Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3091803375', 'doi': 'https://doi.org/10.7554/elife.57117', 'title': 'PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment', 'display_name': 'PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment', 'publication_year': 2020, 'publication_date': '2020-10-13', 'ids': {'openalex': 'https://openalex.org/W3091803375', 'doi': 'https://doi.org/10.7554/elife.57117', 'mag': '3091803375', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33047671', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7599071'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.57117', 'pdf_url': 'https://cdn.elifesciences.org/articles/57117/elife-57117-table1-data1-v2.pdf', 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://cdn.elifesciences.org/articles/57117/elife-57117-table1-data1-v2.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042295923', 'display_name': 'Yukiko Imai', 'orcid': 'https://orcid.org/0000-0002-4716-2563'}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Yukiko Imai', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051225549', 'display_name': 'Mathilde Biot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mathilde Biot', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007529596', 'display_name': 'Julie Clément', 'orcid': 'https://orcid.org/0000-0002-3243-9718'}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Julie a J Clément', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072945237', 'display_name': 'Mariko Teragaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mariko Teragaki', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009888760', 'display_name': 'Serge Urbach', 'orcid': 'https://orcid.org/0000-0001-8663-2006'}, 'institutions': [{'id': 'https://openalex.org/I4210156758', 'display_name': 'Institut de Génomique Fonctionnelle', 'ror': 'https://ror.org/043wmc583', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210156758']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Serge Urbach', 'raw_affiliation_strings': ['IGF - Institut de Génomique Fonctionnelle (141, Rue de la Cardonille 34094 Montpellier cedex 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGF - Institut de Génomique Fonctionnelle (141, Rue de la Cardonille 34094 Montpellier cedex 5 - France)', 'institution_ids': ['https://openalex.org/I4210156758']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058395152', 'display_name': 'Thomas Robert', 'orcid': 'https://orcid.org/0000-0002-2458-7454'}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thomas Robert', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007299990', 'display_name': 'Frédéric Baudat', 'orcid': 'https://orcid.org/0000-0003-2415-8366'}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Frédéric Baudat', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040810375', 'display_name': 'Corinne Grey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Corinne Grey', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052827585', 'display_name': 'Bernard de Massy', 'orcid': 'https://orcid.org/0000-0002-0950-2758'}, 'institutions': [{'id': 'https://openalex.org/I4210163339', 'display_name': 'Institut de Génétique Humaine', 'ror': 'https://ror.org/05ee10k25', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210163339']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Bernard de Massy', 'raw_affiliation_strings': ['IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)'], 'affiliations': [{'raw_affiliation_string': 'IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)', 'institution_ids': ['https://openalex.org/I4210163339']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'fwci': 1.378, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.714392, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '9', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dna-methylation', 'display_name': 'DNA Methylation', 'score': 0.530016}], 'concepts': [{'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.6653955}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.6041679}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.5694748}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53714025}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.488999}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44339496}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.43375635}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.42743757}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.40680516}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19102153}], 'mesh': [{'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D053903', 'descriptor_name': 'DNA Breaks, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011495', 'descriptor_name': 'Histone-Lysine N-Methyltransferase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044503', 'descriptor_name': '5-Methylcytosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004706', 'descriptor_name': 'Endodeoxyribonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004706', 'descriptor_name': 'Endodeoxyribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011495', 'descriptor_name': 'Histone-Lysine N-Methyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011495', 'descriptor_name': 'Histone-Lysine N-Methyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059765', 'descriptor_name': 'Homologous Recombination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013090', 'descriptor_name': 'Spermatocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013090', 'descriptor_name': 'Spermatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013737', 'descriptor_name': 'Testis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 15, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.57117', 'pdf_url': 'https://cdn.elifesciences.org/articles/57117/elife-57117-table1-data1-v2.pdf', 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02996703', 'pdf_url': 'https://hal.science/hal-03765889/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03048706', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03452306', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03765889', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03452306', 'pdf_url': 'https://hal.science/hal-03452306/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/854848377549491da558312ea21dbe9c', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599071', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02996703/file/elife-57117-v2.pdf', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02996703/file/elife-57117-v2.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-03765889/file/elife-57117-v2.pdf', 'pdf_url': 'https://hal.science/hal-03765889/file/elife-57117-v2.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-02996703/document', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-02996703/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03452306/file/elife-57117%281%29.pdf', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-03452306/file/elife-57117%281%29.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.science/hal-03452306/file/elife-57117%281%29.pdf', 'pdf_url': 'https://hal.science/hal-03452306/file/elife-57117%281%29.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03452306/document', 'pdf_url': 'https://hal.archives-ouvertes.fr/hal-03452306/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33047671', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.7554/elife.57117', 'pdf_url': 'https://cdn.elifesciences.org/articles/57117/elife-57117-table1-data1-v2.pdf', 'source': {'id': 'https://openalex.org/S1336409049', 'display_name': 'eLife', 'issn_l': '2050-084X', 'issn': ['2050-084X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311710', 'host_organization_name': 'eLife Sciences Publications Ltd', 'host_organization_lineage': ['https://openalex.org/P4310311710'], 'host_organization_lineage_names': ['eLife Sciences Publications Ltd'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321589', 'funder_display_name': 'Fondation pour la Recherche Médicale', 'award_id': None}, {'funder': 'https://openalex.org/F4320324477', 'funder_display_name': 'Fondation Bettencourt Schueller', 'award_id': None}, {'funder': 'https://openalex.org/F4320334678', 'funder_display_name': 'European Research Council', 'award_id': '322788'}, {'funder': 'https://openalex.org/F4320337898', 'funder_display_name': 'MSDAVENIR', 'award_id': 'Gene-IGH'}], 'datasets': [], 'versions': [], 'referenced_works_count': 109, 'referenced_works': ['https://openalex.org/W1480699894', 'https://openalex.org/W1542544035', 'https://openalex.org/W1876047377', 'https://openalex.org/W1903792504', 'https://openalex.org/W1963998725', 'https://openalex.org/W1966900987', 'https://openalex.org/W1968875669', 'https://openalex.org/W1968963646', 'https://openalex.org/W1969964108', 'https://openalex.org/W1974058116', 'https://openalex.org/W1976457281', 'https://openalex.org/W1981372238', 'https://openalex.org/W1981463058', 'https://openalex.org/W1983916953', 'https://openalex.org/W1991867417', 'https://openalex.org/W1992031539', 'https://openalex.org/W1993243592', 'https://openalex.org/W1993762503', 'https://openalex.org/W1994950146', 'https://openalex.org/W2003217864', 'https://openalex.org/W2006062026', 'https://openalex.org/W2006848427', 'https://openalex.org/W2009940298', 'https://openalex.org/W2011556073', 'https://openalex.org/W2015553373', 'https://openalex.org/W2016492976', 'https://openalex.org/W2023363789', 'https://openalex.org/W2024459631', 'https://openalex.org/W2026130605', 'https://openalex.org/W2036046545', 'https://openalex.org/W2036785063', 'https://openalex.org/W2038756976', 'https://openalex.org/W2042497238', 'https://openalex.org/W2047657819', 'https://openalex.org/W2054305990', 'https://openalex.org/W2061980400', 'https://openalex.org/W2063479593', 'https://openalex.org/W2066707761', 'https://openalex.org/W2068147439', 'https://openalex.org/W2070744469', 'https://openalex.org/W2071365780', 'https://openalex.org/W2071936353', 'https://openalex.org/W2080545378', 'https://openalex.org/W2085231911', 'https://openalex.org/W2086015868', 'https://openalex.org/W2088509777', 'https://openalex.org/W2089218510', 'https://openalex.org/W2091419216', 'https://openalex.org/W2093202557', 'https://openalex.org/W2100238259', 'https://openalex.org/W2100309864', 'https://openalex.org/W2103486606', 'https://openalex.org/W2108664872', 'https://openalex.org/W2109897362', 'https://openalex.org/W2118342658', 'https://openalex.org/W2123921804', 'https://openalex.org/W2124514674', 'https://openalex.org/W2127313212', 'https://openalex.org/W2127863375', 'https://openalex.org/W2130030167', 'https://openalex.org/W2130397743', 'https://openalex.org/W2136828783', 'https://openalex.org/W2142785868', 'https://openalex.org/W2143719385', 'https://openalex.org/W2149013762', 'https://openalex.org/W2150007935', 'https://openalex.org/W2152636479', 'https://openalex.org/W2154875873', 'https://openalex.org/W2157458089', 'https://openalex.org/W2159358696', 'https://openalex.org/W2160563322', 'https://openalex.org/W2162658068', 'https://openalex.org/W2166223300', 'https://openalex.org/W2239269923', 'https://openalex.org/W2256525674', 'https://openalex.org/W2256812860', 'https://openalex.org/W2416340669', 'https://openalex.org/W2463904279', 'https://openalex.org/W2531301510', 'https://openalex.org/W2601341301', 'https://openalex.org/W2604678230', 'https://openalex.org/W2615019156', 'https://openalex.org/W2754299545', 'https://openalex.org/W2783378262', 'https://openalex.org/W2789073377', 'https://openalex.org/W2792470996', 'https://openalex.org/W2887531648', 'https://openalex.org/W2889542049', 'https://openalex.org/W2921833140', 'https://openalex.org/W2924810428', 'https://openalex.org/W2937544611', 'https://openalex.org/W2938997507', 'https://openalex.org/W2949187072', 'https://openalex.org/W2952061719', 'https://openalex.org/W2952363051', 'https://openalex.org/W2952421220', 'https://openalex.org/W2952778924', 'https://openalex.org/W2954018630', 'https://openalex.org/W2967247947', 'https://openalex.org/W2969984643', 'https://openalex.org/W2982298255', 'https://openalex.org/W2994559041', 'https://openalex.org/W3003657069', 'https://openalex.org/W3006123701', 'https://openalex.org/W3012187713', 'https://openalex.org/W3021014705', 'https://openalex.org/W3021896968', 'https://openalex.org/W3022980205', 'https://openalex.org/W3047019796'], 'related_works': ['https://openalex.org/W98379584', 'https://openalex.org/W4366603091', 'https://openalex.org/W4286930115', 'https://openalex.org/W2413824894', 'https://openalex.org/W2118937292', 'https://openalex.org/W2090160141', 'https://openalex.org/W2081832748', 'https://openalex.org/W2055566470', 'https://openalex.org/W2023670712', 'https://openalex.org/W1605106831'], 'abstract_inverted_index': {'Meiotic': [0], 'recombination': [1], 'starts': [2], 'with': [3], 'the': [4, 45, 135, 139], 'formation': [5, 29], 'of': [6, 44, 48, 96, 129, 138], 'DNA': [7], 'double-strand': [8], 'breaks': [9], '(DSBs)': [10], 'at': [11, 70, 81, 92, 118, 144], 'specific': [12], 'genomic': [13], 'locations': [14], 'that': [15, 60, 114], 'correspond': [16], 'to': [17, 27, 35], 'PRDM9-binding': [18], 'sites.': [19, 72, 83, 94], 'The': [20], 'molecular': [21], 'steps': [22], 'occurring': [23], 'from': [24], 'PRDM9': [25, 37, 65, 71, 93, 109, 122], 'binding': [26, 66, 123], 'DSB': [28, 68, 79, 105, 130], 'are': [30], 'unknown.': [31], 'Using': [32], 'proteomic': [33], 'approaches': [34], 'find': [36], 'partners,': [38], 'we': [39, 58], 'identified': [40], 'HELLS,': [41], 'a': [42], 'member': [43], 'SNF2-like': [46], 'family': [47], 'chromatin': [49, 140], 'remodelers.': [50], 'Upon': [51], 'functional': [52], 'analyses': [53], 'during': [54], 'mouse': [55], 'male': [56], 'meiosis,': [57], 'demonstrated': [59], 'HELLS': [61, 74, 84], 'is': [62, 75, 85, 116], 'required': [63, 77], 'for': [64, 78, 88, 101], 'and': [67, 107, 124, 141], 'activity': [69, 80], 'However,': [73], 'not': [76], 'PRDM9-independent': [82], 'also': [86], 'essential': [87], '5-hydroxymethylcytosine': [89], '(5hmC)': [90], 'enrichment': [91], 'Analyses': [95], '5hmC': [97, 115], 'in': [98, 108], 'mice': [99, 112], 'deficient': [100, 111], 'SPO11,': [102], 'which': [103], 'catalyzes': [104], 'formation,': [106], 'methyltransferase': [110], 'reveal': [113], 'triggered': [117], 'DSB-prone': [119], 'sites': [120], 'upon': [121], 'histone': [125], 'modification,': [126], 'but': [127], 'independent': [128], 'activity.': [131], 'These': [132], 'findings': [133], 'highlight': [134], 'complex': [136], 'regulation': [137], 'epigenetic': [142], 'environments': [143], 'PRDM9-specified': [145], 'hotspots.': [146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3091803375', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-09-13T15:25:24.490390', 'created_date': '2020-10-15'}