Publication Information

{'id': 'https://openalex.org/W3118997642', 'doi': None, 'title': 'Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome', 'display_name': 'Targeted therapy against macrophages/monocytes in fatal acute respiratory distress syndrome', 'publication_year': 2020, 'publication_date': '2020-09-01', 'ids': {'openalex': 'https://openalex.org/W3118997642', 'mag': '3118997642'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://covid19.elsevierpure.com/en/publications/targeted-therapy-against-macrophagesmonocytes-in-fatal-acute-resp', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306514839', 'display_name': 'Nihon Kagaku Ryōhō Gakkai zasshi/Nihon Kagaku Ryoho Gakkai zasshi', 'issn_l': '1340-7007', 'issn': ['1340-7007', '1884-5886'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049259561', 'display_name': 'Tetsuji Aoyagi', 'orcid': 'https://orcid.org/0000-0001-6821-9701'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuji Aoyagi', 'raw_affiliation_strings': ['Tohoku University (),'], 'affiliations': [{'raw_affiliation_string': 'Tohoku University (),', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101985483', 'display_name': 'Yukio Sato', 'orcid': 'https://orcid.org/0000-0002-0041-6159'}, 'institutions': [{'id': 'https://openalex.org/I4210116024', 'display_name': 'Sendai Medical Center', 'ror': 'https://ror.org/02cq51909', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210116024', 'https://openalex.org/I4210137409']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukio Sato', 'raw_affiliation_strings': ['Sendai Medical Imaging Clinic'], 'affiliations': [{'raw_affiliation_string': 'Sendai Medical Imaging Clinic', 'institution_ids': ['https://openalex.org/I4210116024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102863645', 'display_name': 'Kazuyoshi Kawakami', 'orcid': 'https://orcid.org/0000-0001-6599-1915'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuyoshi Kawakami', 'raw_affiliation_strings': ['Tohoku University of Graduated Medicine'], 'affiliations': [{'raw_affiliation_string': 'Tohoku University of Graduated Medicine', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5040832259', 'display_name': 'Mitsuo Kaku', 'orcid': 'https://orcid.org/0000-0002-3714-8100'}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mitsuo Kaku', 'raw_affiliation_strings': ['Tohoku Medical and Pharmaceutical University;'], 'affiliations': [{'raw_affiliation_string': 'Tohoku Medical and Pharmaceutical University;', 'institution_ids': ['https://openalex.org/I85324120']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '68', 'issue': '5', 'first_page': '563', 'last_page': '575'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11368', 'display_name': 'Long-Term Effects of COVID-19', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/macrophage-activation-syndrome', 'display_name': 'Macrophage Activation Syndrome', 'score': 0.77842027}, {'id': 'https://openalex.org/keywords/cytokine-storm', 'display_name': 'Cytokine Storm', 'score': 0.77338123}, {'id': 'https://openalex.org/keywords/hemophagocytosis', 'display_name': 'Hemophagocytosis', 'score': 0.6506882}, {'id': 'https://openalex.org/keywords/hemophagocytic-lymphohistiocytosis', 'display_name': 'Hemophagocytic Lymphohistiocytosis', 'score': 0.5794378}, {'id': 'https://openalex.org/keywords/diffuse-alveolar-damage', 'display_name': 'Diffuse alveolar damage', 'score': 0.46440744}], 'concepts': [{'id': 'https://openalex.org/C2776348555', 'wikidata': 'https://www.wikidata.org/wiki/Q344873', 'display_name': 'ARDS', 'level': 3, 'score': 0.932235}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.82446665}, {'id': 'https://openalex.org/C2779613421', 'wikidata': 'https://www.wikidata.org/wiki/Q6725504', 'display_name': 'Macrophage activation syndrome', 'level': 3, 'score': 0.77842027}, {'id': 'https://openalex.org/C2779559532', 'wikidata': 'https://www.wikidata.org/wiki/Q1076369', 'display_name': 'Cytokine storm', 'level': 5, 'score': 0.77338123}, {'id': 'https://openalex.org/C2777363875', 'wikidata': 'https://www.wikidata.org/wiki/Q5712526', 'display_name': 'Hemophagocytosis', 'level': 4, 'score': 0.6506882}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.62710303}, {'id': 'https://openalex.org/C2779079688', 'wikidata': 'https://www.wikidata.org/wiki/Q1642170', 'display_name': 'Hemophagocytic lymphohistiocytosis', 'level': 3, 'score': 0.5794378}, {'id': 'https://openalex.org/C9418649', 'wikidata': 'https://www.wikidata.org/wiki/Q5275407', 'display_name': 'Diffuse alveolar damage', 'level': 4, 'score': 0.46440744}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.31240118}, {'id': 'https://openalex.org/C2909621147', 'wikidata': 'https://www.wikidata.org/wiki/Q344873', 'display_name': 'Acute respiratory distress', 'level': 3, 'score': 0.19267789}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1803683}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.08973274}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.08044633}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.07736266}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2779382419', 'wikidata': 'https://www.wikidata.org/wiki/Q1757427', 'display_name': 'Pancytopenia', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://covid19.elsevierpure.com/en/publications/targeted-therapy-against-macrophagesmonocytes-in-fatal-acute-resp', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306514839', 'display_name': 'Nihon Kagaku Ryōhō Gakkai zasshi/Nihon Kagaku Ryoho Gakkai zasshi', 'issn_l': '1340-7007', 'issn': ['1340-7007', '1884-5886'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3206450324', 'https://openalex.org/W3197383871', 'https://openalex.org/W3190691832', 'https://openalex.org/W3181751401', 'https://openalex.org/W3180253783', 'https://openalex.org/W3163322206', 'https://openalex.org/W3154942836', 'https://openalex.org/W3147275988', 'https://openalex.org/W3123101721', 'https://openalex.org/W3112300343', 'https://openalex.org/W3110244378', 'https://openalex.org/W3087402955', 'https://openalex.org/W3045035401', 'https://openalex.org/W3042676445', 'https://openalex.org/W3036166911', 'https://openalex.org/W3034663845', 'https://openalex.org/W3032254133', 'https://openalex.org/W3028791763', 'https://openalex.org/W3025090657', 'https://openalex.org/W3022206014'], 'abstract_inverted_index': {'The': [0, 64], 'emergence': [1], 'of': [2, 8, 18, 31, 67, 76, 115, 186, 223, 277], 'novel,': [3], 'as': [4, 6, 79], 'well': [5], 're-emergence': [7], 'serious': [9, 100], 'respiratory': [10, 24, 51, 58], 'viral': [11], 'diseases': [12, 149], 'in': [13, 38, 172, 240, 254, 267], 'the': [14, 43, 99, 113, 169, 217, 221, 252, 268, 272, 275], 'current': [15], 'decade': [16], 'is': [17, 90, 120], 'particular': [19], 'concern': [20], 'Fatal': [22], 'acute': [23, 50], 'distress': [25], 'syndrome': [26, 52, 59, 82], '(ARDS)': [27], 'with': [28, 42, 138, 150, 174, 189, 206, 242, 256], 'rapid': [29], 'deterioration': [30], 'vital': [32], 'organ': [33], 'functions': [34], 'has': [35], 'been': [36, 144], 'observed': [37], 'some': [39], 'patients': [40, 173, 241, 255], 'infected': [41], 'highly': [44], 'pathogenic': [45], 'influenza': [46], 'virus': [47, 61], 'strains,': [48], 'severe': [49, 190], 'coronavirus': [53], '(SARS-CoV),': [54], 'and': [55, 74, 102, 135, 156, 177, 194, 261, 279], 'middle': [56], 'east': [57], 'corona': [60], '(MERS-CoV)': [62], 'common': [65], 'manifestations': [66], 'virus-induced': [68], 'fatal': [69, 175, 187, 224, 243, 258], 'ARDS': [70, 176, 225, 244, 278], 'are': [71, 108, 265], 'cytokine': [72], 'storm': [73], 'activation': [75], 'monocytes/macrophages,': [77, 211], 'characterized': [78], 'secondary': [80, 178, 247], 'hemophagocytic': [81, 157], '(HPS)/hemophagocytic': [83], 'lymphohistiocytosis': [84], '(HLH)': [85], 'However,': [87], 'infection-induced': [88, 116, 257], 'HPS/HLH': [89, 179, 248], 'likely': [91], 'to': [92, 98, 146, 219, 270], 'be': [93, 238], 'under-recognized,': [94], 'which': [95], 'could': [96, 237], 'contribute': [97], 'progression': [101], 'high': [103], 'mortality': [104], 'Since': [106], 'there': [107], 'no': [109], 'established': [110, 182], 'criteria': [111], 'for': [112, 122], 'diagnosis': [114], 'HPS/HLH,': [117, 230], 'early': [118], 'recognition': [119], 'crucial': [121], 'any': [123], 'reasonable': [124], 'attempt': [125], 'at': [126], 'curative': [127], 'treatment': [128, 228, 282], 'Etoposide': [130], '(ET),': [131], 'a': [132], 'cytotoxic': [133], 'agent,': [134], 'corticosteroids': [136], '(CS),': [137], 'their': [139], 'strong': [140], 'anti-inflammatory': [141], 'activities,': [142], 'have': [143], 'used': [145], 'treat': [147], 'other': [148], 'similar': [151], 'pathophysiology,': [152], 'namely,': [153], 'cytokine-activated': [154], 'macrophages': [155], 'activity,': [158], 'but': [159, 212], 'it': [160], 'remains': [161], 'unknown': [162], 'whether': [163], 'these': [164], 'agents': [165], 'can': [166], 'also': [167], 'influence': [168], 'clinical': [170, 260], 'outcomes': [171, 253], 'We': [181], 'an': [183], 'animal': [184, 199], 'model': [185], 'ARDS,': [188, 259], 'lung': [191], 'injury,': [192], 'hypercytokinemia,': [193], 'hemophagocytosis': [195], 'Using': [197], 'this': [198], 'model,': [200], 'we': [201], 'demonstrated': [202], 'that': [203], 'combined': [204, 232], 'therapy': [205], 'ET': [207, 233], 'plus': [208, 234], 'CS,': [209], 'targeting': [210], 'not': [213], 'inflammatory': [214], 'cytokines,': [215], 'had': [216], 'potential': [218], 'attenuate': [220], 'severity': [222], 'Specific': [227], 'against': [229], 'including': [231], 'CS': [235], 'therapy,': [236], 'considered': [239], 'complicated': [245], 'by': [246], 'To': [250], 'improve': [251], 'basic': [262], 'science': [263], 'studies': [264], 'needed': [266], 'future': [269], 'elucidate': [271], 'mechanisms': [273], 'underlying': [274], 'pathogenesis': [276], 'identify': [280], 'new': [281], 'targets': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3118997642', 'counts_by_year': [], 'updated_date': '2024-12-11T12:19:17.647464', 'created_date': '2021-01-18'}