Publication Information

{'id': 'https://openalex.org/W3108904450', 'doi': 'https://doi.org/10.1101/2020.08.28.271809', 'title': 'Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions', 'display_name': 'Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting its Protein-Protein Interactions', 'publication_year': 2020, 'publication_date': '2020-08-28', 'ids': {'openalex': 'https://openalex.org/W3108904450', 'doi': 'https://doi.org/10.1101/2020.08.28.271809', 'mag': '3108904450'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.08.28.271809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1101/2020.08.28.271809', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014790463', 'display_name': 'Sara Bobone', 'orcid': 'https://orcid.org/0000-0001-7975-3803'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sara Bobone', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032029637', 'display_name': 'Luca Pannone', 'orcid': 'https://orcid.org/0000-0001-7027-8196'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}, {'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luca Pannone', 'raw_affiliation_strings': ['Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}, {'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047638923', 'display_name': 'Barbara Biondi', 'orcid': 'https://orcid.org/0000-0003-2393-7333'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Barbara Biondi', 'raw_affiliation_strings': ['Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070673502', 'display_name': 'Maja Šolman', 'orcid': 'https://orcid.org/0000-0002-9523-2204'}, 'institutions': [{'id': 'https://openalex.org/I4210115206', 'display_name': 'Hubrecht Institute for Developmental Biology and Stem Cell Research', 'ror': 'https://ror.org/023qc4a07', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I1322597698', 'https://openalex.org/I4210115206']}, {'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Maja Solman', 'raw_affiliation_strings': ['Hubrecht institute - KNAW and University Medical Center Utrecht, Utrecht, 384 CT, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Hubrecht institute - KNAW and University Medical Center Utrecht, Utrecht, 384 CT, The Netherlands', 'institution_ids': ['https://openalex.org/I4210115206', 'https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088240230', 'display_name': 'Elisabetta Flex', 'orcid': 'https://orcid.org/0000-0002-6802-1356'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elisabetta Flex', 'raw_affiliation_strings': ['Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042391643', 'display_name': 'Viviana Claudia Canale', 'orcid': 'https://orcid.org/0000-0002-2311-1251'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Viviana Canale', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036727139', 'display_name': 'Paolo Calligari', 'orcid': 'https://orcid.org/0000-0001-7614-8931'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paolo Calligari', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081969725', 'display_name': 'Chiara De Faveri', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Chiara De Faveri', 'raw_affiliation_strings': ['Department of Chemical Sciences, University of Padova, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences, University of Padova, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070712730', 'display_name': 'Tommaso Gandini', 'orcid': 'https://orcid.org/0000-0002-3682-914X'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tommaso Gandini', 'raw_affiliation_strings': ['Department of Chemical Sciences, University of Padova, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences, University of Padova, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076513587', 'display_name': 'Andrea Quercioli', 'orcid': 'https://orcid.org/0000-0002-8200-9986'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Quercioli', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017993875', 'display_name': 'Giuseppe Torini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Torini', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058491505', 'display_name': 'Martina Venditti', 'orcid': 'https://orcid.org/0000-0003-4026-3772'}, 'institutions': [{'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Martina Venditti', 'raw_affiliation_strings': ['Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027770680', 'display_name': 'Antonella Lauri', 'orcid': 'https://orcid.org/0000-0003-2260-182X'}, 'institutions': [{'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Antonella Lauri', 'raw_affiliation_strings': ['Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037128752', 'display_name': 'Giulia Fasano', 'orcid': 'https://orcid.org/0000-0003-4807-153X'}, 'institutions': [{'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giulia Fasano', 'raw_affiliation_strings': ['Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026214821', 'display_name': 'Jelmer Hoeksma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115206', 'display_name': 'Hubrecht Institute for Developmental Biology and Stem Cell Research', 'ror': 'https://ror.org/023qc4a07', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I1322597698', 'https://openalex.org/I4210115206']}, {'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jelmer Hoeksma', 'raw_affiliation_strings': ['Hubrecht institute - KNAW and University Medical Center Utrecht, Utrecht, 384 CT, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Hubrecht institute - KNAW and University Medical Center Utrecht, Utrecht, 384 CT, The Netherlands', 'institution_ids': ['https://openalex.org/I4210115206', 'https://openalex.org/I3018483916']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064628822', 'display_name': 'Valerio Santucci', 'orcid': 'https://orcid.org/0000-0003-3650-5628'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valerio Santucci', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027357787', 'display_name': 'Giada Cattani', 'orcid': 'https://orcid.org/0000-0002-6217-2209'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giada Cattani', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042831438', 'display_name': 'Alessio Bocedi', 'orcid': 'https://orcid.org/0000-0002-5226-3289'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessio Bocedi', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007646250', 'display_name': 'Giovanna Carpentieri', 'orcid': 'https://orcid.org/0000-0001-5526-6015'}, 'institutions': [{'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}, {'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanna Carpentieri', 'raw_affiliation_strings': ['Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210123352']}, {'raw_affiliation_string': 'Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021954051', 'display_name': 'Valentina Tirelli', 'orcid': 'https://orcid.org/0000-0001-6021-0833'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valentina Tirelli', 'raw_affiliation_strings': ['Centre of Core Facilities, Istituto Superiore di Sanità, Rome, 00161, Italy'], 'affiliations': [{'raw_affiliation_string': 'Centre of Core Facilities, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074404662', 'display_name': 'Massimo Sanchez', 'orcid': 'https://orcid.org/0000-0003-3696-7582'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Sanchez', 'raw_affiliation_strings': ['Centre of Core Facilities, Istituto Superiore di Sanità, Rome, 00161, Italy'], 'affiliations': [{'raw_affiliation_string': 'Centre of Core Facilities, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032879706', 'display_name': 'Cristina Peggion', 'orcid': 'https://orcid.org/0000-0001-9716-800X'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cristina Peggion', 'raw_affiliation_strings': ['Department of Chemical Sciences, University of Padova, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences, University of Padova, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040500402', 'display_name': 'Fernando Formaggio', 'orcid': 'https://orcid.org/0000-0003-2008-4961'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fernando Formaggio', 'raw_affiliation_strings': ['Department of Chemical Sciences, University of Padova, Padova, 35131, Italy', 'Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}, {'raw_affiliation_string': 'Department of Chemical Sciences, University of Padova, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037786135', 'display_name': 'Jeroen den Hertog', 'orcid': 'https://orcid.org/0000-0002-8642-8088'}, 'institutions': [{'id': 'https://openalex.org/I121797337', 'display_name': 'Leiden University', 'ror': 'https://ror.org/027bh9e22', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I121797337']}, {'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Jeroen den Hertog', 'raw_affiliation_strings': ['Institute of Biology Leiden, Leiden University, Leiden, 2333 BE, the Netherlands', 'Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biology Leiden, Leiden University, Leiden, 2333 BE, the Netherlands', 'institution_ids': ['https://openalex.org/I121797337']}, {'raw_affiliation_string': 'Institute of Biomolecular Chemistry, Padova Unit, CNR, Padova, 35131, Italy', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025181249', 'display_name': 'Simone Martinelli', 'orcid': 'https://orcid.org/0000-0002-5843-419X'}, 'institutions': [{'id': 'https://openalex.org/I27897274', 'display_name': 'Istituto Superiore di Sanità', 'ror': 'https://ror.org/02hssy432', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I27897274']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Simone Martinelli', 'raw_affiliation_strings': ['Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Oncologia e Medicina Molecolare, Istituto Superiore di Sanità, Rome, 00161, Italy', 'institution_ids': ['https://openalex.org/I27897274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036358608', 'display_name': 'Gianfranco Bocchinfuso', 'orcid': 'https://orcid.org/0000-0002-5556-7691'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianfranco Bocchinfuso', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048934823', 'display_name': 'Marco Tartaglia', 'orcid': 'https://orcid.org/0000-0001-7736-9672'}, 'institutions': [{'id': 'https://openalex.org/I4210123352', 'display_name': "Bambino Gesù Children's Hospital", 'ror': 'https://ror.org/02sy42d13', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Tartaglia', 'raw_affiliation_strings': ['Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy'], 'affiliations': [{'raw_affiliation_string': 'Genetics and Rare Diseases Research Division, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, 00146, Italy', 'institution_ids': ['https://openalex.org/I4210123352', 'https://openalex.org/I4210153126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052993222', 'display_name': 'Lorenzo Stella', 'orcid': 'https://orcid.org/0000-0002-5489-7381'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Lorenzo Stella', 'raw_affiliation_strings': ['Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Rome, 0033, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5052993222'], 'corresponding_institution_ids': ['https://openalex.org/I116067653'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.529244, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 69}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12104', 'display_name': 'Protein Tyrosine Phosphatases', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12387', 'display_name': 'Galectins and Cancer Biology', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homology', 'display_name': 'Homology', 'score': 0.4181149}], 'concepts': [{'id': 'https://openalex.org/C166342909', 'wikidata': 'https://www.wikidata.org/wiki/Q845326', 'display_name': 'Allosteric regulation', 'level': 3, 'score': 0.6828982}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.59048957}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.49814343}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4948823}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.49207085}, {'id': 'https://openalex.org/C196347352', 'wikidata': 'https://www.wikidata.org/wiki/Q24771787', 'display_name': 'SH3 domain', 'level': 4, 'score': 0.48350742}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.456247}, {'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.44344038}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.43909663}, {'id': 'https://openalex.org/C165525559', 'wikidata': 'https://www.wikidata.org/wiki/Q224180', 'display_name': 'Homology (biology)', 'level': 3, 'score': 0.4181149}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40510947}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38146257}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3435929}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32382953}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.24212354}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.21217877}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12793034}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.08.28.271809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1021/acs.jmedchem.1c01371', 'pdf_url': 'https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01371', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2108/285307', 'pdf_url': 'https://art.torvergata.it/bitstream/2108/285307/1/acs.jmedchem.1c01371.pdf', 'source': {'id': 'https://openalex.org/S4306400993', 'display_name': 'Cineca Institutional Research Information System (Tor Vergata University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I116067653', 'host_organization_name': 'University of Rome Tor Vergata', 'host_organization_lineage': ['https://openalex.org/I116067653'], 'host_organization_lineage_names': ['University of Rome Tor Vergata'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11577/3416163', 'pdf_url': 'https://www.research.unipd.it/bitstream/11577/3476459/1/2020-110-Biorxiv.pdf', 'source': {'id': 'https://openalex.org/S4306402448', 'display_name': 'Padua Research Archive (University of Padua)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I138689650', 'host_organization_name': 'University of Padua', 'host_organization_lineage': ['https://openalex.org/I138689650'], 'host_organization_lineage_names': ['University of Padua'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.08.28.271809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 105, 'referenced_works': ['https://openalex.org/W1031578623', 'https://openalex.org/W1488372279', 'https://openalex.org/W1536598892', 'https://openalex.org/W1555831575', 'https://openalex.org/W1583956984', 'https://openalex.org/W1598285904', 'https://openalex.org/W1674292201', 'https://openalex.org/W1914707730', 'https://openalex.org/W1939276006', 'https://openalex.org/W1967714726', 'https://openalex.org/W1970103851', 'https://openalex.org/W1972299722', 'https://openalex.org/W1975735851', 'https://openalex.org/W1982186905', 'https://openalex.org/W1993388581', 'https://openalex.org/W1995612782', 'https://openalex.org/W1995961820', 'https://openalex.org/W1999821500', 'https://openalex.org/W2000813775', 'https://openalex.org/W2003288421', 'https://openalex.org/W2004077304', 'https://openalex.org/W2005048422', 'https://openalex.org/W2014446732', 'https://openalex.org/W2015152134', 'https://openalex.org/W2021122013', 'https://openalex.org/W2022008947', 'https://openalex.org/W2025485285', 'https://openalex.org/W2026271132', 'https://openalex.org/W2028689547', 'https://openalex.org/W2034341688', 'https://openalex.org/W2037995730', 'https://openalex.org/W2041661780', 'https://openalex.org/W2043094609', 'https://openalex.org/W2043160859', 'https://openalex.org/W2044409894', 'https://openalex.org/W2057477511', 'https://openalex.org/W2066588813', 'https://openalex.org/W2069652627', 'https://openalex.org/W2070094134', 'https://openalex.org/W2078106011', 'https://openalex.org/W2080730448', 'https://openalex.org/W2082175813', 'https://openalex.org/W2082448876', 'https://openalex.org/W2082640324', 'https://openalex.org/W2084440639', 'https://openalex.org/W2085160326', 'https://openalex.org/W2088001545', 'https://openalex.org/W2090681869', 'https://openalex.org/W2091019343', 'https://openalex.org/W2092926394', 'https://openalex.org/W2093144701', 'https://openalex.org/W2095453782', 'https://openalex.org/W2098623515', 'https://openalex.org/W2099540110', 'https://openalex.org/W2104017463', 'https://openalex.org/W2104750134', 'https://openalex.org/W2106415942', 'https://openalex.org/W2107532817', 'https://openalex.org/W2107546866', 'https://openalex.org/W2109912983', 'https://openalex.org/W2113349387', 'https://openalex.org/W2121435438', 'https://openalex.org/W2129901774', 'https://openalex.org/W2130526419', 'https://openalex.org/W2135154684', 'https://openalex.org/W2141073629', 'https://openalex.org/W2141273392', 'https://openalex.org/W2144844081', 'https://openalex.org/W2152479249', 'https://openalex.org/W2157004216', 'https://openalex.org/W2157153072', 'https://openalex.org/W2164076798', 'https://openalex.org/W2169365832', 'https://openalex.org/W2171419502', 'https://openalex.org/W2468923062', 'https://openalex.org/W2475259576', 'https://openalex.org/W2739354616', 'https://openalex.org/W2754068978', 'https://openalex.org/W2757366404', 'https://openalex.org/W2770485188', 'https://openalex.org/W2883238159', 'https://openalex.org/W2885743684', 'https://openalex.org/W2898146177', 'https://openalex.org/W2901280873', 'https://openalex.org/W2902176124', 'https://openalex.org/W2908931800', 'https://openalex.org/W2912278480', 'https://openalex.org/W2913920462', 'https://openalex.org/W2950191568', 'https://openalex.org/W2952505856', 'https://openalex.org/W2986817448', 'https://openalex.org/W3003540174', 'https://openalex.org/W3007852935', 'https://openalex.org/W3013319049', 'https://openalex.org/W3014672374', 'https://openalex.org/W3022855878', 'https://openalex.org/W3023016632', 'https://openalex.org/W3027174726', 'https://openalex.org/W3029948889', 'https://openalex.org/W3032255613', 'https://openalex.org/W3044397953', 'https://openalex.org/W3085717162', 'https://openalex.org/W3106493990', 'https://openalex.org/W3155156029', 'https://openalex.org/W4210729786'], 'related_works': ['https://openalex.org/W409684769', 'https://openalex.org/W3160979978', 'https://openalex.org/W2490261733', 'https://openalex.org/W2074828010', 'https://openalex.org/W2061463391', 'https://openalex.org/W2054442912', 'https://openalex.org/W1967818518', 'https://openalex.org/W1966708072', 'https://openalex.org/W1965028277', 'https://openalex.org/W1964285407'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'developed': [2, 75], 'a': [3, 23, 120, 130, 137], 'new': [4], 'class': [5], 'of': [6, 8, 11, 29, 88, 101, 119, 143, 149], 'inhibitors': [7, 37], 'protein-protein': [9, 144], 'interactions': [10, 145], 'the': [12, 27, 39, 58, 83, 110, 117, 141, 147], 'SHP2': [13, 36, 54, 69, 102], 'phosphatase,': [14], 'which': [15], 'is': [16], 'pivotal': [17], 'in': [18, 26, 124, 146], 'multiple': [19], 'signaling': [20, 64], 'pathways': [21], 'and': [22, 31, 95, 136], 'central': [24], 'target': [25, 38], 'therapy': [28], 'cancer': [30], 'rare': [32], 'diseases.': [33], 'Currently': [34], 'available': [35], 'catalytic': [40], 'site': [41], 'or': [42, 49], 'an': [43, 96], 'allosteric': [44], 'pocket': [45], 'but': [46], 'lack': [47], 'specificity': [48], 'are': [50], 'ineffective': [51], 'on': [52, 57], 'disease-associated': [53], 'mutants.': [55], 'Based': [56], 'consideration': [59], 'that': [60], 'pathogenic': [61, 99, 121], 'lesions': [62], 'cause': [63], 'hyperactivation': [65], 'due': [66], 'to': [67, 93, 104, 139], 'increased': [68], 'association': [70], 'with': [71, 78], 'cognate': [72], 'proteins,': [73], 'we': [74], 'peptide-based': [76], 'molecules': [77], 'low': [79], 'nM': [80], 'affinity': [81, 97], 'for': [82, 98, 109, 133], 'N-terminal': [84], 'Src': [85], 'homology': [86], 'domain': [87], 'SHP2,': [89], 'good': [90], 'selectivity,': [91], 'stability': [92], 'degradation': [94], 'variants': [100], 'up': [103], '20': [105], 'times': [106], 'higher': [107], 'than': [108], 'wild-type': [111], 'protein.': [112], 'The': [113], 'best': [114], 'peptide': [115], 'reverted': [116], 'effects': [118], 'variant': [122], '(D61G)': [123], 'zebrafish': [125], 'embryos.': [126], 'Our': [127], 'results': [128], 'provide': [129], 'novel': [131], 'route': [132], 'SHP2-targeted': [134], 'therapies': [135], 'tool': [138], 'investigate': [140], 'role': [142], 'function': [148], 'SHP2.': [150]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3108904450', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2025-01-19T06:03:41.072745', 'created_date': '2020-12-07'}