Publication Information

{'id': 'https://openalex.org/W3109199714', 'doi': 'https://doi.org/10.1002/bies.202000262', 'title': 'Cause and effect in epigenetics – where lies the truth, and how can experiments reveal it?', 'display_name': 'Cause and effect in epigenetics – where lies the truth, and how can experiments reveal it?', 'publication_year': 2020, 'publication_date': '2020-11-25', 'ids': {'openalex': 'https://openalex.org/W3109199714', 'doi': 'https://doi.org/10.1002/bies.202000262', 'mag': '3109199714', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33236359'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bies.202000262', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27819959', 'display_name': 'BioEssays', 'issn_l': '0265-9247', 'issn': ['0265-9247', '1521-1878'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080025732', 'display_name': 'Michael Klutstein', 'orcid': 'https://orcid.org/0000-0002-4041-3112'}, 'institutions': [{'id': 'https://openalex.org/I197251160', 'display_name': 'Hebrew University of Jerusalem', 'ror': 'https://ror.org/03qxff017', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I197251160']}], 'countries': ['IL'], 'is_corresponding': True, 'raw_author_name': 'Michael Klutstein', 'raw_affiliation_strings': ['Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel', 'institution_ids': ['https://openalex.org/I197251160']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5080025732'], 'corresponding_institution_ids': ['https://openalex.org/I197251160'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.315, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.444549, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '43', 'issue': '2', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epigenome', 'display_name': 'Epigenome', 'score': 0.9312931}, {'id': 'https://openalex.org/keywords/causality', 'display_name': 'Causality', 'score': 0.5726406}, {'id': 'https://openalex.org/keywords/identification', 'display_name': 'Identification', 'score': 0.5552275}, {'id': 'https://openalex.org/keywords/epigenesis', 'display_name': 'Epigenesis', 'score': 0.50881916}], 'concepts': [{'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.9589383}, {'id': 'https://openalex.org/C117717151', 'wikidata': 'https://www.wikidata.org/wiki/Q3589155', 'display_name': 'Epigenome', 'level': 5, 'score': 0.9312931}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6047117}, {'id': 'https://openalex.org/C64357122', 'wikidata': 'https://www.wikidata.org/wiki/Q1149766', 'display_name': 'Causality (physics)', 'level': 2, 'score': 0.5726406}, {'id': 'https://openalex.org/C116834253', 'wikidata': 'https://www.wikidata.org/wiki/Q2039217', 'display_name': 'Identification (biology)', 'level': 2, 'score': 0.5552275}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.52767164}, {'id': 'https://openalex.org/C179463898', 'wikidata': 'https://www.wikidata.org/wiki/Q10273301', 'display_name': 'Epigenesis', 'level': 5, 'score': 0.50881916}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.44296545}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.3653501}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.36097288}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.33546817}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.118810445}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bies.202000262', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27819959', 'display_name': 'BioEssays', 'issn_l': '0265-9247', 'issn': ['0265-9247', '1521-1878'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.41, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 120, 'referenced_works': ['https://openalex.org/W1488647627', 'https://openalex.org/W172975180', 'https://openalex.org/W1812816875', 'https://openalex.org/W1967064280', 'https://openalex.org/W1969670934', 'https://openalex.org/W1970383854', 'https://openalex.org/W1973057702', 'https://openalex.org/W1976626368', 'https://openalex.org/W1977144229', 'https://openalex.org/W1977894730', 'https://openalex.org/W1985308585', 'https://openalex.org/W1987738803', 'https://openalex.org/W1987925568', 'https://openalex.org/W1990998965', 'https://openalex.org/W1994540097', 'https://openalex.org/W1997145913', 'https://openalex.org/W1997948377', 'https://openalex.org/W2003355605', 'https://openalex.org/W2007203150', 'https://openalex.org/W2014541905', 'https://openalex.org/W2016921876', 'https://openalex.org/W2019078072', 'https://openalex.org/W2019845642', 'https://openalex.org/W2021958704', 'https://openalex.org/W2022572059', 'https://openalex.org/W2022662964', 'https://openalex.org/W2024584416', 'https://openalex.org/W2031087599', 'https://openalex.org/W2035393182', 'https://openalex.org/W2036055444', 'https://openalex.org/W2040290929', 'https://openalex.org/W2040506727', 'https://openalex.org/W2052609775', 'https://openalex.org/W2053176849', 'https://openalex.org/W2054894450', 'https://openalex.org/W2058983261', 'https://openalex.org/W2062421371', 'https://openalex.org/W2065890382', 'https://openalex.org/W2076154138', 'https://openalex.org/W2077341010', 'https://openalex.org/W2078291208', 'https://openalex.org/W2078972833', 'https://openalex.org/W2079643856', 'https://openalex.org/W2083556426', 'https://openalex.org/W2096480080', 'https://openalex.org/W2097948853', 'https://openalex.org/W2099900128', 'https://openalex.org/W2101089041', 'https://openalex.org/W2102893853', 'https://openalex.org/W2105298120', 'https://openalex.org/W2105528101', 'https://openalex.org/W2113296450', 'https://openalex.org/W2114970231', 'https://openalex.org/W2115008617', 'https://openalex.org/W2120731353', 'https://openalex.org/W2120749266', 'https://openalex.org/W2126122220', 'https://openalex.org/W2126151185', 'https://openalex.org/W2126525177', 'https://openalex.org/W2126816979', 'https://openalex.org/W2130808015', 'https://openalex.org/W2133920348', 'https://openalex.org/W2134985597', 'https://openalex.org/W2136270288', 'https://openalex.org/W2149426454', 'https://openalex.org/W2149858388', 'https://openalex.org/W2154146356', 'https://openalex.org/W2154471713', 'https://openalex.org/W2155245588', 'https://openalex.org/W2157649587', 'https://openalex.org/W2166355466', 'https://openalex.org/W2264682687', 'https://openalex.org/W2274593450', 'https://openalex.org/W2294540125', 'https://openalex.org/W2302805463', 'https://openalex.org/W2337691219', 'https://openalex.org/W2341474791', 'https://openalex.org/W2347124524', 'https://openalex.org/W2405696064', 'https://openalex.org/W2414449891', 'https://openalex.org/W2507601326', 'https://openalex.org/W2517275410', 'https://openalex.org/W2519975043', 'https://openalex.org/W2529317472', 'https://openalex.org/W2558687414', 'https://openalex.org/W2568369014', 'https://openalex.org/W2589077906', 'https://openalex.org/W2602238152', 'https://openalex.org/W2610504281', 'https://openalex.org/W2737272162', 'https://openalex.org/W2747212860', 'https://openalex.org/W2754250453', 'https://openalex.org/W2759661759', 'https://openalex.org/W2766036023', 'https://openalex.org/W2774807902', 'https://openalex.org/W2777600236', 'https://openalex.org/W2788350317', 'https://openalex.org/W2789281724', 'https://openalex.org/W2791232621', 'https://openalex.org/W2792461052', 'https://openalex.org/W2795164082', 'https://openalex.org/W2796298565', 'https://openalex.org/W2801892046', 'https://openalex.org/W2805162488', 'https://openalex.org/W2883831719', 'https://openalex.org/W2897143766', 'https://openalex.org/W2901467563', 'https://openalex.org/W2912654909', 'https://openalex.org/W2919568651', 'https://openalex.org/W2935761054', 'https://openalex.org/W2937585144', 'https://openalex.org/W2942130405', 'https://openalex.org/W2946801856', 'https://openalex.org/W2971048966', 'https://openalex.org/W2976399766', 'https://openalex.org/W2980407838', 'https://openalex.org/W2980948969', 'https://openalex.org/W3004859565', 'https://openalex.org/W3008569405', 'https://openalex.org/W3037887056'], 'related_works': ['https://openalex.org/W4310701073', 'https://openalex.org/W4287843235', 'https://openalex.org/W3110471831', 'https://openalex.org/W2903081833', 'https://openalex.org/W2883681417', 'https://openalex.org/W2111466280', 'https://openalex.org/W2073587729', 'https://openalex.org/W2051834276', 'https://openalex.org/W2030483896', 'https://openalex.org/W2000021308'], 'abstract_inverted_index': {'Abstract': [0], 'Epigenetic': [1], 'changes': [2, 48], 'are': [3], 'implicated': [4], 'in': [5, 49, 74, 105, 132, 146], 'aging': [6], 'and': [7, 34, 51, 76, 78, 136], 'cancer.': [8], 'Sometimes,': [9], 'it': [10], 'is': [11, 20, 32, 94], 'clear': [12, 69], 'whether': [13], 'the': [14, 18, 29, 56, 72, 89, 100, 111, 114, 124, 127, 138], 'causing': [15], 'agent': [16], 'of': [17, 58, 71, 83, 99, 102, 113, 126, 140], 'condition': [19], 'a': [21, 43, 133], 'genetic': [22, 38], 'factor': [23, 31], 'or': [24, 39], 'epigenetic.': [25, 40], 'In': [26], 'other': [27, 79, 84], 'cases,': [28], 'causative': [30, 59, 115], 'unclear,': [33], 'could': [35, 143], 'be': [36, 130, 144], 'either': [37], 'Is': [41], 'there': [42], 'general': [44], 'role': [45, 125], 'for': [46], 'epigenetic': [47, 63, 106], 'cancer': [50, 75], 'aging?': [52], 'Here,': [53], 'I': [54, 65, 86, 117], 'present': [55, 88], 'paradigm': [57], 'roles': [60, 70], 'executed': [61], 'by': [62, 122], 'changes.': [64], 'discuss': [66], 'cases': [67, 80], 'with': [68], 'epigenome': [73, 128], 'aging,': [77], 'showing': [81], 'involvement': [82], 'factors.': [85], 'also': [87], 'possibility': [90], 'that': [91], 'sometimes': [92], 'causality': [93], 'difficult': [95], 'to': [96], 'assign': [97], 'because': [98], 'presence': [101, 139], 'self‐reinforcing': [103], 'loops': [104, 109, 142], 'regulation.': [107], 'Such': [108], 'hinder': [110], 'identification': [112], 'factor.': [116], 'provide': [118], 'an': [119], 'experimental': [120], 'framework': [121], 'which': [123], 'can': [129], 'examined': [131], 'better': [134], 'setting': [135], 'where': [137], 'such': [141], 'investigated': [145], 'more': [147], 'detail.': [148]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3109199714', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-13T19:06:03.227151', 'created_date': '2020-12-07'}