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1373, 1408, 1512, 1588, 1666, 1685, 1729, 1759, 1800, 1803, 1809, 1822, 1831, 1836, 1858, 1958, 1965, 2000, 2075, 2092, 2111, 2145, 2235, 2260, 2357, 2378, 2391, 2396, 2497, 2530, 2537, 2563, 2591, 2603, 2609, 2623, 2632, 2641, 2654, 2683, 2805, 2850, 2973, 3073, 3076, 3227, 3261, 3435, 3452, 3487, 3515, 3533, 3564, 3628, 3676, 3706, 3898, 3954, 4113, 4165, 4169], 'Pole': [89], 'Cardiovascular': [91, 160, 203, 1302, 2155], 'Research,': [92], 'Institut': [93, 149, 192], 'Recherche': [95], 'Expérimentale': [96], 'et': [97, 836, 839, 842, 1393, 1435, 1506, 2732, 2775, 2840, 2902, 2943, 3172, 3222, 3299, 3606, 3665, 3949], 'Clinique,': [98], 'Université': [99], 'Belgium': [104], '(A.P.).': [105], 'Lopez-SubletMarilucy': [108], 'Lopez-Sublet': [109, 2613, 3030], 'AP-HP': [110], 'Hôpital': [111], 'Avicenne,': [112], 'Excellence': [114], 'Center,': [115], 'Department': [116], 'Internal': [118], 'Medicine,': [119, 1928], 'Bobigny,': [120], 'France': [121], '(M.L.-S.).': [122], 'AlgharablyEngi': [127], 'Algharably': [130], 'Charité': [131, 174], 'Universitätsmedizin': [133, 176], 'Berlin,': [134, 140, 143, 164, 177, 183, 186, 207], 'corporate': [135, 178], 'member': [136, 179], 'Freie': [138, 181], 'Universität': [139, 182], 'Humboldt-Universität': [141, 184], 'zu': [142, 185], 'Berlin': [145, 188], 'Institute': [146, 189], 'Health,': [148, 191], 'für': [150, 193], 'Klinische': [151, 194], 'Pharmakologie': [152, 195], 'und': [153, 196], 'Toxikologie,': [154, 197], 'Germany.': [155, 198], 'DZHK': [156, 199], '(German': [157, 200], 'Centre': [158, 201], 'for': [159, 202, 256, 531, 894, 1257, 1370, 1677, 1709, 1838, 2055, 2088, 2338, 2601, 2616, 2625, 2638, 2643, 2741, 2783, 2792, 2845, 2910, 3370, 3407, 3528, 3699, 3760, 3993], 'Research),': [161, 204], 'partner': [162, 205], 'site': [163, 206], 'Germany': [165, 208], '(E.A.E.-H.A.,': [166, 209], 'R.K.).': [167, 210], 'https://orcid.org/0000-0002-4818-211X': [173], 'Originally': [211, 4265], 'published10': [212], 'Feb': [213], '2021https://doi.org/10.1161/HYPERTENSIONAHA.120.12857Hypertension.': [214], '2021;77:800–805is': [215], 'corrected': [216], 'byCorrection': [217], 'Starting': [219, 4007, 4233], 'Therapy:': [225, 4012, 4239], 'Controversies': [226, 4013, 4240], 'ArgumentOne': [234], 'highlights': [237], 'current': [240, 336], 'recommendations': [241, 1901], 'European': [244, 251, 820, 825, 2800, 2808], 'Society': [245, 252, 702, 821, 826, 832, 1850, 2801, 2809, 2906], 'Cardiology': [247, 2811], '(ESC)': [248], '(ESH)': [255, 2804], 'management': [258, 2743, 2785, 2794, 2851, 2912], 'arterial': [260, 2745, 2787, 2796], 'hypertension': [261, 455, 544, 605, 619, 1610, 1955, 2094, 2128, 2310, 2448, 2456, 2797, 2908, 2914, 2949, 2951, 3077, 3408, 3572, 3682, 3765, 4103, 4145], 'published': [262], '20181': [264, 2552], 'is': [265, 292, 331, 465, 487, 508, 564, 645, 664, 691, 750, 1044, 1205, 1268, 1331, 1359, 1366, 1428, 1840, 1870, 1880, 1961, 2083, 2187, 2243, 2251, 2297, 2379, 2554, 4036, 4039], 'strong': [267, 569, 854, 4041, 4213], 'position': [268, 855], 'favor': [270, 866, 1950, 4063], 'a': [272, 388, 417, 422, 483, 510, 529, 568, 578, 684, 752, 851, 968, 989, 1019, 1032, 1066, 1091, 1101, 1145, 1209, 1230, 1238, 1367, 1381, 1419, 1509, 1577, 1624, 1627, 1696, 1700, 1827, 1832, 2142, 2215, 2225, 2249, 2269, 2342, 2363, 2467, 2528, 2858, 3007, 3013, 3017, 3038, 3143, 3333, 3460, 3530, 3703, 3984, 3990], 'single-pill': [273, 4052], 'combination': [274, 533, 681, 710, 991, 1093, 1102, 1534, 1693, 1887, 1952, 2010, 2270, 2276, 2580, 3009, 3074, 3132, 3519, 3791, 3822], '(SPC)': [275], 'comprising': [276, 2063], '2': [277, 373, 618, 625, 802, 804, 806, 933, 2064, 2445], 'antihypertensive': [278, 374, 414, 612, 761, 775, 936, 2065, 2137, 2206, 2326, 2514, 3231, 3309, 3458, 3624, 3792, 3818, 3854, 4046, 4217], 'drugs': [279, 375, 937, 1407, 1890, 2032, 2345, 3524], 'as': [280, 359, 361, 387, 711, 763, 1126, 1418, 1491, 1844, 1872, 1886, 2300, 2362, 2512, 2527, 3315, 3321, 3525, 3823, 4154], 'first-line': [281, 868, 1868, 1979, 2401, 2468, 2513], 'treatment': [282, 415, 608, 696, 1190, 1220, 1326, 1335, 1363, 1530, 1975, 2208, 2240, 2327, 2515, 2564, 3232, 3266, 3527, 3700, 3762, 3819, 4047, 4219], 'most': [284, 425, 774, 904, 1496, 1875, 1946, 2517, 4049, 4060, 4121], 'hypertensive': [285, 426, 582, 716, 951, 986, 1426, 1876, 2152, 2319, 2518, 2583, 3042, 3141, 3179, 3483], 'patients.': [286, 427, 2584], 'The': [287, 428, 1195, 1255, 1356, 2016, 2656, 2904], 'scope': [288, 2382], 'this': [290, 300, 385, 506, 885, 1141, 1862, 2040, 2102, 2115, 2384, 2504, 2665], 'article': [291, 2666], 'summarize': [294, 340], 'background': [296], 'evidence': [298, 342, 363, 1960], 'supporting': [299, 343, 364, 1413], 'recommendation.': [301], 'First,': [302], 'we': [303, 339, 380, 1348], 'review': [304, 1385, 1511, 3428, 3486, 3532], 'recommendation': [306, 507, 570, 2553, 4214], 'detail': [308], 'show': [310, 931], 'that': [311, 887, 932, 1030, 1153, 1360, 1440, 1739, 1945, 1959, 2018, 2078, 2247, 2375, 4059, 4198, 4202], 'it': [312], 'did': [313, 4099], 'not': [314, 509, 2004, 2140, 2189, 2284, 2323, 2463, 2668, 4100], 'come': [315], 'out': [316, 2499], 'blue': [319], 'but': [320, 512, 667, 2195, 2289, 2328, 2452], 'rather': [321, 513, 571], 'reinforces': [322], 'strategies': [323, 352, 1001, 1281, 1336, 1976, 1984, 3004], 'already': [324, 527, 1845, 2030, 2202, 2302], 'proposed': [325, 883], '2013': [328, 524, 555, 2780], 'guidelines2': [329], 'consistent': [332], 'with': [333, 349, 416, 452, 473, 536, 541, 553, 610, 616, 718, 994, 1090, 1095, 1184, 1229, 1292, 1310, 1327, 1388, 1456, 1472, 1522, 1526, 1531, 1606, 1673, 1694, 2101, 2119, 2163, 2181, 2253, 2309, 2443, 3045, 3186, 3307, 3570, 3680, 3998, 4051, 4073, 4149, 4220], 'other': [334, 350, 1334, 1482, 2657], 'major': [335], 'guidelines.3–5': [337], 'Second,': [338], 'dual': [344, 519, 562, 611, 708, 760, 869, 1263, 1328, 1354, 1523, 1533, 1690, 1883, 2510, 3518], 'therapy': [345, 520, 563, 613, 682, 762, 870, 1264, 1330, 1535, 1953, 2011, 2277, 2511, 2581, 3075, 3098, 3133, 3520], 'per': [346], 'se': [347], 'compared': [348, 660, 993, 1094, 1183, 1471, 1564], 'therapeutic': [351, 1674, 2222, 2291, 3003, 3565, 3987], 'achieve': [354, 490], 'blood': [355, 2459, 2587, 2854, 2969, 3103, 3255, 3522, 3618, 3745, 3889], 'pressure': [356, 2460, 2855, 2970, 3035, 3225, 3256, 3619, 3746, 3890], '(BP)': [357], 'goals,': [358], 'well': [360, 1943, 2245], 'specific': [366, 2143], 'use': [367, 642, 679, 738, 758, 1349, 1415, 1442, 1866, 1882, 2080, 2133, 2273, 2340, 2508], 'SPC': [369, 423, 709, 1320, 1350, 1361, 1417, 1490, 1869, 1980, 2059, 2082, 2227, 2402], 'instead': [370, 1351], 'prescribing': [372], 'free': [377, 1889, 4106], 'combination.': [378], 'Third,': [379], 'discuss': [381], 'advantages': [383], 'strategy': [386, 697, 2403, 3988, 3992], 'pragmatic': [389, 2529], 'approach': [390, 2565, 3980], 'improve': [392, 657, 1422, 1500, 2534, 3479, 3574], 'BP': [393, 464, 476, 485, 492, 538, 634, 671, 685, 881, 890, 899, 945, 976, 1049, 1076, 1120, 1178, 1200, 1219, 1344, 1371, 1542, 1614, 1940, 2180, 2388, 2414, 2424, 2430, 2535, 2585], 'control': [394, 1077, 1179, 1201, 1372, 1615, 2095, 2149, 2536, 2971, 3078, 4104], 'and,': [395, 469], 'therefore,': [396], 'decrease': [398, 686, 2192, 2236, 2366, 2539], 'cardiovascular': [399, 479, 548, 1161, 1243, 1378, 1988, 2193, 2349, 2367, 2484, 2542, 3138, 3183, 3305, 3857, 3960, 3994], 'risk.What': [400], 'Do': [401], '2018': [403, 407, 498, 559, 862, 2407, 2437, 2494, 2738], 'ESC/ESH': [404, 408, 499, 863, 2408, 2438, 2495, 2551, 2739], 'Guidelines': [405, 2740, 2782], 'Say?The': [406], 'guidelines': [409, 2909, 4115], 'recommend': [410, 607, 677], 'initiate': [412, 2205], 'an': [413, 573, 632, 1038, 1104, 1397, 2561, 3308, 4196], '2-drug': [418], 'combination,': [419], 'preferably': [420, 767, 2520], 'exceptions': [429, 2487], 'are': [430, 745, 938, 1109, 1769, 1775, 1781, 1789, 1814, 1893, 1942, 1990, 1995, 2021, 2097, 2321, 2462, 2473, 2481, 2667, 4066], '(1)': [431], 'frail': [432, 725], 'older': [433], 'patients/patients': [434], '≥80': [435], 'years': [436, 911, 925], 'whom,': [438], 'due': [439, 1547, 1568], 'baroreflex': [441], 'impairment,': [442], 'risk': [444, 460, 480, 2238, 2315, 2350, 2368, 3136, 3184, 3369], 'hypotension': [446], 'may': [447, 1561, 2002, 2210, 2228, 2278], 'be': [448, 873, 1562, 2263, 2280, 2568, 4147, 4223], 'higher,': [449], '(2)': [450], 'patients': [451, 472, 535, 896, 905, 923, 987, 1087, 1175, 1267, 1387, 1427, 1448, 1580, 1605, 2153, 2201, 2259, 2308, 2320, 2442, 3043, 3180, 3366, 3569, 3679, 3997, 4050], 'grade': [453, 542, 622, 722, 2444], '1': [454, 543, 623, 723, 796, 798, 800], 'at': [456, 545, 1041, 1180, 1740, 2312, 2390, 2449, 2457, 2482, 2500, 3181, 3367, 4189], 'low': [457, 2483], 'or': [458, 540, 726, 747, 934, 999, 1298, 1467, 1622, 1699, 1895, 2169, 2183, 2332, 2480, 2674, 3016, 3191, 3363, 3405, 4125, 4156], 'moderate': [459], '(particularly': [461], 'if': [462, 1891, 2471], 'systolic': [463, 898, 3254], '<150': [466], 'mm': [467, 636, 689, 787, 789, 892, 901, 920], 'Hg)': [468], 'possibly,': [470], '(3)': [471], 'high': [474, 478, 547, 1602, 2853, 3182, 3368], 'normal': [475], 'because': [481, 2104, 2299], 'only': [482, 2190, 2285, 2324], 'small': [484], 'reduction': [486], 'required': [488, 3316], 'target.1First-Line': [493], 'SPC—a': [494], 'Revolution': [495], 'Guidelines?As': [500], 'acknowledged': [501], 'by': [502, 595, 699, 1208, 1270, 1461, 1724, 2126, 2428, 2435, 3820], 'writing': [504, 858], 'committee,': [505], 'revolution': [511], 'normalizes': [514], 'concept': [516, 4201], 'initial': [518, 561, 764, 1039, 1061, 1105, 1325, 1520, 1982, 2275, 3526], 'expressed': [521, 2663], 'guidelines,2': [525, 556], 'which': [526, 1216, 1365, 1768, 2025, 2042, 2122], 'showed': [528, 1152, 1738], 'preference': [530], 'two-drug': [532, 3821], 'marked': [537], 'elevation': [539], 'high/very': [546], 'risk.': [549], 'However,': [550, 1779, 1992], 'contrast': [552, 2118], 'guidelines,1': [560], 'object': [566], 'than': [572, 1050, 4105], 'advice': [574], 'applies': [576], 'wider': [579], 'spectrum': [580], 'patients,': [583, 717, 731, 1071, 1125, 1186, 1877, 2519, 4120, 4144], 'thus': [584, 751, 2538], 'becoming': [585], 'standard': [587, 1042], 'approach.Is': [588], 'Initiation': [590, 849], 'Dual': [592, 852, 1323], 'Supported': [594], 'Other': [596], 'Guidelines?The': [598], 'American': [599, 811, 816, 2677, 2862, 4260], 'College': [600, 812, 2863], 'Cardiology/American': [602, 2865], 'Heart': [603, 817, 2678, 2747, 2866, 3577, 4261], 'Association': [604, 2867], 'guidelines3': [606], 'initiation': [609], 'adults': [615], 'stage': [617], '(corresponding': [620], 'ESH': [628, 4112], 'classification)1': [629], '(Table)': [630], 'average': [633], '>20/10': [635], 'Hg': [637, 690, 893, 902, 921], 'above': [638], 'target.': [639], 'Although': [640], 'SPCs': [644, 744, 1444, 1636, 1788, 1813, 1892, 2024, 4065, 4160, 4203, 4221], 'left': [646], 'decision': [649], 'physician,': [652], 'its': [653], 'potential': [654], 'usefulness': [655], 'drug': [658, 765, 1033, 1062, 1092, 1280, 1329, 1409, 1423, 1458, 1501, 1586, 1671, 1707, 1711, 2019, 2207, 2233, 2287, 3566, 3748, 4167, 4218], 'adherence': [659, 1424, 1459, 1587, 2288, 3481], 'free-drug': [662, 740, 1353, 1474, 1487], 'equivalents': [663], 'acknowledged.3': [665], 'Similarly,': [666], 'without': [668, 1544, 2167, 3959], 'specification': [669], 'level,': [672], 'Japanese': [674, 2905], 'Guidelines4': [676], 'outright': [678], 'when': [683], '≥20/10': [688], 'targeted.': [692], 'Finally,': [693, 1064, 1480, 2293], 'optimal': [695, 1859, 1873], 'advocated': [698, 2434], 'International': [701, 831, 1654, 1849, 2946], 'Global': [705, 1294, 1853], 'Guidelines5': [706, 1854], 'includes': [707], 'first': [712, 2057, 3080, 3824], 'choice': [713], 'all': [715, 895], 'possible': [719], 'exception': [720], 'hypertension,': [724], 'very': [727, 1996, 2048, 2475], 'old': [728], '(≥80': [729], 'years)': [730], 'while': [732, 1914], 'leaving': [733], 'door': [735], 'open': [736], 'equivalent': [739], 'combinations': [741, 1300, 1475, 1488, 1708, 2138, 3456, 3751, 4053], 'case': [743], 'unavailable': [746, 1894], 'unaffordable.': [748], 'There': [749], 'wide': [753], 'worldwide': [754], 'consensus': [755], 'on': [756, 781, 1144, 1579, 1715, 1978, 1985, 2029, 2039, 2108, 2405, 2549, 2870, 3106, 3189, 3233, 3617], 'treatment,': [766], 'form': [770, 2523], 'SPC,': [772, 2469], 'patients.Table.': [776], 'Classification': [777], 'Based': [780], 'Office': [782], 'Blood': [783, 3034, 3224], 'Pressure': [784, 3329], 'Current': [785], 'GuidelinesCategoriesSystolic,': [786], 'HgDiastolic,': [788], 'HgESC/ESH': [790], '2018*ISH': [791], '2020†ACC/AHA': [792], '2017‡NormalNormalElevated120–129and/or80–84High': [793], 'normalHigh': [794], 'normalStage': [795], 'hypertension130–139and/or85–89Grade': [797], 'hypertensionGrade': [799, 805], 'hypertensionStage': [801], 'hypertension140–159and/or90–99Grade': [803], 'hypertension160–179and/or100–109Grade': [807], '3': [808, 2447, 4077, 4095], 'hypertension≥180and/or≥110ACC': [809], 'indicates': [810, 2586], 'Cardiology;': [814, 823], 'AHA,': [815], 'Association;': [818], 'ESC,': [819], 'ESH,': [824], 'ISH,': [830], 'Hypertension.*': [834], 'Williams': [835, 2710], 'al.1†': [837], 'Unger': [838, 2923], 'al.5‡': [840], 'Whelton': [841, 2819], 'al.3What': [843], 'Is': [844, 1314, 1632], 'Evidence': [846, 1316, 1411, 3826], 'Supporting': [847, 3895], 'Therapy?The': [853], 'committee': [859], 'guidelines1': [864, 2496], 'needs': [871, 2566], 'interpreted': [874], 'context': [877], 'lower': [880], 'goals': [882, 946], 'document,': [886], 'is,': [888], 'diastolic': [889], '<80': [891], '<130': [900], 'below': [906, 4076], 'age': [908], '65': [910, 924], 'within': [913], 'range': [915], '130': [917], '139': [919], 'older.': [927], 'Randomized': [928], 'controlled': [929, 957, 1517, 3336, 3537, 4148], 'studies': [930, 1453, 1560, 1947, 1969, 1994, 4061, 4070], 'more': [935, 1045, 1261, 1537, 4180], 'needed': [939], 'reach': [941, 1924], 'even': [942, 1885, 2170], 'less': [943], 'strict': [944], 'majority': [949], 'patients.6': [952], 'Furthermore,': [953, 1967, 4159], 'French': [955], 'randomized': [956, 1276, 1516, 1968, 3536, 3669, 4091], 'trial': [958, 1136, 1142, 3175, 3670], 'STRATHE': [959, 2998], '(Strategies': [960], 'Hypertension:': [964], 'Evaluation)7': [965], 'has': [966, 1028], 'shown': [967, 1029, 1128, 1396, 2301, 2555], 'higher': [969], 'rate': [970, 1340], 'success': [972, 2223], 'achieving': [974, 1199], 'target': [975], 'after': [977, 1103, 1203, 1623, 2214, 3561, 4094], '3,': [978], '6,': [979], '9': [981, 1742], 'months': [982, 1182, 1226, 4096], 'previously': [984], 'untreated': [985], 'prescribed': [988, 2252], 'low-dose': [990, 2136, 3008], '(62%)': [992], 'sequential': [995, 3014], 'monotherapy': [996, 1040, 1521, 2250, 3015, 3072, 3100], '(49%,': [997], 'P=0.02)': [998], 'stepped-care': [1000, 2120, 3018], '(47%,': [1002], 'P=0.005).': [1003], 'These': [1004, 1107, 2486], 'results': [1005, 3048, 3630], 'were': [1006, 1098, 1171, 1227, 4071, 4080], 'confirmed': [1007], 'further': [1009, 1206, 2037], 'expanded': [1010], 'large': [1012, 1210, 1275, 3039], 'observational': [1013, 4072], 'studies.8,9': [1014], 'Along': [1015], 'same': [1017, 1056, 4191], 'lines,': [1018], 'meta-analysis': [1020, 1432, 1483, 1513, 3105, 3534], 'including': [1021, 1069, 1242, 1386, 1584, 1826, 1910, 2344], '11': [1022], '000': [1023], 'participants': [1024, 3108], 'from': [1025, 1034, 1248, 1251, 1486, 1662, 2374, 2606, 2627, 2645, 3109, 3631, 3827, 3893, 3916, 3983], '42': [1026, 3110], 'trials': [1027, 1277, 1518, 1598], 'adding': [1031, 3313, 3319], 'another': [1035, 2314], 'class': [1036], 'dose': [1043, 1053, 1732, 3433, 3750], 'efficient': [1046, 2397], 'reduce': [1048], 'doubling': [1051], 'drug,': [1057], 'irrespective': [1058, 1187], 'class.10': [1063], 'retrospective': [1067, 1211, 3271], 'analysis': [1068, 1438, 1737], '1700': [1070], 'median': [1073, 1149], 'time': [1074, 2058, 3258, 3262], 'was': [1078, 1454, 1713, 2123], 'significantly': [1079], 'shorter': [1080], '(9.7': [1081], 'versus': [1082, 1981, 3012, 3099, 3317], '11.9': [1083], 'months,': [1084], 'p=0.004)': [1085], 'initially': [1088], 'treated': [1089, 3044, 3185], 'those': [1096, 1825, 2670], 'who': [1097, 1176, 1611, 2209, 2453], 'shifted': [1099], 'monotherapy.11': [1106], 'findings': [1108, 3892], 'relevant': [1110], 'view': [1112, 4208], 'importance': [1115], 'early': [1117, 1202], 'achievement': [1118, 2178], 'target,': [1121, 3257], 'especially': [1122, 2470], 'at-risk': [1124], 'clearly': [1127, 2490], 'Valsartan': [1131], 'Long-term': [1133], 'Use': [1134], 'Evaluation': [1135], '(VALUE).12': [1137], 'A': [1138, 2545, 3426, 3667, 3717, 3978], 'subanalysis': [1139], 'based': [1143, 1714, 1977, 2107, 2404, 2548, 3188, 3270], 'technique': [1146], 'serial': [1148], 'matching13': [1150], 'indeed': [1151], 'hazard': [1155, 1235], 'ratios': [1156], 'fatal': [1158], 'nonfatal': [1160], 'events': [1162, 1244, 1989, 2186, 3139, 3235, 3306], '(cardiac:': [1163], '−25%;': [1164], 'stroke:': [1165], '−45%)': [1166], 'all-cause': [1168, 1246], 'death': [1169, 1247], '(−21%)': [1170], 'substantially': [1172], 'decreased': [1173], 'reached': [1177, 1613], '6': [1181], 'uncontrolled': [1185], 'arm': [1191], 'trial.': [1194, 2999], 'crucial': [1196], 'role': [1197], 'diagnosis': [1204], 'supported': [1207, 2125], 'study': [1212, 1578], '(n=88': [1213], '756)': [1214], 'delays': [1217], 'intensification': [1221], '1.4': [1223], '4.7': [1225], 'associated': [1228, 1455, 2541], 'progressive': [1231], 'increase': [1232], 'ratio': [1236], 'combined': [1239], 'end': [1240], 'point': [1241], 'any': [1249], 'cause': [1250], '1.12': [1252], '1.2.14': [1254], 'option': [1256], 'selection': [1258], 'adequate': [1262], 'individual': [1266, 1585, 2418, 2572], 'extended': [1269], 'availability': [1272, 1679], 'multiple': [1274, 3985, 4187], 'comparing': [1278, 1519, 1971], 'different': [1279, 1452, 1646, 1743, 1749, 1753, 1761, 1772, 3002, 3672], '(Anglo-Scandinavian': [1282], 'Cardiac': [1283, 3326], 'Outcomes': [1284, 3177, 3327], 'Trial': [1285, 1296, 3400, 3611], '[ASCOT];ONgoing': [1286], 'Telmisartan': [1287], 'Alone': [1288], 'Ramipril': [1293], 'Endpoint': [1295], '[ONTARGET])15,16': [1297], 'fixed-dose': [1299, 1629, 2061, 3455], '(Avoiding': [1301, 2154], 'Events': [1303, 2156], 'Patients': [1308, 2161, 4175], 'Living': [1309, 2162], 'Systolic': [1311, 2164], '(ACCOMPLISH)).17What': [1313], 'Favor': [1318], 'Versus': [1321], 'Free-Drug': [1322], 'Therapy?Although': [1324], 'superior': [1332], 'terms': [1338, 1540], 'timing': [1342], 'achievement,': [1345], 'why': [1346], 'shall': [1347], 'therapy?': [1355], 'main': [1357, 2348], 'argument': [1358], 'improves': [1362], 'adherence,': [1364, 2234], 'key': [1368], 'factor': [1369], 'subsequent': [1374], 'prevention': [1375, 1986, 3995], 'BP-related': [1377], 'complications.': [1379], 'In': [1380, 1861, 2117, 2219, 2440, 4088, 4207], 'widely': [1382, 1790, 1907], 'quoted': [1383], 'systematic': [1384, 1510, 3427, 3485, 3531], 'various': [1389], 'clinical': [1390, 1559, 2621, 3234], 'conditions,': [1391], 'Claxton': [1392, 3420], 'al18': [1394], 'have': [1395, 1599, 1902, 1956, 2311, 2454, 2477, 2488], 'inverse': [1398], 'relation': [1399], 'between': [1400, 1856, 3432], 'number': [1402, 1603, 2173], 'daily': [1404, 1731, 3828], 'doses': [1405, 4171], 'adherence.': [1410, 4206], 'directly': [1412, 1970], 'tool': [1420], 'summarized': [1429], 'Gupta': [1434, 3444], 'al.19': [1436], 'This': [1437, 1736], 'demonstrated': [1439], '17': [1446], '999': [1447], 'enrolled': [1449], '5': [1451], 'improved': [1457], 'assessed': [1460], 'indirect': [1462], 'methods': [1463], '(drug': [1464], 'pill': [1465, 1556, 2295, 3986], 'count': [1466], 'medication': [1468, 3436, 3480], 'possession': [1469], 'ratio)': [1470], 'corresponding': [1473, 1717], '(odds': [1476], 'ratio,': [1477], '1.21,': [1478], 'p=0.02).': [1479], 'several': [1481, 2127], 'indicated': [1484], 'shifting': [1485], 'being': [1492, 4037], 'one': [1493], 'effective': [1497, 2281, 2531], 'ways': [1498], 'adherence.20': [1502], 'More': [1503], 'recently,': [1504, 2049, 2131], 'Salam': [1505, 3496, 3716], 'al21': [1507], 'conducted': [1508], '33': [1515], 'therapy.': [1524], 'Compared': [1525], 'standard-dose': [1527], 'monotherapy,': [1528], 'initiating': [1529], 'low-to-standard-dose': [1532], 'proved': [1536], 'efficacious': [1538], 'control,': [1543], 'increasing': [1545, 2168], 'withdrawals': [1546], 'adverse': [1549, 2175, 2185], 'events.Notably,': [1550], 'favorable': [1552], 'impact': [1553, 1573], 'reducing': [1555, 2171, 3102], 'burden': [1557, 2296, 2543], 'underestimated': [1563], 'real': [1566], 'life': [1567, 3829], 'known': [1571, 2246], 'positive': [1572], 'participation': [1575, 2619], 'behavior': [1581], '(Hawthorne': [1582], 'effect),': [1583], 'persistence.22': [1589], 'All': [1590], 'investigators': [1591, 2995], 'involved': [1592], 'recruitment': [1594], 'renal': [1596, 3615, 3673], 'denervation': [1597, 3560, 3616, 3674, 3698], 'experienced': [1600], 'difficult': [1607, 1841, 1997], 'treat': [1609], 'suddenly': [1612], 'during': [1616], 'run-in': [1618], 'period,': [1619], 'either': [1620, 1695], 'spontaneously': [1621], 'shift': [1625, 2267], 'standardized': [1628], 'triple': [1630], 'therapy.23–25Which': [1631], 'Availability': [1634], 'Worldwide?We': [1637], 'checked': [1638], 'databases': [1639], 'listing': [1640], 'information': [1641, 1837], 'about': [1642], 'medications': [1643, 2066, 3855], 'authorized': [1644], 'countries': [1647, 1794, 1817], 'around': [1648], 'world': [1650], '(drugs.com': [1651], '[the': [1652], 'Drugs.com': [1653], 'Name': [1656], 'Database],': [1657], 'drugbank.com,': [1658], 'ema.europa.eu': [1659], '[Public': [1660], 'data': [1661], 'Article': [1663], '57': [1664], 'database]': [1665], 'fda.gov': [1667], '[Orange': [1668], 'Book:': [1669], 'approved': [1670], 'products': [1672], 'equivalence': [1675], 'evaluations])': [1676], 'ACE': [1681, 1744, 1750], '(angiotensin-converting': [1682], 'enzyme)': [1683], 'inhibitors': [1684], 'angiotensin': [1686, 1754, 1762, 1829], 'receptor': [1687, 1755, 1763], 'blockers': [1688], 'SPCs,': [1691, 1765, 2377, 2525, 4093, 4132], 'thiazide/thiazide-like': [1697], 'diuretic': [1698], 'calcium': [1701, 1833], 'channel': [1702, 1746, 1757, 1834], 'blocker.': [1703], 'Research': [1704, 3899], 'available': [1706, 1777, 1791, 1815], 'these': [1710, 1787, 4069, 4210], 'classes': [1712, 4168], 'Anatomical': [1718], 'Therapeutic': [1719], 'Chemical': [1720], '(ATC)': [1721], 'codes': [1722], 'provided': [1723], 'World': [1726, 2051, 2069], 'Health': [1727, 2052, 2070, 3053, 3768], 'Organization–ATC': [1728], 'defined': [1730], '(DDD)': [1733], 'index': [1734], '(https://www.whocc.no/atc_ddd_index/).': [1735], 'least': [1741, 2313], 'inhibitors/calcium': [1745], 'blockers,': [1747, 1758], '12': [1748], 'inhibitors/diuretics,': [1751], '8': [1752, 1760], 'blockers/calcium': [1756], 'blockers/diuretic': [1764], 'many': [1766, 2105, 2303, 2318], 'marketed': [1770], 'dosing': [1773, 4166], 'levels,': [1774], 'potentially': [1776], 'globally.': [1778], 'there': [1780], 'significant': [1782], 'regional': [1783], 'differences.': [1784], 'Indeed,': [1785, 4068], 'although': [1786, 1864], 'some': [1793, 2254], 'Europe,': [1796], 'North': [1797], 'America': [1798], '(Canada': [1799], 'United': [1801], 'States),': [1802], 'Asia': [1805], '(China,': [1806], 'Japan,': [1807], 'India,': [1808], 'South': [1810], 'Korea),': [1811], 'fewer': [1812], 'Middle': [1820], 'East': [1821, 3604], 'Australia,': [1823], 'particularly': [1824, 2361], 'renin': [1828], 'system-blocker': [1830], 'blocker,': [1835], 'Africa': [1839], 'retrieve.Accordingly,': [1843], 'mentioned,': [1846], 'recent': [1848], 'distinguish': [1855], 'essential': [1857, 1879, 3757, 3764], 'measures.': [1860], 'perspective,': [1863], 'considered': [1871], 'therapy,': [1884, 2121], 'unaffordable': [1896], '(see': [1897], 'higher).': [1898], 'Such': [1899], '2-level': [1900], 'advantage': [1904], 'propose': [1906], 'applicable': [1908], 'measures,': [1909], 'low-resource': [1912, 4126], 'countries,': [1913, 4127], 'setting': [1915], 'ambitious': [1916], 'standards': [1917], 'likely': [1918, 4181], 'encourage': [1920], 'local': [1921], 'initiatives': [1922], 'such': [1925, 1993, 4153], 'standards.Beyond': [1926], 'Evidence-Based': [1927], 'Which': [1929], 'Are': [1930], 'Tentative': [1932], 'Advantages': [1933], 'Improve': [1938], 'Overall': [1939], 'Control?We': [1941], 'aware': [1944], 'mentioned': [1948], 'limitations': [1957], 'often': [1962], 'somewhat': [1963], 'weak': [1964], 'contradictory.': [1966], 'benefit': [1973], 'monotherapy-based': [1983], 'lacking.': [1991], 'conduct': [1999], 'they': [2001, 2472], 'nevertheless': [2003], 'capture': [2005], 'full': [2007, 2099], 'benefits': [2008], 'real-life': [2013], 'medical': [2014, 2112, 2212], 'practice.': [2015], 'fact': [2017], 'companies': [2020], 'actively': [2022], 'promoting': [2023], 'allow': [2026, 2147], 'them': [2027], 'capitalizing': [2028], 'existent': [2031], 'beyond': [2033, 2380], 'patent': [2034], 'expiration': [2035], 'raises': [2036], 'suspicion': [2038], 'strategy,': [2041], 'sometimes': [2043], 'elicits': [2044], 'visceral': [2045], 'reactions.': [2046], 'Nevertheless,': [2047], 'Organization': [2053, 2071], 'added': [2054], '(or': [2060], 'combination)': [2062], 'Essential': [2072], 'Medicines': [2073], 'List26': [2074], 'thereby': [2076, 4133], 'acknowledges': [2077], 'emerging': [2085], 'best': [2086], 'practice': [2087, 2952], 'safe,': [2089], 'effective,': [2090], 'rapid,': [2091], 'convenient': [2093], 'worldwide.27We': [2096], 'agreement': [2100], 'recognition': [2103], 'reasons': [2106], 'common': [2109], 'sense': [2110], 'experience': [2113], 'support': [2114, 2624, 2642], 'strategy.': [2116], 'still': [2124], 'specialists': [2129], 'until': [2130], 'validated': [2135], 'does': [2139], 'require': [2141], 'expertise': [2144], 'should': [2146, 4222], '≈80%': [2150], '[ACCOMPLISH])17': [2166], 'events.19': [2176], 'Timely': [2177], 'few': [2182, 2216], 'no': [2184, 2660], 'important': [2188], 'risk13': [2194], 'also': [2196, 2244, 2290, 2329, 2432], 'avoid': [2198], 'discouragement': [2199], 'reluctant': [2203], 'escape': [2211], 'follow-up': [2213, 3264, 4074], 'unsuccessful': [2217], 'attempts.': [2218], 'contrast,': [2220], 'quick': [2221], 'using': [2224], 'well-tolerated': [2226], 'strengthen': [2229], 'physician-patient': [2230], 'relationship,': [2231], 'reinforce': [2232], 'discontinuation.28,29': [2241], 'It': [2242], 'once': [2248], 'improvement': [2255], 'BP,': [2257], 'both': [2258, 3364], 'physicians': [2261], 'will': [2262, 4116], 'tempted': [2264], 'delay': [2266], 'therapy.30': [2271], 'Standard': [2272], 'therefore': [2279], 'prevent': [2283], 'poor': [2286], 'inertia.1': [2292], 'decreasing': [2294], 'critical': [2298], 'decades': [2304], 'ago,': [2305], '75%': [2306], 'factor.31': [2316], 'Thus,': [2317], 'candidates': [2322, 2465], 'lipid-lowering32': [2331], 'antidiabetic': [2333], 'drugs,': [2334, 4152], 'providing': [2335], 'rationale': [2337], 'polypill': [2343], 'targeting': [2346], 'factors.33': [2351], 'Still,': [2352, 2558], 'discussion': [2354], 'pros': [2356], 'cons': [2358], 'polypill,': [2360], 'way': [2364], 'entire': [2370], 'populations': [2371], 'partly': [2372], 'differs': [2373], 'article.Importance': [2385], 'Accurate': [2387], 'Measurement': [2389], 'Outside': [2392], "Physician's": [2394], 'OfficeSafe': [2395], 'implementation': [2398], 'recommendation1': [2409], 'requires': [2410], 'accurate': [2411], 'evaluation': [2412], 'level': [2415], 'patient': [2419], 'according': [2420], 'repeated': [2422], 'office': [2423, 2451], 'measurements,': [2425, 2431], 'ideally': [2426], 'complemented': [2427], 'out-of-office': [2429], 'strongly': [2433], 'guidelines.1': [2439], 'particular,': [2441], 'mild': [2455], 'ambulatory': [2458], 'measurement': [2461], 'necessarily': [2464, 2669], 'frail,': [2474], 'old,': [2476], 'orthostatic': [2478], 'hypotension,': [2479], 'risk.1': [2485], 'been': [2489], 'listed': [2491], 'pointed': [2498], 'beginning': [2502], 'article.ConclusionsIn': [2505], 'conclusion,': [2506], 'appears': [2526], 'means': [2532], 'worldwide.': [2544], 'simple': [2546, 4194], 'algorithm': [2547, 2577], 'Figure.': [2557], 'medicine': [2559], 'remains': [2560], 'art,': [2562], 'tailored': [2569], 'patient.Download': [2573], 'figureDownload': [2574], 'PowerPointFigure.': [2575], 'Decision': [2576], 'start': [2579, 3705, 4045, 4216], 'pressure;': [2588], 'CV,': [2589], 'cardiovascular;': [2590], 'OR,': [2592], 'odds': [2593], 'ratio.Sources': [2594], 'FundingNone.Disclosures': [2596], 'A.': [2597, 3252, 3513, 3740], 'reports': [2599, 2614, 2636, 2659], 'honoraria': [2600, 2615, 2637], 'consultancy': [2602], 'travel': [2604], 'grants': [2605], 'Ablative': [2607], 'Solutions': [2608], 'Quantum': [2610], 'Genomics.': [2611], 'M.': [2612, 3696, 3789], 'consultancy,': [2617, 2639], 'lectures,': [2618], 'trials,': [2622, 4092], 'research': [2626, 2644], 'AddMedica,': [2628], 'Astra': [2629], 'Zeneca,': [2630], 'Elsevier,': [2631], 'Servier.': [2633, 2655], 'R.': [2634], 'lectures': [2640], 'Bayer': [2646], 'Pharma,': [2647], 'Berlin-Chemie': [2648], 'Menarini,': [2649], 'Daiichi': [2650], 'Sankyo,': [2651], 'Ferrer,': [2652], 'Sanofi,': [2653], 'author': [2658], 'conflicts.FootnotesThe': [2661], 'opinions': [2662], 'editors': [2673], 'Association.For': [2679], 'Sources': [2680], 'Funding': [2682], 'Disclosures,': [2684], 'see': [2685], 'page': [2686], '804.Correspondence': [2687], 'alexandre.[email': 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