Publication Information

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'https://openalex.org/W2163128710', 'https://openalex.org/W2171693939', 'https://openalex.org/W2316846621', 'https://openalex.org/W2332879618', 'https://openalex.org/W2511142927', 'https://openalex.org/W2706387899', 'https://openalex.org/W2732353044', 'https://openalex.org/W2740337431', 'https://openalex.org/W2751560497', 'https://openalex.org/W2752435269', 'https://openalex.org/W2889302616', 'https://openalex.org/W2890937451', 'https://openalex.org/W2904906610', 'https://openalex.org/W2922226239', 'https://openalex.org/W2926355588'], 'related_works': ['https://openalex.org/W3126521987', 'https://openalex.org/W2948807893', 'https://openalex.org/W2899084033', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2607424097', 'https://openalex.org/W2587905983', 'https://openalex.org/W2345304003', 'https://openalex.org/W1948951863', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Open': [0], 'AccessCCS': [1], 'ChemistryRESEARCH': [2], 'ARTICLE1': [3], 'Aug': [4], '2021A': [5], 'Monochromophoric': [6], 'Approach': [7], 'to': [8, 479, 504, 693, 714, 745, 824, 860, 872, 894, 941, 1150, 1199, 1257, 1288, 1310, 1333, 1478, 1544, 1625, 1730, 1747, 1773, 1848, 1988, 1993, 2038, 2086, 2272, 2364, 2459, 2509, 2578, 2584, 2669, 2736, 2827, 3202, 3234, 3296, 3418, 3422, 3493, 3528, 3656, 3682, 3711, 3714, 3738, 3775], 'Succinct': [9], 'Ratiometric': [10, 485, 881, 1009, 3151], 'Fluorescent': [11], 'Probes': [12], 'without': [13, 1433], 'Probe-Product': [14], 'Crosstalk': [15], 'Kai': [16, 51], 'Xin†,': [17], 'Xinxing': [18, 75], 'Li†,': [19], 'Yinghua': [20, 86], 'Guo†,': [21], 'Youhuan': [22, 110], 'Zhong†,': [23], 'Jungang': [24, 127], 'Wang,': [25, 41], 'Haotian': [26, 145], 'Yang,': [27, 45], 'Jie': [28, 161], 'Zhao,': [29], 'Chunlei': [30, 185], 'Guo,': [31], 'Yunxia': [32, 209], 'Huang,': [33], 'Zuhai': [34, 233], 'Lei,': [35], 'Yi-Lun': [36, 257], 'Ying,': [37], 'Xiao': [38, 275], 'Luo,': [39], 'Haolu': [40, 317], 'Xuhong': [42, 333], 'Qian,': [43], 'Wen': [44, 357], 'Xiaowen': [46, 392], 'Liang': [47, 393], 'and': [48, 70, 105, 115, 132, 140, 180, 204, 228, 252, 262, 270, 312, 352, 380, 433, 471, 492, 533, 542, 576, 591, 609, 640, 648, 655, 701, 726, 738, 763, 797, 816, 836, 944, 977, 1109, 1184, 1207, 1236, 1249, 1265, 1308, 1398, 1426, 1431, 1458, 1528, 1539, 1549, 1594, 1605, 1629, 1636, 1707, 1787, 1842, 1885, 1908, 1958, 1995, 2034, 2114, 2152, 2161, 2176, 2190, 2209, 2268, 2357, 2420, 2465, 2529, 2554, 2594, 2610, 2614, 2631, 2731, 2811, 2819, 2916, 2944, 2987, 3019, 3037, 3044, 3063, 3082, 3092, 3135, 3271, 3325, 3350, 3380, 3402, 3429, 3455, 3548, 3587, 3636, 3648, 3667, 3702, 3726, 3797, 3811, 3822, 3828, 3832, 3845, 3853, 3889, 3895, 3915, 3936, 3955, 3974, 3993, 4016, 4023, 4052, 4072, 4078, 4095, 4118, 4148, 4177], 'Youjun': [49, 434], 'Yang': [50, 146, 358, 435, 3856], 'Xin†': [52], 'State': [53, 88, 163, 187, 211, 235, 295, 335, 454], 'Key': [54, 60, 89, 95, 164, 170, 188, 194, 212, 218, 236, 242, 296, 302, 336, 342, 455, 461], 'Laboratory': [55, 61, 90, 96, 165, 171, 189, 195, 213, 219, 237, 243, 297, 303, 337, 343, 456, 462], 'of': [56, 62, 68, 78, 91, 97, 103, 113, 119, 130, 138, 149, 155, 166, 172, 178, 190, 196, 202, 214, 220, 226, 238, 244, 250, 260, 268, 298, 304, 310, 321, 327, 338, 344, 350, 378, 384, 413, 422, 428, 457, 463, 469, 510, 526, 562, 600, 668, 690, 706, 718, 731, 752, 784, 808, 813, 829, 935, 947, 1002, 1013, 1018, 1035, 1043, 1051, 1058, 1061, 1069, 1093, 1136, 1141, 1157, 1160, 1166, 1263, 1323, 1338, 1472, 1486, 1577, 1581, 1592, 1639, 1693, 1704, 1723, 1763, 1776, 1812, 1827, 1852, 1871, 1877, 1892, 1925, 1948, 1952, 1962, 2019, 2047, 2067, 2076, 2084, 2101, 2112, 2136, 2183, 2186, 2207, 2217, 2237, 2253, 2263, 2283, 2315, 2323, 2337, 2349, 2367, 2375, 2377, 2381, 2390, 2438, 2449, 2542, 2560, 2571, 2582, 2621, 2660, 2678, 2682, 2700, 2753, 2774, 2786, 2807, 2843, 2854, 2958, 2978, 3001, 3014, 3030, 3046, 3057, 3065, 3077, 3089, 3099, 3104, 3155, 3189, 3205, 3220, 3239, 3307, 3334, 3371, 3385, 3396, 3426, 3432, 3443, 3449, 3457, 3469, 3478, 3498, 3517, 3532, 3561, 3585, 3605, 3609, 3625, 3671, 3717, 3748, 3755, 3767, 3773, 3789, 3804, 3809, 3813, 3835, 3861, 3866, 4021, 4045, 4075, 4113], 'Bioreactor': [57, 92, 167, 191, 215, 239, 299, 339, 458], 'Engineering,': [58, 93, 134, 168, 192, 216, 240, 264, 300, 340, 459], 'Shanghai': [59, 72, 83, 94, 107, 121, 124, 142, 169, 182, 193, 206, 217, 230, 241, 254, 272, 301, 314, 341, 354, 386, 389, 418, 460, 473, 3805, 3814, 3836, 3840], 'Chemical': [63, 98, 173, 197, 221, 245, 305, 345, 464], 'Biology,': [64, 99, 174, 198, 222, 246, 306, 346, 465], 'East': [65, 100, 135, 175, 199, 223, 247, 265, 307, 347, 466], 'China': [66, 101, 136, 176, 200, 224, 248, 266, 308, 348, 467, 3790, 3847], 'University': [67, 102, 137, 148, 154, 177, 201, 225, 249, 267, 309, 320, 326, 349, 421, 427, 468], 'Science': [69, 104, 139, 179, 203, 227, 251, 269, 311, 351, 470, 3787, 3810, 3831, 3849], 'Technology,': [71, 106, 141, 181, 205, 229, 253, 271, 313, 353, 472], '200237': [73, 108, 143, 183, 207, 231, 255, 273, 315, 355, 474], ',': [74, 85, 109, 126, 144, 160, 184, 208, 232, 256, 274, 316, 332, 356, 391], 'Li†': [76], 'Department': [77, 112, 377, 412], 'General': [79, 414], 'Surgery,': [80, 415], 'Changzheng': [81, 416], 'Hospital,': [82, 417], '200003': [84, 419], 'Guo†': [87], 'Zhong†': [111], 'Molecular': [114, 133, 263, 379], 'Cellular': [116, 381, 3890, 3919], 'Biochemistry,': [117, 382], 'School': [118, 129, 259, 383], 'Medicine,': [120, 385], 'Jiaotong': [122, 387], 'University,': [123, 388], '200025': [125, 390], 'Wang': [128, 318], 'Chemistry': [131, 261], 'The': [147, 153, 319, 325, 420, 426, 716, 933, 1139, 1261, 1316, 1326, 1418, 1455, 1469, 1488, 1501, 1537, 1567, 1588, 1633, 1742, 1755, 1824, 1839, 1915, 1946, 2065, 2221, 2259, 2308, 2320, 2334, 2347, 2372, 2648, 3101, 3187, 3214, 3330, 3368, 3394, 3466, 3559, 3688], 'Queensland': [150, 322, 423], 'Diamantina': [151, 323, 424], 'Institute,': [152, 324, 425], 'Queensland,': [156, 328, 429], 'Woolloongabba,': [157, 329, 430], 'QLD': [158, 330, 431], '4102': [159, 331, 432], 'Zhao': [162], 'Guo': [186], 'Huang': [210, 3907], 'Lei': [234], 'Ying': [258], 'Luo': [276, 4034], '*Corresponding': [277, 359, 394, 436], 'authors.': [278, 360, 395, 437], 'E-mail': [279, 283, 287, 291, 361, 365, 369, 373, 396, 400, 404, 408, 438, 442, 446, 450], 'Address:': [280, 284, 288, 292, 362, 366, 370, 374, 397, 401, 405, 409, 439, 443, 447, 451], '[email': [281, 285, 289, 293, 363, 367, 371, 375, 398, 402, 406, 410, 440, 444, 448, 452], 'protected]': [282, 286, 290, 294, 364, 368, 372, 376, 399, 403, 407, 411, 441, 445, 449, 453], 'Qian': [334], 'https://doi.org/10.31635/ccschem.020.202000480': [475], 'SectionsSupplemental': [476], 'MaterialAboutAbstractPDF': [477], 'ToolsAdd': [478], 'favoritesDownload': [480], 'CitationsTrack': [481], 'Citations': [482], 'ShareFacebookTwitterLinked': [483], 'InEmail': [484], 'probes': [486, 512, 661, 747, 827, 843, 882, 907, 930, 1010, 1083, 1125, 1147, 1202, 1819, 2431], 'facilitate': [487], 'quantitative': [488, 646, 911, 2846], 'studies': [489, 912, 1612, 1632], 'via': [490, 1011, 2226, 2478, 3336, 3352, 3600, 3694], 'self-calibration': [491, 890], 'are': [493, 772, 848, 883, 903, 908, 931, 1079, 1789, 1801, 2387], 'cherished': [494, 885], 'for': [495, 548, 585, 662, 670, 748, 844, 910, 1037, 1145, 1203, 1222, 1368, 1439, 1781, 1817, 2098, 2443, 2452, 2470, 2801, 2845, 2911, 2972, 3008, 3050, 3069, 3207, 3253, 3322, 3409, 3519, 3597, 3838, 4049, 4116], 'bioimaging.': [496], 'Often,': [497], 'a': [498, 531, 545, 637, 749, 776, 804, 831, 853, 918, 937, 942, 968, 1019, 1027, 1062, 1070, 1101, 1217, 1277, 1352, 1465, 1497, 1508, 1518, 1523, 1529, 1578, 1608, 1656, 1675, 1691, 1731, 1779, 1791, 1980, 2054, 2132, 2163, 2205, 2304, 2461, 2516, 2557, 2586, 2643, 2657, 2679, 2714, 2725, 2741, 2750, 2765, 2805, 2866, 2926, 3218, 3272, 3593, 3653], 'small': [499], 'probe-product': [500, 515, 628, 987, 1822, 3686], 'spectral': [501, 972, 1916, 2006], 'separation': [502, 973, 990, 1248], 'leads': [503], 'crosstalk,': [505, 988], 'but': [506, 779, 1291, 1975, 2482, 2892, 3638], 'the': [507, 520, 550, 559, 597, 601, 610, 633, 704, 753, 764, 781, 818, 825, 841, 850, 923, 948, 952, 957, 971, 975, 978, 986, 989, 995, 1003, 1014, 1032, 1040, 1044, 1052, 1059, 1067, 1085, 1094, 1107, 1110, 1132, 1142, 1158, 1161, 1167, 1172, 1187, 1213, 1223, 1324, 1335, 1339, 1347, 1355, 1473, 1479, 1484, 1574, 1585, 1599, 1708, 1724, 1760, 1774, 1810, 1813, 1850, 1869, 1873, 1923, 1949, 1953, 1959, 1963, 2017, 2045, 2068, 2074, 2089, 2094, 2099, 2102, 2110, 2126, 2198, 2202, 2227, 2251, 2324, 2338, 2350, 2365, 2436, 2439, 2447, 2483, 2486, 2495, 2512, 2539, 2569, 2579, 2615, 2618, 2622, 2632, 2670, 2676, 2696, 2718, 2737, 2760, 2772, 2783, 2820, 2833, 2841, 2852, 2859, 2895, 2930, 3042, 3061, 3240, 3298, 3304, 3337, 3353, 3372, 3381, 3386, 3397, 3403, 3419, 3424, 3441, 3446, 3450, 3458, 3470, 3495, 3515, 3530, 3602, 3606, 3614, 3658, 3668, 3672, 3685, 3715, 3784, 3807, 3818, 3830, 3839, 3846, 3858, 3862, 4073], 'rational': [508], 'development': [509, 730, 3754], 'ratiometric': [511, 634, 919, 929, 964, 1082, 1124, 1146, 1201, 1792, 1818, 3184, 3598], 'with': [513, 636, 956, 1351, 1522, 1584, 1602, 1622, 1674, 1820, 1912, 2014, 2239, 2300, 2312, 2362, 2403, 2429, 2485, 2494, 2519, 2525, 2535, 2606, 2675, 2759, 2768, 2794, 2817, 2832, 2865, 2967, 2992, 3006, 3024, 3080, 3114, 3163, 3200, 3250, 3266, 3278, 3318, 3328, 3485, 3540, 3552, 3581, 3731], 'zero': [514], 'crosstalk': [516], 'remains': [517], 'challenging.': [518], 'Harnessing': [519], 'recent': [521], 'progress': [522], 'on': [523, 698, 1117, 1464, 1496, 1507, 3753], 'photophysical': [524], 'modulation': [525], 'xanthenoid': [527, 1168, 1224, 1258, 1349, 3610], 'fluorochromes,': [528], 'we': [529, 2564, 3524], 'propose': [530], 'powerful': [532], 'versatile': [534], 'probe': [535, 547, 602, 806, 855, 896, 901, 920, 938, 976, 1004, 1045, 1108, 1219, 1253, 1954, 2103, 2127, 2325, 2513, 2633, 2798, 2909, 3206, 3373, 3451, 3616, 3655], 'design': [536, 1153, 1200, 1220, 1254, 3595], 'principle,': [537], 'that': [538, 1050, 1192, 1212, 1759, 2173, 2548, 2566, 2851, 2876, 2936, 3285, 3456, 3617], 'is,': [539, 2174], '"bridging-group': [540, 1814], 'modification,"': [541], 'developed': [543, 1208], 'totalROX,': [544, 604, 2635, 2730], 'robust': [546], 'monitoring': [549, 671], 'total': [551, 2039, 3479, 3659], 'cellular': [552, 707, 719, 819, 1204, 2040, 3090, 3311, 3480, 3521, 3660], 'oxidative': [553, 565, 583, 664, 708, 720, 761, 770, 814, 868, 875, 1091, 1205, 1297, 1825, 1856, 1860, 2033, 2041, 2169, 2289, 2316, 2383, 2497, 2543, 2574, 2593, 2598, 2727, 2802, 3300, 3312, 3427, 3481, 3499, 3522, 3533, 3562, 3661, 3718], 'capacity.': [554, 2042, 3662], 'First,': [555, 927, 2121], 'totalRox': [556], 'affirmatively': [557], 'detected': [558], 'complete': [560], 'set': [561, 1543], 'biorelevant': [563, 3626], 'highly': [564, 884, 2496, 2592, 2789], 'species:': [566], 'per-acids': [567], '(2': [568, 790], 'e−),': [569, 572], 'radicals': [570], '(1': [571, 786, 2664, 2870], 'nitrosative': [573, 798], '(NO+)': [574, 799], 'species,': [575, 1206, 2498, 3428, 3628, 3635], 'singlet': [577, 793], 'oxygen': [578, 794, 846, 871], '(1O2).': [579], 'Nonoxidative': [580], 'or': [581, 900, 1016, 1090, 1164, 2446, 2665, 2686, 2963, 2984, 3733, 3757], 'mildly': [582], 'pro-oxidants,': [584], 'example,': [586, 1369], 'O2•–,': [587], 'H2O2,': [588, 1864], 'NO,': [589, 3646], 'ONOO–,': [590], 'ClO–': [592], 'were': [593, 619, 675, 1126, 1304, 1363, 1429, 1462, 1476, 1494, 1505, 1515, 1542, 1553, 1613, 1641, 1845, 1918, 2008, 2270, 3316, 3366, 3405, 3435, 3571], 'not': [594, 773, 857, 967, 1024, 1919, 1971, 2012, 2032, 2036, 2124, 2476, 2745, 2890, 3231, 3639], 'detected.': [595], 'Second,': [596, 970], 'absorption/fluorescence': [598], 'maxima': [599, 1800, 2922, 3670], '(': [603, 613, 1343, 1750, 1767, 1834, 2021, 2138, 2625, 2634, 2705, 3223, 3507, 3543, 3554, 3675], 'λabs/λem': [605, 615], '=': [606, 616, 1534, 1649, 1667, 1681, 1714, 1718, 1736, 1740, 1910, 2145, 2150, 2155, 2298, 2329, 2342, 2628, 2637, 3107, 3118, 3128, 3138, 3147, 3341, 3345, 3357, 3361], '425/525': [607], 'nm)': [608, 618, 1661, 2630, 2639, 3113, 3349, 3365], 'detection': [611, 979, 1053, 1057, 1267, 1341, 1743, 2069, 2261, 2450, 2514, 3673, 3689, 3700], 'product': [612, 980, 1054, 1111, 1268, 1342, 1744, 1964, 2070, 2339, 2624, 3387, 3459, 3674], 'Ox670,': [614, 2626], '650/675': [617], 'separated': [620, 1803], 'by': [621, 775, 780, 1031, 1443, 1451, 1572, 1615, 1804, 1973, 1976, 2287, 2552, 2642, 2695, 2702, 2717, 2740, 2862, 2880, 3159, 3193, 3504, 3574, 3621, 3640, 3678, 3783], 'ca.': [622, 1805], '225/150': [623, 1806, 3679], 'nm,': [624, 1716, 1738, 1807, 3343, 3359, 3680], 'respectively,': [625, 1808, 2361, 3681], 'which': [626, 1345, 1978, 2590, 3257], 'eliminated': [627, 2858], 'crosstalk.': [629, 1250, 1823, 3687], 'Third,': [630, 1039], 'it': [631, 3259], 'renders': [632], 'signal': [635, 1793, 2056], 'single': [638, 805], 'chromophore': [639], 'is': [641, 689, 727, 822, 939, 966, 1073, 1131, 1216, 1276, 1292, 1346, 1794, 1941, 1979, 2027, 2031, 2093, 2166, 2455, 2501, 2546, 2550, 2573, 2591, 2693, 2711, 2744, 2749, 2878, 3294, 3613, 3618, 3652, 3665, 3764, 3770, 3781], 'structurally': [642], 'succinct.': [643], 'TotalROX': [644, 2600, 2710, 3210, 3244, 3612, 3697, 3708], 'allowed': [645], 'analysis': [647], 'was': [649, 1331, 1406, 1413, 1441, 1449, 1570, 1596, 1683, 1700, 1745, 1765, 1829, 1897, 1927, 1937, 1970, 1991, 2213, 2538, 2604, 2640, 2654, 2662, 2815, 2825, 2906, 3191, 3211, 3230, 3242, 3247, 3260, 3375, 3389, 3400, 3416, 3691, 3709], 'more': [650], 'sensitive': [651], 'than': [652, 994, 1049, 1944, 2060, 2729, 3704], 'Amplex': [653, 2523, 2761, 2769, 2836, 2899, 2979, 3015, 3058], 'Red': [654, 2524, 2770, 2905, 2915, 2980, 3016, 3491], 'CellROX': [656, 2530, 2903, 2913, 3083, 3093, 3489, 3575], 'Deep': [657, 2531, 2904, 2914, 3084, 3094, 3490, 3576], 'Red,': [658, 3577], 'two': [659, 1300, 2520, 3398, 3471, 3568, 3705], 'commercial': [660, 2430, 2797, 3706], 'cell': [663, 672, 680, 769, 3153, 3299, 3332, 3420, 3430, 3569], 'species.': [665, 876, 1298, 2317, 2369, 2384, 2544, 2803], 'Bioimaging': [666], 'potentials': [667, 3516], 'totalROX': [669, 1264, 1275, 1593, 1626, 1640, 1694, 1786, 1828, 1853, 1900, 1994, 2015, 2077, 2117, 2208, 2233, 2238, 2246, 2254, 2264, 2284, 2653, 2661, 2683, 2701, 2787, 2808, 2844, 2877, 2917, 2937, 2959, 3002, 3031, 3081, 3091, 3190, 3229, 3241, 3286, 3308, 3319, 3335, 3518, 3527, 3651, 3664, 3737], 'redox': [673, 820], 'status': [674, 821], 'exemplified': [676, 1030], 'in': [677, 729, 849, 886, 913, 1066, 1483, 1555, 1643, 1832, 1859, 1868, 1894, 1903, 2016, 2058, 2104, 2128, 2167, 2219, 2224, 2291, 2435, 2568, 2601, 2771, 2829, 3041, 3060, 3289, 3309, 3501, 3535, 3565, 3578, 3720, 3742, 3870, 3893, 3918, 3933, 3952, 3968], 'three': [678], 'different': [679, 1623, 2119, 2313], 'lines.': [681], 'Download': [682, 684, 877, 879, 1270, 1272, 2424, 2426, 3178, 3180], 'figure': [683, 878, 1271, 2425, 3179], 'PowerPoint': [685, 880, 1273, 2427, 3181], 'Introduction': [686], 'Redox': [687, 3916, 3934, 4056], 'homeostasis': [688], 'vital': [691], 'importance': [692], 'biological': [694, 724, 915, 3744], 'systems,': [695], 'and,': [696], 'depending': [697], 'their': [699, 889, 1129, 1798, 2168, 3582], 'nature': [700], 'spatiotemporal': [702], 'flux,': [703], 'roles': [705], 'species': [709, 847, 1619, 2096, 2290, 2704, 2792], 'may': [710], 'vary': [711], 'from': [712, 870, 1365, 1408, 1415, 1517, 2652, 2835, 2898], 'signaling': [713], 'damaging.1–3': [715], 'accumulation': [717], 'damages': [721, 762], 'overtime': [722], 'impairs': [723], 'functions': [725], 'implicated': [728, 1858], 'chronic': [732], 'inflammation,': [733], 'diabetes,': [734], 'degenerative': [735], 'disorders,': [736], 'cancers,': [737], 'aging.4–13': [739], 'Intensive': [740], 'efforts': [741], 'have': [742, 2918, 3591], 'been': [743, 858, 1285], 'devoted': [744], 'developing': [746], 'better': [750], 'understanding': [751], 'firmly': [754], 'established': [755], 'yet': [756], 'loosely': [757], 'delineated': [758, 2782], 'causation': [759], 'between': [760, 974, 2617], 'associated': [765, 955], 'pathological': [766], 'conditions.14–17': [767], 'Mechanistically,': [768], 'injuries': [771], 'induced': [774, 2053], 'singular': [777], 'mechanism': [778, 2230, 2481, 2699, 3690], 'cumulative': [782], 'results': [783, 2834], 'radical': [785, 2703, 2715, 2743, 2791, 2883, 3642], 'e−)': [787, 791], 'chemistry,': [788, 792, 796], 'per-acid': [789], '(1O2)': [795], 'chemistry': [800], '(Figure': [801, 1007, 1241, 1281, 1887, 2646, 2777, 2823, 2838, 2884, 2901, 2942, 2949, 3291, 3377, 3391, 3463], '1).18': [802], 'Therefore,': [803, 1299], 'capable': [807, 828], 'detecting': [809, 830], 'all': [810, 3622], 'four': [811, 925, 3623], 'groups': [812, 1165, 1303, 3624], 'entities': [815], 'assessing': [817], 'superior': [823, 3654], 'existing': [826, 1143, 1228, 2796], 'subset': [832], '(e.g.,': [833], 'DCHF/DHR,19': [834], 'APF,20': [835], 'CellROX21).': [837], 'As': [838], 'diverse': [839], 'as': [840, 1081, 1230, 1354, 1607, 1778, 1928, 1930, 2159, 2303, 2556], 'fluorescent': [842, 3281], 'reactive': [845, 1618, 2790], 'literature,22,23': [851], 'such': [852, 936, 1227], 'one-for-all': [854], 'has': [856, 1284], 'reported': [859, 1600], 'our': [861], 'knowledge.': [862], 'Figure': [863, 1243, 1837, 2024, 2141, 2277, 2708, 2951, 3226, 3510, 3546, 3557], '1': [864, 1982, 2596, 3632], '|': [865, 1245, 2279, 2953], 'A': [866, 1017, 1671, 1889, 3263, 4019], 'simplified': [867], 'network': [869], 'various': [873, 1617, 1855, 2288, 2382], 'biodamaging': [874], 'bioimaging.24,25': [887], 'With': [888], 'capability,': [891], 'artifacts': [892], 'due': [893, 1772], 'uneven': [895, 898], 'loading,': [897], 'illumination,': [899], 'photobleaching': [902, 946, 2948], 'mitigated,': [904], 'thus,': [905], 'these': [906, 3567], 'advantageous': [909], 'complex': [914], 'milieu.': [916], 'Ideally,': [917], 'should': [921, 981, 991, 1046, 1112], 'meet': [922], 'following': [924], 'criteria.': [926], 'monochromophoric': [928], 'preferred.': [932], 'size': [934], 'kept': [940], 'minimum': [943], 'preferential': [945], 'acceptor': [949], '(A)': [950], 'over': [951, 1445, 1453, 3221], 'donor': [953], '(D)': [954], 'dual-chromophric': [958], 'fluorescence': [959, 1336, 1550, 1589, 1843, 2351, 2619, 2649, 2671, 2757, 2821, 2860, 2896, 2940, 3075, 3185, 3305, 3331, 3370, 3447], 'resonance': [960], 'energy': [961, 1182], 'transfer': [962, 1121, 1239], '(FRET)-type': [963], 'probes26': [965], 'concern.': [969], 'be': [982, 992, 1047, 1113, 1196, 1748, 2273, 2467, 2492, 2828], 'large.': [983], 'To': [984, 3512], 'avoid': [985, 3684], 'larger': [993], 'full': [996], 'width': [997], 'at': [998, 1306, 1329, 1564, 1663, 1677, 1687, 1726, 1955, 1967, 2118, 2131, 2180, 2296, 2353, 2393, 2398, 2405, 2410, 2415, 2684], 'half': [999], 'maximum': [1000, 1676], '(FWHM)': [1001], 'emission': [1005, 1041, 1065, 1072, 1540, 1637, 1673, 1733, 2321, 2335, 3384], 'band': [1006, 1659, 1734, 1951, 1966], '2a).': [1008], 'protection/deprotection': [1012], 'D': [1015], 'D–π–A': [1020], 'type': [1021], 'fluorophore': [1022], 'do': [1023], 'usually': [1025, 2502], 'yield': [1026, 1135, 1591], 'large': [1028, 2751], 'separation,': [1029], 'classic': [1033], 'example': [1034], 'Fura-2': [1036], 'Ca2+.27': [1038], 'wavelength': [1042, 1064], 'shorter': [1048, 1063], 'because': [1055, 2575], 'accurate': [1056], 'increase': [1060, 1961, 3477], 'presence': [1068, 2500, 2570, 2853, 3045, 3064], 'long-wavelength': [1071], 'technically': [1074], 'cumbersome.': [1075], 'Many': [1076], 'dye-hemicyanine': [1077], 'hybrids': [1078], 'synthesized': [1080], 'harnessing': [1084], 'reactivity': [1086, 1313, 1851, 2111, 2252], 'toward': [1087, 1295, 1314, 1854, 2116, 2255, 2265, 2788, 2947], 'nucleophilic': [1088], 'addition': [1089, 2046, 2185, 2380], 'cleavage': [1092], 'double': [1095], 'bond.28,29': [1096], 'However,': [1097, 2179, 2488, 2563], 'they': [1098, 2122], 'typically': [1099, 3406], 'furnish': [1100], 'shorter-wavelength': [1102], 'emitting': [1103], 'product.': [1104], 'Fourth,': [1105], 'both': [1106, 1785, 2147, 3433, 3566], 'bright': [1114], 'fluorophores.': [1115, 1138], 'Based': [1116], 'excited-state': [1118], 'intramolecular': [1119], 'proton': [1120], '(ESIPT),': [1122], 'elegant': [1123], 'reported.30,31': [1127], 'Yet,': [1128], 'disadvantage': [1130], 'low-fluorescence': [1133], 'quantum': [1134, 1590], 'ESIPT-type': [1137], 'limitations': [1140], 'approaches': [1144], 'prompted': [1148], 'us': [1149], 'develop': [1151], 'alternative': [1152, 2507], 'principles.': [1154], 'Recently,': [1155], 'enhancing': [1156], 'electronegativity': [1159], 'bridging': [1162, 1356, 3607], 'atom': [1163], 'dyes': [1169], 'dramatically': [1170], 'lowers': [1171], 'highest': [1173], 'occupied': [1174], 'molecular': [1175, 1179], 'orbital': [1176, 1180], '(HOMO)–lowest': [1177], 'unoccupied': [1178], '(LUMO)': [1181], 'gap,': [1183], 'hence': [1185], 'redshifts': [1186], 'absorption/emission': [1188, 1799, 2066, 2075, 2921, 3669], 'maxima.32–36': [1189], 'We': [1190, 1210, 2107, 2504, 2848, 2934, 3302, 3487, 3590, 3735], 'envisage': [1191], 'this': [1193, 2105, 2489, 2722, 3749], 'phenomenon': [1194], 'can': [1195], 'judiciously': [1197], 'harnessed': [1198], 'totalROX.': [1209, 2196, 2754, 3100, 3164], 'note': [1211], 'bridging-group': [1214], 'modification': [1215], 'novel': [1218, 3594], 'principle': [1221, 3596], 'chromophores,': [1225], 'complementing': [1226], 'principles': [1229, 1255], 'push–pull': [1231], 'modification,37–39': [1232], 'conjugation': [1233], 'disruption,40,41': [1234], 'covalent-assembly,42–45': [1235], 'photo-induced': [1237], 'electron': [1238], '(PET)46–48': [1240], '2b).': [1242], '2': [1244, 1545, 3254, 3630], '(a)': [1246, 2391, 2954], 'Probe-product': [1247], '(b)': [1251, 2396, 2975], 'Four': [1252], 'applicable': [1256], 'fluorochromes.': [1259], '(c)': [1260, 2401, 2997], 'structure': [1262], 'its': [1266, 1312, 2733], '(Ox670).': [1269], 'Structurally,': [1274], 'substituted': [1278], 'anthracene': [1279], 'derivative': [1280], '2c).': [1282], 'Anthracene': [1283], 'routinely': [1286], 'used': [1287, 1432, 2663, 3526], 'trap': [1289], '1O2,': [1290, 2422, 3637], 'generally': [1293], 'unreactive': [1294], 'other': [1296, 2480], 'electron-donating': [1301, 3603], 'diethylamino': [1302], 'installed': [1305], 'C-2': [1307], 'C-7': [1309], 'promote': [1311, 1334], 'oxidation.': [1315], 'carboxyethyl': [1317], '(–CH2CH2COOH)': [1318], 'moiety': [1319], 'improved': [1320], 'aqueous': [1321, 2129], 'solubility': [1322], 'probe.': [1325, 2203, 2487], 'o-tolyl': [1327], 'group': [1328, 3608], 'C-10': [1330], 'introduced': [1332], 'brightness': [1337], 'proposed': [1340], 'Ox670),': [1344], 'first': [1348, 2719, 3248, 3615], 'dye': [1350, 1582], '–CR(OH)–': [1353], 'group.': [1357], 'Experimental': [1358], 'Methods': [1359], 'All': [1360, 1547], 'chemical': [1361], 'reagents': [1362], 'purchased': [1364, 1407, 1414, 1430], 'Chinese': [1366], 'suppliers,': [1367], 'Aladdin': [1370], '(Shanghai,': [1371, 1374, 1377, 1382, 1387, 1390, 1393, 1401], 'China);': [1372, 1375, 1378, 1383, 1388, 1391, 1394, 1397], 'Energy': [1373], 'Titan': [1376], 'TCI': [1379], 'Shanghai;': [1380], 'Macklin': [1381], 'Sinopharm': [1384], 'hemical': [1385], 'Reagent': [1386, 3492], 'Meryer': [1389], 'Adamas-beta': [1392], 'ZhongHe': [1395, 1409], 'Chemistry(Shanghai,': [1396], 'Xushuo': [1399, 1416], 'Biology': [1400], 'China).': [1402], 'Coumarin': [1403], '153': [1404], '(98%)': [1405], 'Chemistry.': [1410], 'Cy5': [1411], '(95%)': [1412], 'Biology.': [1417], 'analytical': [1419], 'grade': [1420], 'organic': [1421], 'solvents,': [1422], 'EtOAc,': [1423], 'MeOH,': [1424], 'CH2Cl2,': [1425], 'petroleum': [1427], 'ether': [1428], 'further': [1434, 2734, 3513], 'purification.': [1435], 'Anhydrous': [1436, 1447], 'tetrahydrofuran': [1437], '(THF)': [1438], 'reactions': [1440], 'obtained': [1442, 1450, 1516, 2493, 2674], 'distillation': [1444], 'benzophenone-sodium.': [1446], 'CH2Cl2': [1448], 'drying': [1452], 'CaH2.': [1454], '1H': [1456], 'NMR': [1457, 1460, 1474, 1756], '13C': [1459], 'spectra': [1461, 1475, 1493, 1504, 1514, 1551, 1576, 1638, 1757], 'collected': [1463, 1506, 2641, 3436], 'Bruker': [1466], 'AV-400': [1467], 'spectrometer.': [1468, 1500], 'chemicals': [1470], 'shifts': [1471], 'referenced': [1477], 'residual': [1480], 'solvent': [1481], 'peaks': [1482], 'unit': [1485], 'ppm.': [1487], 'high-resolution': [1489], 'mass': [1490, 3695], 'spectrometry': [1491], '(HRMS)': [1492], 'acquired': [1495, 1642, 2469], 'Micromass': [1498], 'GCT': [1499], 'UV–vis': [1502, 1511, 1634, 1840, 2309], 'absorption': [1503, 1548, 1575, 1635, 1658, 1841, 1950, 1965, 2310], 'SHIMADZU': [1509], 'UV-2600': [1510], 'spectrophotometer.': [1512], 'Fluorescence': [1513, 1610, 2955, 2976, 2998, 3012, 3027, 3055], 'PTI-QM4': [1519], 'steady-state': [1520, 2473], 'fluorimeter': [1521], '75': [1524], 'W': [1525], 'Xenon': [1526], 'arc-lamp': [1527], 'model': [1530], '810': [1531], 'PMT': [1532], '(voltage': [1533], '950': [1535], 'V).': [1536], 'excitation': [1538, 1686], 'slits': [1541], 'nm.': [1546, 1689], 'data': [1552, 2282, 2389], 'corrected': [1554], '50': [1556, 2687, 2964, 2985], 'mM': [1557, 1907, 2295], 'phosphate': [1558, 1644, 1698, 1904, 2292, 2602], 'buffer': [1559, 1645, 1905, 2130, 2293, 2603], 'containing': [1560, 1651], '1%': [1561, 1652, 1913, 2301], 'dimethylformamide': [1562], '(DMF)': [1563], 'pH': [1565, 1648, 1909, 2134, 2144, 2182, 2297], '7.4.': [1566], 'molar': [1568], 'absorptivity': [1569], 'calculated': [1571], 'fitting': [1573], 'serial': [1579], 'dilution': [1580], 'solutions': [1583], 'Beer–Lambert': [1586], 'equation.': [1587], 'Ox670': [1595, 1749, 1764, 1788, 2378, 2739, 3105, 3351], 'measured': [1597, 1684], 'per': [1598], 'literature': [1601, 3583], 'coumarin': [1603], '15349': [1604], 'Cy550': [1606], 'reference.': [1609], 'titration': [1611, 2281, 2311, 2322, 2336, 2388], 'conducted': [1614], 'adding': [1616], 'stock': [1620, 1890], 'solution': [1621, 1692, 1709, 1725, 1891, 2206], 'concentrations': [1624], 'solution.': [1627], 'Results': [1628], 'Discussion': [1630], 'Spectral': [1631, 2280], '(50': [1646, 1906, 2294, 3048, 3067, 3161, 3414], 'mM,': [1647], '7.4)': [1650, 1911, 2299], 'DMF.': [1653, 1914], 'It': [1654, 2079, 2545], 'had': [1655], 'broad': [1657], '(350–540': [1660], 'peaking': [1662], '425': [1664, 1688, 1956, 2330], 'nm': [1665, 1679, 1728, 1957, 1969, 2355, 2359], '(ɛ': [1666], '5100': [1668], 'cm−1': [1669, 1720], 'M−1).': [1670, 1721], 'green': [1672, 3280, 3338, 3369], '537': [1678], '(φ': [1680], '0.34)': [1682], 'upon': [1685, 2379, 2923, 3483], 'Into': [1690, 2204], '(5': [1695, 1901, 2285, 3245], 'μM,': [1696], 'neutral': [1697, 2181], 'buffer)': [1699], 'added': [1701, 1898, 1992, 2214, 3417], 'an': [1702, 2215, 2240, 2456, 2506, 2561, 2795, 3475], 'aliquot': [1703, 2216], 'hypochlorite': [1705], '(ClO−)': [1706], 'turned': [1710], 'light': [1711], 'aqua-blue': [1712], '(λabs': [1713], '650': [1715, 1727, 1968, 2343], 'ɛ': [1717], '42,600': [1719], 'Excitation': [1722], 'led': [1729], 'deep-red': [1732], '(λem': [1735], '670': [1737, 3362], 'φ': [1739], '0.40).': [1741], 'characterized': [1746], 'Supporting': [1751, 1768, 1835, 2022, 2139, 2706, 3224, 3508, 3544, 3555, 3760, 3762], 'Information': [1752, 1769, 1836, 2023, 2140, 2707, 3225, 3509, 3545, 3556, 3761, 3763, 3778], 'Figures': [1753, 1770], 'S1–S11).': [1754], 'showed': [1758, 2764], 'MeOH': [1761, 1777], 'analogue': [1762], 'isolated': [1766], 'S37–S39)': [1771], 'use': [1775, 2677], 'cosolvent': [1780], 'chromatographic': [1782], 'isolation.': [1783], 'Since': [1784], 'fluorescent,': [1790], 'attainable.': [1795], 'In': [1796, 2001, 2043, 2755, 2886, 3182], 'addition,': [1797], 'widely': [1802], 'highlighting': [1809], 'strength': [1811], 'modification"': [1815], 'approach': [1816], 'minimal': [1821], 'potential': [1826, 2728, 2842], '0.24': [1830], 'V': [1831], 'CH3CN': [1833], 'S12).': [1838], 'titrations': [1844], 'carried': [1846], 'out': [1847], 'study': [1849, 3265], 'substrates': [1857], 'damages,': [1861], 'including': [1862, 3629], 'O2•−,': [1863, 1974], 'nitric': [1865], 'oxide': [1866], '(NO)': [1867], 'absence/presence': [1870], 'O2,': [1872], 'conjugate': [1874], 'acid/base': [1875], 'pairs': [1876], 'peroxynitrous': [1878], 'acid/peroxynitrite': [1879], '(HOONO/ONOO−),': [1880], 'hypochlorous': [1881], 'acid/hypochlorite': [1882], '(HOCl/ClO−),': [1883], 'HO•,': [1884, 2419], '1O2': [1886, 2256], '3).': [1888], 'KO2': [1893], 'anhydrous': [1895], 'DMF': [1896, 2302], 'into': [1899, 2247, 2713], 'μM)': [1902, 2212, 2286, 2810, 2965, 3004, 3018, 3162, 3246, 3321, 3415], 'changes': [1917, 2007], 'obvious': [1920, 3476], 'even': [1921], 'though': [1922], 'dose': [1924, 2314, 2366, 2659, 2681], 'O2•−': [1926, 1940, 2392, 2549, 2567, 2576], 'high': [1929, 2133, 2784, 2867], '100': [1931, 1989, 2399], 'eq': [1932, 2083], '(Figures': [1933, 1999, 2063, 2188, 2192, 2234, 2257], '3a1–3a5).': [1934], 'This': [1935, 2026, 2249, 2689, 2779, 3779], 'result': [1936, 2692], 'anticipated': [1938], 'since': [1939, 2029], 'reductive': [1942], 'rather': [1943], 'oxidative.51': [1945], 'decrease': [1947], 'minor': [1960], 'caused': [1972], 'HOO•,': [1977], 'potent': [1981], 'e−': [1983, 2597], 'oxidizing': [1984, 2368, 3627], 'agent.': [1985], 'H2O2': [1986, 2210, 2397], '(up': [1987], 'eq)': [1990], 'reacted': [1996], 'quite': [1997], 'sluggishly': [1998], '3b1–3b5).': [2000], '500': [2002], 's,': [2003], 'no': [2004, 3771], 'noticeable': [2005], 'observed.': [2009], 'NO': [2010, 2030, 2048, 2085, 2402], 'did': [2011, 2123, 2889], 'react': [2013], 'absence': [2018, 3043, 3062], 'O2': [2020], 'S14).': [2025, 3558], 'desirable': [2028], 'does': [2035, 2475], 'contribute': [2037], 'contrast,': [2044], 'under': [2049, 2929], 'aerobic': [2050], 'conditions': [2051], 'quickly': [2052, 2231], 'dramatic': [2055], 'change': [2057, 2348, 3306], 'less': [2059], '60': [2061, 3438], 's': [2062], '3c1–3c5).': [2064], 'rose': [2071], 'abruptly,': [2072], 'while': [2073], 'decreased.': [2078], 'took': [2080], 'approximately': [2081], '4': [2082, 2952], 'fully': [2087], 'activate': [2088], 'signal.': [2090], 'Likely,': [2091], 'N2O3': [2092], 'NO+': [2095, 3634], 'accounting': [2097], 'oxidation': [2100, 2698, 2735, 2924], 'scenario.': [2106], 'then': [2108, 3326], 'tested': [2109], 'OONO−': [2113, 2148, 2187], 'ClO−': [2115, 2153], 'pH.': [2120], 'oxidize': [2125], 'value': [2135], '12': [2137], 'S22).': [2142], 'At': [2143], '12,': [2146, 4058], '(pKa': [2149, 2154], '6.8)': [2151], '7.5)': [2156], 'predominantly': [2157, 3287], 'exist': [2158], 'anions': [2160], 'only': [2162], 'negligible': [2164, 3390], 'amount': [2165], 'conjugative': [2170, 2199], 'acid': [2171], 'form,': [2172], 'HOONO': [2175, 2409], 'HOCl,': [2177, 2267], 'respectively.': [2178, 2423, 3053, 3072], '7.4,': [2184], '3d1–3d5)': [2189], 'OCl−': [2191], '3e1–3e5)': [2193], 'instantaneously': [2194], 'oxidized': [2195, 2201, 2232, 2245, 2623, 2712, 2879, 3620], 'Obviously,': [2197], 'acids': [2200], '(100': [2211, 2989, 3021], 'Fe(ClO4)2': [2218], 'H2O.': [2220], '•OH': [2222], 'generated': [2223, 2551], 'situ': [2225], 'well-known': [2228], 'Fenton': [2229], '3f1–3f5).': [2235], 'Irradiation': [2236], 'infrared': [2241], 'photosensitizer': [2242], 'ECXf52': [2243], 'readily': [2244, 3212, 3619, 3712], 'Ox670.': [2248], 'confirmed': [2250], '3g1–3g5).': [2258], 'lower': [2260], 'limits': [2262], 'HOONO,': [2266], 'NO/O2': [2269], 'estimated': [2271], 'low': [2274, 3407], 'nM': [2275], 'range.': [2276], '3': [2278], 'cosolvent.': [2305], 'Column': [2306, 2318, 2332, 2345, 2370], '1:': [2307], '2:': [2319], 'channel': [2326, 3339, 3355, 3374, 3388, 3452, 3460], '(totalROX,': [2327], 'λex': [2328, 2341], 'nm).': [2331, 2344, 3144], '3:': [2333], '(Ox670,': [2340], '4:': [2346], 'intensity': [2352, 2941, 2977, 3013, 3056, 3076, 3448], '525': [2354], '(blue)': [2356], '675': [2358], '(red),': [2360], 'respect': [2363], '5:': [2371], 'kinetic': [2373, 2868], 'trace': [2374], 'formation': [2376], 'Rows': [2385], 'a–h': [2386], '300': [2394], 'eq,': [2395, 2400, 2407, 2412, 2417], 'air': [2404], '2.0': [2406, 2411, 2416], '(d)': [2408, 3011], '(e)': [2413, 3026], 'HClO': [2414], '(f)': [2418, 3054], '(g)': [2421, 3073], 'Comparisons': [2428], 'Detection': [2432], 'sensitivity,': [2433], 'either': [2434], 'form': [2437], 'dissociation': [2440], 'constant': [2441], '(KD)': [2442], 'equilibrium-based': [2444], 'sensors': [2445], 'limit': [2448], '(LOD)': [2451], 'activity-based': [2453], 'probes,': [2454, 2522, 3599], 'important': [2457], 'parameter': [2458], 'evaluate': [2460], "probe's": [2462], 'overall': [2463], 'performance': [2464], 'must': [2466], 'reliably': [2468], 'substrates,': [2471], 'whose': [2472, 2499], 'concentration': [2474], 'decay': [2477], 'any': [2479], 'reaction': [2484], 'property': [2490], 'cannot': [2491], 'transient.': [2503], 'adopted': [2505], 'method': [2508], 'qualitatively': [2510, 2781], 'assess': [2511], 'sensitivity:': [2515], 'side-by-side': [2517, 2927], 'comparison': [2518, 2928], 'known': [2521, 2547, 3295], 'horseradish': [2526], 'peroxidase': [2527], '(HRP)': [2528], 'Red.': [2532, 3085, 3095], 'Xanthine': [2533], 'oxidase': [2534], 'xanthine': [2536, 2611, 2812, 3038], '(XO/X)': [2537], 'standardized': [2540], 'source': [2541], 'XO/X': [2553, 2968, 2993, 3007], 'acts': [2555], 'reductant': [2558], 'instead': [2559], 'oxidant.': [2562], 'emphasize': [2565], 'XO': [2572, 2583, 2607, 3034], 'coordinates': [2577], 'metal': [2580, 2881], 'centers': [2581], 'afford': [2585], 'metal-based': [2587], 'peroxyl': [2588, 2882], 'radical,': [2589], 'elicits': [2595], 'chemistry.': [2599], 'mixed': [2605], '(0.4': [2608, 2969, 2994, 3035], 'mU)': [2609, 2990, 3022, 3049, 3068], '(0.05': [2612, 2813, 3039], 'mM),': [2613], 'ratio': [2616, 2651, 2673, 2957, 3000, 3029, 3395, 3467], 'intensities': [2620], 'λex/λem': [2627, 2636], '640/680': [2629], '425/537': [2638], 'plate': [2644], 'reader': [2645], '4a).': [2647], 'turn-on': [2650, 2672, 2822, 2861, 2897, 2956, 2999, 3028], 'higher': [2655, 2680, 2726, 2939, 2945, 3699], 'when': [2656, 2747], 'smaller': [2658], '5': [2666, 3148], 'μM),': [2667, 3033], 'compared': [2668, 2793], '10': [2685, 3167], 'μM.': [2688, 3236], 'seemingly': [2690], 'counterintuitive': [2691], 'rationalized': [2694], 'two-step': [2697], 'S1).': [2709], 'intermediate': [2716, 2723], 'radical.': [2720], 'Presumably,': [2721], 'exhibits': [2724, 3698], 'therefore,': [2732], 'final': [2738], 'second': [2742], 'favored': [2746], 'there': [2748], 'excess': [2752], 'comparison,': [2756, 2887], 'enhancement': [2758], 'Red/HRP': [2762, 2900, 3059], 'system': [2763], 'good': [2766, 3579], 'correlation': [2767], 'range': [2773], '1–10': [2775], 'μM': [2776, 3204], '4b).': [2778], 'experiment': [2780], 'sensitivity': [2785, 3701], '(Amplex': [2799], 'Red)': [2800], 'Then,': [2804, 3412], 'mixture': [2806], '(10': [2809, 3003, 3017, 3032, 3320], 'mM)': [2814, 2971, 2986, 3040], 'titrated': [2816], 'XO,': [2818], '4c)': [2824], 'found': [2826, 2850], 'excellent': [2830], 'agreement': [2831, 3580], 'Red/HPR': [2837], '4d),': [2839], 'confirming': [2840], 'studies.': [2847, 3745], 'also': [2849, 3473, 3525, 3572], 'superoxide': [2855, 2864, 3641], 'dismutase': [2856], '(SOD)': [2857], 'disproportionating': [2863], 'rate': [2869], '×': [2871], '109': [2872], 'M−1': [2873], 's−1)': [2874], 'proving': [2875], '4e).': [2885], 'SOD': [2888, 3047, 3066], 'inhibit': [2891], 'slightly': [2893], 'promoted': [2894], '4f).': [2902], 'another': [2907], 'reference': [2908], 'chosen': [2910], 'comparison.': [2912], 'almost': [2919], 'identical': [2920], 'facilitating': [2925], 'same': [2931], 'microscopic': [2932], 'setup.': [2933], 'noted': [2935], 'exhibited': [2938, 3474], '4g)': [2943], 'resistance': [2946], '4h).': [2950], '(1,': [2960, 2981], '5,': [2961, 2982, 3981], '10,': [2962, 2983], 'incubated': [2966, 2991, 3005, 3023, 3249, 3317], 'mU/0.05': [2970, 2995], '15': [2973, 3009, 3051, 3070, 3123, 3133, 3143, 3364], 'min.': [2974, 3010], 'HRP': [2988, 3020], 'mM).': [2996], 'XO/X.': [3025], 'mU),': [3036], 'min,': [3052, 3071, 3324, 3445], 'Average': [3074], 'cells': [3078, 3157, 3198, 3252, 3315, 3503, 3550, 3724, 3728], 'treated': [3079, 3158, 3539, 3551, 3730], '(h)': [3086], 'Photobleaching': [3087], 'kinetics': [3088], '(i)': [3096], 'Subcellular': [3097, 3237], 'localization': [3098, 3238], 'epi-fluorescence': [3102], 'images': [3103, 3333, 3431, 3468], '(λex/λem': [3106, 3117, 3127, 3137], '620': [3108], '±': [3109, 3111, 3120, 3122, 3130, 3132, 3140, 3142, 3347, 3363], '30/700': [3110], '38': [3112], 'MitoTracker': [3115, 3267], 'Green': [3116, 3126], '480': [3119, 3129, 3139], '20/527': [3121, 3131, 3141], 'nm),': [3124, 3134], 'LysoTracker': [3125, 3269], 'PEX14:EGFP': [3136], 'Scale': [3145, 3165], 'bar': [3146], 'μm.': [3149, 3168], '(j)': [3150], 'confocal': [3152], 'imaging': [3154, 3186, 3520], 'HCT116': [3156, 3314, 3502, 3549], 'menadione': [3160, 3413, 3732], 'bar:': [3166], '**P': [3169], '<': [3170, 3173, 3176], '0.01,': [3171], '***P': [3172], '0.001,': [3174], '****P': [3175], '0.0001.': [3177], 'vitro': [3183], 'cytotoxicity': [3188], 'assessed': [3192], 'incubating': [3194], 'human': [3195, 3721], 'colon': [3196], 'cancer': [3197], '(HCT116)': [3199, 3725], 'up': [3201, 3233], '40': [3203, 3235], '24': [3208], 'h.': [3209], 'membrane-permeable.': [3213], 'MTT': [3215], 'assay': [3216], 'yielded': [3217], 'viability': [3219], '95%': [3222], 'S23)': [3227], 'suggesting': [3228], 'cytotoxic': [3232], 'investigated.': [3243], 'HeLa': [3251], 'h,': [3255], 'during': [3256], 'time': [3258], 'partially': [3261], 'oxidized.': [3262], 'colocalization': [3264], 'Green,': [3268, 3270], 'peroxisomal': [3273], 'membrane': [3274], 'protein': [3275, 3282], '(PEX14)': [3276], 'fused': [3277], 'enhanced': [3279], '(EGFP)': [3283], 'revealed': [3284], 'localized': [3288], 'mitochondria': [3290], '4i).': [3292], 'Menadione': [3293], 'enhance': [3297], 'capacity.53': [3301], 'investigated': [3303, 3693], 'menadione-induced': [3310, 3496], 'stress.': [3313], '30': [3323], 'rinsed': [3327], 'buffer.': [3329], '(λex': [3340, 3356], '488': [3342], 'λem': [3344, 3360], '530': [3346], '20': [3348], 'red': [3354], '640': [3358], 'acquired.': [3367], 'strong': [3376], '4j,': [3378, 3392, 3464], 'top),': [3379], 'near-infrared': [3382], '(NIR)': [3383], 'middle).': [3393], 'channels': [3399, 3434, 3472], 'calculated,': [3401], 'values': [3404], 'except': [3408], 'some': [3410], 'hotspots.': [3411], 'culture': [3421], 'trigger': [3423], 'generation': [3425], 'every': [3437], 's.': [3439], 'Over': [3440], 'course': [3442], '14': [3444], 'steadily': [3453, 3461], 'decreased': [3454], 'increased': [3462], 'bottom).': [3465], 'capacity': [3482], 'treatment': [3484], 'menadione.': [3486], 'employed': [3488], 'verify': [3494], 'rise': [3497, 3531, 3560, 3716], 'stress': [3500, 3534, 3563, 3719], 'flow': [3505], 'cytometry': [3506], 'S24).': [3511], 'exhibit': [3514], 'status,': [3523], 'monitor': [3529, 3657], 'hepatocytes': [3536, 3727], '(PH5CH8': [3537], 'cells)': [3538], 'acetaminophen': [3541, 3586], '(APAP)': [3542], 'S25)': [3547], 'cisplatin': [3553], 'levels': [3564], 'models': [3570], 'verified': [3573], 'pharmacology': [3584], 'cisplatin.': [3588, 3734], 'Conclusion': [3589], 'devised': [3592], 'modulating': [3601], 'capability': [3604], 'dyes.': [3611], 'e−,': [3631, 3633], 'anion,': [3643], 'hydrogen': [3644], 'peroxide,': [3645], 'hypohalides,': [3647], 'peroxynitrite.': [3649], 'Hence,': [3650], 'Importantly,': [3663], 'ratiometric,': [3666], 'Ox670)': [3676], 'red-shifted': [3677], 'completely': [3683], 'thoroughly': [3692], 'spectrometry.': [3696], 'photostability': [3703], 'probes.': [3707], 'showcased': [3710], 'respond': [3713], 'colorectal': [3722], 'tumor': [3723], '(PH5CH8)': [3729], 'expect': [3736], 'find': [3739], 'practical': [3740], 'applications': [3741], 'cell-based': [3743], 'Future': [3746], 'endeavors': [3747], 'project': [3750], 'will': [3751], 'focus': [3752], 'organelle-': [3756], 'protein-targeting': [3758], 'analogs.': [3759], 'available.': [3765], 'Conflict': [3766], 'Interest': [3768], 'There': [3769], 'conflict': [3772], 'interest': [3774], 'report.': [3776], 'Funding': [3777], 'work': [3780], 'supported': [3782], 'National': [3785, 3820], 'Natural': [3786], 'Foundation': [3788, 3850], '(nos.': [3791, 3826, 3851], '21822805,': [3792], '21908065,': [3793], '31871430,': [3794], '81802979,': [3795], '818800585,': [3796], '8180032537),': [3798], 'Young': [3799], 'Medical': [3800, 3823], 'Talents': [3801], 'Training': [3802], 'Program': [3803, 3843], '(2018),': [3806], 'Commission': [3808, 3834], 'Technology': [3812, 3833], 'Municipality': [3815, 3837], '(no.': [3816], '18430711000),': [3817], 'Australian': [3819], 'Health': [3821, 4051, 4117], 'Research': [3824], 'Council': [3825], 'APP1126091': [3827], 'APP1125794),': [3829], 'International': [3841], 'Cooperation': [3842], '(18430711000),': [3844], 'Postdoctoral': [3848], '2019M651427': [3852], '2020T130197),': [3854], 'W.': [3855], 'acknowledges': [3857], 'financial': [3859], 'support': [3860], 'innovative': [3863], 'research': [3864], 'team': [3865], 'high-level': [3867], 'local': [3868], 'universities': [3869], 'Shanghai.': [3871], 'References': [3872], '1.': [3873], 'Calabrese': [3874], 'V.;': [3875, 4010], 'Cornelius': [3876], 'C.;': [3877, 3879], 'Mancuso': [3878], 'Lentile': [3880], 'R.;': [3881, 4040], 'Stella': [3882], 'A.': [3883, 3991, 4009], 'M.;': [3884, 3928, 3987, 4035], 'Butterfield': [3885], 'D.': [3886, 4110], 'A.Redox': [3887], 'Homeostasis': [3888, 3914, 4094], 'Stress': [3891, 3967, 4015], 'Response': [3892], 'Aging': [3894], 'Neurodegeneration.Methods': [3896], 'Mol.': [3897], 'Biol.2010,': [3898], '610,': [3899], '285–308.': [3900], 'Google': [3901, 3924, 3942, 3962, 3983, 4003, 4031, 4060, 4086, 4104, 4123, 4154, 4184], 'Scholar': [3902, 3925, 3943, 3963, 3984, 4004, 4032, 4061, 4087, 4105, 4124, 4155, 4185], '2.': [3903], 'Ray': [3904], 'P.': [3905, 4162, 4166], 'D.;': [3906, 4137], 'B.-W.;': [3908], 'Tsuji': [3909], 'Y.Reactive': [3910], 'Oxygen': [3911, 4174], 'Species': [3912, 4175], '(ROS)': [3913, 4176], 'Regulation': [3917, 4044], 'Signaling.Cell.': [3920], 'Signal.2012,': [3921], '24,': [3922, 3940], '981–990.': [3923], '3.': [3926], 'Schieber': [3927], 'Chandel': [3929], 'N.': [3930], 'S.ROS': [3931], 'Function': [3932], 'Signaling': [3935], 'Oxidative': [3937, 3956], 'Stress.Curr.': [3938], 'Biol.2014,': [3939], '453–462.': [3941], '4.': [3944], 'Berlett': [3945], 'B.': [3946, 4092], 'S.;': [3947], 'Stadtman': [3948], 'E.': [3949], 'R.Protein': [3950], 'Oxidation': [3951], 'Aging,': [3953, 4147], 'Disease,': [3954], 'Stress.J.': [3957], 'Biol.': [3958, 4082], 'Chem.1997,': [3959], '272,': [3960], '20313–20316.': [3961], '5.': [3964], 'Förstermann': [3965], 'U.Oxidative': [3966], 'Vascular': [3969], 'Disease:': [3970], 'Causes,': [3971], 'Defense': [3972], 'Mechanisms': [3973], 'Potential': [3975], 'Therapies.Nat.': [3976], 'Clin.': [3977, 3997], 'Pract.': [3978], 'Cardiovasc.': [3979], 'Med.2008,': [3980], '338–349.': [3982], '6.': [3985], 'Navab': [3986], 'Gharavi': [3988], 'N.;': [3989], 'Watson': [3990], 'D.Inflammation': [3992], 'Metabolic': [3994], 'Disorders.Curr.': [3995], 'Opin.': [3996, 4099], 'Nutr.': [3998], 'Metab.': [3999], 'Care2008,': [4000], '11,': [4001], '459–464.': [4002], '7.': [4005], 'Uttara': [4006], 'B.;': [4007], 'Singh': [4008], 'Zamboni': [4011], 'P.;': [4012], 'Mahajan': [4013], 'R.Oxidative': [4014], 'Neurodegenerative': [4017], 'Diseases:': [4018], 'Review': [4020], 'Upstream': [4022], 'Downstream': [4024], 'Antioxidant': [4025], 'Therapeutic': [4026, 4054], 'Options.Curr.': [4027], 'Neuropharmacol.2009,': [4028], '7,': [4029], '65–74.': [4030], '8.': [4033], 'He': [4036], 'H.;': [4037, 4163], 'Kelley': [4038], 'M.': [4039, 4042, 4159, 4167], 'Georgiadis': [4041], 'M.Redox': [4043], 'DNA': [4046], 'Repair:': [4047], 'Implications': [4048, 4115], 'Human': [4050], 'Cancer': [4053], 'Development.Antioxid.': [4055], 'Signal.2010,': [4057], '1247–1269.': [4059], '9.': [4062], 'Dasuri': [4063], 'K.;': [4064], 'Zhang': [4065], 'L.;': [4066, 4135], 'Keller': [4067], 'J.': [4068, 4170], 'N.Oxidative': [4069], 'Stress,': [4070, 4146], 'Neurodegeneration,': [4071], 'Balance': [4074], 'Protein': [4076, 4079], 'Degradation': [4077], 'Synthesis.Free': [4080], 'Radical': [4081], 'Med.2013,': [4083], '62,': [4084], '170–185.': [4085], '10.': [4088], 'Agmon': [4089], 'E.;': [4090], 'Stockwell': [4091], 'R.Lipid': [4093], 'Regulated': [4096], 'Cell': [4097], 'Death.Curr.': [4098], 'Chem.': [4100], 'Biol.2017,': [4101], '39,': [4102], '83–89.': [4103], '11.': [4106], 'Go': [4107], 'Y.-M.;': [4108], 'Jones': [4109], 'P.Redox': [4111], 'Theory': [4112], 'Aging:': [4114], 'Disease.Clin.': [4119], 'Sci.2017,': [4120], '131,': [4121], '1669–1688.': [4122], '12.': [4125], 'Liguori': [4126], 'I.;': [4127], 'Russo': [4128], 'G.;': [4129, 4133, 4139, 4141], 'Curcio': [4130], 'F.;': [4131, 4143, 4168], 'Bulli': [4132], 'Aran': [4134], 'Della-Morte': [4136], 'Gargiulo': [4138], 'Testa': [4140], 'Cacciatore': [4142], 'Bonaduce': [4144], 'D.Oxidative': [4145], 'Diseases.Clin.': [4149], 'Interv.': [4150], 'Aging2018,': [4151], '13,': [4152], '757.': [4153], '13.': [4156], 'Volpe': [4157], 'C.': [4158, 4188], 'O.;': [4160], 'Villar-Delfino': [4161], 'dos': [4164], 'Anjos': [4165], 'Nogueira-Machado': [4169], 'A.Cellular': [4171], 'Death,': [4172], 'Reactive': [4173], 'Diabetic': [4178], 'Complications.Cell': [4179], 'Death': [4180], 'Dis.2018,': [4181], '9,': [4182], '1–9.': [4183], '14.': [4186], 'Winterbourn': [4187], 'C.Reconcili': [4189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3091202990', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-12T12:59:43.511526', 'created_date': '2020-10-08'}