Publication Information

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[26], 'not': [27, 253, 318], 'respond': [28], 'anti-PD1': [30], 'or': [31, 207], 'CTLA4': [32], 'therapy<sup>1-3</sup>': [33], 'novel': [34, 389], 'therapeutics': [35], 'that': [36, 75, 316, 360], 'target': [37, 218, 339], 'additional': [38], 'immune-suppressive': [39], 'mechanisms': [40], 'are': [41], 'needed.': [42], 'Regulatory': [43, 734], 'T': [44, 248, 303, 704, 735, 821], 'cells': [45, 213, 219, 340, 705, 736], '(Tregs)': [46], 'inhibit': [47], 'responses': [49], 'in': [50, 108, 119, 159, 176, 271, 279, 294, 377, 395, 454, 541, 622, 663, 740], 'tumor': [52, 111, 149, 161, 182, 263, 269, 460, 658], 'microenvironment': [53, 397], 'via': [54], 'multiple': [55, 109, 148, 238], 'suppressive': [56], 'mechanisms.<sup>4': [57], '5</sup>': [58], 'Existing': [59], 'Treg-targeting': [60], 'agents': [61], 'lack': [62, 81], 'specificity': [63], 'for': [64, 130, 364], 'intratumoral': [65, 99, 295, 301, 348], 'Tregs': [66, 118, 187, 296, 372], 'can': [68], 'also': [69], 'deplete': [70], 'effector': [71, 247], 'cells,': [72], 'a': [73, 134, 272, 292, 307, 353, 388, 458], 'property': [74], 'has': [76], 'likely': [77], 'contributed': [78], 'activity': [84, 359, 376], 'observed': [85, 345], 'date.': [87], 'CCR8': [88, 143, 157, 230, 251, 314, 342], '(C-C': [89], 'chemokine': [90, 322], 'receptor': [91], '8)': [92], 'is': [93, 306, 352, 361], 'selectively': [94], 'expressed': [95], 'on': [96, 246, 255, 346], 'highly': [97, 233, 308], 'activated': [98], 'Tregs,': [100], 'its': [101], 'high': [102, 459], 'expression': [103, 144, 155, 231], 'correlates': [104], 'with': [105, 216, 235, 291, 357, 457, 536], 'poor': [106], 'prognosis': [107], 'human': [110, 136, 206, 211, 258, 310, 347, 399, 741, 814], 'types<sup>6': [112], '7</sup>': [113], 'depletion': [115, 185, 649, 700], 'CCR8+': [117, 217, 371], 'preclinical': [120], 'models': [121], 'elicited': [122, 334], 'potent': [123, 335], 'activity.': [125, 228], 'These': [126], 'observations': [127], 'provided': [128], 'rationale': [129], 'development': [132, 284], 'CCR8-specific': [135, 354], 'depleting': [137], 'antibody.': [138], '<h3>Methods</h3>': [139], 'Human': [140], 'FOXP3': [141], 'was': [145, 174, 191, 232, 242, 252, 289, 325], 'correlated': [146, 234], 'across': [147, 237], 'types': [150], 'using': [151, 202], 'TCGA': [152], 'datasets': [153], 'evaluated': [158, 175], 'primary': [160], 'explants': [162], 'PBMCs': [164], 'by': [165, 193], 'flow': [166, 194, 221], 'cytometry.': [167, 195], 'efficacy': [169, 708], 'anti-CCR8': [171, 189, 265], 'antibody': [172, 266, 315, 356], 'treatment': [173, 190, 267, 366], 'MC38': [178], 'CT26': [180], 'murine': [181, 262], 'models.': [183], 'following': [188], 'assessed': [192], 'Flow': [196], 'cytometric-based': [197], 'binding': [198], 'assays': [199], 'were': [200, 214], 'performed': [201], 'cell': [203], 'lines': [204], 'expressing': [205, 341], 'cynomolgus': [208, 312], 'CCR8.': [209], 'Purified': [210], 'NK': [212], 'co-cultured': [215], 'cytometry': [222], 'used': [223], 'evaluate': [225], 'antibody-dependent': [226, 329], 'killing': [227, 337], '<h3>Results</h3>': [229], 'FoxP3': [236], 'cancer': [239, 456], 'subtypes': [240], 'low': [243], 'absent': [245], 'cells.': [249, 304, 823], 'Importantly,': [250], 'detected': [254], 'any': [256], 'peripheral': [257], 'leukocyte': [259], 'subset.': [260], 'In': [261], 'models,': [264, 379], 'reduced': [268], 'growth': [270, 659], 'dose-': [273], 'Fc-gamma-receptor-dependent': [275], 'manner': [276], 'resulted': [278], 'complete': [280], 'regressions': [281], 'memory.': [286], 'Tumor': [287], 'shrinkage': [288], 'associated': [290], 'reduction': [293], 'increased': [298], 'representation': [299], 'CD8': [302], 'FPA157': [305, 324, 351, 386], 'specific': [309], 'crossreactive': [313], 'does': [317], 'bind': [319], 'closely': [320], 'related': [321], 'receptors.': [323], 'engineered': [326], 'enhance': [328], 'cell-mediated': [330], 'cytotoxicity': [331], '(eADCC)': [332], 'NK-mediated': [336], 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