Regulation of intestinal LDLR by the LXR-IDOL axis

Name: Work Video:
Duration: 3 min 30 s
Nienke M. van Loon; Suzanne A.E. van Wouw; Roelof Ottenhoff; Jessica K. Nelson; Jenina Kingma; Saskia Scheij; Martina Moeton; Noam Zelcer
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128, 149, 163, 213, 221, 276, 282, 288], 'development': [22], 'coronary': [24], 'artery': [25], 'disease': [26], 'associated': [28], 'complications.': [29], 'In': [30], 'recent': [31], 'years,': [32], 'it': [33], 'has': [34], 'become': [35], 'apparent': [36], 'that': [37, 66, 178, 206, 275, 291], 'next': [38], 'to': [39, 87, 90, 246], 'liver,': [41], 'intestine': [43, 110, 222, 283], 'plays': [44], 'key': [46], 'role': [47, 126], 'in': [48, 108, 131, 136, 154, 157, 174, 179, 199, 227, 254, 268, 281, 295], 'systemic': [49], 'governing': [53], 'absorption,': [55], 'secretion,': [56], 'incorporation': [58], 'into': [59], 'lipoprotein': [60, 97], 'particles.': [61], 'We': [62], 'have': [63, 237], 'previously': [64], 'demonstrated': [65], 'Liver': [68], 'X': [69], 'receptor': [70, 98], '(LXR)-regulated': [71], 'E3': [72], 'ubiquitin': [73], 'ligase': [74], 'inducible': [75], 'degrader': [76], 'LDLR': [78, 107, 153, 190], '(IDOL)': [79], 'regulator': [82], 'uptake': [85, 198], 'owing': [86], 'its': [88], 'ability': [89], 'promote': [91], 'ubiquitylation': [93], 'low-density': [96], '(LDLR).': [99], 'However,': [100], 'whether': [101, 112, 242], 'LXR-IDOL-LDLR': [103, 129, 277], 'axis': [104, 130, 278], 'regulates': [105], 'this': [113, 121, 269], 'influences': [114], 'intestinal': [115, 152, 184], 'homeostasis': [117, 294], 'not': [119], 'known.In': [120], 'study,': [122], 'we': [123, 147, 168, 204, 250], 'evaluated': [124], 'enterocyte': [132], 'cell': [133, 185, 193], 'models': [134], 'primary': [137, 231], 'enterocytes': [138, 232], 'isolated': [139, 233], 'from': [140, 234], 'Idol(-/-)': [141, 155, 175, 235, 264], 'wild': [143, 158], 'type': [144, 159], 'mice.': [145], 'Furthermore,': [146], 'studied': [148], 'regulation': [150], 'mice': [160, 211, 236, 255, 267], 'treated': [161], 'with': [162, 212, 223], 'LXR': [164, 187, 214], 'agonist': [165, 215], 'GW3965.': [166], 'Finally,': [167], 'assessed': [169], 'ezetimibe-induced': [170], 'trans-intestinal': [171, 247], 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