Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3091360487', 'doi': 'https://doi.org/10.3892/or.2020.7783', 'title': 'Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome‑mediated circ‑HMGCS1 via the miR‑34a‑5p/SGPP1 axis', 'display_name': 'Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome‑mediated circ‑HMGCS1 via the miR‑34a‑5p/SGPP1 axis', 'publication_year': 2020, 'publication_date': '2020-09-29', 'ids': {'openalex': 'https://openalex.org/W3091360487', 'doi': 'https://doi.org/10.3892/or.2020.7783', 'mag': '3091360487', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33125091', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7610314'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2020.7783', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2020.7783/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.spandidos-publications.com/10.3892/or.2020.7783/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101545824', 'display_name': 'Juan He', 'orcid': 'https://orcid.org/0000-0002-3887-0082'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Juan He', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101527261', 'display_name': 'Huaping Zhao', 'orcid': 'https://orcid.org/0000-0001-7113-176X'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huaping Zhao', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100381459', 'display_name': 'Xing Liu', 'orcid': 'https://orcid.org/0000-0002-3255-5399'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xing Liu', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100408272', 'display_name': 'Dongmei Wang', 'orcid': 'https://orcid.org/0000-0001-9532-6203'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dongmei Wang', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100424406', 'display_name': 'Yong Wang', 'orcid': 'https://orcid.org/0000-0002-0979-8835'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong Wang', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056655700', 'display_name': 'Yanqiu Ai', 'orcid': 'https://orcid.org/0000-0002-3657-6728'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanqiu Ai', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057382778', 'display_name': 'Jianjun Yang', 'orcid': 'https://orcid.org/0000-0001-6785-9627'}, 'institutions': [{'id': 'https://openalex.org/I4210156804', 'display_name': 'First Affiliated Hospital of Zhengzhou University', 'ror': 'https://ror.org/056swr059', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156804']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianjun Yang', 'raw_affiliation_strings': ['Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China', 'institution_ids': ['https://openalex.org/I4210156804']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.15, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.690713, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '44', 'issue': '6', 'first_page': '2429', 'last_page': '2442'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11765', 'display_name': 'Circular RNAs in diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11765', 'display_name': 'Circular RNAs in diseases', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9875, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T14486', 'display_name': 'Cardiovascular, Neuropeptides, and Oxidative Stress Research', 'score': 0.9069, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.7441982}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.5061764}, {'id': 'https://openalex.org/keywords/exosome', 'display_name': 'Exosome', 'score': 0.41836527}], 'concepts': [{'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.7441982}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6922246}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.67950296}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.6411102}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.5061764}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5021951}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.48663172}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46861252}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.463366}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.46020597}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.44689283}, {'id': 'https://openalex.org/C2781261824', 'wikidata': 'https://www.wikidata.org/wiki/Q903634', 'display_name': 'Exosome', 'level': 5, 'score': 0.41836527}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4162842}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.41194415}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.40594792}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.38123015}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33309785}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.30211055}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.22420007}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07956225}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000079962', 'descriptor_name': 'RNA, Circular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000077149', 'descriptor_name': 'Sevoflurane', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003106', 'descriptor_name': 'Colon', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064368', 'descriptor_name': 'Healthy Volunteers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007413', 'descriptor_name': 'Intestinal Mucosa', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000079962', 'descriptor_name': 'RNA, Circular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000079962', 'descriptor_name': 'RNA, Circular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000077149', 'descriptor_name': 'Sevoflurane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077149', 'descriptor_name': 'Sevoflurane', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2020.7783', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2020.7783/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610314', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33125091', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/or.2020.7783', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/or.2020.7783/download', 'source': {'id': 'https://openalex.org/S124357017', 'display_name': 'Oncology Reports', 'issn_l': '1021-335X', 'issn': ['1021-335X', '1791-2431'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1986639355', 'https://openalex.org/W2011537287', 'https://openalex.org/W2020218669', 'https://openalex.org/W2062380899', 'https://openalex.org/W2064293567', 'https://openalex.org/W2085223354', 'https://openalex.org/W2107277218', 'https://openalex.org/W2151821775', 'https://openalex.org/W2235523093', 'https://openalex.org/W2414038664', 'https://openalex.org/W2473455681', 'https://openalex.org/W2564450069', 'https://openalex.org/W2594373254', 'https://openalex.org/W2734945090', 'https://openalex.org/W2761494803', 'https://openalex.org/W2802755724', 'https://openalex.org/W2883062882', 'https://openalex.org/W2889646458', 'https://openalex.org/W2895877601', 'https://openalex.org/W2913365246', 'https://openalex.org/W2914531847', 'https://openalex.org/W2923272925', 'https://openalex.org/W2956599875', 'https://openalex.org/W2960780530', 'https://openalex.org/W2968570321', 'https://openalex.org/W2973682929', 'https://openalex.org/W2980406603', 'https://openalex.org/W2983354423', 'https://openalex.org/W2997589276', 'https://openalex.org/W31191503', 'https://openalex.org/W4322719806', 'https://openalex.org/W75952966'], 'related_works': ['https://openalex.org/W60177492', 'https://openalex.org/W574198516', 'https://openalex.org/W4387804390', 'https://openalex.org/W3030667680', 'https://openalex.org/W2961705167', 'https://openalex.org/W2791767507', 'https://openalex.org/W2389310297', 'https://openalex.org/W2341333145', 'https://openalex.org/W2321931350', 'https://openalex.org/W2079454806'], 'abstract_inverted_index': {'As': [0, 133], 'a': [1, 134, 153, 195], 'novel': [2], 'halogenated': [3], 'hydroxyl': [4], 'ether‑inhaled': [5], 'general': [6], 'anesthetic,': [7], 'sevoflurane': [8, 34, 140, 173, 187, 232], 'has': [9], 'been': [10], 'reported': [11], 'to': [12, 26, 48, 61, 109, 125], 'affect': [13], 'the': [14, 21, 28, 63, 111, 127, 161, 184, 203, 239], 'progression': [15, 236], 'of': [16, 33, 66, 75, 85, 129, 165, 186, 197, 205, 223], 'diverse': [17], 'human': [18], 'cancers.': [19], 'In': [20, 230], 'present': [22], 'study,': [23], 'we': [24], 'aimed': [25], 'explore': [27, 110], 'functions': [29], 'and': [30, 43, 53, 73, 81, 94, 103, 115, 144, 146, 163, 179, 199], 'underlying': [31], 'mechanisms': [32], 'in': [35, 131, 149, 152, 160, 175, 228], 'colon': [36, 150, 166, 176, 189, 209, 234], 'cancer.': [37], 'MTT': [38], 'assay,': [39], 'flow': [40], 'cytometric': [41], 'analysis': [42, 58], 'Transwell': [44], 'assay': [45], 'were': [46, 77, 97, 107], 'conducted': [47], 'evaluate': [49], 'cell': [50, 142, 191, 211], 'viability,': [51], 'apoptosis': [52, 148], 'invasion,': [54], 'respectively.': [55], 'Western': [56], 'blot': [57], 'was': [59, 123, 137, 158, 170, 194], 'performed': [60], 'determine': [62], 'protein': [64], 'level': [65], 'sphingosine‑1‑phosphate': [67], 'phosphatase': [68], '1': [69, 90], '(SGPP1).': [70], 'The': [71, 83], 'morphology': [72], 'size': [74], 'exosomes': [76], 'analyzed': [78], 'by': [79, 99, 172, 237], 'TEM': [80], 'NTA.': [82], 'levels': [84], 'circular': [86], 'RNA': [87, 104], '3‑hydroxy‑3‑methylglutaryl‑CoA': [88], 'synthase': [89], '(circ‑HMGCS1),': [91], 'microRNA': [92], '(miR)‑34a‑5p': [93], 'SGPP1': [95, 217], 'mRNA': [96], 'examined': [98], 'RT‑qPCR.': [100], 'Dual‑luciferase': [101], 'reporter': [102], 'RIP': [105], 'assays': [106], 'utilized': [108], 'interaction': [112], 'between': [113], 'miR‑34a‑5p': [114, 193, 200], 'circ‑HMGCS1': [116, 130, 157, 180, 198, 206, 214, 224], 'or': [117], 'SGPP1.': [118], 'A': [119], 'murine': [120], 'xenograft': [121], 'model': [122], 'established': [124], 'investigate': [126], 'effect': [128, 185, 204], 'vivo.': [132, 229], 'result,': [135], 'it': [136], 'determined': [138], 'that': [139], 'suppressed': [141, 216], 'viability': [143], 'invasion': [145], 'induced': [147], 'cancer': [151, 167, 177, 190, 210, 235], 'dose‑dependent': [154], 'way.': [155], 'Exosomal': [156], 'increased': [159], 'serums': [162], 'cells': [164, 178], 'patients.': [168], 'Circ‑HMGCS1': [169], 'downregulated': [171], 'treatment': [174], 'overexpression': [181], 'could': [182], 'restore': [183], 'on': [188, 208], 'development.': [192], 'target': [196], 'inhibition': [201], 'reversed': [202], 'silencing': [207], 'progression.': [212], 'Moreover,': [213], 'knockdown': [215], 'expression': [218], 'via': [219], 'sponging': [220], 'miR‑34a‑5p.': [221], 'Knockdown': [222], 'blocked': [225], 'tumor': [226], 'growth': [227], 'conclusion,': [231], 'inhibited': [233], 'modulating': [238], 'exosome‑transmitted': [240], 'circ‑HMGCS1/miR‑34a‑5p/SGPP1': [241], 'axis.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3091360487', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 10}], 'updated_date': '2025-01-06T04:14:38.658445', 'created_date': '2020-10-08'}