Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors

Name: Work Video:
Duration: 3 min 30 s
Rhiannon Bates; Wei Huang; Lei Cao
{'id': 'https://openalex.org/W3088327373', 'doi': 'https://doi.org/10.1016/j.omtm.2020.09.009', 'title': 'Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors', 'display_name': 'Adipose Tissue: An Emerging Target for Adeno-associated Viral Vectors', 'publication_year': 2020, 'publication_date': '2020-09-20', 'ids': {'openalex': 'https://openalex.org/W3088327373', 'doi': 'https://doi.org/10.1016/j.omtm.2020.09.009', 'mag': '3088327373', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33102616', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7566077'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtm.2020.09.009', 'pdf_url': 'https://www.cell.com/article/S2329050120301947/pdf', 'source': {'id': 'https://openalex.org/S2764588101', 'display_name': 'Molecular Therapy — Methods & Clinical Development', 'issn_l': '2329-0501', 'issn': ['2329-0501'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.cell.com/article/S2329050120301947/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112158689', 'display_name': 'Rhiannon Bates', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rhiannon Bates', 'raw_affiliation_strings': ['Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008771021', 'display_name': 'Wei Huang', 'orcid': 'https://orcid.org/0000-0002-1775-6512'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Huang', 'raw_affiliation_strings': ['Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059711692', 'display_name': 'Lei Cao', 'orcid': 'https://orcid.org/0000-0003-0322-4985'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Lei Cao', 'raw_affiliation_strings': ['Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cancer Biology & Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}, {'raw_affiliation_string': 'The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA', 'institution_ids': ['https://openalex.org/I52357470']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5059711692'], 'corresponding_institution_ids': ['https://openalex.org/I52357470'], 'apc_list': {'value': 3200, 'currency': 'USD', 'value_usd': 3200, 'provenance': 'doaj'}, 'apc_paid': {'value': 3200, 'currency': 'USD', 'value_usd': 3200, 'provenance': 'doaj'}, 'fwci': 0.767, 'has_fulltext': False, 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.999119, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '19', 'issue': None, 'first_page': '236', 'last_page': '249'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tissue-tropism', 'display_name': 'Tissue tropism', 'score': 0.7883618}, {'id': 'https://openalex.org/keywords/adeno-associated-virus', 'display_name': 'Adeno-associated virus', 'score': 0.43354416}], 'concepts': [{'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.9352366}, {'id': 'https://openalex.org/C33602714', 'wikidata': 'https://www.wikidata.org/wiki/Q7809666', 'display_name': 'Tissue tropism', 'level': 4, 'score': 0.7883618}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.57966065}, {'id': 'https://openalex.org/C151955695', 'wikidata': 'https://www.wikidata.org/wiki/Q654528', 'display_name': 'White adipose tissue', 'level': 3, 'score': 0.5637106}, {'id': 'https://openalex.org/C35693153', 'wikidata': 'https://www.wikidata.org/wiki/Q239762', 'display_name': 'Tropism', 'level': 3, 'score': 0.54304785}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.5430107}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.46976992}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.44016117}, {'id': 'https://openalex.org/C2778107364', 'wikidata': 'https://www.wikidata.org/wiki/Q355989', 'display_name': 'Adeno-associated virus', 'level': 5, 'score': 0.43354416}, {'id': 'https://openalex.org/C92087593', 'wikidata': 'https://www.wikidata.org/wiki/Q427389', 'display_name': 'Vector (molecular biology)', 'level': 4, 'score': 0.38921028}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.32280177}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.30280247}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1803248}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.15763527}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.097841024}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtm.2020.09.009', 'pdf_url': 'https://www.cell.com/article/S2329050120301947/pdf', 'source': {'id': 'https://openalex.org/S2764588101', 'display_name': 'Molecular Therapy — Methods & Clinical Development', 'issn_l': '2329-0501', 'issn': ['2329-0501'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/b7d8105fef524878865d5b47faffee75', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7566077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33102616', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.omtm.2020.09.009', 'pdf_url': 'https://www.cell.com/article/S2329050120301947/pdf', 'source': {'id': 'https://openalex.org/S2764588101', 'display_name': 'Molecular Therapy — Methods & Clinical Development', 'issn_l': '2329-0501', 'issn': ['2329-0501'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'AG041250'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA166590'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'CA163640'}], 'datasets': [], 'versions': [], 'referenced_works_count': 125, 'referenced_works': ['https://openalex.org/W1153412892', 'https://openalex.org/W1504723104', 'https://openalex.org/W1505196125', 'https://openalex.org/W1512875938', 'https://openalex.org/W1963623233', 'https://openalex.org/W1964959966', 'https://openalex.org/W1965079305', 'https://openalex.org/W1965786463', 'https://openalex.org/W1967200408', 'https://openalex.org/W1985040895', 'https://openalex.org/W1988152924', 'https://openalex.org/W1988777057', 'https://openalex.org/W1991845771', 'https://openalex.org/W1995324236', 'https://openalex.org/W1997746648', 'https://openalex.org/W1998177393', 'https://openalex.org/W2005827500', 'https://openalex.org/W2008150005', 'https://openalex.org/W2008207428', 'https://openalex.org/W2009330135', 'https://openalex.org/W2014018936', 'https://openalex.org/W2016108853', 'https://openalex.org/W2016855436', 'https://openalex.org/W2025728946', 'https://openalex.org/W2026039549', 'https://openalex.org/W2033115423', 'https://openalex.org/W2034958364', 'https://openalex.org/W2035101755', 'https://openalex.org/W2040328785', 'https://openalex.org/W2045117117', 'https://openalex.org/W2047608515', 'https://openalex.org/W2047667011', 'https://openalex.org/W2051072233', 'https://openalex.org/W2052424035', 'https://openalex.org/W2057548071', 'https://openalex.org/W2065258739', 'https://openalex.org/W2065380345', 'https://openalex.org/W2065821427', 'https://openalex.org/W2077186175', 'https://openalex.org/W2082360533', 'https://openalex.org/W2084656248', 'https://openalex.org/W2086500311', 'https://openalex.org/W2087396336', 'https://openalex.org/W2098880579', 'https://openalex.org/W2103918419', 'https://openalex.org/W2111124876', 'https://openalex.org/W2112004869', 'https://openalex.org/W2112702228', 'https://openalex.org/W2113444875', 'https://openalex.org/W2113637218', 'https://openalex.org/W2119625192', 'https://openalex.org/W2121791963', 'https://openalex.org/W2122236774', 'https://openalex.org/W2126400402', 'https://openalex.org/W2126812330', 'https://openalex.org/W2133112334', 'https://openalex.org/W2134766536', 'https://openalex.org/W2139166113', 'https://openalex.org/W2140523898', 'https://openalex.org/W2143271015', 'https://openalex.org/W2145365087', 'https://openalex.org/W2148245224', 'https://openalex.org/W2148537305', 'https://openalex.org/W2149757665', 'https://openalex.org/W2149778261', 'https://openalex.org/W2154329712', 'https://openalex.org/W2157125849', 'https://openalex.org/W2158079900', 'https://openalex.org/W2161582292', 'https://openalex.org/W2166540858', 'https://openalex.org/W2166739815', 'https://openalex.org/W2169845602', 'https://openalex.org/W2210547729', 'https://openalex.org/W2212034801', 'https://openalex.org/W2233798936', 'https://openalex.org/W2256554417', 'https://openalex.org/W2266837556', 'https://openalex.org/W2283176855', 'https://openalex.org/W2285742659', 'https://openalex.org/W2290621892', 'https://openalex.org/W2398436462', 'https://openalex.org/W2475768353', 'https://openalex.org/W2508778705', 'https://openalex.org/W2520032353', 'https://openalex.org/W2550119581', 'https://openalex.org/W2558431515', 'https://openalex.org/W2560576333', 'https://openalex.org/W2571393656', 'https://openalex.org/W2587002666', 'https://openalex.org/W2588757737', 'https://openalex.org/W2610125817', 'https://openalex.org/W2614098846', 'https://openalex.org/W2620406790', 'https://openalex.org/W2706983644', 'https://openalex.org/W2738579800', 'https://openalex.org/W2753323627', 'https://openalex.org/W2763207225', 'https://openalex.org/W2767825527', 'https://openalex.org/W2774511679', 'https://openalex.org/W2783265227', 'https://openalex.org/W2791408070', 'https://openalex.org/W2881519211', 'https://openalex.org/W2912631497', 'https://openalex.org/W2912684492', 'https://openalex.org/W2913212173', 'https://openalex.org/W2915035571', 'https://openalex.org/W2935889084', 'https://openalex.org/W2951400985', 'https://openalex.org/W2954368479', 'https://openalex.org/W2954423091', 'https://openalex.org/W2964737681', 'https://openalex.org/W2969759941', 'https://openalex.org/W2972588675', 'https://openalex.org/W2977044516', 'https://openalex.org/W2985194635', 'https://openalex.org/W2991022372', 'https://openalex.org/W2991520000', 'https://openalex.org/W2992974653', 'https://openalex.org/W2995575022', 'https://openalex.org/W2999858469', 'https://openalex.org/W3000219265', 'https://openalex.org/W3004887743', 'https://openalex.org/W4206826545', 'https://openalex.org/W4242474094', 'https://openalex.org/W4391962668'], 'related_works': ['https://openalex.org/W4366091465', 'https://openalex.org/W4319761902', 'https://openalex.org/W2924149018', 'https://openalex.org/W2510758757', 'https://openalex.org/W2384093552', 'https://openalex.org/W2174387488', 'https://openalex.org/W2037673317', 'https://openalex.org/W2001397790', 'https://openalex.org/W1594053245', 'https://openalex.org/W138586086'], 'abstract_inverted_index': {'Adipose': [0, 171, 2070, 2416, 2437, 2570, 2787, 2943], 'tissue': [1, 27, 54, 78, 154, 172, 198, 225, 249, 325, 846, 2071, 2081, 2086, 2214, 2250, 2290, 2438, 2571, 2592, 2719, 2788, 2944, 2952, 3150, 3272, 3411, 3418, 3447, 3495, 4154, 4180, 4261], 'is': [2, 173, 366, 469, 539, 757, 1091, 1151, 1212, 1428, 1539, 1563, 1597, 1880, 2072, 2118, 2137, 2306, 2439, 2482, 2575, 2609, 2621, 2738, 2751, 2789, 2932, 2968, 3291, 3392, 3397, 4292], 'one': [3, 174, 371, 3292], 'of': [4, 15, 93, 104, 175, 186, 264, 275, 372, 381, 432, 439, 504, 547, 568, 600, 664, 710, 731, 800, 845, 883, 976, 1066, 1155, 1251, 1268, 1303, 1364, 1376, 1425, 1453, 1478, 1486, 1527, 1702, 1710, 1972, 2061, 2097, 2113, 2120, 2145, 2211, 2320, 2349, 2441, 2471, 2543, 2581, 2587, 2604, 2614, 2659, 2679, 2684, 2692, 2755, 2902, 2947, 2982, 3020, 3051, 3088, 3112, 3165, 3171, 3204, 3226, 3299, 3304, 3307, 3312, 3322, 3328, 3401, 3430, 3470, 3602, 3682, 3689, 3697, 3720, 3736, 3742, 3855, 3887, 3923, 3969, 4010, 4203, 4237, 4243, 4251, 4277], 'the': [5, 37, 60, 94, 121, 138, 176, 208, 231, 265, 292, 309, 373, 464, 573, 644, 662, 708, 863, 881, 999, 1088, 1193, 1199, 1228, 1266, 1283, 1368, 1429, 1450, 1462, 1484, 1525, 1535, 1543, 1703, 1708, 1975, 2059, 2106, 2127, 2140, 2155, 2347, 2541, 2602, 2612, 2752, 2928, 3163, 3174, 3305, 3310, 3350, 3395, 3428, 3559, 3679, 3687, 3718, 3725, 3734, 3782, 3885, 4079, 4194, 4248, 4255, 4285], 'largest': [6, 177], 'organs,': [7, 178], 'playing': [8, 179], 'important': [9, 180, 348, 470], 'roles': [10, 181], 'in': [11, 36, 91, 95, 123, 182, 207, 262, 266, 294, 350, 391, 393, 572, 643, 682, 823, 862, 880, 912, 982, 1072, 1102, 1123, 1146, 1198, 1265, 1354, 1674, 1751, 1756, 1823, 2105, 2126, 2134, 2139, 2160, 2215, 2251, 2291, 2346, 2404, 2546, 2551, 2626, 2791, 2840, 2868, 2950, 3016, 3159, 3234, 3457, 3532, 3558, 3733, 3758, 3760, 3790, 3881, 3884, 3944, 4020, 4047, 4099, 4101, 4247, 4266, 4284], 'physiology': [12, 183], 'and': [13, 41, 65, 87, 110, 115, 131, 140, 145, 155, 168, 184, 212, 236, 258, 281, 286, 302, 311, 316, 326, 339, 353, 359, 370, 463, 552, 667, 677, 702, 718, 759, 805, 831, 840, 855, 908, 920, 1001, 1049, 1126, 1220, 1253, 1350, 1373, 1399, 1449, 1465, 1503, 1518, 1524, 1660, 1669, 1746, 1777, 1785, 1792, 1810, 1978, 1980, 2064, 2083, 2093, 2108, 2129, 2142, 2157, 2209, 2309, 2317, 2354, 2369, 2419, 2443, 2459, 2464, 2473, 2489, 2583, 2682, 2698, 2721, 2742, 2796, 2837, 2899, 2979, 3012, 3049, 3082, 3086, 3117, 3142, 3161, 3317, 3320, 3345, 3352, 3357, 3378, 3394, 3413, 3423, 3432, 3448, 3462, 3552, 3621, 3650, 3739, 3784, 3836, 3841, 4037, 4078, 4086, 4166, 4191, 4216, 4241, 4281, 4295], 'pathologies': [14, 185], 'multiple': [16, 187, 1314, 4289], 'diseases.': [17, 188], 'However,': [18, 189, 1331, 2058, 3309, 4148, 4227, 4287], 'research': [19, 167, 190, 338, 355, 1454], 'related': [20, 191], 'to': [21, 52, 57, 75, 107, 142, 160, 192, 223, 228, 246, 278, 313, 331, 639, 733, 825, 1031, 1094, 1205, 1214, 1257, 1367, 1431, 1530, 1541, 1584, 1632, 1749, 1821, 2362, 2374, 2677, 2802, 2846, 3080, 3115, 3153, 3382, 3415, 3444, 3556, 3572, 3618, 4052, 4152, 4161, 4254, 4258], 'adeno-associated': [22, 193, 506, 574, 601, 801, 938, 977, 1067, 1306, 1437, 1567, 1601, 1713, 1788, 1851, 1886, 1909, 1947, 2008, 2042, 2661, 3820, 3927, 3973, 4017], 'virus': [23, 194, 343, 419, 507, 535, 575, 602, 633, 751, 802, 1120, 1171, 1307, 1438, 1568, 1602, 1624, 1656, 1714, 1789, 1852, 1887, 1910, 2009, 2662, 3821, 3876, 3928, 3974, 4018, 4128], '(AAV)': [24, 195, 344, 536, 1308], 'targeting': [25, 196, 1469, 3416, 4224], 'adipose': [26, 53, 77, 129, 153, 162, 197, 224, 248, 300, 324, 333, 1208, 1470, 2080, 2085, 2114, 2213, 2249, 2289, 2322, 2591, 2718, 2951, 3149, 3155, 3271, 3376, 3410, 3417, 3446, 3453, 3494, 3528, 4153, 4179, 4186, 4225, 4260], 'has': [28, 55, 199, 226, 1261, 4155], 'been': [29, 73, 89, 200, 244, 260, 838, 1045, 1203, 1262, 1819, 3465, 3668, 3788, 4084, 4156], 'left': [30, 201], 'far': [31, 85, 202, 256], 'behind': [32, 203], 'studies': [33, 204, 1964, 3145], 'carried': [34, 205], 'out': [35, 206], 'liver,': [38, 209, 4073, 4214], 'brain,': [39, 210], 'heart,': [40, 211, 4074, 4215], 'muscle.': [42, 213], 'Despite': [43, 214], 'initial': [44, 215], 'reports': [45, 216, 1332], 'indicating': [46, 217, 2695], 'poor': [47, 218], 'performance,': [48, 219], 'AAV-mediated': [49, 220, 392, 3409, 3759, 4100, 4149], 'gene': [50, 105, 221, 276, 351, 363, 395, 656, 688, 886, 947, 1147, 1177, 1250, 1365, 1754, 2402, 3198, 3274, 3306, 3441, 3497, 3525, 3574, 3762, 3822, 3878, 4054, 4090, 4103, 4134, 4150, 4181], 'delivery': [51, 222, 1375, 3275, 3442, 3498, 4019, 4151, 4234], 'continued': [56, 227], 'rise': [58, 229], 'during': [59, 230, 2611, 3009, 3237], 'past': [61, 232], 'two': [62, 233, 446, 665, 2076], 'decades.': [63, 234], 'AAV8': [64, 235, 3431], 'a': [66, 237, 357, 367, 377, 417, 424, 433, 640, 729, 843, 1141, 1174, 1278, 1304, 1479, 1490, 1505, 1509, 1564, 1598, 1711, 1881, 1906, 2101, 2111, 2150, 2444, 2469, 2624, 2689, 2804, 2969, 3017, 3121, 3331, 3433, 3440, 4049, 4131, 4157, 4207, 4221, 4278], 'novel': [67, 147, 238, 318, 1712, 3196, 3434], 'engineered': [68, 239, 1466, 3424, 3435], 'hybrid': [69, 240, 3436], 'serotype,': [70, 241, 1523, 3437], 'Rec2,': [71, 242, 3438], 'have': [72, 88, 243, 259, 837, 1044, 1202, 1817, 1965, 3464, 3667, 3787, 3833, 3939, 4083], 'shown': [74, 245, 1204], 'transduce': [76, 247, 1207, 1627, 3445, 3838], 'more': [79, 250, 1038, 4262], 'efficiently': [80, 251, 1206], 'than': [81, 252, 1039, 3399], 'other': [82, 253, 1981, 2405, 3346], 'serotypes': [83, 148, 254, 319, 549, 836, 853, 859, 916, 1197, 1316, 1581, 3422, 4205], 'so': [84, 255], 'tested': [86, 257], 'applied': [90, 261, 1034], 'most': [92, 263, 4196, 4202], 'vivo': [96, 267, 394, 1752, 3761, 4102], 'studies.': [97, 170, 268, 341], 'The': [98, 269, 428, 654, 686, 1743, 2922, 3167, 3287, 3390], 'Rec2': [99, 270], 'serotype': [100, 271, 1274, 1285, 1467, 1657, 4171, 4183], 'displays': [101, 272], 'high': [102, 273, 3118], 'efficacy': [103, 274], 'transfer': [106, 277, 1366, 1755, 3526], 'both': [108, 279, 1662, 3839], 'brown': [109, 280, 2084, 2121, 2212, 2248, 2288, 2321, 2544, 2553], 'white': [111, 282, 2079, 2098, 2547, 2874], 'fat': [112, 283, 2486, 2548, 2798, 2807, 2842, 2851, 2875, 2906, 2924, 2930, 3343, 3354, 3384, 4290, 4299], 'via': [113, 284], 'local': [114, 285], 'systemic': [116, 287, 2376], 'administration.': [117, 288], 'This': [118, 289, 3404], 'review': [119, 290, 3405], 'summarizes': [120, 291], 'advances': [122, 293], 'developing': [124, 295], 'AAV': [125, 157, 296, 328, 365, 429, 548, 683, 723, 835, 852, 1101, 1196, 1235, 1246, 1269, 1284, 1315, 1341, 1378, 1394, 1481, 1522, 1532, 1580, 1824, 1976, 2062, 3743, 4044, 4204, 4256], 'vectors': [126, 297, 345, 944, 1270, 1468, 1626, 3365, 3684, 3729, 3744], 'with': [127, 149, 298, 320, 376, 445, 725, 842, 1217, 1248, 1319, 1435, 1493, 1634, 1949, 2044, 2088, 2100, 2123, 2623, 2740, 2934, 3179, 3419, 3459, 3467, 3646, 4023, 4168], 'enhanced': [128, 299], 'tropism': [130, 150, 301, 321, 4167, 4184], 'restricting': [132, 303], 'off-target': [133, 304, 4218, 4274], 'transgene': [134, 163, 305, 334, 3233, 3380, 3714, 3942, 4013, 4188], 'expression.': [135, 306], 'We': [136, 307, 3426], 'discuss': [137, 308, 3427], 'challenges': [139, 310, 3414], 'strategies': [141, 312], 'search': [143, 314], 'for': [144, 152, 165, 315, 323, 336, 362, 423, 471, 544, 877, 945, 1143, 1176, 1231, 1566, 1588, 1600, 1667, 1850, 1883, 1908, 2007, 2736, 2953, 2973, 3162, 3670, 3712, 3926, 3972, 4089, 4133, 4178, 4185, 4199, 4210, 4223, 4297], 'generate': [146, 317], 'tailoring': [151, 322], 'develop': [156, 327], 'vector': [158, 329, 1172, 1280, 1311, 1352, 1426, 1459, 1482, 3648, 3877, 3888, 4045, 4129], 'systems': [159, 330], 'improve': [161, 332, 1750], 'expression': [164, 335, 1499, 2403, 3225, 3381, 3715, 3879, 3943, 4014, 4189], 'basic': [166, 337], 'translational': [169, 340], 'Adeno-associated': [342, 534, 632, 750, 1119, 1170, 1623, 1655, 3875, 4127], 'play': [346], 'an': [347, 541, 569, 711, 722, 735, 1498, 2337, 2359, 3046, 3227, 3367, 4238], 'role': [349, 3087, 3158], 'therapy': [352, 1178, 3575, 4135], 'biomedical': [354], 'as': [356, 421, 458, 943, 1173, 1344, 1552, 1806, 2149, 2336, 2358, 2477, 3273, 3349, 3439, 3496, 4130, 4213], 'safe': [358], 'effective': [360], 'method': [361], 'delivery.': [364], 'non-pathogenic': [368], 'parvovirus': [369], 'smallest': [374], 'viruses': [375, 939, 978, 1000, 1068, 1948, 2043, 3547], 'non-enveloped': [378], 'capsid': [379, 502, 545, 691, 724, 755, 803, 878, 1041, 1709, 2657], 'size': [380, 2580], '25': [382], 'nm.1Colella': [383], 'P.': [384, 1731, 2244, 2286, 3000, 3257, 3261, 3263, 3480, 3484, 3486, 3751, 4006, 4092], 'Ronzitti': [385, 3752, 4093], 'G.': [386, 631, 962, 1052, 1169, 1391, 1926, 2021, 2192, 2415, 3638, 3753, 3902, 3918, 3948, 3964, 4002, 4094, 4126], 'Mingozzi': [387, 3754, 4042, 4095], 'F.': [388, 478, 1291, 2633, 3755, 4043, 4096], 'Emerging': [389, 3756, 4097], 'issues': [390, 3757, 4098], 'therapy.Mol.': [396, 3763, 4104], 'Ther.': [397, 888, 1380, 1401, 3278, 3501, 3577, 3764, 4028, 4056, 4105], 'Methods': [398, 889, 3765, 4106], 'Clin.': [399, 890, 1758, 2422, 3766, 3824, 4107], 'Dev.': [400, 891, 3767, 4108], '2017;': [401, 555, 2407, 3768, 4109], '8:': [402, 3769, 4110], '87-104Abstract': [403, 3770, 4111], 'Full': [404, 406, 895, 897, 1405, 1407, 2177, 2179, 2427, 2429, 2517, 2519, 2560, 2562, 2777, 2779, 2824, 2826, 2912, 2914, 3027, 3029, 3130, 3132, 3581, 3583, 3771, 3773, 4060, 4062, 4112, 4114], 'Text': [405, 407, 896, 898, 1406, 1408, 2178, 2180, 2428, 2430, 2518, 2520, 2561, 2563, 2778, 2780, 2825, 2827, 2913, 2915, 3028, 3030, 3131, 3133, 3582, 3584, 3772, 3774, 4061, 4063, 4113, 4115], 'PDF': [408, 899, 1409, 2181, 2431, 2521, 2564, 2781, 2828, 2916, 3031, 3134, 3585, 3775, 4064, 4116], 'PubMed': [409, 513, 558, 586, 613, 651, 773, 811, 900, 956, 989, 1079, 1133, 1186, 1326, 1384, 1410, 1444, 1576, 1610, 1642, 1683, 1721, 1763, 1798, 1857, 1893, 1918, 1958, 2014, 2053, 2182, 2224, 2260, 2300, 2329, 2410, 2432, 2522, 2565, 2668, 2727, 2782, 2829, 2880, 2917, 2961, 3032, 3059, 3095, 3135, 3211, 3244, 3282, 3505, 3541, 3586, 3612, 3659, 3703, 3776, 3829, 3865, 3899, 3935, 3981, 4032, 4065, 4117, 4143], 'Scopus': [410, 514, 559, 614, 774, 812, 901, 957, 990, 1080, 1134, 1187, 1327, 1385, 1411, 1445, 1684, 1722, 1764, 1799, 1858, 1894, 1919, 1959, 2015, 2054, 2183, 2225, 2261, 2301, 2330, 2411, 2433, 2523, 2566, 2669, 2728, 2783, 2830, 2881, 2918, 2962, 3033, 3060, 3136, 3212, 3245, 3283, 3506, 3542, 3587, 3613, 3660, 3704, 3777, 3866, 4033, 4066, 4118, 4144], '(197)': [411, 3778, 4119], 'Google': [412, 516, 561, 587, 616, 652, 776, 814, 903, 959, 992, 1082, 1136, 1189, 1329, 1387, 1413, 1447, 1577, 1611, 1643, 1686, 1724, 1766, 1801, 1860, 1896, 1921, 1961, 2017, 2056, 2185, 2227, 2263, 2303, 2332, 2413, 2435, 2525, 2568, 2671, 2730, 2785, 2832, 2883, 2920, 2964, 3035, 3062, 3096, 3138, 3214, 3247, 3285, 3508, 3544, 3589, 3615, 3662, 3706, 3779, 3830, 3868, 3900, 3936, 3982, 4035, 4068, 4120, 4146], 'Scholar': [413, 653, 815, 904, 1028, 1083, 1137, 1190, 1330, 1448, 1578, 1962, 2057, 2304, 2333, 2436, 2569, 2672, 2731, 2786, 2833, 2921, 2965, 3139, 3286, 3545, 3616, 3663, 3707, 3780, 3831, 3937, 3983, 4036, 4069, 4147], 'AAVs': [414, 1238, 3710, 3832, 4270], 'depend': [415], 'on': [416, 579, 1340, 1458, 1707, 1969, 3375, 3408], 'helper': [418, 1529], 'such': [420, 457, 1343, 1805, 3348, 4212], 'adenovirus': [422], 'productive': [425], 'infection': [426, 1884], 'cycle.': [427], 'genome': [430, 438, 684, 1247, 1312, 1353, 3722, 4257], 'consists': [431, 2096], 'linear': [434], 'single-stranded': [435], 'DNA': [436, 581, 597, 637, 1233, 3747, 3889], '(ssDNA)': [437], 'approximately': [440], '4.7': [441], 'or': [442, 2479, 2499, 2573, 2616, 2747, 3169, 3182, 3302, 3339, 3455], '4.9': [443], 'kb': [444], '145-nt': [447], 'palindromic': [448], 'inverted': [449], 'terminal': [450], 'repeats': [451], '(ITRs),': [452], 'which': [453, 468, 679, 1138, 2450], 'flank': [454], 'viral': [455, 580, 3364, 3573], 'genes,': [456], 'Rep': [459, 634, 655, 1287, 1513], '(replication),': [460], 'Cap': [461, 687, 1519], '(capsid),': [462], 'assembly-activating': [465, 499, 537, 2654], 'protein': [466, 500, 538, 696, 700, 705, 756, 2655, 3231], '(AAP),': [467], 'some,': [472], 'but': [473, 1672, 2549, 2606, 2629, 2757, 2926], 'not': [474, 540, 1630, 2550, 2607, 2630, 2758, 2927, 3335, 3360], 'all': [475], 'AAV,': [476, 1095, 1538], 'serotypes.2Sonntag': [477], 'Köther': [479, 2634], 'K.': [480, 482, 488, 523, 629, 1738, 1863, 2635, 2637, 2643, 3038, 3250, 3473, 4041], 'Schmidt': [481, 2636], 'Weghofer': [483, 2638], 'M.': [484, 621, 1689, 1697, 1740, 1773, 1934, 2029, 2272, 2278, 2384, 2386, 2639, 2994, 3067, 3109, 3255, 3478, 3514, 3591, 3630, 3844, 3906, 3952, 3987, 3989], 'Raupp': [485, 2640], 'C.': [486, 1293, 1556, 1590, 1865, 1899, 2388, 2641, 2893, 3065, 3567, 3991, 3998], 'Nieto': [487, 2642], 'Kuck': [489, 2644], 'A.': [490, 792, 1614, 1873, 2206, 2645, 2992, 3069, 3073, 3077, 3192, 3219, 3259, 3482, 3593, 3599, 3846, 3852, 3914, 3960, 3996], 'Gerlach': [491, 2646], 'B.': [492, 494, 784, 790, 1015, 2527, 2647, 2649, 2855, 3101, 3904, 3950], 'Böttcher': [493, 2648], 'Müller': [495, 2650], 'O.J.': [496, 2651], 'et': [497, 797, 1943, 2038, 2207, 2397, 2652, 3005, 3643, 3921, 3967, 4007], 'al.The': [498, 2653], 'promotes': [501, 2656], 'assembly': [503, 546, 2658], 'different': [505, 2660, 2873], 'serotypes.J.': [508, 2663], 'Virol.': [509, 554, 647, 769, 807, 985, 1075, 1322, 1440, 1572, 1606, 1638, 1679, 1717, 1794, 2664, 3931, 3977], '2011;': [510, 1130, 1760, 2665], '85:': [511, 2666], '12686-12697Crossref': [512, 2667], '(78)': [515, 2670], 'Scholar,': [517, 562, 588, 617, 960, 993, 1388, 1414, 1612, 1644, 1687, 1725, 1767, 1861, 1897, 1922, 2186, 2228, 2264, 3036, 3063, 3097, 3215, 3248], '3Earley': [518], 'L.F.': [519], 'Powers': [520], 'J.M.': [521, 936, 974, 1064, 1118, 1742, 2382, 2984, 3071], 'Adachi': [522], 'Baumgart': [524], 'J.T.': [525], 'Meyer': [526, 1827, 1984], 'N.L.': [527, 1828, 1985], 'Xie': [528], 'Q.': [529], 'Chapman': [530, 1843, 2000], 'M.S.': [531, 1844, 2001, 2715], 'Nakai': [532], 'H.': [533, 1106, 1295, 1620, 1940, 2035, 2704, 3518, 3522], 'essential': [542, 1848, 2005, 3152], 'requirement': [543, 1230], '4,': [550, 907], '5,': [551, 919], '11.J.': [553], '91': [556], '(e01980-16)Crossref': [557], '(34)': [560], '4Chejanovsky': [563], 'N.': [564, 749, 786, 995, 1646, 1695, 3801, 4000], 'Carter': [565], 'B.J.': [566], 'Mutagenesis': [567], 'AUG': [570], 'codon': [571], 'rep': [576], 'gene:': [577], 'effects': [578, 3374, 4219, 4275], 'replication.Virology.': [582], '1989;': [583], '173:': [584], '120-128Crossref': [585], '5King': [589], 'J.A.': [590, 596, 1393, 1654, 1699], 'Dubielzig': [591], 'R.': [592, 782, 796, 932, 970, 1060, 1104, 1110, 1924, 2019, 2274, 2394, 3624, 3920, 3966], 'Grimm': [593], 'D.': [594, 788, 1114, 1165, 2196, 3223, 3628, 3908, 3916, 3954, 3962, 4122], 'Kleinschmidt': [595], 'helicase-mediated': [598], 'packaging': [599, 1232], 'type': [603, 752, 1309, 1569, 1603, 1911, 2974], '2': [604, 753, 1286, 1310, 1570, 1604, 1912], 'genomes': [605, 1427], 'into': [606, 828, 1234, 1277, 1313, 2066, 2075, 3527, 3745], 'preformed': [607], 'capsids.EMBO': [608], 'J.': [609, 874, 934, 1112, 1618, 1652, 1834, 1867, 1991, 2219, 2255, 2270, 2280, 2295, 2324, 2709, 3054, 3090, 3099, 3105, 3626, 3891, 3994], '2001;': [610, 1680, 3538], '20:': [611, 1382], '3282-3291Crossref': [612], '(168)': [615], '6Surosky': [618], 'R.T.': [619], 'Urabe': [620], 'Godwin': [622], 'S.G.': [623], 'McQuiston': [624], 'S.A.': [625, 3872], 'Kurtzman': [626], 'G.J.': [627, 2240], 'Ozawa': [628, 3515], 'Natsoulis': [630], 'proteins': [635, 660, 672, 817], 'target': [636, 4245, 4259], 'sequences': [638], 'unique': [641], 'locus': [642], 'human': [645, 946, 983, 1048, 1073, 1089], 'genome.J.': [646], '1997;': [648], '71:': [649], '7951-7959Crossref': [650], 'encodes': [657], 'four': [658], 'regulatory': [659, 671, 1254, 1507], 'through': [661, 707, 1396, 2577], 'use': [663, 709, 1485, 3696, 4236], 'promoters': [666], 'alternative': [668, 712, 3293, 3369], 'splicing.': [669], 'These': [670, 3546], 'are': [673, 680, 818, 850, 979, 1037, 1069, 1227, 1473, 2068, 2152, 3151, 3548, 3554, 3748, 4193, 4220, 4264], 'Rep78,': [674], 'Rep68,': [675], 'Rep52,': [676], 'Rep40,': [678], 'involved': [681], 'replication.': [685, 1533], 'generates': [689], 'three': [690, 1487, 4195], 'proteins,': [692], 'i.e.,': [693, 2078], 'VP1': [694], '(virion': [695, 699, 704], '1),': [697], 'VP2': [698, 754], '2),': [701], 'VP3': [703, 719], '3),': [706], 'splice': [713], 'acceptor': [714], 'site.': [715], 'VP1,': [716], 'VP2,': [717], 'make': [720], 'up': [721, 1256, 2110, 2676], 'each': [726, 1273, 2841], 'subunit': [727], 'at': [728, 765, 856, 2734, 3045, 3330, 3386], 'ratio': [730], '1:1:10': [732], 'form': [734, 2348], 'icosahedron': [736], 'structure.7Warrington': [737], 'Jr.,': [738], 'K.H.': [739], 'Gorbatyuk': [740], 'O.S.': [741], 'Harrison': [742], 'J.K.': [743], 'Opie': [744], 'S.R.': [745], 'Zolotukhin': [746], 'S.': [747, 780, 866, 1693, 1826, 1869, 1938, 1983, 2033, 2190, 2284, 2859, 3217, 3510, 3516], 'Muzyczka': [748], 'nonessential': [758], 'can': [760, 1240, 2492, 3295, 3371, 3837, 4230], 'tolerate': [761], 'large': [762, 3984], 'peptide': [763], 'insertions': [764], 'its': [766, 1553, 1747, 3157], 'N': [767], 'terminus.J.': [768], '2004;': [770, 986, 1076, 1441], '78:': [771, 987, 1077, 1442], '6595-6609Crossref': [772], '(127)': [775], 'Scholar,8Rayaprolu': [777], 'V.': [778, 870, 1871, 3103, 3807, 3912, 3958], 'Kruse': [779], 'Kant': [781], 'Venkatakrishnan': [783], 'Movahed': [785], 'Brooke': [787], 'Lins': [789], 'Bennett': [791], 'Potter': [793], 'T.': [794, 2276, 2378, 2885, 2887, 3186, 3520, 4004], 'McKenna': [795], 'al.Comparative': [798], 'analysis': [799, 3019], 'stability': [804], 'dynamics.J.': [806], '2013;': [808, 1381, 2909, 2958, 3208], '87:': [809], '13150-13160Crossref': [810], '(55)': [813], 'Capsid': [816], 'currently': [819], 'being': [820], 'heavily': [821], 'researched': [822], 'order': [824], 'gain': [826], 'insights': [827], 'cell': [829, 1544, 1585], 'binding': [830, 1583, 1666, 1784, 3230], 'entry.': [832], 'Naturally': [833], 'occurring': [834, 1464, 3421, 4170], 'identified': [839, 854, 1046], 'characterized': [841, 1537], 'variety': [844], 'tropisms.': [847], 'Currently': [848], 'there': [849, 1036], '13': [851], 'least': [857, 2735], '11': [858], 'commonly': [860, 1194], 'available': [861, 1195], 'laboratory': [864, 1200], 'setting.9Pipe': [865], 'Leebeek': [867], 'F.W.G.': [868], 'Ferreira': [869], 'Sawyer': [871], 'E.K.': [872], 'Pasi': [873], 'Clinical': [875, 3695], 'considerations': [876], 'choice': [879], 'development': [882, 1267, 2542, 3164, 3377], 'liver-targeted': [884], 'AAV-based': [885], 'transfer.Mol.': [887, 4055], '2019;': [892, 1183, 1955, 2050, 4029, 4140], '15:': [893, 3242], '170-178Abstract': [894], '(6)': [902], 'Serotypes': [905], '1,': [906], '7–11': [909], 'were': [910, 922], 'discovered': [911], 'non-human': [913, 1158], 'primates,': [914], 'while': [915, 2341, 3550, 3716], '2,': [917], '3,': [918], '6': [921], 'isolated': [923], 'from': [924, 940, 1047, 1157, 1495, 1514, 1520, 2872, 3173, 3270, 3493], 'humans.10Gao': [925], 'G.-P.': [926, 1735], 'Alvira': [927, 965, 1055], 'M.R.': [928, 966, 1056], 'Wang': [929, 1107], 'L.': [930, 1108, 1691, 1928, 1942, 2023, 2037, 2988, 3221], 'Calcedo': [931, 969, 1059], 'Johnston': [933], 'Wilson': [935, 973, 1063, 1117, 1741], 'Novel': [937], 'rhesus': [941], 'monkeys': [942], 'therapy.Proc.': [948], 'Natl.': [949], 'Acad.': [950], 'Sci.': [951], 'USA.': [952], '2002;': [953, 1323], '99:': [954], '11854-11859Crossref': [955], '(1125)': [958], '11Gao': [961], 'Vandenberghe': [963, 1053, 1728], 'L.H.': [964, 1054, 1729], 'Lu': [967, 1057], 'Y.': [968, 1058, 1836, 1932, 1936, 1993, 2027, 2031, 2853, 2889, 2940, 3512], 'Zhou': [971, 1061, 1868, 3100], 'X.': [972, 1062, 1299], 'Clades': [975, 1065], 'widely': [980, 1070, 1263], 'disseminated': [981, 1071], 'tissues.J.': [984, 1074], '6381-6388Crossref': [988, 1078], '(660)': [991, 1081], '12Muzyczka': [994], 'Berns': [996], 'K.I.': [997], 'Parvoviridae:': [998], 'their': [1002, 1950, 2045, 2490], 'replication.in:': [1003], 'Knipe': [1004], 'D.M.': [1005], 'Howley': [1006], 'P.M.': [1007], 'Griffen': [1008], 'D.E.': [1009], 'Lamb': [1010], 'R.A.': [1011, 2535], 'Martin': [1012], 'M.A.': [1013, 1422, 2380, 2857, 3194], 'Roizman': [1014], 'Straus': [1016], 'S.E.': [1017, 3184], 'Fields': [1018], 'Virology.': [1019], 'Volume': [1020], '2.': [1021], 'Lippincott': [1022], 'Williams': [1023, 2191], '&': [1024], 'Wilkins,': [1025], '2001:': [1026], '2327-2359Google': [1027], 'In': [1029, 2351, 2467, 2597, 2673, 3708, 4070], 'addition': [1030, 1526], 'these': [1032], 'mostly': [1033], 'serotypes,': [1035], '100': [1040], 'variants': [1042, 1216, 1221], 'that': [1043, 1087, 1097, 1153, 1334, 1472, 2601, 3294, 3370, 3400, 3678], 'nonhuman': [1050, 4021], 'primates.11Gao': [1051], 'One': [1084], 'study': [1085, 3154], 'showed': [1086], 'population': [1090], 'serologically': [1092], 'positive': [1093], 'suggesting': [1096], 'antibodies': [1098], 'existed': [1099], 'against': [1100], 'humans,13Calcedo': [1103], 'Morizono': [1105], 'McCarter': [1109], 'He': [1111, 1931, 2026], 'Jones': [1113], 'Batshaw': [1115], 'M.L.': [1116], 'antibody': [1121], 'profiles': [1122], 'newborns,': [1124], 'children,': [1125], 'adolescents.Clin.': [1127], 'Vaccine': [1128], 'Immunol.': [1129, 2423], '18:': [1131, 1184, 4141], '1586-1588Crossref': [1132], '(143)': [1135], 'could': [1139], 'pose': [1140, 4206], 'challenge': [1142, 4158], 'human-derived': [1144], 'capsids': [1145, 1156], 'therapy.': [1148], 'Thus,': [1149, 1210, 2732, 3140, 3363, 3664], 'it': [1150, 1211, 2599], 'suggested': [1152], 'isolation': [1154], 'sources': [1159], 'may': [1160, 1336, 2844, 3176, 3334, 3359], 'help': [1161], 'overcome': [1162], 'pre-existing': [1163, 1223], 'immunity.14Wang': [1164], 'Tai': [1166, 4123], 'P.W.L.': [1167, 4124], 'Gao': [1168, 1734, 4125], 'platform': [1175, 3443, 4132], 'delivery.Nat.': [1179, 4136], 'Rev.': [1180, 4137], 'Drug': [1181, 4138], 'Discov.': [1182, 4139], '358-378Crossref': [1185, 4142], '(155)': [1188, 4145], 'Few': [1191], 'among': [1192, 2484, 2806, 2849, 2905], 'setting': [1201], 'tissue.': [1209, 2115, 4226], 'necessary': [1213], 'obtain': [1215], 'specific': [1218, 3342, 3383], 'tropisms,': [1219], 'evading': [1222], 'immunity.': [1224], 'Because': [1225], 'ITRs': [1226, 1494], 'sole': [1229], 'capsids,': [1236], 'recombinant': [1237], '(rAAVs)': [1239], 'be': [1241, 2493, 2803, 3361, 4231], 'produced': [1242], 'by': [1243, 1271, 1545, 1787, 1885, 2595, 3146, 3724, 4233], 'exchanging': [1244], 'wild-type': [1245], 'any': [1249, 3387], 'interest': [1252], 'elements': [1255], '4.7–4.9': [1258], 'kb.': [1259], 'Pseudo-serotyping': [1260], 'adopted': [1264], 'cloning': [1272], 'capsid-coding': [1275], 'domain': [1276, 1706], 'common': [1279], 'backbone': [1281], 'containing': [1282, 1512], 'gene.15Rabinowitz': [1288], 'J.E.': [1289, 1840, 1846, 1997, 2003], 'Rolling': [1290], 'Li': [1292, 1937, 1939, 2032, 2034], 'Conrath': [1294], 'Xiao': [1296, 1298], 'W.': [1297, 3805], 'Samulski': [1300, 1557, 1591, 1774, 1902], 'R.J.': [1301, 1558, 1592, 1775, 1903, 3793], 'Cross-packaging': [1302], 'single': [1305, 2102], 'enables': [1317], 'transduction': [1318, 1434, 1633, 1671, 1705, 1786, 3412, 3471, 4164], 'broad': [1320], 'specificity.J.': [1321, 1678], '76:': [1324], '791-801Crossref': [1325], '(586)': [1328], 'suggest': [1333, 3677], 'pseudo-serotyping': [1335, 1456], 'confer': [1337], 'distinct': [1338, 2089], 'properties': [1339], 'vectors,': [1342], 'receptor': [1345, 1565, 1599, 1745, 1814, 1849, 1878, 1952, 1977, 2006, 2047], 'binding,': [1346], 'intracellular': [1347], 'trafficking,': [1348], 'transcytosis,': [1349], 'uncoating': [1351, 1424], 'nucleus,16Dane': [1355], 'A.P.': [1356], 'Wowro': [1357], 'S.J.': [1358], 'Cunningham': [1359], 'S.C.': [1360], 'Alexander': [1361], 'I.E.': [1362], 'Comparison': [1363], 'murine': [1369], 'liver': [1370, 1433], 'following': [1371, 4015], 'intraperitoneal': [1372], 'intraportal': [1374], 'hepatotropic': [1377], 'pseudo-serotypes.Gene': [1379], '460-464Crossref': [1383], '(30)': [1386, 1723], '17Di': [1389], 'Pasquale': [1390], 'Chiorini': [1392, 1653, 1698], 'transcytosis': [1395], 'barrier': [1397], 'epithelia': [1398], 'endothelium.Mol.': [1400], '2006;': [1402, 1795, 3241], '13:': [1403], '506-516Abstract': [1404], '(80)': [1412], '18Thomas': [1415], 'C.E.': [1416], 'Storm': [1417], 'T.A.': [1418], 'Huang': [1419], 'Z.': [1420, 1769, 1930, 2025, 2702, 2711], 'Kay': [1421], 'Rapid': [1423], 'key': [1430], 'efficient': [1432, 1670, 1783], 'pseudotyped': [1436], 'vectors.J.': [1439, 1636], '3110-3122Crossref': [1443], '(277)': [1446], 'vast': [1451], 'majority': [1452, 2112], 'using': [1455, 1546], 'focuses': [1457, 3406], 'tropism,': [1460], 'including': [1461, 1489, 2794], 'naturally': [1463, 3420, 4169], 'tissues': [1471, 3236, 3347, 3454, 3529, 4211], 'discussed': [1474], 'hereafter.': [1475], 'Typically,': [1476], 'generation': [1477, 3311, 3681], 'pseudo-serotype': [1480], 'requires': [1483, 3315], 'plasmids,': [1488], 'cis': [1491], 'plasmid': [1492, 1511], 'AAV2': [1496, 1515, 1979], 'flanking': [1497], 'cassette': [1500], '(promoter,': [1501], 'transgene,': [1502], 'optionally': [1504], 'post-transcriptional': [1506], 'element),': [1508], 'trans': [1510], '(most': [1516], 'commonly)': [1517], 'another': [1521], 'adeno': [1528], 'promote': [1531], 'AAV2,': [1534], 'best': [1536], 'known': [1540], 'enter': [1542], 'membrane-associated': [1547], 'heparan': [1548, 1560, 1594], 'sulfate': [1549, 1561, 1595], 'proteoglycan': [1550, 1562, 1596], '(HSPG)': [1551], 'primary': [1554, 2753], 'receptor.19Summerford': [1555], 'Membrane-associated': [1559, 1593], 'virions.J.': [1571, 1605], '1998;': [1573, 1607], '72:': [1574, 1608], '1438-1445Crossref': [1575, 1609], 'Other': [1579, 1803], 'require': [1582, 1663], 'surface': [1586], 'glycans': [1587], 'infection19Summerford': [1589], '20Handa': [1613], 'Muramatsu': [1615], 'S.-I.': [1616], 'Qiu': [1617], 'Mizukami': [1619], 'Brown': [1621, 1647, 2147], 'K.E.': [1622, 1648], '(AAV)-3-based': [1625], 'haematopoietic': [1628], 'cells': [1629, 2456, 2871, 3269, 3492, 3883], 'susceptible': [1631], 'AAV-2-based': [1635], 'Gen.': [1637], '2000;': [1639], '81:': [1640], '2077-2084Crossref': [1641], '21Kaludov': [1645], 'Walters': [1649], 'R.W.': [1650, 3569], 'Zabner': [1651], '4': [1658], '(AAV4)': [1659], 'AAV5': [1661], 'sialic': [1664, 1675, 1780], 'acid': [1665, 1676, 3229], 'hemagglutination': [1668], 'differ': [1673], 'linkage': [1677], '75:': [1681], '6884-6893Crossref': [1682], '(293)': [1685], '22Schmidt': [1688], 'Govindasamy': [1690], 'Afione': [1692, 3871], 'Kaludov': [1694], 'Agbandje-McKenna': [1696, 1739, 1772], 'Molecular': [1700, 3600, 3853], 'characterization': [1701], 'heparin-dependent': [1704], 'isolate,': [1715], 'AAV(VR-942).J.': [1716], '2008;': [1718], '82:': [1719], '8911-8916Crossref': [1720], '23Bell': [1726], 'C.L.': [1727], 'Bell': [1730], 'Limberis': [1732], 'M.P.': [1733], 'Van': [1736], 'Vliet': [1737], 'AAV9': [1744], 'modification': [1748], 'lung': [1753], 'mice.J.': [1757], 'Invest.': [1759, 3825], '121:': [1761], '2427-2435Crossref': [1762], '(103)': [1765], '24Wu': [1768], 'Miller': [1770], 'E.': [1771, 3597, 3850], 'α2,3': [1776], 'α2,6': [1778], 'N-linked': [1779], 'acids': [1781], 'facilitate': [1782], 'types': [1790, 2981], '1': [1791, 1815, 1879], '6.J.': [1793], '80:': [1796], '9093-9103Crossref': [1797], '(201)': [1800], 'Scholar.': [1802], 'candidates,': [1804], 'AAVR,': [1807], 'αVβ5': [1808, 1904], 'integrin,': [1809], 'fibroblast': [1811, 1875], 'growth': [1812, 1876, 2367], 'factor': [1813, 1877, 2972], '(FGFR1),': [1816], 'also': [1818, 2356], 'reported': [1820, 3466], 'participate': [1822], 'attachment.25Pillay': [1825], 'Puschnik': [1829, 1986], 'A.S.': [1830, 1987, 2713], 'Davulcu': [1831, 1988], 'O.': [1832, 1989], 'Diep': [1833, 1990], 'Ishikawa': [1835, 1992], 'Jae': [1837, 1994], 'L.T.': [1838, 1995], 'Wosen': [1839, 1996], 'Nagamine': [1841, 1998], 'C.M.': [1842, 1999, 2986], 'Carette': [1845, 2002], 'An': [1847, 2004], 'infection.Nature.': [1853, 2010], '2016;': [1854, 2011, 3092, 3656], '530:': [1855, 2012], '108-112Crossref': [1856, 2013], '(166)': [1859, 2016], '26Qing': [1862], 'Mah': [1864], 'Hansen': [1866], 'Dwarki': [1870], 'Srivastava': [1872], 'Human': [1874], 'co-receptor': [1882, 1907], '2.Nat.': [1888], 'Med.': [1889, 1914, 2220, 2256, 2296, 2957, 3655], '1999;': [1890, 1915, 3932, 3978], '5:': [1891, 1916], '71-77Crossref': [1892], '(0)': [1895, 3543], '27Summerford': [1898], 'Bartlett': [1900], 'J.S.': [1901, 3803], 'integrin:': [1905], 'infection.Nat.': [1913], '78-82Crossref': [1917], '(560)': [1920], '28Zhang': [1923], 'Xu': [1925, 2020], 'Cao': [1927, 2022], 'Sun': [1929, 1935, 2024, 2030], 'Cui': [1933, 2028], 'Qin': [1941, 2036], 'al.Divergent': [1944, 2039], 'engagements': [1945, 2040], 'between': [1946, 1974, 2041, 3341], 'cellular': [1951, 2046], 'AAVR.Nat.': [1953, 2048], 'Commun.': [1954, 2049], '10:': [1956, 2051], '3760Crossref': [1957, 2052], '(8)': [1960, 2055], 'Recent': [1963, 3674], 'shed': [1966], 'new': [1967], 'light': [1968], 'molecular': [1970], 'mechanisms': [1971, 2060, 2839, 3601, 3854], 'engagement': [1973], 'serotypes.25Pillay': [1982], 'Scholar,28Zhang': [2018], 'attachment': [2063], 'entry': [2065], 'adipocytes': [2067, 2099, 2122, 2148, 2442, 2545, 2681, 2686, 3329, 3456], 'unknown.': [2069], 'traditionally': [2073], 'classified': [2074], 'types,': [2077], '(WAT)': [2082], '(BAT),': [2087], 'developmental': [2090], 'origin,': [2091], 'morphology,': [2092], 'function.': [2094], 'WAT': [2095, 2334, 2353], 'uniocular': [2103], 'droplet': [2104], 'cytoplasm': [2107, 2128], 'making': [2109], 'BAT,': [2116], 'alternatively,': [2117], 'composed': [2119, 2440], 'multiocular': [2124], 'droplets': [2125], 'abundant': [2130], 'uncoupling': [2131], 'protein-1': [2132], '(UCP1)': [2133], 'mitochondria.': [2135], 'BAT': [2136, 2305, 2342, 2355], 'located': [2138], 'interscapular': [2141, 2552], 'perirenal': [2143], 'regions': [2144], 'rodents.': [2146], 'cluster': [2151, 2470], 'distributed': [2153, 2790], 'over': [2154], 'neck': [2156], 'shoulder': [2158], 'areas': [2159], 'humans.29Rosen': [2161], 'E.D.': [2162, 2502, 2762, 2809], 'Spiegelman': [2163, 2503, 2763, 2810], 'B.M.': [2164, 2504, 2764, 2811], 'What': [2165, 2505, 2765, 2812], 'we': [2166, 2170, 2506, 2510, 2766, 2770, 2813, 2817], 'talk': [2167, 2171, 2507, 2511, 2767, 2771, 2814, 2818], 'about': [2168, 2172, 2508, 2512, 2768, 2772, 2815, 2819], 'when': [2169, 2509, 2769, 2816, 4174], 'fat.Cell.': [2173, 2513, 2773, 2820], '2014;': [2174, 2514, 2774, 2821, 3609, 3862], '156:': [2175, 2515, 2775, 2822], '20-44Abstract': [2176, 2516, 2776, 2823], '(957)': [2184, 2524, 2784, 2831], '30Cypess': [2187], 'A.M.': [2188], 'Lehman': [2189], 'Tal': [2193], 'I.': [2194, 2891, 3910, 3956], 'Rodman': [2195], 'Goldfine': [2197], 'A.B.': [2198], 'Kuo': [2199], 'F.C.': [2200], 'Palmer': [2201], 'E.L.': [2202], 'Tseng': [2203, 2862], 'Y.H.': [2204], 'Doria': [2205], 'al.Identification': [2208], 'importance': [2210], 'adult': [2216], 'humans.N.': [2217], 'Engl.': [2218, 2254, 2294], '2009;': [2221, 2257, 2297], '360:': [2222, 2258, 2298], '1509-1517Crossref': [2223], '(2580)': [2226], '31van': [2229], 'Marken': [2230], 'Lichtenbelt': [2231], 'W.D.': [2232], 'Vanhommerig': [2233], 'J.W.': [2234, 2707, 2996], 'Smulders': [2235], 'N.M.': [2236], 'Drossaerts': [2237], 'J.M.A.F.L.': [2238], 'Kemerink': [2239], 'Bouvy': [2241], 'N.D.': [2242], 'Schrauwen': [2243], 'Teule': [2245], 'G.J.J.': [2246], 'Cold-activated': [2247], 'healthy': [2252, 2292], 'men.N.': [2253], '1500-1508Crossref': [2259], '(2151)': [2262], '32Virtanen': [2265], 'K.A.': [2266], 'Lidell': [2267], 'M.E.': [2268], 'Orava': [2269], 'Heglind': [2271], 'Westergren': [2273], 'Niemi': [2275], 'Taittonen': [2277], 'Laine': [2279], 'Savisto': [2281], 'N.J.': [2282], 'Enerbäck': [2283], 'Nuutila': [2285], 'Functional': [2287], 'adults.N.': [2293], '1518-1525Crossref': [2299], '(1966)': [2302], 'highly': [2307], 'innervated': [2308], 'vascularized.33Bartness': [2310], 'T.J.': [2311, 2861], 'Vaughan': [2312], 'C.H.': [2313], 'Song': [2314], 'C.K.': [2315], 'Sympathetic': [2316], 'sensory': [2318], 'innervation': [2319], 'tissue.Int.': [2323], 'Obes.': [2325], '2010;': [2326], '34:': [2327, 2959], 'S36-S42Crossref': [2328], '(193)': [2331], 'acts': [2335], 'energy': [2338, 2345, 2749], 'storage': [2339], 'site': [2340, 3605, 3858], 'dissipates': [2343], 'stored': [2344], 'heat.': [2350], 'addition,': [2352], 'serve': [2357], 'endocrine': [2360], 'organ': [2361], 'secrete': [2363], 'numerous': [2364], 'adipokines,': [2365, 2418], 'cytokines,': [2366], 'factors,': [2368], 'circulating': [2370, 2399], 'exosomal': [2371], 'microRNAs': [2372], '(miRNAs)': [2373], 'exert': [2375], 'effects.34Thomou': [2377], 'Mori': [2379, 2856], 'Dreyfuss': [2381], 'Konishi': [2383], 'Sakaguchi': [2385], 'Wolfrum': [2387], 'Rao': [2389], 'T.N.': [2390], 'Winnay': [2391], 'J.N.': [2392], 'Garcia-Martin': [2393], 'Grinspoon': [2395], 'S.K.': [2396, 2942], 'al.Adipose-derived': [2398], 'miRNAs': [2400], 'regulate': [2401], 'tissues.Nature.': [2406], '542:': [2408], '450-455Crossref': [2409], '(472)': [2412], 'Scholar,35Fantuzzi': [2414], 'tissue,': [2417, 4187], 'inflammation.J.': [2420], 'Allergy': [2421], '2005;': [2424], '115:': [2425], '911-919Abstract': [2426], '(1709)': [2434], 'stromal': [2445], 'vascular': [2446], 'fraction': [2447], '(or': [2448], 'cells),': [2449], 'includes': [2451], 'preadipocytes,': [2452], 'fibroblasts,': [2453], 'mesenchymal': [2454], 'stem': [2455], '(MSCs),': [2457], 'endothelial': [2458], 'smooth': [2460], 'muscle': [2461], 'cells,': [2462, 2475, 3738], 'macrophages,': [2463], 'immune': [2465], 'cells.': [2466], 'rodents,': [2468, 2737], 'UCP1-positive': [2472], 'brown-like': [2474], 'termed': [2476], 'beige': [2478], 'brite': [2480], 'adipocytes,': [2481, 2605], 'found': [2483], 'various': [2485, 2792, 2850, 3468], 'pad': [2487], 'depots,': [2488], 'appearance': [2491], 'dramatically': [2494], 'increased': [2495], 'upon': [2496], 'cold': [2497], 'exposure': [2498], 'sympathetic': [2500], 'stimulation.29Rosen': [2501], 'Scholar,36Xue': [2526], 'Rim': [2528], 'J.-S.': [2529], 'Hogan': [2530], 'J.C.': [2531], 'Coulter': [2532], 'A.A.': [2533], 'Koza': [2534], 'Kozak': [2536], 'L.P.': [2537], 'Genetic': [2538], 'variability': [2539], 'affects': [2540], 'fat.J.': [2554], 'Lipid': [2555], 'Res.': [2556, 3240, 3608, 3861], '2007;': [2557, 2724], '48:': [2558], '41-51Abstract': [2559], '(188)': [2567], 'expansion': [2572], 'adipogenesis': [2574, 2759], 'achieved': [2576], 'hypertrophy': [2578, 2741], '(increasing': [2579, 2585], 'cells)': [2582], 'hyperplasia': [2584], 'number': [2586, 2603], 'cells).': [2588], 'Upon': [2589], 'over-nutrition,': [2590], 'expands': [2593], 'first': [2594], 'hypertrophy.': [2596], 'humans,': [2598], 'appears': [2600, 2801], 'size,': [2608], 'stable': [2610], 'state': [2613], 'overfeeding': [2615], 'obesity.': [2617], 'Even': [2618], 'weight': [2619], 'loss': [2620], 'associated': [2622, 2739, 2933, 3645], 'reduction': [2625], 'adipocyte': [2627, 2869, 3180], 'volume,': [2628], 'overall': [2631], 'number.2Sonntag': [2632], 'rodents': [2674], 'however,': [2675], '80%': [2678], 'epididymal': [2680], '3%': [2683], 'inguinal': [2685], 'died': [2687], 'after': [2688, 3819], 'few': [2690], 'months': [2691], 'high-fat': [2693], 'feeding,': [2694], 'depot-specific': [2696], 'proliferation': [2697], 'differentiation.37Strissel': [2699], 'K.J.': [2700], 'Stancheva': [2701], 'Miyoshi': [2703], 'Perfield': [2705], '2nd,': [2706], 'DeFuria': [2708], 'Jick': [2710], 'Greenberg': [2712], 'Obin': [2714], 'Adipocyte': [2716], 'death,': [2717], 'remodeling,': [2720], 'obesity': [2722, 2954, 3008, 3079], 'complications.Diabetes.': [2723], '56:': [2725], '2910-2918Crossref': [2726], '(589)': [2729], 'obesity,': [2733, 2756], 'hyperplasia.': [2743], 'Of': [2744], 'note,': [2745], 'over-nutrition': [2746], 'reduced': [2748], 'expenditure': [2750], 'driver': [2754], 'per': [2760], 'se.29Rosen': [2761], 'locations,': [2793], 'visceral': [2795, 2923, 4298], 'subcutaneous': [2797, 2929], 'depots.': [2799, 4300], 'There': [2800], 'distinction': [2805, 3356], 'depots.29Rosen': [2808], 'Unique': [2834], 'innervation,': [2835], 'vascularization,': [2836], 'cell-autonomous': [2838], 'depot': [2843, 2948, 3355], 'contribute': [2845], 'distinctive': [2847], 'functions': [2848], 'depots.38Macotela': [2852], 'Emanuelli': [2854], 'Gesta': [2858], 'Schulz': [2860], 'Y.-H.': [2863], 'Kahn': [2864], 'C.R.': [2865], 'Intrinsic': [2866], 'differences': [2867, 2904, 2949], 'precursor': [2870], 'depots.Diabetes.': [2876], '2012;': [2877], '61:': [2878], '1691-1699Crossref': [2879], '(179)': [2882], 'Scholar,39Tchkonia': [2884], 'Thomou': [2886], 'Zhu': [2888, 3254, 3477], 'Karagiannides': [2890], 'Pothoulakis': [2892], 'Jensen': [2894], 'M.D.': [2895], 'Kirkland': [2896], 'J.L.': [2897, 3562], 'Mechanisms': [2898], 'metabolic': [2900, 2935, 2977], 'implications': [2901], 'regional': [2903], 'depots.Cell': [2907], 'Metab.': [2908], '17:': [2910], '644-656Abstract': [2911], '(279)': [2919], 'depot,': [2925, 2931], 'disease': [2936], 'risk.40Lee': [2937], 'M.-J.': [2938], 'Wu': [2939, 3804], 'Fried': [2941], 'heterogeneity:': [2945], 'implication': [2946], 'complications.Mol.': [2955], 'Aspects': [2956], '1-11Crossref': [2960], '(351)': [2963], 'Excessive': [2966], 'adiposity': [2967], 'well-recognized': [2970], 'risk': [2971, 3050, 3123, 3688], 'II': [2975], 'diabetes,': [2976], 'syndrome,': [2978], 'certain': [2980], 'cancer.41Genkinger': [2983], 'Kitahara': [2985], 'Bernstein': [2987], 'Berrington': [2989], 'de': [2990, 3563], 'Gonzalez': [2991], 'Brotzman': [2993], 'Elena': [2995], 'Giles': [2997], 'G.G.': [2998], 'Hartge': [2999], 'Singh': [3001], 'P.N.': [3002], 'Stolzenberg-Solomon': [3003], 'R.Z.': [3004], 'al.Central': [3006], 'adiposity,': [3007], 'early': [3010, 3047], 'adulthood,': [3011], 'pancreatic': [3013], 'cancer': [3014, 3113], 'mortality': [3015], 'pooled': [3018], 'cohort': [3021], 'studies.Ann.': [3022], 'Oncol.': [3023], '2015;': [3024, 3826], '26:': [3025], '2257-2266Abstract': [3026], '(63)': [3034], '42Hidayat': [3037], 'Yang': [3039, 3633], 'C.-M.': [3040], 'Shi': [3041], 'B.-M.': [3042], 'Body': [3043], 'fatness': [3044], 'age': [3048], 'colorectal': [3052], 'cancer.Int.': [3053], 'Cancer.': [3055, 3091], '2018;': [3056, 3127, 3700], '142:': [3057], '729-740Crossref': [3058], '(20)': [3061, 3661, 4067], '43García-Jiménez': [3064], 'Gutiérrez-Salmerón': [3066], 'Chocarro-Calvo': [3068], 'García-Martinez': [3070], 'Castaño': [3072], 'De': [3074, 3251, 3474], 'la': [3075], 'Vieja': [3076], 'From': [3078], 'diabetes': [3081, 3116], 'cancer:': [3083], 'epidemiological': [3084], 'links': [3085], 'therapies.Br.': [3089], '114:': [3093], '716-722Crossref': [3094], '44Pearson-Stuttard': [3098], 'Kontis': [3102], 'Bentham': [3104], 'Gunter': [3106], 'M.J.': [3107], 'Ezzati': [3108], 'Worldwide': [3110], 'burden': [3111], 'attributable': [3114], 'body-mass': [3119], 'index:': [3120], 'comparative': [3122], 'assessment.Lancet': [3124], 'Diabetes': [3125], 'Endocrinol.': [3126, 3207], '6:': [3128], 'e6-e15Abstract': [3129], '(94)': [3137], 'gain-': [3141], 'loss-of': [3143], 'function': [3144, 3358], 'genetically': [3147], 'manipulating': [3148], 'physiology,': [3156], 'disease,': [3160], 'therapeutics.': [3166], 'deletion': [3168, 3199, 3301], 'overexpression': [3170, 3303], 'genes': [3172], 'germline': [3175, 3300], 'sometimes': [3177], 'interfere': [3178], 'differentiation': [3181], 'development.45Mullican': [3183], 'Tomaru': [3185], 'Gaddis': [3187], 'C.A.': [3188], 'Peed': [3189], 'L.C.': [3190], 'Sundaram': [3191], 'Lazar': [3193], 'A': [3195], 'adipose-specific': [3197, 4239], 'model': [3200, 3290], 'demonstrates': [3201], 'potential': [3202, 3429], 'pitfalls': [3203], 'existing': [3205], 'methods.Mol.': [3206], '27:': [3209], '127-134Crossref': [3210], '(62)': [3213], '46Urs': [3216], 'Harrington': [3218], 'Liaw': [3220], 'Small': [3222], 'Selective': [3224], 'aP2/fatty': [3228], '4-Cre': [3232], 'non-adipogenic': [3235], 'embryonic': [3238], 'development.Transgenic': [3239], '647-653Crossref': [3243], '(83)': [3246], '47Morizono': [3249], 'Ugarte': [3252, 3475], 'D.A.': [3253, 3476], 'Zuk': [3256, 3479], 'Elbarbary': [3258, 3481], 'Ashjian': [3260, 3483], 'Benhaim': [3262, 3485], 'Chen': [3264, 3487], 'I.S.': [3265, 3488], 'Hedrick': [3266, 3489], 'M.H.': [3267, 3490], 'Multilineage': [3268, 3491], 'vehicles.Hum.': [3276, 3499], 'Gene': [3277, 3500, 4027], '2003;': [3279, 3502], '14:': [3280, 3503], '59-66Crossref': [3281, 3504], '(129)': [3284, 3507], 'inducible': [3288, 4012], 'transgenic': [3289, 3313, 3402], 'avoid': [3296, 3372], 'unintended': [3297, 3373, 3619], 'consequences': [3298, 3620], 'interest.': [3308], 'models': [3314, 3925, 3971], 'costly': [3316], 'time-consuming': [3318], 'selection': [3319], 'maintenance': [3321], 'rodent': [3323], 'lines.': [3324], 'Moreover,': [3325], 'genetic': [3326], 'manipulation': [3327], 'whole-body': [3332], 'level': [3333], 'necessarily': [3336], 'reveal': [3337], 'cross-talk': [3338], 'interactions': [3340], 'depots': [3344, 3385, 4291], 'hypothalamus,': [3351], 'individual': [3353], 'noticed.': [3362], 'become': [3366], 'attractive': [3368], 'restrict': [3379], 'given': [3388], 'age.': [3389], 'turnaround': [3391], 'faster': [3393], 'expense': [3396], 'less': [3398], 'models.': [3403], 'specifically': [3407], 'serotypes.': [3425], 'yield': [3449], 'therapeutic': [3450], 'efficacy.': [3451], 'Targeting': [3452], 'culture': [3458], 'adenovirus,': [3460], 'retrovirus,': [3461], 'lentivirus': [3463, 3672, 3683], 'degrees': [3469], 'efficiencies.47Morizono': [3472], 'Scholar,48Nagamatsu': [3509], 'Nakamichi': [3511], 'Ohara-Imaizumi': [3513], 'Katahira': [3517], 'Watanabe': [3519], 'Ishida': [3521], 'Adenovirus-mediated': [3523], 'preproinsulin': [3524], 'ameliorates': [3530], 'hyperglycemia': [3531], 'obese': [3533], 'diabetic': [3534], 'KKAy': [3535], 'mice.FEBS': [3536], 'Lett.': [3537], '509:': [3539], '106-110Crossref': [3540], 'immunogenic': [3549], 'γ-retroviruses': [3551], 'lentiviruses': [3553], 'able': [3555], 'integrate': [3557], 'host': [3560, 3746], 'genome,49Shirley': [3561], 'Jong': [3564], 'Y.P.': [3565], 'Terhorst': [3566], 'Herzog': [3568], 'Immune': [3570], 'responses': [3571], 'vectors.Mol.': [3576], '2020;': [3578, 4057], '28:': [3579, 4058], '709-722Abstract': [3580], '(28)': [3588], 'Scholar,50Kvaratskhelia': [3590], 'Sharma': [3592, 3845], 'Larue': [3594, 3847], 'R.C.': [3595, 3848], 'Serrao': [3596, 3849], 'Engelman': [3598, 3851], 'retroviral': [3603, 3856], 'integration': [3604, 3741, 3857], 'selection.Nucleic': [3606, 3859], 'Acids': [3607, 3860], '42:': [3610, 3863], '10209-10225Crossref': [3611, 3864], '(67)': [3614, 3867], 'leading': [3617], 'carcinogenic': [3622], 'risk.51Schlimgen': [3623], 'Howard': [3625], 'Wooley': [3627], 'Thompson': [3629], 'Baden': [3631], 'L.R.': [3632], 'O.O.': [3634], 'Christiani': [3635], 'D.C.': [3636], 'Mostoslavsky': [3637], 'Diamond': [3639], 'D.V.': [3640], 'Duane': [3641], 'E.G.': [3642], 'al.Risks': [3644], 'lentiviral': [3647, 3698], 'exposures': [3649], 'prevention': [3651], 'strategies.J.': [3652], 'Occup.': [3653], 'Environ.': [3654], '58:': [3657], '1159-1166Crossref': [3658], 'many': [3665], 'efforts': [3666], 'made': [3669], 'safer': [3671], 'vectors.': [3673, 4172], 'clinical': [3675], 'data': [3676], 'newer': [3680], 'strongly': [3685], 'reduce': [3686], 'insertional': [3690], 'mutagenesis.52Milone': [3691], 'M.C.': [3692, 3795], "O'Doherty": [3693], 'U.': [3694], 'vectors.Leukemia.': [3699], '32:': [3701], '1529-1541Crossref': [3702], '(118)': [3705], 'contrast,': [3709], 'allow': [3711], 'long-term': [3713], 'circumventing': [3717], 'problem': [3719], 'frequent': [3721], 'insertion': [3723], 'retrovirus': [3726], 'family.': [3727], 'rAAV': [3728, 4176], 'primarily': [3730], 'remain': [3731], 'episomal': [3732], 'nucleus': [3735], 'transduced': [3737], 'random': [3740], 'low-frequency': [3749], 'events,1Colella': [3750], 'although': [3781], 'integrations': [3783], 'subsequent': [3785], 'toxicity': [3786], 'observed': [3789], 'mouse': [3791], 'models.53Chandler': [3792], 'LaFave': [3794], 'Varshney': [3796], 'G.K.': [3797], 'Trivedi': [3798], 'N.S.': [3799], 'Carrillo-Carrasco': [3800], 'Senac': [3802], 'Hoffmann': [3806], 'Elkahloun': [3808], 'A.G.': [3809], 'Burgess': [3810], 'S.M.': [3811], 'Venditti': [3812], 'C.P.': [3813], 'Vector': [3814], 'design': [3815], 'influences': [3816], 'hepatic': [3817], 'genotoxicity': [3818], 'therapy.J.': [3823], '125:': [3827], '870-880Crossref': [3828], 'low': [3834, 4163], 'immunogenicity': [3835, 4046], 'dividing': [3840], 'non-dividing': [3842], 'tissues.50Kvaratskhelia': [3843], 'Scholar,54Flotte': [3869], 'T.R.': [3870], 'Zeitlin': [3873], 'P.L.': [3874], 'occurs': [3880], 'nondividing': [3882], 'absence': [3886], 'integration.Am.': [3890], 'Respir.': [3892], 'Cell': [3893], 'Mol.': [3894], 'Biol.': [3895], '1994;': [3896], '11:': [3897], '517-521Crossref': [3898], 'Scholar,55Rizzuto': [3901], 'Gorgoni': [3903, 3949], 'Cappelletti': [3905, 3951], 'Lazzaro': [3907, 3953], 'Gloaguen': [3909, 3955], 'Poli': [3911, 3957], 'Sgura': [3913, 3959], 'Cimini': [3915, 3961], 'Ciliberto': [3917, 3963], 'Cortese': [3919, 3965], 'al.Development': [3922, 3968], 'animal': [3924, 3946, 3970, 3985, 4071], 'site-specific': [3929, 3975], 'integration.J.': [3930, 3976], '73:': [3933, 3979], '2517-2526Crossref': [3934, 3980], 'They': [3938], 'exhibited': [3940], 'sustained': [3941], 'small': [3945], 'models,55Rizzuto': [3947], 'models,56Guilbaud': [3986], 'Devaux': [3988], 'Couzinié': [3990], 'Le': [3992], 'Duff': [3993], 'Toromanoff': [3995], 'Vandamme': [3997], 'Jaulin': [3999], 'Gernoux': [4001], 'Larcher': [4003], 'Moullier': [4005], 'al.Five': [4008], 'years': [4009], 'successful': [4011, 4053], 'locoregional': [4016], 'primates': [4022], 'no': [4024], 'detectable': [4025], 'immunity.Hum.': [4026], '30:': [4030], '802-813Crossref': [4031], '(10)': [4034], 'humans.57Verdera': [4038], 'H.C.': [4039], 'Kuranda': [4040], 'humans:': [4048], 'long': [4050], 'journey': [4051], '723-746Abstract': [4059], 'models,': [4072], 'skeletal': [4075], 'muscle,': [4076, 4217], 'eyes,': [4077], 'central': [4080], 'nervous': [4081], 'system': [4082], 'safely': [4085], 'successfully': [4087], 'targeted': [4088], 'transfer.1Colella': [4091], 'Scholar,14Wang': [4121], 'largely': [4159], 'due': [4160], 'relatively': [4162], 'efficiency': [4165], 'Therefore,': [4173], 'choosing': [4175], 'platforms': [4177], 'transfer,': [4182], 'efficacy,': [4190], 'specificity': [4192], 'influential': [4197], 'factors': [4198], 'consideration.': [4200], 'As': [4201], 'broad-spectrum': [4208], 'affinity': [4209], 'hurdle': [4222], 'this': [4228], 'issue': [4229], 'mitigated': [4232], 'route,': [4235], 'promoter,': [4240], 'incorporation': [4242], 'miRNA': [4244], 'sites': [4246], '3′': [4249], 'UTR': [4250], 'transgene.': [4252], 'Modifications': [4253], 'effectively': [4263], 'illustrated': [4265], 'Figure': [4267], '1.': [4268], 'Delivering': [4269], 'locally': [4271], 'helps': [4272], 'mitigate': [4273], 'because': [4276], 'lower': [4279], 'dose': [4280], 'fewer': [4282], 'leaks': [4283], 'circulation.': [4286], 'injecting': [4288], 'time-consuming,': [4293], 'invasive,': [4294], 'difficult': [4296], 'Systemic': [4301], 'delivery,': [4302], 'alterna': [4303]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3088327373', 'counts_by_year': [{'year': 2024, 'cited_by_count': 15}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-29T16:41:36.404263', 'created_date': '2020-10-01'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
