Publication Information

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2039, 2116, 2147, 2254, 2327, 2356, 2387, 2408, 2605, 2608, 2744, 2753, 2779, 2801, 2809, 2866], 'urticaria': [16], '(Weidinger': [17], 'Novak,': [19], '2016Weidinger': [20], 'S.': [21, 404, 501, 892, 1486, 1518, 1990, 2031, 2241, 2473, 2658], 'Novak': [22], 'N.': [23, 687, 1145], 'dermatitis.Lancet.': [25], '2016;': [26], '387:': [27], '1109-1122Abstract': [28], 'Full': [29, 31, 89, 91, 306, 308, 427, 429, 524, 526, 915, 917, 2199, 2201, 2268, 2270, 2496, 2498, 2681, 2683], 'Text': [30, 32, 90, 92, 307, 309, 428, 430, 525, 527, 916, 918, 2200, 2202, 2269, 2271, 2497, 2499, 2682, 2684], 'PDF': [33, 93, 310, 431, 528, 919, 2203, 2272, 2500, 2685], 'PubMed': [34, 94, 231, 311, 372, 432, 529, 587, 711, 789, 859, 920, 994, 1169, 1384, 1420, 1468, 1505, 1553, 1599, 1645, 1885, 1955, 2014, 2053, 2273, 2382, 2501, 2686], 'Scopus': [35, 95, 181, 232, 312, 373, 433, 530, 588, 712, 790, 860, 921, 995, 1170, 1385, 1421, 1469, 1506, 1554, 1600, 1646, 1886, 1956, 2015, 2054, 2204, 2274, 2383, 2502, 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773, 1048, 1176, 1183, 1197, 1283, 1300, 1318, 1412, 1660, 1696, 1758, 1818, 1968, 2070, 2298, 2337, 2370, 2396, 2436, 2539, 2546, 2584, 2625, 2713, 2818, 2831, 2835], 'be': [49, 240, 476, 1177, 1198, 1969, 2071, 2338, 2427, 2629, 2836], 'higher': [50, 1961], 'children': [52], 'than': [53], 'adults': [54, 175], '(Drucker': [55], 'et': [56, 115, 140, 336, 350, 395, 409, 492, 506, 551, 565, 682, 753, 767, 823, 837, 883, 897, 970, 1140, 1351, 1365, 1392, 1406, 1429, 1444, 1475, 1489, 1515, 1529, 1565, 1577, 1611, 1626, 1923, 1981, 1995, 2020, 2034, 2162, 2176, 2232, 2246, 2464, 2478, 2649, 2663], 'al.,': [57, 116, 141, 337, 396, 493, 552, 683, 754, 824, 884, 971, 1141, 1352, 1393, 1430, 1476, 1516, 1566, 1612, 1924, 1982, 2021, 2163, 2233, 2465, 2650], '2017Drucker': [58], 'A.M.': [59], 'Wang': [60], 'A.R.': [61, 1526], 'Li': [62], 'W.-Q.': [63], 'Sevetson': [64], 'E.': [65, 349, 766, 2029, 2304], 'Block': [66], 'J.K.': [67], 'Qureshi': [68], 'A.A.': [69], 'The': [70, 794, 1655, 2113, 2208, 2412, 2454, 2717, 2795], 'burden': [71], 'of': [72, 76, 157, 188, 223, 243, 261, 275, 326, 440, 445, 453, 467, 570, 797, 812, 842, 934, 949, 1026, 1080, 1117, 1228, 1240, 1256, 1272, 1306, 1323, 1344, 1408, 1451, 1460, 1532, 1542, 1584, 1633, 1675, 1690, 1703, 1718, 1812, 1823, 1860, 1877, 1896, 1997, 2047, 2097, 2118, 2135, 2224, 2248, 2350, 2374, 2392, 2418, 2520, 2534, 2588, 2592, 2620, 2723, 2731, 2782, 2821], 'atopic': [73, 129, 167, 224, 363, 581, 780, 853, 1878], 'dermatitis:': [74, 168, 364, 781], 'summary': [75, 705, 868, 989, 1112, 1163, 2828], 'a': [77, 169, 252, 262, 270, 365, 464, 619, 678, 782, 1081, 1136, 1229, 1704, 1760, 1813, 1998, 2007, 2083, 2094, 2132, 2213, 2221, 2259, 2757], 'report': [78, 2160], 'for': [79, 105, 127, 272, 299, 413, 510, 543, 580, 697, 852, 901, 1012, 1064, 1155, 1348, 1496, 1540, 1592, 1738, 1773, 1780, 1805, 2075, 2216, 2346, 2439, 2459, 2482, 2636, 2667, 2708, 2748, 2798, 2825], 'National': [81], 'Eczema': [82], 'Association.J': [83], 'Invest': [84, 301, 2263], 'Dermatol.': [85, 302, 1949, 2264], '2017;': [86, 370, 787, 992, 1502, 1642, 2379], '137:': [87], '26-30Abstract': [88], '(236)': [96], 'Vitamin': [99, 152, 218, 1872], 'D': [100, 153, 159, 219, 328, 352, 392, 415, 457, 512, 722, 769, 803, 874, 903, 1312, 1329, 1851, 1867, 1873, 1910, 2041, 2066, 2111, 2139, 2149, 2191, 2422, 2456, 2461, 2484, 2515, 2562, 2571, 2599, 2604, 2638, 2669], 'supplementation': [101, 160, 2067, 2393, 2462, 2572], 'has': [102, 317, 1965, 2082, 2150, 2334, 2702], 'been': [103, 202, 318, 1901, 1966, 2151, 2335], 'suggested': [104, 2336], 'treatment,': [106], 'with': [107, 166, 208, 480, 607, 746, 808, 1015, 1067, 1107, 1191, 1201, 1331, 1335, 1376, 1545, 1663, 1666, 1707, 1782, 1845, 1857, 1862, 1864, 1905, 1972, 2087, 2187, 2405, 2407, 2511, 2876], 'conflicting': [108], 'results': [109], 'reported': [110, 474, 751, 815, 2153], 'literature': [113], '(Bath-Hextall': [114], '2012Bath-Hextall': [117], 'F.J.': [118], 'Jenkinson': [119], 'C.': [120, 1403, 1482, 1927, 1994, 2027, 2169, 2245], 'Humphreys': [121], 'R.': [122, 400, 497, 888, 2469, 2654, 2692], 'Williams': [123], 'H.C.': [124], 'Dietary': [125], 'supplements': [126], 'established': [128], 'eczema.Cochrane': [130], 'Database': [131], 'Syst': [132], 'Rev.': [133], '2012;': [134, 2196], '2:': [135], 'CD005205PubMed': [136], 'Scholar;': [138, 2018], 'Hattangdi-Haridas': [139], '2019Hattangdi-Haridas': [142], 'S.R.': [143], 'Lanham-New': [144], 'S.A.': [145], 'Wong': [146], 'W.H.S.': [147], 'Ho': [148], 'M.H.K.': [149], 'Darling': [150], 'A.L.': [151], 'deficiency': [154, 210], 'effects': [156, 702, 1160, 1907, 2400, 2431], 'vitamin': [158, 195, 327, 391, 414, 456, 511, 721, 802, 873, 902, 1311, 1328, 1850, 1866, 1909, 1943, 2040, 2065, 2088, 2110, 2138, 2148, 2313, 2329, 2375, 2421, 2449, 2455, 2460, 2483, 2514, 2521, 2561, 2570, 2598, 2603, 2637, 2668], 'on': [161, 282, 332, 459, 801, 1084, 1232, 1310, 1327, 1763, 1827, 1908, 2137, 2420, 2596, 2646], 'disease': [162, 1309], 'severity': [163], 'patients': [165, 1861, 2404], 'systematic': [170], 'review': [171], 'meta-analysis': [173, 393, 549, 620, 1492], 'children.Nutrients.': [177], '2019;': [178, 303, 2012], '11:': [179], '1854Crossref': [180], '(26)': [182], 'There': [185, 716, 1251], 'evidence': [187, 439, 719, 933, 1000, 1025, 1079, 1116, 1227, 1255, 1271, 1539, 1674, 1702, 1757, 1839, 2063, 2117, 2559], 'observational': [190, 237, 1858], 'association': [191, 411, 508, 568, 617, 840, 899, 1367, 1446, 1628, 1665, 1781, 2480, 2665], 'between': [192, 983, 1790, 2001, 2037, 2145], 'AD': [193, 214, 333, 460, 547, 726, 798, 810, 820, 935, 950, 1007, 1013, 1108, 1130, 1223, 1301, 1667, 1774, 1792, 1824, 1841, 1863, 1912, 1974, 2091, 2105, 2129, 2406, 2419, 2452, 2512, 2578, 2593], 'D,': [196, 2089], 'where': [197], 'sufferers,': [198], 'especially': [199], 'children,': [200], 'have': [201, 205, 1837, 1900, 2508, 2540], 'found': [203, 1196, 1672, 1838, 1967, 2630], 'reduced': [206], 'levels,': [207, 361, 778], 'greater': [209, 1011], 'seen': [211, 2438], 'severe': [213], '(Palmer,': [215, 1869], '2015Palmer': [216, 1870], 'D.J.': [217, 1871, 2025], 'development': [222, 1876], 'eczema.J': [225, 1879], 'Clin': [226, 1880, 2194], 'Med.': [227, 369, 786, 1881, 2011, 2050], '2015;': [228, 584, 856, 1465, 1550, 1882], '4:': [229, 1883], '1036-1050Crossref': [230, 1884], '(11)': [233, 1887], 'Traditional': [236], 'studies': [238], 'can': [239, 2628], 'biased': [241], 'because': [242, 2519], 'confounding': [244], 'reverse': [246], 'causation.': [247], 'Mendelian': [248, 366, 694, 783, 1152, 2008, 2044, 2714], 'randomization': [249, 367, 695, 784, 1153, 2009, 2045, 2715], '(MR)': [250], 'useful': [253], 'tool': [254], 'investigate': [256, 278, 322, 646, 2397], 'presence': [258], 'direction': [260, 444, 2096, 2157], 'causal': [263, 280, 324, 446, 451, 603, 748, 795, 981, 1057, 1082, 1230, 1295, 1321, 1543, 1705, 1761, 1999, 2416, 2590], 'relationship.': [264], 'Exposure-associated': [265], 'SNPs': [266, 470, 814, 1662, 2092], 'are': [267, 1811, 2401, 2816], 'used': [268, 320], 'proxy': [271], 'exposure': [274, 2450], 'interest': [276], 'effect': [281, 325, 452, 796, 1083, 1231, 1305, 1322, 1762, 1822, 2098, 2591], 'outcome': [284, 659], '(Budu-Aggrey': [285, 1980], 'Paternoster,': [287], '2019Budu-Aggrey': [288, 1983], 'A.': [289, 406, 503, 894, 1576, 1984, 2475, 2660], 'Paternoster': [290, 340, 757], 'L.': [291, 341, 554, 758, 826, 1617, 2239], 'Research': [292, 2765, 2807], 'techniques': [293], 'made': [294, 877, 2641], 'simple:': [295], 'using': [296, 384, 597, 703, 987, 1161], 'genetic': [297, 465, 654, 799, 936, 1008, 1332, 1494, 1680, 1711, 1770, 1793, 1825, 2594], 'variants': [298, 1131, 1544, 1591], 'randomization.J': [300], '139': [304], '(1416–21.e1)Abstract': [305], '(4)': [313], 'MR': [316, 593, 1314], 'previously': [319, 750, 2152], '(25-hydroxycholecalciferol': [329], '[25-OHD])': [330], 'levels': [331, 353, 416, 458, 482, 513, 723, 735, 770, 804, 904, 1017, 1086, 1134, 1203, 1234, 1330, 1684, 1765, 1829, 1868, 1979, 2485, 2670], 'risk': [334, 461, 578, 727, 800, 850, 937, 1372, 1681, 1712, 1771, 1794, 1826, 1975, 2595], '(Manousaki': [335, 394, 491, 752, 882, 2463, 2648], '2017Manousaki': [338, 755], 'D.': [339, 398, 495, 756, 886, 1397, 2467, 2652, 2746], 'Standl': [342, 555, 759, 827, 2170], 'M.': [343, 347, 556, 562, 691, 760, 764, 828, 834, 1149, 1488, 2171, 2235], 'Moffatt': [344, 761], 'M.F.': [345, 762, 1574], 'Farrall': [346, 763], 'Bouzigon': [348, 765], 'al.Vitamin': [351, 768], 'susceptibility': [355, 772, 1536, 1590], 'asthma,': [357, 774], 'elevated': [358, 775], 'immunoglobulin': [359, 776], 'E': [360, 777], 'study.PLoS': [368, 785, 2010], '14e1002294Crossref': [371, 788], '(48)': [374, 791], 'In': [377, 925, 1833, 2550], 'this': [378, 382, 1834, 2101, 2543, 2551, 2626, 2727, 2833], 'study,': [379, 1835, 2552], 'we': [380, 1836, 2159, 2553], 'extend': [381], 'analysis': [383, 594, 1106, 2046], 'GWAS': [385, 487, 538, 548, 821, 867, 875, 988, 1111, 2457, 2634], 'data': [386, 539, 869, 1113, 2635], 'from': [387, 870, 1221, 1342, 2296, 2706, 2771], 'most': [389, 477, 485, 545, 818], 'current': [390, 819], '2020Manousaki': [397, 494, 885, 2466, 2651], 'Mitchell': [399, 496, 887, 2468, 2653], 'Dudding': [401, 498, 889, 2470, 2655], 'T.': [402, 499, 890, 1401, 2471, 2656], 'Haworth': [403, 500, 891, 2472, 2657], 'Harroud': [405, 502, 893, 2474, 2659], 'Forgetta': [407, 504, 895, 2476, 2661], 'V.': [408, 505, 896, 2477, 2662], 'al.Genome-wide': [410, 507, 898, 1627, 2479, 2664], 'study': [412, 509, 569, 841, 900, 1368, 1629, 2481, 2666], 'reveals': [417, 514, 905, 2486, 2671], '69': [418, 515, 906, 2487, 2533, 2672], 'independent': [419, 469, 516, 907, 2488, 2673], 'loci.Am': [420, 517, 908, 2489, 2674], 'J': [421, 518, 909, 2490, 2675], 'Hum': [422, 519, 910, 2491, 2676], 'Genet.': [423, 520, 583, 707, 855, 911, 991, 1165, 1380, 1464, 1549, 1595, 1641, 2492, 2677], '2020;': [424, 521, 708, 912, 1166, 2493, 2678], '106:': [425, 522, 913, 2494, 2679], '327-337Abstract': [426, 523, 914, 2495, 2680], '(42)': [434, 531, 922, 2503, 2688], 'Scholar)': [436, 533, 863, 998, 1649, 1889, 2505], 'identify': [438], 'causality': [441], 'effect.': [447], 'We': [448, 1291, 1671, 2815], 'investigated': [449, 667, 807], 'genetically': [454], 'predicted': [455], 'by': [462, 612, 668, 676, 879, 943, 1005, 1180, 1903, 2181, 2429, 2611, 2643, 2738, 2761, 2790], 'deriving': [463], 'instrument': [466, 811, 1009, 1224, 1657, 2130], '59': [468], '(r2': [471], '<': [472, 1019, 1033, 1337, 1669], '0.001)': [473, 957], 'strongly': [478, 1189, 1199], 'associated': [479, 1190, 1200, 1499, 1844, 1971, 2186], '25-OHD': [481, 734, 941, 1016, 1085, 1110, 1133, 1202, 1233, 1683, 1764, 1828, 1978], 'recent': [486, 546, 872], '(N': [488], '=': [489, 736, 740, 743, 953, 956, 1030, 1042, 1046, 1051, 1088, 1092, 1095, 1125, 1244, 1247, 1260, 1263, 1277, 1281, 1286, 1694, 1699, 1722, 1725], '443,734)': [490], '(Supplementary': [534, 864, 1059, 1214, 1288, 1650, 1727, 1766, 1830], 'Table': [535, 865], 'S2).': [536, 963], 'Summary': [537, 673, 1103, 2633], 'were': [540, 642, 876, 1316, 2537], 'also': [541, 643, 666, 806, 1114, 1195, 2060], 'available': [542, 878, 2642, 2830], '(Paternoster': [550, 822], '2015Paternoster': [553, 825], 'Waage': [557, 829], 'J.': [558, 685, 830, 1143, 1362, 1432, 1988, 2175, 2237], 'Baurecht': [559, 831], 'H.': [560, 832], 'Hotze': [561, 833], 'Strachan': [563, 835], 'D.P.': [564, 836], 'al.Multi-ancestry': [566, 838], 'genome-wide': [567, 704, 839, 1162], '21,000': [571, 843], 'cases': [572, 844], '95,000': [574, 846], 'controls': [575, 847], 'identifies': [576, 848, 1369, 1587], 'new': [577, 849, 1370, 1589], 'loci': [579, 851, 1373, 1537, 1586], 'dermatitis.Nat': [582, 854], '47:': [585, 857, 1466, 1551], '1449-1456Crossref': [586, 858], '(308)': [589, 861], 'Two-sample': [592], 'was': [595, 605, 665, 717, 805, 931, 1010, 1024, 1076, 1194, 1269, 1298, 1303, 1658, 1754, 1775, 2517, 2640], 'performed': [596, 644, 1317, 2726], 'TwoSampleMR': [599], 'R': [600], 'package.': [601], 'A': [602, 1769, 2143], 'estimate': [604, 749, 1058, 1319], 'obtained': [606], 'inverse-variance': [609, 927], 'weighting': [610, 928], 'method': [611, 641], 'combining': [613], 'SNP-exposure': [614], 'SNP-outcome': [616], 'assuming': [621], 'multiplicative': [622], 'random': [623], 'effects.': [624], 'MR-Egger': [625], 'regression,': [626], 'weighted': [627, 631], 'median': [628], 'analysis,': [629], 'mode-based': [632], 'estimate,': [633], 'MR-Pleiotropy': [636, 1069], 'Residual': [637, 1070], 'Sum': [638, 1071], 'Outlier': [640, 1073], 'potential': [647, 1783], 'horizontal': [648, 1038, 1118, 1273, 2119], 'pleiotropy,': [649], 'ensure': [651], 'instruments': [655, 1333], 'only': [656, 2532], 'affect': [657], 'via': [660, 1135], 'exposure.': [662], 'Horizontal': [663], 'pleiotropy': [664, 1039, 1066, 1119, 1274, 2120], 'performing': [669], 'Causal': [670, 1100], 'Analysis': [671, 1101], 'Using': [672, 1102], 'Effect': [674, 1104], 'Estimates': [675, 1105], 'adopting': [677], 'whole-genome': [679], 'approach': [680], '(Morrison': [681, 1139], '2020Morrison': [684, 1142], 'Knoblauch': [686, 1144], 'Marcus': [688, 1146], 'J.H.': [689, 1147], 'Stephens': [690, 1148], 'He': [692, 1150], 'X.': [693, 1151], 'accounting': [696, 1154], 'correlated': [698, 1156], 'uncorrelated': [700, 1158], 'pleiotropic': [701, 1159], 'statistics.Nat': [706, 1164], '52:': [709, 1167], '740-747Crossref': [710, 1168], '(43)': [713, 1171], 'little': [718, 1756], 'causally': [724, 938, 1843, 1970, 2563], 'influence': [725, 1132, 2134, 2417], '(OR': [728, 1087], 'per': [729, 946, 1237, 1687, 1715], 'SD': [730, 945, 1236, 1686, 1714], 'change': [731], 'log-transformed': [733, 940], '1.233;': [737], '95%': [738, 1044, 1090, 1242, 1279, 1692, 1720], 'CI': [739, 952, 1045, 1091, 1243, 1280, 1693, 1721], '0.927–1.639;': [741], 'P-value': [742, 955, 1032, 1050, 1094, 1246, 1262, 1285, 1698, 1724], '0.150),': [744], 'consistent': [745, 1856, 2095], '24': [813], 'S3).': [866, 1216], 'authors': [881, 2645, 2719, 2820], 'method,': [929, 1074], 'there': [930, 1023, 1075, 1268, 1753, 2556], 'strong': [932, 1078, 2085], 'increasing': [939], 'concentrations': [942], '0.043': [944], 'doubling': [947, 1238, 1688, 1716], 'odds': [948, 1239, 1689, 1717], '(95%': [951], '0.017–0.069;': [954], '(Figure': [958, 1249], '1': [959, 1511, 1534, 1677], 'Supplementary': [961, 2879], 'Figure': [962, 1060, 1215, 1289, 1728, 1767, 1831], 'Performing': [964, 1099], 'Steiger': [966], 'directionality': [967], 'test': [968], '(Hemani': [969], '2017Hemani': [972], 'G.': [973, 978, 1399], 'Tilling': [974], 'K.': [975, 1405], 'Davey': [976], 'Smith': [977], 'Orienting': [979], 'relationship': [982, 1296, 1898, 2000, 2036, 2086], 'imprecisely': [984], 'measured': [985], 'traits': [986, 1326, 1751], 'data.PLoS': [990], '13e1007081Crossref': [993], '(196)': [996], 'gave': [999, 1115, 1226], 'variance': [1003], 'explained': [1004, 2428], 'compared': [1014], '(P-value': [1018], '2.2': [1020, 1034], '×': [1021, 1035, 1053, 1097, 1265, 1339], '10−16).However,': [1022], 'heterogeneity': [1027, 1257, 2115], '(Cochran': [1028], 'Q': [1029, 1259], '282;': [1031], '10−16)': [1036], '(Egger': [1040, 1275], 'intercept': [1041, 1276], '−0.012;': [1043], '−0.018': [1047], '−0.006;': [1049], '5.4': [1052], '10−4)': [1054], 'S1).': [1061], 'When': [1062], 'correcting': [1063], 'detected': [1065, 1297, 1787], 'still': [1077, 1225, 1252], '0.024;': [1089], '0.012–0.036;': [1093], '6.0': [1096], '10−4).': [1098], '(P-valueexpected': [1120], 'log': [1121], 'pointwise': [1122], 'posterior': [1123], 'density': [1124], '0.13),': [1126], 'suggesting': [1127, 2103], 'some': [1129, 1254, 1673], 'shared': [1137], 'pathway': [1138], 'This': [1174, 1853, 2332, 2425], 'appeared': [1175], 'mostly': [1178], 'driven': [1179], 'rs61816761,': [1181], 'mapping': [1182, 1531], 'RX501X': [1185], 'functional': [1186], 'FLG': [1187, 1206, 1219, 2080, 2125, 2136, 2146, 2295, 2351, 2410, 2440, 2612], 'mutation': [1188, 2282, 2352], 'AD,': [1192], 'which': [1193, 2787], 'other': [1205, 2090], 'mutations': [1207, 2184, 2368], 'including': [1208, 2123], 'R2447X': [1209], '(rs138726443)': [1210], 'S3247X': [1212], '(rs150597413)': [1213], 'Excluding': [1217], 'locus': [1220, 2126], '(0.018': [1235], 'AD;': [1241], '0.004–0.031;': [1245], '0.008)': [1248], '1).': [1250], 'remained': [1253], "(Cochran's": [1258], '60,': [1261], '2.3': [1264], '10−5),': [1266], 'but': [1267, 1976, 2506], 'weak': [1270, 1788, 2558], '0.001;': [1278], '−0.005': [1282], '0.006;': [1284], '0.782)': [1287], 'S4).': [1290], 'explored': [1292], 'if': [1293], 'limited': [1299], 'or': [1302, 2394, 2441], 'any': [1307], 'levels.': [1313, 1852, 2112, 2600], 'analyses': [1315, 1447, 1786, 2610], 'various': [1324], '(SNPs': [1334], 'P': [1336], '5': [1338], '10−8)': [1340], 'derived': [1341], 'individuals': [1343, 2510], 'white': [1345], 'European': [1346], 'ancestry': [1347], 'asthma': [1349, 1371, 1656], '(Demenais': [1350], '2018Demenais': [1353], 'F.': [1354, 2243], 'Margaritte-Jeannin': [1355], 'P.': [1356, 1441], 'Barnes': [1357], 'K.C.': [1358], 'Cookson': [1359], 'W.O.C.': [1360], 'Altmüller': [1361], 'Ang': [1363], 'W.': [1364], 'al.Multiancestry': [1366], 'colocalize': [1375], 'immune-cell': [1377], 'enhancer': [1378], 'marks.Nat': [1379], '2018;': [1381], '50:': [1382], '42-53Crossref': [1383], '(194)': [1386], 'Scholar),': [1388, 1424, 1472, 1509, 1557, 1603, 2386], 'rheumatoid': [1389, 1409], 'arthritis': [1390, 1410], '(Okada': [1391], '2014Okada': [1394], 'Y.': [1395, 1623], 'Wu': [1396], 'Trynka': [1398], 'Raj': [1400], 'Terao': [1402], 'Ikari': [1404], 'al.Genetics': [1407], 'contributes': [1411], 'biology': [1413], 'drug': [1415], 'discovery.Nature.': [1416], '2014;': [1417], '506:': [1418], '376-381Crossref': [1419], '(1242)': [1422], 'systemic': [1425, 1461, 1708], 'lupus': [1426, 1462, 1709], 'erythematosus': [1427, 1710], '(Bentham': [1428], '2015Bentham': [1431], 'Morris': [1433], 'D.L.': [1434], 'Cunninghame': [1435], 'Graham': [1436], 'D.S.': [1437], 'Pinder': [1438], 'C.L.': [1439], 'Tombleson': [1440], 'Behrens': [1442], 'T.W.': [1443], 'al.Genetic': [1445], 'implicate': [1448], 'aberrant': [1449], 'regulation': [1450], 'innate': [1452], 'adaptive': [1454], 'immunity': [1455], 'genes': [1456, 1636], 'pathogenesis': [1459], 'erythematosus.Nat': [1463], '1457-1464Crossref': [1467], '(342)': [1470], 'psoriasis': [1473, 1498], '(Tsoi': [1474], '2017Tsoi': [1477], 'L.C.': [1478], 'Stuart': [1479], 'P.E.': [1480], 'Tian': [1481], 'Gudjonsson': [1483], 'J.E.': [1484], 'Das': [1485], 'Zawistowski': [1487], 'al.Large': [1490], 'scale': [1491], 'characterizes': [1493], 'architecture': [1495], 'common': [1497], 'variants.Nat': [1500], 'Commun.': [1501], '8:': [1503], '15382Crossref': [1504], '(131)': [1507], 'type': [1510, 1533, 1676], 'diabetes': [1512, 1535, 1678], 'mellitus': [1513, 1679], '(Onengut-Gumuscu': [1514], '2015Onengut-Gumuscu': [1517], 'Chen': [1519], 'W.M.': [1520], 'Burren': [1521], 'O.': [1522], 'Cooper': [1523], 'N.J.': [1524], 'Quinlan': [1525], 'Mychaleckyj': [1527], 'J.C.': [1528, 1619], 'al.Fine': [1530], 'colocalization': [1541], 'lymphoid': [1546], 'gene': [1547, 2081, 2367], 'enhancers.Nat': [1548], '381-386Crossref': [1552], '(335)': [1555], 'multiple': [1558, 1593, 1634, 1739, 2048], 'sclerosis': [1559], '(International': [1560], 'Multiple': [1561, 1579], 'Sclerosis': [1562, 1580], 'Genetics': [1563, 1581], 'Consortium': [1564, 1582], '2013Beecham': [1567], 'A.H.': [1568], 'Patsopoulos': [1569], 'N.A.': [1570, 1625], 'Xifara': [1571], 'D.K.': [1572], 'Davis': [1573], 'Kemppinen': [1575], 'al.International': [1578], '(IMSGC)Analysis': [1583], 'immune-related': [1585], '48': [1588], 'sclerosis.Nat': [1594], '2013;': [1596, 1950, 2051], '45:': [1597], '1353-1360Crossref': [1598], '(869)': [1601], "Crohn's": [1604], 'Disease,': [1605], 'ulcerative': [1607], 'colitis': [1608], '(de': [1609], 'Lange': [1610, 1614], '2017de': [1613], 'K.M.': [1615], 'Moutsianas': [1616], 'Lee': [1618], 'Lamb': [1620], 'C.A.': [1621], 'Luo': [1622], 'Kennedy': [1624], 'implicates': [1630], 'immune': [1631], 'activation': [1632], 'integrin': [1635], 'bowel': [1639], 'disease.Nat': [1640], '49:': [1643], '256-261Crossref': [1644], '(390)': [1647], 'Tables': [1651], 'S1': [1652], 'S4–S11).': [1654], 'filtered': [1659], 'exclude': [1661], 'nominal': [1664], '(P': [1668], '0.05).': [1670], 'decreasing': [1682], '(−0.004': [1685], 'disease;': [1691, 1719], '−0.007': [1695], '0.000;': [1697], '0.044)': [1700], 'increase': [1706, 1847, 2371], '(0.003': [1713], '0.000–0.005;': [1723], '0.017)': [1726], 'S5).': [1729, 1768], 'Although': [1730, 2077], 'these': [1731, 1809], 'estimates': [1732, 1810], 'do': [1733], 'not': [1734, 1855, 2574], 'pass': [1735], 'threshold': [1737], 'testing': [1740], '(0.006),': [1741], 'they': [1742], 'may': [1743, 1899, 2426, 2445, 2507, 2614], 'warrant': [1744], 'further': [1745, 2062], 'investigation.': [1746], 'For': [1747], 'remaining': [1749, 2718], 'investigated,': [1752], 'very': [1755], 'suggest': [1759, 2568], 'score': [1772, 1795], 'tested': [1776], 'UK': [1778, 2527, 2763], 'Biobank': [1779, 2528], 'confounders.': [1784], 'Regression': [1785], 'associations': [1789], 'lower': [1797, 1865, 1977], 'body': [1798, 1962, 2002], 'mass': [1799, 1963, 2003], 'index': [1800, 1964, 2004], 'educational': [1802], 'attainment': [1803], '(proxy': [1804], 'socioeconomic': [1806, 1916], 'status);': [1807], 'however,': [1808], 'small': [1814], 'magnitude': [1815], 'unlikely': [1817, 2069, 2545], 'impact': [1819], 'casual': [1821], 'S6).': [1832], 'serum': [1849, 2109, 2189, 2597], 'reports': [1859], 'suggests': [1891, 2131], 'true': [1894], 'nature': [1895], 'masked': [1902], 'confounders': [1904], 'opposing': [1906], 'such': [1913], 'obesity,': [1915], 'status,': [1917], 'pollution,': [1918], 'latitude': [1920], '(Mesquita': [1921], 'Kde': [1922, 1926], '2013Mesquita': [1925], 'Igreja': [1928], 'A.C.': [1929], 'Costa': [1930], 'I.M.': [1931], 'Dermatite': [1932], 'atópica': [1933], 'e': [1934, 1938], 'vitamina': [1935], 'D:': [1936, 1944], 'fatos': [1937], 'controvérsias': [1939], '[Atopic': [1940], 'facts': [1945], 'controversies].An': [1947], 'Bras': [1948], '88': [1951], '([in': [1952], 'Portuguese]):': [1953], '945-953Crossref': [1954], '(30)': [1957], 'Notably,': [1960], 'increased': [1973, 2188, 2324, 2328], 'Brumpton': [1985], 'B.': [1986, 2167], 'Tyrrell': [1987], 'Watkins': [1989], 'Modalsli': [1991], 'E.H.': [1992], 'Celis-Morales': [1993], 'al.Evidence': [1996], 'psoriasis:': [2006], '16e1002739Crossref': [2013], '(69)': [2016], 'Vimaleswaran': [2019], '2013Vimaleswaran': [2022], 'K.S.': [2023], 'Berry': [2024], 'Lu': [2026], 'Tikkanen': [2028], 'Pilz': [2030], 'Hiraki': [2032], 'L.T.': [2033], 'al.Causal': [2035], 'obesity': [2038], 'status:': [2042], 'bi-directional': [2043], 'cohorts.PLoS': [2049], '10e1001383Crossref': [2052], '(609)': [2055], 'Our': [2058, 2566], 'findings': [2059, 2567], 'provide': [2061], 'effective': [2073], 'treatment': [2074], 'AD.': [2076, 2142, 2565], 'AD-associated': [2079], 'particularly': [2084], 'show': [2093], 'when': [2099, 2122], 'omitting': [2100], 'locus,': [2102], 'more': [2106], 'generally': [2107], 'influences': [2108, 2564], 'substantial': [2114], 'direct': [2133], 'bypasses': [2141], 'link': [2144], 'same': [2156], '(Thyssen': [2161, 2355], '2012Thyssen': [2164], 'J.P.': [2165, 2359], 'Thuesen': [2166], 'Huth': [2168], 'Carson': [2172], 'C.G.': [2173], 'Heinrich': [2174], 'al.Skin': [2177], 'barrier': [2178, 2252], 'abnormality': [2179], 'caused': [2180], 'filaggrin': [2182, 2249, 2366], '(FLG)': [2183], '25-hydroxyvitamin': [2190], 'concentrations.J': [2192], 'Allergy': [2193], 'Immunol.': [2195], '130': [2197], '(1204–7.e2)Abstract': [2198], '(60)': [2205], 'UVB–vitamin': [2209], 'D3': [2210, 2330], 'hypothesis': [2211], 'provides': [2212, 2226], 'proposed': [2214], 'mechanism': [2215, 2333, 2413], 'this,': [2217], 'whereby': [2218], 'trans-urocanic': [2219], 'acid,': [2220], 'breakdown': [2222], 'product': [2223], 'FLG,': [2225, 2289], 'epidermal': [2227], 'protection': [2228], 'against': [2229], 'UVB': [2230], '(Mildner': [2231], '2010Mildner': [2234], 'Jin': [2236], 'Eckhart': [2238], 'Kezic': [2240], 'Gruber': [2242], 'Barresi': [2244], 'al.Knockdown': [2247], 'impairs': [2250], 'diffusion': [2251], 'function': [2253], 'increases': [2255], 'UV': [2256, 2309, 2325, 2447], 'sensitivity': [2257], 'human': [2260], 'model.J': [2262], '2010;': [2265], '130:': [2266], '2286-2294Abstract': [2267], '(211)': [2275], 'Therefore,': [2278], 'inheriting': [2279], 'FLG-null': [2281], '(particularly': [2283], 'one': [2284], 'reduces': [2286, 2294], 'histidine': [2287, 2300], 'i.e.,': [2290], 'R501X': [2292], 'truncation': [2293], '413': [2297], '35': [2299], 'residues': [2301], '[Fauman,': [2302], '2020Fauman': [2303], '"No': [2305], 'FLG->No': [2306], 'His->No': [2307], 'urocanate->more': [2308], 'radiation->more': [2310], 'cholecalciferol': [2311], 'production->more': [2312], 'D".https://twitter.com/Eric_Fauman/status/1235188076143611904Date:': [2314], '2020Date': [2315], 'accessed:': [2316], 'October': [2317], '30,': [2318], '2020Google': [2319], 'Scholar])': [2320], 'would': [2321], 'result': [2322], 'absorption': [2326], 'synthesis.': [2331], 'advantageous': [2339], 'northern': [2341], 'latitudes,': [2342], 'providing': [2343], 'explanation': [2345], 'latitude-dependent': [2348], 'gradients': [2349], 'frequency': [2353], 'Elias,': [2357], '2017Thyssen': [2358], 'Elias': [2360], 'P.M.': [2361], 'It': [2362], 'remains': [2363], 'unknown': [2364], 'whether': [2365, 2398], 'evolved': [2369], 'cutaneous': [2372], 'synthesis': [2373], 'D.Genome': [2376], 'Biol': [2377], 'Evol.': [2378], '9:': [2380], '900-901Crossref': [2381], '(6)': [2384], 'warrants': [2388], 'future': [2389, 2602], 'clinical': [2390], 'trials': [2391, 2607], 'phototherapy': [2395, 2606], 'different': [2399, 2621], 'without': [2409], 'mutations.': [2411], 'explaining': [2414], 'unclear.': [2424], 'biological': [2430], 'similar': [2435], 'those': [2437], 'behavioral': [2442], 'mechanisms': [2443, 2587], 'alter': [2446], 'and/or': [2448], 'sufferers.': [2453], 'adjusted': [2458], 'included': [2509], 'whose': [2513], 'status': [2516, 2613], 'raised': [2518], 'D–raising': [2522], 'therapy.': [2523, 2579], 'However,': [2524], 'showcase': [2529], 'indicates': [2530], '410,256': [2535], 'participants': [2536], 'recorded': [2538], 'received': [2541, 2703, 2769], 'phototherapy,': [2542], 'explain': [2547], 'our': [2548], 'findings.': [2549], 'confirm': [2554], 'supported': [2575, 2789], 'Further': [2580], 'investigation': [2581], 'required': [2583], 'determine': [2585], 'Stratifying': [2601], 'epidemiological': [2609], 'assist': [2615], 'evaluating': [2617], 'contribution': [2619], 'mechanisms.': [2622], 'Datasets': [2623], 'related': [2624, 2712], 'article': [2627], 'at': [2631], 'https://github.com/abudu-aggrey/Atopic_Dermatitis_25OHD_MR.': [2632], '(25-OHD)': [2639], 'request': [2647], 'Daniel': [2691], 'Drodge:': [2693], 'http://orcid.org/0000-0002-2733-8509': [2694], 'Ashley': [2695], 'Budu-Aggrey:': [2696], 'http://orcid.org/0000-0002-8911-2492': [2697], 'Lavinia': [2698], 'Paternoster:': [2699], 'http://orcid.org/0000-0003-2514-0889': [2700], 'LP': [2701, 2768, 2870], 'personal': [2704], 'fees': [2705], 'Merck': [2707], 'Scientific': [2709], 'Input': [2710], 'Engagement': [2711], 'methodology.': [2716], 'state': [2720], 'no': [2721], 'conflict': [2722], 'interest.': [2724], 'DRD': [2725], 'research': [2728, 2758], 'part': [2730], 'academic': [2733], 'foundation': [2734], 'training': [2735], 'program': [2736], 'organized': [2737], 'Health': [2739], 'Education': [2740], 'England': [2741], 'South': [2742], 'West': [2743], 'thanks': [2745], 'Gunnell': [2747], 'mentoring': [2749], 'support.': [2750], 'DRD,': [2751, 2843, 2849, 2860, 2868], 'LP,': [2752, 2839, 2853], 'AB-A': [2754], 'work': [2755, 2834], 'unit': [2759], 'funded': [2760], 'Medical': [2764, 2783], 'Council': [2766], '(MC_UU_00011/1).': [2767], 'funding': [2770], 'British': [2773, 2811], 'Skin': [2774], 'Foundation': [2775, 2813], '(8010': [2776], 'Innovative': [2777], 'Project)': [2778], 'Academy': [2781], 'Sciences': [2784], 'Springboard': [2785], 'Award,': [2786], 'Wellcome': [2792], 'Trust': [2793], ',': [2794], 'Government': [2796], 'Department': [2797], 'Business,': [2799], 'Energy': [2800], 'Industrial': [2802], 'Strategy,': [2803], 'Global': [2805], 'Challenges': [2806], 'Fund,': [2808], 'Heart': [2812], '[SBF003∖1094].': [2814], 'grateful': [2817], 'published': [2823], 'GWASs': [2824], 'making': [2826], 'their': [2827], 'statistics': [2829], 'allow': [2832], 'possible.': [2837], 'Conceptualization:': [2838], 'AB-A;': [2840, 2844, 2854], 'Data': [2841], 'Curation:': [2842], 'Formal': [2845], 'Analysis:': [2846], 'DRD;': [2847], 'Investigation:': [2848], 'AB-A,': [2850, 2861, 2869], 'LP;': [2851, 2862], 'Supervision:': [2852], 'Writing': [2855, 2863], '-': [2856, 2864], 'Original': [2857], 'Draft': [2858], 'Preparation:': [2859], 'Review': [2865], 'Editing:': [2867], 'Download': [2871], '.pdf': [2872], '(.48': [2873], 'MB)': [2874], 'Help': [2875], 'pdf': [2877], 'files': [2878], 'Information': [2880]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3093082098', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}], 'updated_date': '2024-12-14T00:48:00.098700', 'created_date': '2020-10-22'}