Title: Strategic Therapies with Epigenetic Drugs: A Review
Abstract:With recent advances in DNA sequencing (high-throughput analysis), researchers have been able to examine epigenetic changes across the whole genome, and recent studies have shown that epigenetics play...With recent advances in DNA sequencing (high-throughput analysis), researchers have been able to examine epigenetic changes across the whole genome, and recent studies have shown that epigenetics play a central role in many types of diseases.Epigenetic variations have been found in various pathologies and their involvement in the cancerous transformation has been demonstrated.Given that epigenetic dysregulation is potentially reversible and given that many diseases have an epigenetic etiology, the researchers hypothesized that inhibition epigenetic changes may have therapeutic potential.This is what has encouraged the development of new pharmacological opportunities that can be defined with the term "epigenetic therapy".A number of epigenetic drugs have already been approved or are currently undergoing clinical trials.This paper is a review of the literature to illustrate the therapeutic potential of these drugs and evaluate their clinical application.Read More