'levels': [208], 'cleaved': [210, 215], 'caspase‑3': [211], '‑7': [213], 'PARP.': [216], 'radiation‑induced': [219], 'while': [221], 'reducing': [222], 'following': [225], 'radiotherapy,': [226], 'well': [228], 'lenvatinib': [230], 'treatment.': [231], 'In': [232, 250], 'addition,': [233], 'tissues': [236], 'high': [238, 242], 'Livin‑expression': [239], 'exhibited': [240], 'Ki‑67': [243], 'labeling': [244], 'low': [247], 'apoptotic': [248], 'index.': [249], 'summary,': [251], 'these': [252], 'findings': [253], 'indicate': [254], 'contribution': [256], 'ATC.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3128069535', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-09-15T08:54:53.500570', 'created_date': '2021-02-15'}