Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3110237167', 'doi': 'https://doi.org/10.3390/ijms21239074', 'title': 'Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide', 'display_name': 'Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide', 'publication_year': 2020, 'publication_date': '2020-11-28', 'ids': {'openalex': 'https://openalex.org/W3110237167', 'doi': 'https://doi.org/10.3390/ijms21239074', 'mag': '3110237167', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33260658', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7730713'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21239074', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/23/9074/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/21/23/9074/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075930979', 'display_name': 'Alessia D’Aloia', 'orcid': 'https://orcid.org/0000-0002-6501-0379'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessia D’Aloia', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021242300', 'display_name': 'Federica Arrigoni', 'orcid': 'https://orcid.org/0000-0003-0691-7517'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Federica Arrigoni', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050232933', 'display_name': 'Renata Tisi', 'orcid': 'https://orcid.org/0000-0002-0869-3345'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Renata Tisi', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy"], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy", 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071242228', 'display_name': 'Alessandro Palmioli', 'orcid': 'https://orcid.org/0000-0002-5287-1663'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessandro Palmioli', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy"], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy", 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064991791', 'display_name': 'Michela Ceriani', 'orcid': 'https://orcid.org/0000-0002-3060-5620'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Michela Ceriani', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007211130', 'display_name': 'Valentina Artusa', 'orcid': 'https://orcid.org/0000-0003-4267-2596'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valentina Artusa', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032149151', 'display_name': 'Cristina Airoldi', 'orcid': 'https://orcid.org/0000-0002-3670-6262'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Airoldi', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy"], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}, {'raw_affiliation_string': "Milan Center for Neuroscience (NeuroMI), University of Milano-Bicocca, P.zza dell'Ateneo Nuovo 1, 20126 Milano, Italy", 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004803072', 'display_name': 'Giuseppe Zampella', 'orcid': 'https://orcid.org/0000-0003-0517-6016'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Zampella', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018577895', 'display_name': 'Barbara Costa', 'orcid': 'https://orcid.org/0000-0002-2910-6736'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Barbara Costa', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054311630', 'display_name': 'Laura Cipolla', 'orcid': 'https://orcid.org/0000-0003-2678-8329'}, 'institutions': [{'id': 'https://openalex.org/I66752286', 'display_name': 'University of Milano-Bicocca', 'ror': 'https://ror.org/01ynf4891', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I66752286']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Laura Cipolla', 'raw_affiliation_strings': ['Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy', 'institution_ids': ['https://openalex.org/I66752286']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5018577895', 'https://openalex.org/A5054311630'], 'corresponding_institution_ids': ['https://openalex.org/I66752286', 'https://openalex.org/I66752286'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2034, 'currency': 'EUR', 'value_usd': 2193, 'provenance': 'openapc'}, 'fwci': 0.152, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.545962, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '21', 'issue': '23', 'first_page': '9074', 'last_page': '9074'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10414', 'display_name': 'Cannabis and Cannabinoid Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11207', 'display_name': 'Alcohol Consumption and Health Effects', 'score': 0.9906, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/palmitoylethanolamide', 'display_name': 'Palmitoylethanolamide', 'score': 0.99308926}, {'id': 'https://openalex.org/keywords/amidase', 'display_name': 'Amidase', 'score': 0.46918085}, {'id': 'https://openalex.org/keywords/nutraceutical', 'display_name': 'Nutraceutical', 'score': 0.43556482}], 'concepts': [{'id': 'https://openalex.org/C2777767828', 'wikidata': 'https://www.wikidata.org/wiki/Q2159860', 'display_name': 'Palmitoylethanolamide', 'level': 5, 'score': 0.99308926}, {'id': 'https://openalex.org/C2781144285', 'wikidata': 'https://www.wikidata.org/wiki/Q21113274', 'display_name': 'Fatty acid amide hydrolase', 'level': 5, 'score': 0.94106764}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6670606}, {'id': 'https://openalex.org/C46721173', 'wikidata': 'https://www.wikidata.org/wiki/Q368952', 'display_name': 'Endocannabinoid system', 'level': 3, 'score': 0.47179145}, {'id': 'https://openalex.org/C65588867', 'wikidata': 'https://www.wikidata.org/wiki/Q24775735', 'display_name': 'Amidase', 'level': 3, 'score': 0.46918085}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46845934}, {'id': 'https://openalex.org/C17857428', 'wikidata': 'https://www.wikidata.org/wiki/Q533025', 'display_name': 'Nutraceutical', 'level': 2, 'score': 0.43556482}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38613415}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3068992}, {'id': 'https://openalex.org/C148001335', 'wikidata': 'https://www.wikidata.org/wiki/Q421237', 'display_name': 'Cannabinoid receptor', 'level': 4, 'score': 0.13523719}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.060399354}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21239074', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/23/9074/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/222416f5742440febf92aabfcdddc43e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://dx.doi.org/10.3390/ijms21239074', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/23/9074/pdf?version=1606795820', 'source': {'id': 'https://openalex.org/S4306400947', 'display_name': 'MDPI (MDPI AG)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210097602', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute (Switzerland)', 'host_organization_lineage': ['https://openalex.org/I4210097602'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute (Switzerland)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10281/296453', 'pdf_url': 'https://boa.unimib.it/bitstream/10281/296453/1/ijms-21-09074-v2.pdf', 'source': {'id': 'https://openalex.org/S4306401259', 'display_name': 'BOA (University of Milano-Bicocca)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I66752286', 'host_organization_name': 'University of Milano-Bicocca', 'host_organization_lineage': ['https://openalex.org/I66752286'], 'host_organization_lineage_names': ['University of Milano-Bicocca'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730713', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms21239074', 'pdf_url': 'https://www.mdpi.com/1422-0067/21/23/9074/pdf', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.42}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 92, 'referenced_works': ['https://openalex.org/W1433747404', 'https://openalex.org/W1513097147', 'https://openalex.org/W1515994079', 'https://openalex.org/W1524506477', 'https://openalex.org/W1568732803', 'https://openalex.org/W1581947086', 'https://openalex.org/W1819429514', 'https://openalex.org/W1872852415', 'https://openalex.org/W1886167013', 'https://openalex.org/W1895277992', 'https://openalex.org/W1941251942', 'https://openalex.org/W1968933287', 'https://openalex.org/W1969338731', 'https://openalex.org/W1972888570', 'https://openalex.org/W1975414101', 'https://openalex.org/W1976382352', 'https://openalex.org/W1981645153', 'https://openalex.org/W1984026160', 'https://openalex.org/W1984563050', 'https://openalex.org/W1985588649', 'https://openalex.org/W1995770177', 'https://openalex.org/W1995793646', 'https://openalex.org/W2006574739', 'https://openalex.org/W2008418201', 'https://openalex.org/W2009034382', 'https://openalex.org/W2009423060', 'https://openalex.org/W2012308597', 'https://openalex.org/W2016800344', 'https://openalex.org/W2018283522', 'https://openalex.org/W2023453362', 'https://openalex.org/W2027149291', 'https://openalex.org/W2027991357', 'https://openalex.org/W2030687437', 'https://openalex.org/W2036917805', 'https://openalex.org/W2037971418', 'https://openalex.org/W2047895583', 'https://openalex.org/W2048152744', 'https://openalex.org/W2049106125', 'https://openalex.org/W2049376260', 'https://openalex.org/W2049460970', 'https://openalex.org/W2050058776', 'https://openalex.org/W2051381895', 'https://openalex.org/W2065648126', 'https://openalex.org/W2071335916', 'https://openalex.org/W2073328513', 'https://openalex.org/W2083183504', 'https://openalex.org/W2084107039', 'https://openalex.org/W2085878806', 'https://openalex.org/W2086676026', 'https://openalex.org/W2086957099', 'https://openalex.org/W2087251303', 'https://openalex.org/W2088220499', 'https://openalex.org/W2088511433', 'https://openalex.org/W2092157292', 'https://openalex.org/W2095720174', 'https://openalex.org/W2095833996', 'https://openalex.org/W2099828575', 'https://openalex.org/W2109491705', 'https://openalex.org/W2109689212', 'https://openalex.org/W2109759840', 'https://openalex.org/W2124343538', 'https://openalex.org/W2126669642', 'https://openalex.org/W2127934565', 'https://openalex.org/W2129319296', 'https://openalex.org/W2132886768', 'https://openalex.org/W2135050229', 'https://openalex.org/W2141567458', 'https://openalex.org/W2145992691', 'https://openalex.org/W2146008698', 'https://openalex.org/W2148119611', 'https://openalex.org/W2151283331', 'https://openalex.org/W2157400187', 'https://openalex.org/W2165128851', 'https://openalex.org/W2168677934', 'https://openalex.org/W2222589778', 'https://openalex.org/W2405713730', 'https://openalex.org/W2420330191', 'https://openalex.org/W2528606756', 'https://openalex.org/W2535803653', 'https://openalex.org/W2596523885', 'https://openalex.org/W2599663184', 'https://openalex.org/W2769681746', 'https://openalex.org/W2776645015', 'https://openalex.org/W2791222964', 'https://openalex.org/W2896083380', 'https://openalex.org/W3001942189', 'https://openalex.org/W3012076695', 'https://openalex.org/W3022898944', 'https://openalex.org/W3025424660', 'https://openalex.org/W3087730919', 'https://openalex.org/W3097943335', 'https://openalex.org/W4240370181'], 'related_works': ['https://openalex.org/W4289732221', 'https://openalex.org/W2111910036', 'https://openalex.org/W2085016276', 'https://openalex.org/W2067592086', 'https://openalex.org/W2059131067', 'https://openalex.org/W2052646320', 'https://openalex.org/W2045702564', 'https://openalex.org/W2001441318', 'https://openalex.org/W1994099277', 'https://openalex.org/W1973721274'], 'abstract_inverted_index': {'Palmitoylethanolamide': [0], '(PEA)': [1], 'belongs': [2], 'to': [3, 99, 120, 144, 156, 161, 195], 'the': [4, 53, 81, 84, 88, 122, 132], 'class': [5], 'of': [6, 19, 83, 92, 105, 137], 'N-acylethanolamine': [7], 'and': [8, 45, 50, 76, 90, 110, 115, 141, 152, 160, 206], 'is': [9, 57, 181], 'an': [10], 'endogenous': [11], 'lipid': [12], 'potentially': [13], 'useful': [14], 'in': [15, 29, 60, 73, 77, 135, 174, 186, 200], 'a': [16, 32, 34, 69], 'wide': [17], 'range': [18], 'therapeutic': [20], 'areas;': [21], 'products': [22], 'containing': [23, 172], 'PEA': [24, 56, 93, 106], 'are': [25, 96], 'licensed': [26], 'for': [27, 39, 42], 'use': [28], 'humans': [30], 'as': [31, 131], 'nutraceutical,': [33], 'food': [35, 38], 'supplement,': [36], 'or': [37], 'medical': [40], 'purposes': [41], 'its': [43, 163], 'analgesic': [44], 'anti-inflammatory': [46, 164], 'properties': [47], 'demonstrating': [48], 'efficacy': [49], 'tolerability.': [51], 'However,': [52], 'exogenously': [54], 'administered': [55], 'rapidly': [58], 'inactivated;': [59], 'this': [61], 'process,': [62], 'fatty': [63], 'acid': [64], 'amide': [65], 'hydrolase': [66], '(FAAH)': [67], 'plays': [68], 'key': [70], 'role': [71], 'both': [72, 138, 201], 'hepatic': [74], 'metabolism': [75], 'intracellular': [78], 'degradation.': [79], 'So,': [80], 'aim': [82], 'present': [85], 'study': [86], 'was': [87, 108, 150], 'design': [89], 'synthesis': [91], 'analogues': [94, 107], 'that': [95, 179], 'more': [97, 123], 'resistant': [98], 'FAAH-mediated': [100, 145, 158], 'hydrolysis.': [101, 146], 'A': [102], 'small': [103], 'library': [104], 'designed': [109], 'tested': [111], 'by': [112, 184], 'molecular': [113], 'docking': [114], 'density': [116], 'functional': [117], 'theory': [118], 'calculations': [119], 'find': [121], 'stable': [124], 'analogue.': [125], 'The': [126, 147], 'computational': [127], 'investigation': [128], 'identified': [129], 'RePEA': [130, 180, 191], 'best': [133], 'candidate': [134], 'terms': [136], 'synthetic': [139], 'accessibility': [140], 'metabolic': [142], 'stability': [143], 'selected': [148], 'compound': [149], 'synthesized': [151], 'assayed': [153], 'ex': [154], 'vivo': [155], 'monitor': [157], 'hydrolysis': [159], 'confirm': [162], 'properties.': [165], '1H-NMR': [166], 'spectroscopy': [167], 'performed': [168], 'on': [169], 'membrane': [170, 176], 'samples': [171], 'FAAH': [173], 'integral': [175], 'protein': [177], 'demonstrated': [178], 'not': [182], 'processed': [183], 'FAAH,': [185], 'contrast': [187], 'with': [188], 'PEA.': [189], 'Moreover,': [190], 'retains': [192], 'PEA’s': [193], 'ability': [194], 'inhibit': [196], 'LPS-induced': [197], 'cytokine': [198], 'release': [199], 'murine': [202], 'N9': [203], 'microglial': [204], 'cells': [205], 'human': [207], 'PMA-THP-1': [208], 'cells.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3110237167', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2025-01-07T20:40:18.416990', 'created_date': '2020-12-07'}