Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3117839071', 'doi': 'https://doi.org/10.1371/journal.pone.0244620', 'title': 'Real-world efficacy of biological agents in moderate-to-severe plaque psoriasis: An analysis of 75 patients in Taiwan', 'display_name': 'Real-world efficacy of biological agents in moderate-to-severe plaque psoriasis: An analysis of 75 patients in Taiwan', 'publication_year': 2020, 'publication_date': '2020-12-29', 'ids': {'openalex': 'https://openalex.org/W3117839071', 'doi': 'https://doi.org/10.1371/journal.pone.0244620', 'mag': '3117839071', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33373425', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7771674'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0244620', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244620&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244620&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5106890492', 'display_name': 'Sheau‐Chiou Chao', 'orcid': 'https://orcid.org/0000-0002-9467-0325'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Yu-Chen Chen', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101505091', 'display_name': 'Yi‐Ting Huang', 'orcid': 'https://orcid.org/0000-0003-2240-7840'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Yi-Ting Huang', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079424383', 'display_name': 'Chao‐Chun Yang', 'orcid': 'https://orcid.org/0000-0002-3897-6522'}, 'institutions': [{'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}, {'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Chao-Chun Yang', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}, {'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037135870', 'display_name': 'Edward Chia‐Cheng Lai', 'orcid': 'https://orcid.org/0000-0002-5852-7652'}, 'institutions': [{'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Edward Chia-Cheng Lai', 'raw_affiliation_strings': ['School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047562180', 'display_name': 'Cheng-Han Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Cheng-Han Liu', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047301891', 'display_name': 'Chao‐Kai Hsu', 'orcid': 'https://orcid.org/0000-0003-4365-4533'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}, {'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Chao-Kai Hsu', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}, {'raw_affiliation_string': 'International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058459378', 'display_name': 'Tak‐Wah Wong', 'orcid': 'https://orcid.org/0000-0002-0131-7339'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}, {'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Tak-Wah Wong', 'raw_affiliation_strings': ['Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan', 'Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}, {'raw_affiliation_string': 'Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016441173', 'display_name': 'Sheau-Chiou Chao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Sheau-Chiou Chao', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057384994', 'display_name': 'Hamm‐Ming Sheu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Hamm-Ming Sheu', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018210604', 'display_name': 'Chaw‐Ning Lee', 'orcid': 'https://orcid.org/0000-0002-0848-0657'}, 'institutions': [{'id': 'https://openalex.org/I4210158999', 'display_name': 'National Cheng Kung University Hospital', 'ror': 'https://ror.org/04zx3rq17', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158999']}, {'id': 'https://openalex.org/I91807558', 'display_name': 'National Cheng Kung University', 'ror': 'https://ror.org/01b8kcc49', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I91807558']}], 'countries': ['TW'], 'is_corresponding': True, 'raw_author_name': 'Chaw-Ning Lee', 'raw_affiliation_strings': ['Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I4210158999']}, {'raw_affiliation_string': 'School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan', 'institution_ids': ['https://openalex.org/I91807558']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5106890492', 'https://openalex.org/A5101505091', 'https://openalex.org/A5079424383', 'https://openalex.org/A5037135870', 'https://openalex.org/A5047562180', 'https://openalex.org/A5047301891', 'https://openalex.org/A5058459378', 'https://openalex.org/A5016441173', 'https://openalex.org/A5057384994', 'https://openalex.org/A5018210604'], 'corresponding_institution_ids': ['https://openalex.org/I4210158999', 'https://openalex.org/I4210158999', 'https://openalex.org/I91807558', 'https://openalex.org/I4210158999', 'https://openalex.org/I91807558', 'https://openalex.org/I4210158999', 'https://openalex.org/I4210158999', 'https://openalex.org/I91807558', 'https://openalex.org/I4210158999', 'https://openalex.org/I91807558', 'https://openalex.org/I4210158999', 'https://openalex.org/I4210158999', 'https://openalex.org/I4210158999', 'https://openalex.org/I91807558'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 0.834, 'has_fulltext': False, 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.636743, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '15', 'issue': '12', 'first_page': 'e0244620', 'last_page': 'e0244620'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10469', 'display_name': 'Reciprocal Development of TH17 and Treg Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10469', 'display_name': 'Reciprocal Development of TH17 and Treg Cells', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10837', 'display_name': 'Atopic Dermatitis and Skin Microbiome', 'score': 0.9861, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11730', 'display_name': 'Pathogenesis and Treatment of Pemphigoid Diseases', 'score': 0.9592, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ustekinumab', 'display_name': 'Ustekinumab', 'score': 0.9836323}, {'id': 'https://openalex.org/keywords/psoriasis', 'display_name': 'Psoriasis', 'score': 0.448788}], 'concepts': [{'id': 'https://openalex.org/C2778975655', 'wikidata': 'https://www.wikidata.org/wiki/Q420305', 'display_name': 'Ustekinumab', 'level': 4, 'score': 0.9836323}, {'id': 'https://openalex.org/C2779786854', 'wikidata': 'https://www.wikidata.org/wiki/Q7444755', 'display_name': 'Secukinumab', 'level': 4, 'score': 0.97570336}, {'id': 'https://openalex.org/C2777226972', 'wikidata': 'https://www.wikidata.org/wiki/Q415343', 'display_name': 'Etanercept', 'level': 3, 'score': 0.94823086}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.91746676}, {'id': 'https://openalex.org/C2780132546', 'wikidata': 'https://www.wikidata.org/wiki/Q348260', 'display_name': 'Adalimumab', 'level': 3, 'score': 0.91018546}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.6651245}, {'id': 'https://openalex.org/C2777011040', 'wikidata': 'https://www.wikidata.org/wiki/Q390643', 'display_name': 'Psoriasis Area and Severity Index', 'level': 3, 'score': 0.65086263}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5275371}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.49029043}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44458762}, {'id': 'https://openalex.org/C2776260265', 'wikidata': 'https://www.wikidata.org/wiki/Q511097', 'display_name': 'Psoriatic arthritis', 'level': 3, 'score': 0.28781766}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.14084741}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.09639716}], 'mesh': [{'descriptor_ui': 'D000068879', 'descriptor_name': 'Adalimumab', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000068800', 'descriptor_name': 'Etanercept', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000069549', 'descriptor_name': 'Ustekinumab', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000068879', 'descriptor_name': 'Adalimumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068879', 'descriptor_name': 'Adalimumab', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001685', 'descriptor_name': 'Biological Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001685', 'descriptor_name': 'Biological Factors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001685', 'descriptor_name': 'Biological Factors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000068800', 'descriptor_name': 'Etanercept', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000068800', 'descriptor_name': 'Etanercept', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013624', 'descriptor_name': 'Taiwan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069549', 'descriptor_name': 'Ustekinumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069549', 'descriptor_name': 'Ustekinumab', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0244620', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244620&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9d9b0a4a870c42b49534adbcaf3bb0a8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7771674', 'pdf_url': 'https://europepmc.org/articles/pmc7771674?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771674', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33373425', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0244620', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244620&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [{'funder': 'https://openalex.org/F4320309618', 'funder_display_name': 'Ministry of Science and Technology', 'award_id': '109-2628-B-006 -035'}], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1957267795', 'https://openalex.org/W1973354423', 'https://openalex.org/W1977350622', 'https://openalex.org/W1985951317', 'https://openalex.org/W2001563541', 'https://openalex.org/W2050172669', 'https://openalex.org/W2079442787', 'https://openalex.org/W2080390872', 'https://openalex.org/W2103750969', 'https://openalex.org/W2121126920', 'https://openalex.org/W2561759163', 'https://openalex.org/W2596969813', 'https://openalex.org/W2745179561', 'https://openalex.org/W2766460886', 'https://openalex.org/W2789656381', 'https://openalex.org/W2801472507', 'https://openalex.org/W2807259109', 'https://openalex.org/W2810745227', 'https://openalex.org/W2898119276', 'https://openalex.org/W2985489166', 'https://openalex.org/W2993100020', 'https://openalex.org/W3009203668'], 'related_works': ['https://openalex.org/W4398222403', 'https://openalex.org/W4225328944', 'https://openalex.org/W3117839071', 'https://openalex.org/W2804016076', 'https://openalex.org/W2766130161', 'https://openalex.org/W2615432978', 'https://openalex.org/W2591728499', 'https://openalex.org/W2162495586', 'https://openalex.org/W2075153701', 'https://openalex.org/W2048986416'], 'abstract_inverted_index': {'Background': [0], 'Real-world': [1], 'clinical': [2, 50], 'data': [3, 51, 211], 'on': [4], 'psoriasis': [5, 58], 'patients': [6, 54, 95], 'receiving': [7], 'different': [8], 'biological': [9, 32, 220], 'agents': [10, 33], 'is': [11, 20], 'needed,': [12], 'especially': [13], 'in': [14, 39, 43, 80, 84, 93, 98, 104, 111, 116, 122, 133, 138, 149], 'Asian': [15], 'populations.': [16], 'Objectives': [17], 'Our': [18], 'aim': [19], 'to': [21], 'compare': [22], 'and': [23, 27, 37, 61, 77, 120, 136, 144, 165, 189, 202, 215], 'analyze': [24], 'the': [25, 49, 129, 147, 218], 'efficacy': [26, 214], 'safety': [28, 216], 'profile': [29], 'of': [30, 52, 89, 128, 172, 195, 199, 205, 217], 'four': [31, 219], '(etanercept,': [34], 'adalimumab,': [35, 70], 'ustekinumab': [36, 71, 157, 187], 'secukinumab)': [38], 'a': [40, 81], 'real-world': [41], 'setting': [42], 'Taiwan.': [44, 85], 'Methods': [45], 'We': [46], 'retrospectively': [47], 'analyzed': [48], 'all': [53], 'with': [55], 'moderate-to-severe': [56], 'plaque': [57], '(Psoriasis': [59], 'Area': [60], 'Severity': [62], 'Index': [63], '(PASI)': [64], '≥': [65], '10)': [66], 'who': [67], 'received': [68], 'etanercept,': [69], 'or': [72], 'secukinumab': [73, 110, 139, 150, 181], 'between': [74], 'January': [75], '2011': [76], 'December': [78], '2018': [79], 'tertiary': [82], 'hospital': [83], 'Results': [86], 'A': [87], 'total': [88], '119': [90], 'treatment': [91, 106, 113, 118, 124, 177], 'episodes': [92, 119], '75': [94], 'were': [96, 146], 'included': [97], 'this': [99], 'study.': [100], 'Ustekinumab': [101], 'was': [102, 131, 178], 'used': [103], '49': [105], 'episodes,': [107, 114], 'followed': [108, 155, 183], 'by': [109, 156, 184], '46': [112], 'adalimumab': [115, 161, 185], '14': [117], 'etanercept': [121, 134, 166, 190], '10': [123], 'episodes.': [125], 'The': [126, 141, 170], 'proportion': [127], 'biologic-naïve': [130], 'highest': [132, 148, 179], '(100%)': [135], 'lowest': [137], '(23.9%).': [140], 'PASI-75,': [142], '-90': [143], '-100': [145], '(91.3%,': [151], '82.6%,': [152], '41.3%,': [153], 'respectively),': [154], '(79.6%,': [158], '44.9%,': [159], '16.3%),': [160], '(64.3%,': [162], '28.6%,': [163], '7.1%)': [164], '(50.0%,': [167], '30.0%,': [168], '0%).': [169], 'rate': [171], 'adverse': [173], 'events': [174], 'that': [175], 'required': [176], 'for': [180], '(15.2%),': [182], '(14.3%),': [186], '(8.2%),': [188], '(0%),': [191], 'including': [192], '4': [193, 203], 'cases': [194, 198, 204], 'infections,': [196], '2': [197], 'cardiovascular': [200], 'diseases': [201], 'cancers.': [206], 'Conclusions': [207], 'This': [208], 'real': [209], 'world': [210], 'showed': [212], 'differential': [213], 'agents.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3117839071', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-09-03T02:17:13.836585', 'created_date': '2021-01-05'}