Title: Metabolic syndrome in moderate to severe obstructive sleep apnea?
Abstract: <b>Introduction:</b> Moderate to severe obstructive sleep apnea (OSA) is almost recognized as an independent risk factor for metabolic syndrome (MS). <b>Aim:</b> Assess characteristics of OSA in case of MS <b>Methods:</b> Retrospective three-year study of patient records referred to our sleep unity and diagnosed of moderate to severe OSA according to Apnea Hypopnea Index (IAH) showed by respiratory polygraphs. Two groups were defined: G1 (MS+) and G0 (MS-) according to the WHO definition of MS <b>Results:</b> One hundred-twenty records were reviewed (G1=38; G0=82). OSA was severe in 100% of cases in G1 vs 79% in G0 (p=0,002) [Mean IAH being respectively 51,3±17 and 42,5±17 in G1 and G0; p=0,01]. Sex-ratio M/F was 0,65 in G1 vs 1,41 in G0 (p=0,04). Mean age was 54,7±11 years in G1 vs 48,9±13 in G0 (p=0,02). Mean BMI was 41±7 kg/m2 in G1 vs 35±6 in G0 (p<10-4). Patients of G1 reported less observed apneas (17% vs 40% p=NS); less drowsiness (24% vs 52% p=NS) and less non-repairing sleep (19,2% vs 26,7% p=0,02). G1 presented with higher Desaturation index (DSI) (55±17,6 vs 36±20,5/h; p<10-4), longer prolonged apneas (63±17,8 vs 59±17s ; p=NS) and lowest nadir SpO2 ( 69±10% vs 76±9% p=0,009) <b>Conclusion:</b> MS must to be considered especially in patients with higher BMI, DSI and degree of desaturation. Weight loss and decreasing nocturnal hypoxia are essential in managing moderate to severe OSA, in order to reduce cardiovascular risk
Publication Year: 2020
Publication Date: 2020-09-07
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot