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1031, 1151, 1721, 1812, 2181], 'treated': [558, 1057], '(5).NONSMOKING': [559], 'COPD:': [560], 'NEGLECTED': [561], 'BUT': [562], 'VERY': [563], 'IMPORTANTAlmost': [564], 'all': [565, 592, 810], 'emphasis': [568], 'placed': [571], 'cigarette': [573], 'smoking': [574, 582, 608, 661, 710, 734, 2836], 'risk': [577, 616, 642, 663, 1919], 'factor': [578, 617], 'cessation': [583], 'important': [586, 659, 1793], 'component': [587], 'management.': [590], 'Almost': [591], 'trials': [601, 753, 803], 'conducted': [606], 'predominant': [615], 'high': [619, 1497], 'income': [620], 'countries.': [621], 'about': [623], 'half': [624], 'world': [630], 'never-smokers,': [632], 'low-': [635, 2895], 'middle-oncome': [637], 'countries': [638], '(LMIC),': [639], 'where': [640], 'factors,': [643], 'exposure': [646, 701, 1119, 1278], 'household': [648, 2965], 'air': [649, 2966], 'pollution': [650], '(biomass': [651], 'smoke)': [652], 'occupational': [654], 'dust': [655], 'exposure,': [656], 'factors': [664], '(27).': [665], 'There': [666, 746, 873, 1077, 1259], 'great': [669, 749], 'understand': [672, 1049, 1153], 'nonsmoking': [674, 757], 'terms': [679], 'their': [681, 1405], 'mechanisms,': [683], 'progression,': [685], 'manifestations,': [687], 'In': [690, 791, 2133], 'rural': [691], 'India,': [692], 'women': [695], 'wood': [699], 'smoke': [700, 1118], 'ventilated': [704], 'houses': [705], 'and,': [706], 'although': [707, 759, 786], 'similar': [708, 732], 'less': [713], 'likely': [714, 1007, 1237], 'associated': [717, 1516, 2866], 'emphysema.': [719, 2630], 'inflammatory': [722, 1194, 1200, 1223, 1233, 1304, 1423, 1440], 'profile': [723], 'defective': [725, 1521, 2404], 'bacterial': [726, 2407], 'phagocytosis': [727, 2408], 'alveolar': [729], 'macrophages': [730], 'perhaps': [736], 'indicating': [737], 'susceptibility': [743], '(17,': [744], '24).': [745], 'these': [760, 1675], 'challenging': [763], 'resource-poor': [765], 'settings': [766], '(26).': [767], 'occur': [770], 'pulmonary': [772, 783, 1929, 2072, 2356, 2674, 2733, 2841, 2869, 3026, 3188, 3247, 3311], 'tuberculosis': [773, 781], 'sometimes': [775], 'treatment—so': [779], 'called': [780], 'obstructive': [782, 1928, 2071, 2355, 2673, 2732, 2840, 2868, 3025, 3187, 3246, 3310], '(TOPD);': [785], 'LMIC,': [792], '(25).THE': [804], 'PRESSING': [805], 'NEED': [806, 1024], 'FOR': [807, 1025], 'DISEASE-MODIFYING': [808], 'THERAPIESAlmost': [809], 'pf': [811], 'approved': [815, 1869], 'known': [820, 1425], 'classes': [821], 'drug.': [823], 'choice': [828], 'several': [830, 902], 'β2-agonists': [832], 'muscarinic': [834], 'antagonists': [835, 904], 'similarly': [838], 'combination': [843], 'inhalers': [844], 'additive': [846], 'bronchodilator': [847], 'effects,': [848, 946], 'improve': [850], 'symptoms': [851], 'target': [858, 884, 1016, 1186, 1559, 1568, 1667, 2150], 'process': [863, 1195, 1671, 1704, 1745, 1784], 'therefore': [865], 'fail': [866], 'mortality.': [872], 'unmet': [878], 'find': [881], 'treatments': [882, 893, 984, 1227], 'inflammation': [887, 1267], 'immune': [889], 'dysfunction.': [890], 'Many': [891], 'anti-inflammatory': [892, 907, 912, 983, 2067], 'tested': [897, 1620], 'including': [901, 1572, 1584], 'mediator': [903], 'broad-spectrum': [906], 'therapies.': [908], 'novel': [911, 1596], 'developed': [916], 'oral': [919, 939], 'phosphodiesterase-4': [920, 966], 'inhibitor': [921], 'roflumilast,': [922], 'animal': [927], 'models': [928, 1113], 'dose': [940], 'limited': [942], 'systemic': [944], 'side': [945, 963, 1002], 'headache,': [949], 'diarrhea,': [950], 'nausea,': [952], 'popular': [956], '(7).': [959], 'Attempts': [960], 'effects': [964, 2963], '(PDE4)': [967], 'inhibitors': [968, 977], 'inhaler': [970], 'delivery': [971], 'development': [973, 1615, 1650], 'selective': [976], 'unsuccessful.': [980], 'Several': [981, 1565], 'development,': [987, 1583], 'failed': [991], 'either': [992], 'because': [993, 999], 'lack': [995], 'efficacy': [997], 'unacceptable': [1001], 'effects.': [1003], 'also': [1006, 1412, 1508, 1613, 1633, 1647, 1806], 'too': [1011], 'complexity': [1018], 'if': [1019, 1680], 'process.THE': [1023], 'BETTER': [1026], 'UNDERSTANDING': [1027], 'DISEASE': [1029], 'MECHANISMSWe': [1030], 'much': [1033, 1312, 1814], 'better': [1034, 1746, 1799], 'cellular': [1038, 1454, 1569], 'driving': [1042, 1451], 'pathology': [1044], 'endotypes': [1052, 1072, 2893], 'Patients': [1055], 'relatively': [1058], 'late': [1059], 'course': [1062], 'progressive': [1065], 'when': [1067], 'differences': [1069], 'between': [1070, 2835], 'lost.': [1076], 'growing': [1079], 'evidence': [1080], 'small': [1082, 1093, 1105, 1140, 1157, 1164, 1175, 1734], 'earliest': [1088], 'abnormality,': [1089], 'loss': [1091, 1293, 1374], 'airways': [1094, 2725], 'narrowing': [1096], 'fibrosis': [1098, 1159, 1189, 2094], 'others,': [1100], '(22).': [1111], 'Animal': [1112], 'mice': [1121], 'guinea': [1123], 'pigs,': [1124], 'focused': [1126], 'emphysema': [1128], 'parenchymal': [1134], 'destruction': [1135], 'ignored': [1139], 'fibrosis,': [1142], 'prominent': [1146], 'rodent': [1148], 'models.': [1149], 'role': [1162, 1554], 'fibroblasts,': [1166], 'regulated': [1170], 'mediators': [1172, 1441], 'released': [1173], 'epithelial': [1177, 2010], 'cells': [1178, 1348, 1397, 1602, 2540], 'involve': [1181, 1694], 'repair': [1191, 1408, 1765], '(8).The': [1192], 'involves': [1198], 'cells,': [1201], 'macrophages,': [1203], 'neutrophils,': [1204], 'subtypes': [1208], 'lymphocyte': [1210], '(Tc1,': [1211], 'Th1,': [1212], 'Th17,': [1213], 'ILC2,': [1214], 'ILC3,': [1215], 'NK': [1216], 'cells)': [1217], 'hundred': [1221], 'mediators,': [1224], 'suggesting': [1225], 'upstream': [1230], 'cascade': [1234], 'useful.': [1240], 'Cigarette': [1241, 3149], 'biomass': [1243, 2410], 'smoke,': [1244], 'oxidative': [1246, 1531], 'stress': [1247, 1447, 1532, 1996], 'drive': [1249], 'low-grade': [1252], 'eventually': [1255], 'becomes': [1256, 1709], 'self-perpetuating': [1257], '(1).': [1258], 'appears': [1260], 'amplification': [1264, 1290], 'smokers': [1273, 1321], 'same': [1276, 1640], 'tobacco': [1277], 'who': [1279], 'airflow': [1283], 'obstruction.': [1284], 'One': [1285], 'mechanism': [1287, 1452, 2148], 'key': [1296], 'regulator': [1297, 2788], 'histone': [1298, 2668], 'deactylase-2': [1299], '(HDAC2),': [1300], 'normally': [1302], 'terminates': [1303], 'gene': [1305], 'expression': [1306, 2004], 'reduced': [1309, 1387], 'extent': [1314], 'normal': [1320], 'nonsmokers': [1323], '(21).ACCELERATED': [1324], 'AGING': [1325], 'AS': [1326], 'A': [1327, 2781], 'KEY': [1328], 'MECHANISMThere': [1329], 'increasing': [1331], 'support': [1332], 'view': [1335], 'represents': [1338], 'accelerated': [1339, 1371, 1468, 1511, 1644], 'aging,': [1341], 'resulting': [1342, 1482], 'accumulation': [1345], 'senescent': [1347, 1601, 2539], 'lungs': [1351, 1361, 1390], '(10).': [1355], 'Most': [1356], 'cell': [1357, 1400, 1476, 1478, 1608, 1759, 2210, 2627], 'types': [1358], 'show': [1365], 'senescence': [1366, 1455, 1514, 1542, 1570, 2145, 2628], 'endogenous': [1376], 'anti-aging': [1377], 'molecules,': [1378], 'sirtuin-1': [1381, 2006], 'sirtuin-6,': [1383], '(4,': [1394], '23).': [1395], 'Senescent': [1396], 'cycle': [1401], 'arrest': [1402], 'lose': [1404], 'ability': [1406], 'damage.': [1409], 'They': [1410], 'metabolically': [1413], 'active': [1414], '(“zombie': [1415], 'cells”)': [1416], 'secrete': [1418], 'characteristic': [1420], 'pattern': [1421, 1438], 'proteins': [1424], 'senescence-associated': [1428], 'secretory': [1429], 'phenotype': [1430], '(SASP),': [1431], 'corresponds': [1433], 'closely': [1435], 'secreted': [1442], 'cells.': [1445, 2011], 'Oxidative': [1446, 1995], '(stress-induced': [1456], 'senescence)': [1457], 'induces': [1459], 'micro-RNA-34a': [1460], 'inhibits': [1462], 'sirtuins-1': [1463], '-6,': [1465], 'leading': [1466], 'aging': [1469, 1645], '(4).': [1470], 'MicroRNAs': [1471], 'transported': [1474], 'via': [1479, 2000], 'extracellular': [1480], 'vesicles,': [1481], 'spread': [1487], 'organs': [1490], '(14).': [1491], 'account': [1494], 'frequency': [1498], 'comorbidities': [1500, 1636], 'aging.': [1512], 'Cellular': [1513, 2144, 3008, 3036, 3263], 'mitochondrial': [1518], 'dysfunction': [1519], 'autophagy;': [1522], 'dysfunctional': [1523], 'mitochondria': [1524], 'source': [1529], '(12,': [1536], '15).': [1537], 'being': [1547], 'elucidated': [1548], 'highlighted': [1551], 'critical': [1553], 'phosphoinositide': [1557], '3-kinase-mammalian': [1558], 'rapamycin': [1561], '(PI3K-mTOR)': [1562], '(20).': [1564], 'therapies': [1566, 1653, 1760], '(senotherapies),': [1571], 'inhibit': [1575], 'PI3K-mTOR': [1577], 'pathway': [1578, 2623], '(senostatics),': [1579], 'repurposing': [1585], 'existing': [1586], 'treatments,': [1587], 'metformin': [1590], 'rapamycin,': [1592], '(3).': [1598], 'Removal': [1599], 'senolytic': [1604], 'promote': [1607], 'apoptosis': [1609], 'removal': [1611], 'already': [1618], 'humans': [1622], '(19).': [1623], 'Senotherapies': [1624], '.not': [1628], 'COPD.': [1631, 1883, 2096, 2412], 'involved.FUTURE': [1648], 'DIRECTIONSThe': [1649], 'disappointing': [1659], 'needed.': [1664], 'Drugs': [1665], 'required': [1673], 'used': [1681], 'early': [1683, 1773], 'before': [1685, 1707], 'structural': [1687], 'irreversible': [1689], 'changes': [1690, 2999], 'occur.': [1691], 'finding': [1695], 'at': [1697], 'earlier': [1699], 'stage': [1700], 'spirometry': [1708], 'abnormal,': [1710], 'currently': [1713], 'define': [1714], 'means': [1718], 'redefine': [1723, 2183], 'future': [1727, 1787], 'use': [1729], 'sensitive': [1731], 'tests': [1732], 'function': [1736], 'structure': [1739], '(11).': [1740], 'By': [1741], 'possible': [1751], 'develop': [1753], 'can': [1762], 'restore': [1763], 'lost': [1772], 'might': [1779], 'reverse': [1781], '(9).': [1788], 'highlighting': [1795], 'importance': [1797], 'recognition': [1800], 'raising': [1808], 'devastating': [1819], 'lethal': [1821], 'disease.DISCLOSURESP.': [1823], 'Barnes': [1825, 1957, 1993, 2026, 2043, 2064, 2090, 2114, 2138, 2173, 2203, 2399, 2665, 2777, 2831, 2890, 2926, 2986], 'reports': [1826], 'grants': [1828], 'AstraZeneca': [1830], 'Boehringer-Ingelheim': [1832], 'personal': [1834], 'fees': [1835], 'scientific': [1837], 'advisory': [1838], 'boards': [1839], 'lectures': [1841], 'AstraZeneca,': [1843], 'Boehringer-Ingelheim,': [1844], 'Epi-Endo,': [1845], 'Novartis,': [1846], 'Pieris': [1847], 'Teva.': [1849], 'He': [1850], 'member': [1853], 'Scientific': [1856], 'Advisory': [1857], 'Board': [1858], 'GOLD.AUTHOR': [1860], 'CONTRIBUTIONSP.J.B.': [1861], 'drafted': [1862], 'manuscript;': [1863, 1867], 'edited': [1864], 'revised': [1866], 'manuscript.REFERENCES1.': [1873], 'Agustí': [1874], 'A,': [1875, 2251, 2259, 2332, 2334, 2525, 2579, 2593, 2605, 2658, 2699, 2822, 2889, 2923, 2929], 'Hogg': [1876, 2663, 2720, 2767], 'JC.': [1877], 'Update': [1878], 'pathogenesis': [1881], 'Reply.': 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[1988, 2344, 2601, 2709, 2776, 2942], 'L,': [1990, 2255, 2342, 2589], 'Ito': [1991, 2645, 2647, 2761, 2779], 'dependent': [1997], 'microRNA-34a': [1998], 'activation': [1999, 2624], 'PI3Kα': [2001], 'sirtuin-6': [2008], 'Sci': [2012], 'Rep': [2013], '35871,': [2015], '2016.': [2016, 2033, 2315], 'doi:10.1038/srep35871.': [2017], 'Scholar5.': [2025], 'Asthma-COPD': [2028], 'overlap.': [2029], '149:': [2031], '7–8,': [2032], 'doi:10.1016/j.chest.2015.08.017.': [2034], 'Scholar6.': [2042], 'Endo-phenotyping': [2045], 'patients.': [2048], 'Exp': [2049], 'Rev': [2050, 2075], 'Resp': [2051], 'Med:': [2052], '1–11,': [2053], 'doi:10.1080/17476348.2020.1804364.': [2055], 'Scholar7.': [2063], 'New': [2066], 'targets': [2068], 'Nat': [2074], 'Drug': [2076], 'Discov': [2077], '12:': [2078], '543–559,': [2079], '2013.': [2080], 'doi:10.1038/nrd4025.': [2081], 'Scholar8.': [2089], 'Small': [2092, 2724], 'Int': [2097], 'Biochem': [2099], 'Cell': [2100], 'Biol': [2101], '116:': [2102], '105598,': [2103], 'doi:10.1016/j.biocel.2019.105598.': [2105], 'Scholar9.': [2113], 'PJ,': [2115, 2139, 2174, 2204, 2778, 2927], 'Anderson': [2116], 'GP,': [2117], 'Fageras': [2118], 'Belvisi': [2120], 'diseases:': [2124], 'prospects': [2125], 'regeneration': [2127], 'repair.': [2129], 'Eur': [2130, 2413, 2968], 'Rev.': [2132], 'press.ISI': [2134], 'Scholar10.': [2137], 'J,': [2141, 2176, 2202, 2276, 2595, 2611, 2768, 2810], 'LE.': [2143], 'Am': [2155, 2904], 'Crit': [2158, 2907], 'Care': [2159, 2908], '200:': [2161], '556–564,': [2162], 'doi:10.1164/rccm.201810-1975TR.': [2164], 'Scholar11.': [2172], 'Vestbo': [2175], 'PM.': [2178], 'pressing': [2180], '“COPD”.': [2184], 'Obstr': [2186], 'Pulm': [2187], 'Dis': [2188], '380–383,': [2190], 'doi:10.15326/jcopdf.6.5.2019.017.': [2192], 'Scholar12.': [2200], 'Birch': [2201], 'Passos': [2205, 2508], 'JF.': [2206], 'Mitochondria,': [2207], 'telomeres': [2208], 'senescence:': [2211], 'Implications': [2212], 'ageing': [2215], 'Pharmacol': [2218], 'Ther': [2219], '183:': [2220], '34–49,': [2221], 'doi:10.1016/j.pharmthera.2017.10.005.': [2223], 'Scholar13.': [2231], 'Bloom': [2232, 2240], 'DE,': [2233], 'Cafiero': [2234], 'ET,': [2235], 'Jané-Llopis': [2236], 'E,': [2237, 2587], 'Abrahams-Gessel': [2238], 'LR,': [2241], 'Fathima': [2242], 'Feigl': [2244], 'AB,': [2245, 2497], 'Gaziano': [2246], 'Mowafi': [2248], 'Pandya': [2250], 'Prettner': [2252], 'Rosenberg': [2254], 'Seligman': [2256], 'B,': [2257, 2380, 2386, 2603, 2652], 'Stein': [2258], 'Weinstein': [2260], 'C.': [2261], 'economic': [2264], 'burden': [2265, 2437], 'non-communicable': [2267], '(Online).': [2269], 'https://www.weforum.org/reports/global-economic-burden-non-communicable-diseases': [2270], '[2': [2271], 'October': [2272, 3292, 3296], '2020].Google': [2273], 'Scholar14.': [2274], 'Chen': [2275], 'Hu': [2277], 'Pan': [2279], 'P.': [2280, 2348, 2984], 'Extracellular': [2281], 'vesicle': [2282], 'microRNA': [2283], 'transfer': [2284], 'Front': [2288], 'Physiol': [2289], '8:': [2290, 2367, 2457], '1028,': [2291], '2017.': [2292, 2453, 2876], 'doi:10.3389/fphys.2017.01028.': [2293], 'Scholar15.': [2301], 'Cloonan': [2302], 'SM,': [2303, 2483, 2824], 'Choi': [2304], 'AM.': [2305], 'Mitochondria': [2306], 'Clin': [2311, 2871], 'Invest': [2312], '126:': [2313], '809–820,': [2314], 'doi:10.1172/JCI81113.': [2316], 'Scholar16.': [2324], 'Criner': [2325], 'GJ,': [2326], 'Celli': [2327], 'BR,': [2328], 'Singh': [2329], 'D,': [2330, 2591, 2609, 2617], 'Agusti': [2331], 'Papi': [2333], 'Jison': [2335], 'Makulova': [2337], 'N,': [2338, 2479, 2599, 2703], 'Shih': [2339], 'VH,': [2340], 'Brooks': [2341], 'Barker': [2343], 'Martin': [2345, 2938], 'UJ,': [2346], 'Newbold': [2347], 'Predicting': [2349], 'benralizumab': [2352], 'analyses': [2358], 'GALATHEA': [2360], 'TERRANOVA': [2362], 'studies.': [2363], '158–170,': [2368], 'doi:10.1016/S2213-2600(19)30338-8.': [2370], 'Scholar17.': [2378], 'Ghosh': [2379], 'Gaike': [2381], 'AH,': [2382], 'Pyasi': [2383, 2811], 'Brashier': [2385, 2807], 'Das': [2387], 'VV,': [2388], 'Londhe': [2389, 2809], 'JD,': [2390, 2715], 'Juvekar': [2391, 2827], 'Shouche': [2393], 'YS,': [2394], 'Salvi': [2397, 2805], 'SS,': [2398, 2806, 2816], 'Bacterial': [2401], 'load': [2402], 'monocyte-derived': [2405], 'macrophage': [2406], 'smoke-related': [2411], '53:': [2416], '1702273,': [2417], 'doi:10.1183/13993003.02273-2017.': [2419], 'Scholar18.': [2427], 'GBD': [2428], 'Respiratory': [2430], 'Disease': [2431, 2451, 3097, 3122], 'Collaborators.': [2432], 'Prevalence': [2433], 'attributable': [2435], 'health': [2436, 2962, 3012, 3233], 'respiratory': [2440, 2961], 'diseases,': [2441], '1990-2017:': [2442], 'systematic': [2444], 'Global': [2448], 'Burden': [2449], 'Study': [2452], '585–596,': [2458], 'doi:10.1016/S2213-2600(20)30105-3.': [2460], 'Scholar19.': [2468], 'Hickson': [2469], 'LJ,': [2470], 'Langhi': [2471], 'Prata': [2472], 'LGP,': [2473], 'Bobart': [2474], 'SA,': [2475], 'Evans': [2476], 'TK,': [2477], 'Giorgadze': [2478], 'Hashmi': [2480], 'SK,': [2481], 'Herrmann': [2482], 'Jensen': [2484], 'MD,': [2485], 'Jia': [2486], 'Q,': [2487], 'Jordan': [2488], 'KL,': [2489], 'Kellogg': [2490], 'TA,': [2491], 'Khosla': [2492], 'Koerber': [2494], 'DM,': [2495, 2695], 'Lagnado': [2496], 'Lawson': [2498], 'DK,': [2499], 'LeBrasseur': [2500], 'NK,': [2501], 'Lerman': [2502], 'LO,': [2503], 'McDonald': [2504], 'KM,': [2505], 'McKenzie': [2506], 'TJ,': [2507], 'JF,': [2509], 'Pignolo': [2510], 'RJ,': [2511], 'Pirtskhalava': [2512], 'Saadiq': [2514], 'IM,': [2515, 2662], 'Schaefer': [2516], 'KK,': [2517], 'Textor': [2518], 'SC,': [2519], 'Victorelli': [2520], 'SG,': [2521], 'Volkman': [2522], 'TL,': [2523], 'Xue': [2524], 'Wentworth': [2526], 'Wissler': [2528], 'Gerdes': [2529], 'EO,': [2530], 'Zhu': [2531], 'Y,': [2532, 2754, 2952], 'Tchkonia': [2533], 'Kirkland': [2535], 'JL.': [2536], 'Senolytics': [2537], 'decrease': [2538], 'humans:': [2542], 'preliminary': [2543], 'report': [2544, 2959], 'trial': [2548], 'Dasatinib': [2550], 'plus': [2551], 'Quercetin': [2552], 'individuals': [2554], 'diabetic': [2556], 'kidney': [2557], 'EBioMedicine': [2559, 2565], '47:': [2560], '446–456,': [2561], '2019': [2562], '[Erratum': [2563], '52:': [2566], '102595,': [2567], '2020].': [2568], 'doi:10.1016/j.ebiom.2019.08.069.': [2569], 'Scholar20.': [2577], 'Houssaini': [2578], 'Breau': [2580], 'Kebe': [2582], 'Abid': [2584], 'Marcos': [2586], 'Lipskaia': [2588], 'Rideau': [2590], 'Parpaleix': [2592], 'Huang': [2594], 'Amsellem': [2596], 'V,': [2597, 2814], 'Vienney': [2598], 'Validire': [2600], 'Maitre': [2602], 'Attwe': [2604], 'Lukas': [2606], 'Vindrieux': [2608], 'Boczkowski': [2610], 'Derumeaux': [2612], 'G,': [2613, 2654], 'Pende': [2614], 'Bernard': [2616], 'Meiners': [2618], 'Adnot': [2620], 'S.': [2621], 'mTOR': [2622], 'drives': [2625], 'JCI': [2631], 'Insight': [2632], '3:': [2633], 'e93203,': [2634], 'doi:10.1172/jci.insight.93203.': [2636], 'Scholar21.': [2644], 'Elliott': [2649, 2704, 2775], 'WM,': [2650, 2705], 'Cosio': [2651], 'Caramori': [2653], 'Kon': [2655], 'OM,': [2656], 'Barczyk': [2657], 'Hayashi': [2659], 'Adcock': [2661], 'JC,': [2664, 2721, 2760], 'Decreased': [2667], 'deacetylase': [2669, 2783], 'activity': [2670], '352:': [2680], '1967–1976,': [2681], '2005.': [2682], 'doi:10.1056/NEJMoa041892.': [2683], 'Scholar22.': [2691], 'Koo': [2692], 'HK,': [2693], 'Vasilescu': [2694], 'Booth': [2696], 'Hsieh': [2698], 'Katsamenis': [2700], 'OL,': [2701], 'Fishbane': [2702], 'Kirby': [2706], 'Lackie': [2708], 'Sinclair': [2710], 'I,': [2711, 2862], 'Warner': [2712], 'JA,': [2713], 'Cooper': [2714], 'Coxson': [2716], 'HO,': [2717], 'Paré': [2718], 'PD,': [2719], 'Hackett': [2722], 'TL.': [2723], 'mild': [2728], 'moderate': [2730], 'cross-sectional': [2736], 'study.': [2737], '591–602,': [2742], 'doi:10.1016/S2213-2600(18)30196-6.': [2744], 'Scholar23.': [2752], 'Nakamaru': [2753], 'Wada': [2757], 'H,': [2758, 2772, 2935], 'Milne': [2759], 'Rossios': [2763], 'Elliot': [2765], 'Kharitonov': [2769], 'Goto': [2771], 'Bemis': [2773], 'JE,': [2774], 'K.': [2780, 2864], 'protein': [2782], 'SIRT1': [2784], 'negative': [2787], 'metalloproteinase-9.': [2790], 'FASEB': [2791], '23:': [2793], '2810–2819,': [2794], '2009.': [2795], 'doi:10.1096/fj.08-125468.': [2796], 'Scholar24.': [2804], 'BB,': [2808], 'Vincent': [2813], 'Kajale': [2815], 'Tambe': [2817], 'Mandani': [2819], 'Nair': [2821], 'Mak': [2823], 'Madas': [2825], 'Phenotypic': [2833], 'comparison': [2834], 'non-smoking': [2838], 'Res': [2844], '21:': [2845], '50,': [2846], 'doi:10.1186/s12931-020-1310-9.': [2848], 'Scholar25.': [2856], 'Sarkar': [2857], 'Srinivasa': [2859], ',': [2860], 'Madabhavi': [2861], 'Kumar': [2863], 'Tuberculosis': [2865], '11:': [2874], '285–295,': [2875], 'doi:10.1111/crj.12621.': [2877], 'Scholar26.': [2885], 'Siddharthan': [2886], 'Gupte': [2888], 'middle-income': [2897], 'country': [2898], 'settings:': [2899], 'precision': [2900], 'medicine': [2901], 'all.': [2903], '202:': [2910], '171–172,': [2911], 'doi:10.1164/rccm.202001-0165ED.': [2913], 'Scholar27.': [2921], 'Sood': [2922], 'Assad': [2924], 'NA,': [2925], 'Churg': [2928], 'Gordon': [2930], 'SB,': [2931], 'Harrod': [2932], 'KS,': [2933], 'Irshad': [2934], 'Kurmi': [2936], 'OP,': [2937], 'WJ': [2939], 'II,': [2940], 'Meek': [2941], 'Mortimer': [2943], 'Noonan': [2945], 'CW,': [2946], 'Perez-Padilla': [2947], 'R,': [2948], 'Smith': [2949], 'KR,': [2950], 'Tesfaigzi': [2951], 'Ward': [2953], 'Balmes': [2955], 'ERS/ATS': [2957], 'workshop': [2958], 'pollution.': [2967], '51:': [2971], '1700698,': [2972], 'doi:10.1183/13993003.00698-2017.': [2974], 'ScholarAUTHOR': [2982], 'NOTESCorrespondence:': [2983], '(p.j.[email': [2987], 'protected]ac.uk).': [2988], 'Download': [2989], 'Previous': [2991], 'Back': [2992], 'Top': [2994], 'Next': [2995], 'FiguresReferencesRelatedInformationRelated': [2996], 'articlesCOPD': [2997], 'challenges': [3001], '04': [3002, 3030], '2020American': [3004, 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