Title: Langerhans Cell Histiocytosis-A Case Report
Abstract: Abstract Langerhans Cell Histiocytosis (LCH) is among the group of diseases that was originally called Histiocytosis X. This syndrome has an unknown etiology and originates from an excessive proliferation of Langerhans cells. The histiocytes can cause the development of other pathological conditions. LCH has a predilection for men and children and is classified into the following three types: LCH with solitary lesion, multiple lesions and disseminated/with visceral involvement. A common feature of these variants is the presence of a lytic lesion that can be identified by imaging. This study aimed to report a clinical case of LCH with multiple lesions and wide systemic repercussions but with no significative oral alteration. The patient, a 31-year-old woman, leucoderma, presented with a more than 10-year history of pain in the lower limbs. It was requested imaging examinations to assess the presence of bone rarefactions in the femur and iliac. An incisional biopsy of the lesion revealed a well-differentiated fragment of bone tissue in the cortical and medullary regions, without histopathological changes. However, deposits of histiocytic cells with eosinophilic cytoplasm and multinucleated giant cells were present in some areas. A final histopathological diagnosis of LCH was established based on these findings. Since then, the patient's condition has been effectively controlled with bisphosphonate therapy. This case report might contribute to a better understanding of the pathogenesis of LCH and will help to expand the knowledge of health professionals, especially dental surgeons, about this condition.
Publication Year: 2020
Publication Date: 2020-12-31
Language: en
Type: article
Indexed In: ['crossref']
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