Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3098813693', 'doi': 'https://doi.org/10.1038/s41598-020-75206-2', 'title': 'Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer', 'display_name': 'Electroporation outperforms in vivo-jetPEI for intratumoral DNA-based reporter gene transfer', 'publication_year': 2020, 'publication_date': '2020-11-11', 'ids': {'openalex': 'https://openalex.org/W3098813693', 'doi': 'https://doi.org/10.1038/s41598-020-75206-2', 'mag': '3098813693', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33177564', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7659317'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-020-75206-2', 'pdf_url': 'https://www.nature.com/articles/s41598-020-75206-2.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41598-020-75206-2.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040803680', 'display_name': 'Liesl Jacobs', 'orcid': 'https://orcid.org/0000-0001-6259-9467'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Liesl Jacobs', 'raw_affiliation_strings': ['Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042935379', 'display_name': 'Elien De Smidt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Elien De Smidt', 'raw_affiliation_strings': ['Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071251967', 'display_name': 'Nick Geukens', 'orcid': 'https://orcid.org/0000-0001-5706-1072'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Nick Geukens', 'raw_affiliation_strings': ['PharmAbs – the KU Leuven Antibody Center, KU Leuven – University of Leuven, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'PharmAbs – the KU Leuven Antibody Center, KU Leuven – University of Leuven, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074388972', 'display_name': 'Paul Declerck', 'orcid': 'https://orcid.org/0000-0003-1259-9105'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Paul Declerck', 'raw_affiliation_strings': ['PharmAbs – the KU Leuven Antibody Center, KU Leuven – University of Leuven, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'PharmAbs – the KU Leuven Antibody Center, KU Leuven – University of Leuven, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027152621', 'display_name': 'Kevin Hollevoet', 'orcid': 'https://orcid.org/0000-0001-9647-2528'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Kevin Hollevoet', 'raw_affiliation_strings': ['Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven – University of Leuven, Campus Gasthuisberg O&N II, Herestraat 49 Box 820, 3000, Leuven, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 0.931, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.538026, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 84}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11255', 'display_name': 'Microfluidic and Bio-sensing Technologies', 'score': 0.9871, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C186852380', 'wikidata': 'https://www.wikidata.org/wiki/Q1142521', 'display_name': 'Electroporation', 'level': 3, 'score': 0.9696225}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.8450146}, {'id': 'https://openalex.org/C161733203', 'wikidata': 'https://www.wikidata.org/wiki/Q911828', 'display_name': 'Reporter gene', 'level': 4, 'score': 0.7829516}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.7701386}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.5935474}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.5892246}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.58180577}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5534648}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.5251729}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.5060598}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.4297694}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.42333254}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.37192315}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.33085135}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27943087}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16568196}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.060189694}], 'mesh': [{'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D018274', 'descriptor_name': 'Electroporation', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017930', 'descriptor_name': 'Genes, Reporter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018274', 'descriptor_name': 'Electroporation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049409', 'descriptor_name': 'Luciferases, Firefly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049409', 'descriptor_name': 'Luciferases, Firefly', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011094', 'descriptor_name': 'Polyethyleneimine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011094', 'descriptor_name': 'Polyethyleneimine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-020-75206-2', 'pdf_url': 'https://www.nature.com/articles/s41598-020-75206-2.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://lirias.kuleuven.be/handle/123456789/663225', 'pdf_url': 'https://lirias.kuleuven.be/bitstream/123456789/663225/2/Jacobs%20et%20al_Sci%20Rep_2020.pdf', 'source': {'id': 'https://openalex.org/S4306401954', 'display_name': 'Lirias (KU Leuven)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I99464096', 'host_organization_name': 'KU Leuven', 'host_organization_lineage': ['https://openalex.org/I99464096'], 'host_organization_lineage_names': ['KU Leuven'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659317', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33177564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-020-75206-2', 'pdf_url': 'https://www.nature.com/articles/s41598-020-75206-2.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.73, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321730', 'funder_display_name': 'Fonds Wetenschappelijk Onderzoek', 'award_id': '1133220N'}, {'funder': 'https://openalex.org/F4320321730', 'funder_display_name': 'Fonds Wetenschappelijk Onderzoek', 'award_id': 'G0E2117N'}], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W171417757', 'https://openalex.org/W1983831181', 'https://openalex.org/W1983893899', 'https://openalex.org/W2018838263', 'https://openalex.org/W2023071514', 'https://openalex.org/W2038718892', 'https://openalex.org/W2055353965', 'https://openalex.org/W2118420698', 'https://openalex.org/W2549307927', 'https://openalex.org/W2621841059', 'https://openalex.org/W2792638493', 'https://openalex.org/W2991805330', 'https://openalex.org/W3003520466', 'https://openalex.org/W3005597080', 'https://openalex.org/W3036238597', 'https://openalex.org/W3046042268', 'https://openalex.org/W753861416'], 'related_works': ['https://openalex.org/W77671357', 'https://openalex.org/W612523068', 'https://openalex.org/W3098813693', 'https://openalex.org/W2413456745', 'https://openalex.org/W2008134889', 'https://openalex.org/W2002449019', 'https://openalex.org/W1995870358', 'https://openalex.org/W1978137506', 'https://openalex.org/W1890366598', 'https://openalex.org/W1587611090'], 'abstract_inverted_index': {'Abstract': [0], 'Intratumoral': [1, 80, 101], 'delivery': [2], 'of': [3, 13, 37, 105, 145, 167, 178, 189], 'drug-encoding': [4], 'plasmid': [5], 'DNA': [6], '(pDNA)': [7], 'enables': [8], 'localised': [9], 'in': [10, 46, 51, 74, 83, 119, 138, 171], 'vivo': [11], 'expression': [12, 86, 102, 134, 162], 'biological': [14], 'drugs,': [15], 'offering': [16], 'an': [17], 'attractive': [18], 'alternative': [19], 'to': [20, 31, 90, 110, 143, 164, 194], 'conventional': [21], 'protein': [22], 'treatment.': [23], 'However,': [24], 'this': [25], 'requires': [26], 'physical': [27], 'or': [28], 'chemical': [29], 'methods': [30, 67], 'enhance': [32], 'the': [33, 44, 52, 91, 117, 139, 149, 176], 'low': [34], 'transfection': [35], 'efficiency': [36], 'naked': [38], 'pDNA.': [39], 'Electroporation': [40], 'and': [41, 94, 122, 159, 185, 198], 'complexation': [42], 'with': [43, 129, 170], 'polycation': [45], 'vivo-jetPEI': [47], 'are': [48], 'both': [49, 66], 'evaluated': [50], 'clinic': [53], 'for': [54, 68, 96, 180], 'intratumoral': [55, 69, 165, 181], 'pDNA': [56, 168], 'delivery,': [57], 'but': [58], 'lack': [59], 'head-to-head': [60], 'comparison.': [61], 'This': [62], 'study': [63], 'therefore': [64], 'compared': [65, 163], 'DNA-based': [70, 182], 'reporter': [71, 85, 133, 161], 'gene': [72, 183], 'transfer': [73], 'a': [75], 'subcutaneous': [76], 'mouse': [77], 'tumour': [78, 92], 'model.': [79], 'electroporation': [81, 154, 179], 'resulted': [82], 'strong': [84], 'that': [87], 'was': [88, 108, 135], 'restricted': [89], 'area': [93], 'persisted': [95], 'at': [97], 'least': [98], 'ten': [99], 'days.': [100], 'after': [103], 'injection': [104, 166], 'pDNA-jetPEI': [106, 146, 190], 'complexes': [107, 147, 191], 'two': [109], 'three': [111], 'logs': [112], 'lower,': [113], 'did': [114], 'not': [115], 'exceed': [116], 'background': [118], 'most': [120], 'mice,': [121], 'lasted': [123], 'less': [124], 'than': [125], 'five': [126], 'days': [127], 'even': [128], 'repeated': [130], 'dosing.': [131], 'Remarkably,': [132], 'primarily': [136], 'detected': [137], 'lungs,': [140], 'presumably': [141], 'due': [142], 'leakage': [144], 'into': [148], 'systemic': [150], 'circulation.': [151], 'In': [152], 'conclusion,': [153], 'enabled': [155], 'more': [156], 'efficient,': [157], 'prolonged': [158], 'tumour-specific': [160], 'complexed': [169], 'vivo-jetPEI.': [172], 'These': [173], 'results': [174], 'favour': [175], 'use': [177], 'transfer,': [184], 'suggest': [186], 'further': [187], 'optimisation': [188], 'is': [192], 'needed': [193], 'improve': [195], 'their': [196], 'efficacy': [197], 'biosafety.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3098813693', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}], 'updated_date': '2025-01-19T04:35:07.939866', 'created_date': '2020-11-23'}