Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3119089136', 'doi': 'https://doi.org/10.7554/elife.59629', 'title': 'Use of signals of positive and negative selection to distinguish cancer genes and passenger genes', 'display_name': 'Use of signals of positive and negative selection to distinguish cancer genes and passenger genes', 'publication_year': 2021, 'publication_date': '2021-01-11', 'ids': {'openalex': 'https://openalex.org/W3119089136', 'doi': 'https://doi.org/10.7554/elife.59629', 'mag': '3119089136', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33427197', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7877913'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.59629', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.7554/elife.59629', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071827404', 'display_name': 'László Bányai', 'orcid': 'https://orcid.org/0000-0003-2122-0996'}, 'institutions': [{'id': 'https://openalex.org/I4210151515', 'display_name': 'Institute of Enzymology', 'ror': 'https://ror.org/04t4pws42', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151515', 'https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}, {'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'László Bányai', 'raw_affiliation_strings': ['Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary', 'institution_ids': ['https://openalex.org/I4210151515', 'https://openalex.org/I80251312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052204988', 'display_name': 'Mária Trexler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151515', 'display_name': 'Institute of Enzymology', 'ror': 'https://ror.org/04t4pws42', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151515', 'https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}, {'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Maria Trexler', 'raw_affiliation_strings': ['Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary', 'institution_ids': ['https://openalex.org/I4210151515', 'https://openalex.org/I80251312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054949493', 'display_name': 'Krisztina Kerekes', 'orcid': 'https://orcid.org/0000-0002-6541-8980'}, 'institutions': [{'id': 'https://openalex.org/I4210151515', 'display_name': 'Institute of Enzymology', 'ror': 'https://ror.org/04t4pws42', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151515', 'https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}, {'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Krisztina Kerekes', 'raw_affiliation_strings': ['Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary', 'institution_ids': ['https://openalex.org/I4210151515', 'https://openalex.org/I80251312']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075494029', 'display_name': 'Orsolya Csuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119956', 'display_name': 'National Institute of Oncology', 'ror': 'https://ror.org/02kjgsq44', 'country_code': 'HU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210119956']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'Orsolya Csuka', 'raw_affiliation_strings': ['Department of Pathogenetics, National Institute of Oncology, Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathogenetics, National Institute of Oncology, Budapest, Hungary', 'institution_ids': ['https://openalex.org/I4210119956']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082077647', 'display_name': 'László Patthy', 'orcid': 'https://orcid.org/0000-0003-1329-0484'}, 'institutions': [{'id': 'https://openalex.org/I4210151515', 'display_name': 'Institute of Enzymology', 'ror': 'https://ror.org/04t4pws42', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151515', 'https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}, {'id': 'https://openalex.org/I80251312', 'display_name': 'HUN-REN Research Centre for Natural Sciences', 'ror': 'https://ror.org/03zwxja46', 'country_code': 'HU', 'type': 'facility', 'lineage': ['https://openalex.org/I4387152226', 'https://openalex.org/I80251312']}], 'countries': ['HU'], 'is_corresponding': False, 'raw_author_name': 'László Patthy', 'raw_affiliation_strings': ['Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary'], 'affiliations': [{'raw_affiliation_string': 'Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary', 'institution_ids': ['https://openalex.org/I4210151515', 'https://openalex.org/I80251312']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'fwci': 1.809, 'has_fulltext': False, 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.999893, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '10', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11764', 'display_name': 'Evolutionary Dynamics of Genetic Adaptation and Mutation', 'score': 0.9838, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13937', 'display_name': 'Challenges and Innovations in Bioinformatics Education', 'score': 0.9714, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/negative-selection', 'display_name': 'Negative selection', 'score': 0.7401074}, {'id': 'https://openalex.org/keywords/cancer-genomics', 'display_name': 'Cancer Genomics', 'score': 0.573621}, {'id': 'https://openalex.org/keywords/tumor-evolution', 'display_name': 'Tumor Evolution', 'score': 0.553496}, {'id': 'https://openalex.org/keywords/genetic-dynamics', 'display_name': 'Genetic Dynamics', 'score': 0.515174}], 'concepts': [{'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.7569383}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7432286}, {'id': 'https://openalex.org/C7386963', 'wikidata': 'https://www.wikidata.org/wiki/Q3954859', 'display_name': 'Negative selection', 'level': 4, 'score': 0.7401074}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.6907897}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.62888694}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5635119}, {'id': 'https://openalex.org/C134305767', 'wikidata': 'https://www.wikidata.org/wiki/Q725508', 'display_name': 'Somatic cell', 'level': 3, 'score': 0.47764006}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46871322}, {'id': 'https://openalex.org/C113968399', 'wikidata': 'https://www.wikidata.org/wiki/Q7559241', 'display_name': 'Somatic evolution in cancer', 'level': 3, 'score': 0.45915595}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.42863813}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41069096}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.38883877}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.20662364}], 'mesh': [{'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.59629', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9873b379f6844defa777b01f1b4523b9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877913', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.06.04.133199', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/06/17/2020.06.04.133199.full.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33427197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.59629', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 322, 'referenced_works': ['https://openalex.org/W102715436', 'https://openalex.org/W1122070062', 'https://openalex.org/W1523751628', 'https://openalex.org/W1544851750', 'https://openalex.org/W1550376883', 'https://openalex.org/W1568188518', 'https://openalex.org/W1569081728', 'https://openalex.org/W1579239145', 'https://openalex.org/W1597653392', 'https://openalex.org/W1603158107', 'https://openalex.org/W1671858809', 'https://openalex.org/W1713707107', 'https://openalex.org/W1768419209', 'https://openalex.org/W1812340183', 'https://openalex.org/W1927263528', 'https://openalex.org/W1934704664', 'https://openalex.org/W1963502651', 'https://openalex.org/W1965310482', 'https://openalex.org/W1965856472', 'https://openalex.org/W1967319983', 'https://openalex.org/W1970312353', 'https://openalex.org/W1972738957', 'https://openalex.org/W1973018054', 'https://openalex.org/W1974351849', 'https://openalex.org/W1978828082', 'https://openalex.org/W1979715005', 'https://openalex.org/W1982387674', 'https://openalex.org/W1983733452', 'https://openalex.org/W1983807480', 'https://openalex.org/W1987480626', 'https://openalex.org/W1989347619', 'https://openalex.org/W1989456683', 'https://openalex.org/W1991331097', 'https://openalex.org/W1991429659', 'https://openalex.org/W1993981670', 'https://openalex.org/W1996507796', 'https://openalex.org/W1998359234', 'https://openalex.org/W1999363650', 'https://openalex.org/W2000391750', 'https://openalex.org/W2002631420', 'https://openalex.org/W2003268137', 'https://openalex.org/W2003910815', 'https://openalex.org/W2005841680', 'https://openalex.org/W2009720434', 'https://openalex.org/W2010770452', 'https://openalex.org/W2013808701', 'https://openalex.org/W2014058353', 'https://openalex.org/W2020392597', 'https://openalex.org/W2022101765', 'https://openalex.org/W2023103376', 'https://openalex.org/W2023494868', 'https://openalex.org/W2024244901', 'https://openalex.org/W2030961146', 'https://openalex.org/W2034103831', 'https://openalex.org/W2034605371', 'https://openalex.org/W2035983112', 'https://openalex.org/W2040789365', 'https://openalex.org/W2043878795', 'https://openalex.org/W2044433401', 'https://openalex.org/W2045937953', 'https://openalex.org/W2052258308', 'https://openalex.org/W2052427812', 'https://openalex.org/W2052580925', 'https://openalex.org/W2056327299', 'https://openalex.org/W2057690410', 'https://openalex.org/W2061102940', 'https://openalex.org/W2065613827', 'https://openalex.org/W2067084776', 'https://openalex.org/W2068913852', 'https://openalex.org/W2072451938', 'https://openalex.org/W2072572998', 'https://openalex.org/W2072929879', 'https://openalex.org/W2072933484', 'https://openalex.org/W2073294762', 'https://openalex.org/W2075661710', 'https://openalex.org/W2075800992', 'https://openalex.org/W2077217951', 'https://openalex.org/W2079561996', 'https://openalex.org/W2081760508', 'https://openalex.org/W2082851628', 'https://openalex.org/W2084291827', 'https://openalex.org/W2085039090', 'https://openalex.org/W2086239585', 'https://openalex.org/W2087080448', 'https://openalex.org/W2087555199', 'https://openalex.org/W2091068407', 'https://openalex.org/W2092664001', 'https://openalex.org/W2094805920', 'https://openalex.org/W2094920355', 'https://openalex.org/W2096460732', 'https://openalex.org/W2100697297', 'https://openalex.org/W2101897262', 'https://openalex.org/W2102140136', 'https://openalex.org/W2102720938', 'https://openalex.org/W2105265620', 'https://openalex.org/W2105323385', 'https://openalex.org/W2107063353', 'https://openalex.org/W2108040084', 'https://openalex.org/W2113407988', 'https://openalex.org/W2114031931', 'https://openalex.org/W2114446881', 'https://openalex.org/W2115213957', 'https://openalex.org/W2117692326', 'https://openalex.org/W2126315841', 'https://openalex.org/W2127049578', 'https://openalex.org/W2132000514', 'https://openalex.org/W2134775102', 'https://openalex.org/W2134931983', 'https://openalex.org/W2140197827', 'https://openalex.org/W2143394009', 'https://openalex.org/W2147050655', 'https://openalex.org/W2147785707', 'https://openalex.org/W2148253349', 'https://openalex.org/W2149107345', 'https://openalex.org/W2151441244', 'https://openalex.org/W2152061559', 'https://openalex.org/W2152093423', 'https://openalex.org/W2153056550', 'https://openalex.org/W2155788351', 'https://openalex.org/W2155819889', 'https://openalex.org/W2160210604', 'https://openalex.org/W2160457444', 'https://openalex.org/W2162133018', 'https://openalex.org/W2163881418', 'https://openalex.org/W2165454946', 'https://openalex.org/W2166771322', 'https://openalex.org/W2167888624', 'https://openalex.org/W2169786616', 'https://openalex.org/W2169880577', 'https://openalex.org/W2173818354', 'https://openalex.org/W2176556985', 'https://openalex.org/W2178296763', 'https://openalex.org/W2179504521', 'https://openalex.org/W2201808132', 'https://openalex.org/W2206969062', 'https://openalex.org/W2220812108', 'https://openalex.org/W2228251759', 'https://openalex.org/W2229207320', 'https://openalex.org/W2233214336', 'https://openalex.org/W2252382072', 'https://openalex.org/W2263310282', 'https://openalex.org/W2265720901', 'https://openalex.org/W2271045634', 'https://openalex.org/W2281046076', 'https://openalex.org/W2292856360', 'https://openalex.org/W2293102240', 'https://openalex.org/W2296948836', 'https://openalex.org/W2301960350', 'https://openalex.org/W2310876240', 'https://openalex.org/W2312022076', 'https://openalex.org/W2327909695', 'https://openalex.org/W2331136216', 'https://openalex.org/W2341730933', 'https://openalex.org/W2401860366', 'https://openalex.org/W2405648137', 'https://openalex.org/W2410306399', 'https://openalex.org/W2417380023', 'https://openalex.org/W2423676146', 'https://openalex.org/W2433212187', 'https://openalex.org/W2471304467', 'https://openalex.org/W2496738621', 'https://openalex.org/W2508267303', 'https://openalex.org/W2509062016', 'https://openalex.org/W2519711400', 'https://openalex.org/W2519732232', 'https://openalex.org/W2537167162', 'https://openalex.org/W2549912424', 'https://openalex.org/W2553025329', 'https://openalex.org/W2553101863', 'https://openalex.org/W2555130359', 'https://openalex.org/W2561287270', 'https://openalex.org/W2566429177', 'https://openalex.org/W2586384386', 'https://openalex.org/W2586467157', 'https://openalex.org/W2587331820', 'https://openalex.org/W2588023800', 'https://openalex.org/W2592734850', 'https://openalex.org/W2592973432', 'https://openalex.org/W2594883857', 'https://openalex.org/W2597594016', 'https://openalex.org/W2598773960', 'https://openalex.org/W2600983503', 'https://openalex.org/W2606360769', 'https://openalex.org/W2611387862', 'https://openalex.org/W2618323003', 'https://openalex.org/W2621636286', 'https://openalex.org/W2623889753', 'https://openalex.org/W2625192816', 'https://openalex.org/W2724740174', 'https://openalex.org/W2736228003', 'https://openalex.org/W2739475312', 'https://openalex.org/W2744731119', 'https://openalex.org/W2745340115', 'https://openalex.org/W2748237445', 'https://openalex.org/W2751013199', 'https://openalex.org/W2751620257', 'https://openalex.org/W2753395944', 'https://openalex.org/W2753460349', 'https://openalex.org/W2753687033', 'https://openalex.org/W2762351536', 'https://openalex.org/W2762693247', 'https://openalex.org/W2765219824', 'https://openalex.org/W2766427688', 'https://openalex.org/W2767376686', 'https://openalex.org/W2767399544', 'https://openalex.org/W2767912766', 'https://openalex.org/W2767997645', 'https://openalex.org/W2769234034', 'https://openalex.org/W2770753164', 'https://openalex.org/W2771003698', 'https://openalex.org/W2771048020', 'https://openalex.org/W2771794752', 'https://openalex.org/W2772116600', 'https://openalex.org/W2772446613', 'https://openalex.org/W2773074337', 'https://openalex.org/W2773643184', 'https://openalex.org/W2775263281', 'https://openalex.org/W2776596084', 'https://openalex.org/W2781110167', 'https://openalex.org/W2783363449', 'https://openalex.org/W2788008230', 'https://openalex.org/W2790501767', 'https://openalex.org/W2790598717', 'https://openalex.org/W2790904299', 'https://openalex.org/W2790923755', 'https://openalex.org/W2792595511', 'https://openalex.org/W2793598054', 'https://openalex.org/W2794673197', 'https://openalex.org/W2796408191', 'https://openalex.org/W2796464520', 'https://openalex.org/W2797079426', 'https://openalex.org/W2797121391', 'https://openalex.org/W2800037441', 'https://openalex.org/W2801137679', 'https://openalex.org/W2803399933', 'https://openalex.org/W2803537101', 'https://openalex.org/W2803994580', 'https://openalex.org/W2805422732', 'https://openalex.org/W2806397309', 'https://openalex.org/W2806991293', 'https://openalex.org/W2807541399', 'https://openalex.org/W2808637251', 'https://openalex.org/W2809827516', 'https://openalex.org/W2884610229', 'https://openalex.org/W2884946361', 'https://openalex.org/W2888426499', 'https://openalex.org/W2888989467', 'https://openalex.org/W2889778242', 'https://openalex.org/W2891387143', 'https://openalex.org/W2892226978', 'https://openalex.org/W2892613404', 'https://openalex.org/W2894573839', 'https://openalex.org/W2896532260', 'https://openalex.org/W2897789847', 'https://openalex.org/W2898337719', 'https://openalex.org/W2898789672', 'https://openalex.org/W2898900122', 'https://openalex.org/W2899765160', 'https://openalex.org/W2903034744', 'https://openalex.org/W2904099822', 'https://openalex.org/W2904862932', 'https://openalex.org/W2908586471', 'https://openalex.org/W2908888879', 'https://openalex.org/W2911679685', 'https://openalex.org/W2913210371', 'https://openalex.org/W2915667467', 'https://openalex.org/W2921068977', 'https://openalex.org/W2922323966', 'https://openalex.org/W2923804334', 'https://openalex.org/W2924107965', 'https://openalex.org/W2924903871', 'https://openalex.org/W2925155273', 'https://openalex.org/W2937319208', 'https://openalex.org/W2941892184', 'https://openalex.org/W2945368745', 'https://openalex.org/W2946507269', 'https://openalex.org/W2946906978', 'https://openalex.org/W2947479746', 'https://openalex.org/W2948644318', 'https://openalex.org/W2949129392', 'https://openalex.org/W2950373563', 'https://openalex.org/W2952902464', 'https://openalex.org/W2953901678', 'https://openalex.org/W2955858171', 'https://openalex.org/W2956135855', 'https://openalex.org/W2959034083', 'https://openalex.org/W2960898128', 'https://openalex.org/W2961221173', 'https://openalex.org/W2963298763', 'https://openalex.org/W2964554577', 'https://openalex.org/W2966169904', 'https://openalex.org/W2966410905', 'https://openalex.org/W2967168232', 'https://openalex.org/W2969709096', 'https://openalex.org/W2971026971', 'https://openalex.org/W2971580085', 'https://openalex.org/W2972114072', 'https://openalex.org/W2980163931', 'https://openalex.org/W2981480342', 'https://openalex.org/W2982780080', 'https://openalex.org/W2986601289', 'https://openalex.org/W2988474811', 'https://openalex.org/W2990580978', 'https://openalex.org/W2996914533', 'https://openalex.org/W2998206203', 'https://openalex.org/W3000710304', 'https://openalex.org/W3004480399', 'https://openalex.org/W3004498009', 'https://openalex.org/W3004584205', 'https://openalex.org/W3004647847', 'https://openalex.org/W3004859565', 'https://openalex.org/W3006500278', 'https://openalex.org/W3009570993', 'https://openalex.org/W3022927847', 'https://openalex.org/W3028113548', 'https://openalex.org/W3084492169', 'https://openalex.org/W4245638064', 'https://openalex.org/W4246664388', 'https://openalex.org/W4294025268', 'https://openalex.org/W4319308571', 'https://openalex.org/W778824472', 'https://openalex.org/W822399980'], 'related_works': ['https://openalex.org/W81105053', 'https://openalex.org/W4280546997', 'https://openalex.org/W4251027247', 'https://openalex.org/W3104388341', 'https://openalex.org/W2550169079', 'https://openalex.org/W2438531772', 'https://openalex.org/W2060908277', 'https://openalex.org/W2048083752', 'https://openalex.org/W1992103432', 'https://openalex.org/W1881137434'], 'abstract_inverted_index': {'A': [0], 'major': [1], 'goal': [2], 'of': [3, 33, 55, 64, 67, 74, 98, 121, 140], 'cancer': [4, 48], 'genomics': [5], 'is': [6, 133], 'to': [7, 95], 'identify': [8], 'all': [9], 'genes': [10, 21, 84, 117], 'that': [11, 26, 41, 81, 118, 129], 'play': [12], 'critical': [13], 'roles': [14], 'in': [15, 47, 58], 'carcinogenesis.': [16], 'Most': [17], 'approaches': [18], 'focused': [19], 'on': [20], 'positively': [22, 86], 'selected': [23, 87], 'for': [24, 88, 102, 108, 135], 'mutations': [25, 69, 104], 'drive': [27], 'carcinogenesis': [28], 'and': [29, 105, 138], 'neglected': [30], 'the': [31, 53, 62, 65, 71, 136], 'role': [32, 46, 54], 'negative': [34, 42, 56, 100, 123], 'selection.': [35], 'Some': [36], 'studies': [37], 'have': [38, 51, 79, 113], 'actually': [39], 'concluded': [40], 'selection': [43, 57, 101, 107, 124], 'has': [44], 'no': [45], 'evolution.': [49], 'We': [50], 're-examined': [52], 'tumor': [59, 82, 126, 141], 'evolution': [60], 'through': [61], 'analysis': [63], 'patterns': [66], 'somatic': [68], 'affecting': [70], 'coding': [72], 'sequences': [73], 'human': [75, 116], 'genes.': [76], 'Our': [77], 'analyses': [78], 'confirmed': [80], 'suppressor': [83], 'are': [85], 'inactivating': [89, 103], 'mutations,': [90], 'oncogenes,': [91], 'however,': [92], 'were': [93], 'found': [94], 'display': [96], 'signals': [97], 'both': [99], 'positive': [106], 'activating': [109], 'mutations.': [110], 'Significantly,': [111], 'we': [112], 'identified': [114], 'numerous': [115], 'show': [119], 'signs': [120], 'strong': [122], 'during': [125], 'evolution,': [127], 'suggesting': [128], 'their': [130], 'functional': [131], 'integrity': [132], 'essential': [134], 'growth': [137], 'survival': [139], 'cells.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3119089136', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2024-09-01T08:54:36.993518', 'created_date': '2021-01-18'}