Title: Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis
Abstract: Wu, S. E. et al. Microbiota-derived metabolite promotes HDAC3 activity in the gut. Nature. https://doi.org/10.1038/s41586-020-2604-2 (2020) Odenwald, M. A. & Turner, J. R. The intestinal epithelial barrier: a therapeutic target? Nat. Rev. Gastroenterol. Hepatol. 14, 9–21 (2017). CAS Article Google Scholar Alenghat, T. et al. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature 504, 153–157 (2013). CAS Article Google Scholar Nicolas, G. R. & Chang, P. V. Deciphering the chemical lexicon of host-gut microbiota interactions. Trends Pharm. Sci. 40, 430–445 (2019). CAS Article Google Scholar Lim, D., Golovan, S., Forsberg, C. W. & Jia, Z. Crystal structures of Escherichia coli phytase and its complex with phytate. Nat. Struct. Biol. 7, 108–113 (2000). CAS Article Google Scholar Download references This work was supported was supported by National Key RD RGC-CRF Hong Kong (C4039-19G), and RGC-GRF Hong Kong (14163817). Institute of Precision Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Xiaoxing Li & Jun Yu Institute of Digestive Disease, Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Sha Tin, NewTerritories, Hong Kong Harry Cheuk Hay Lau & Jun Yu You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar Correspondence to Jun Yu. The authors declare no competing interests. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and Permissions Li, X., Lau, H.C.H. & Yu, J. Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis. Sig Transduct Target Ther 5, 211 (2020). https://doi.org/10.1038/s41392-020-00321-5 Download citation Received: 14 August 2020 Revised: 24 August 2020 Accepted: 02 September 2020 Published: 21 September 2020 DOI: https://doi.org/10.1038/s41392-020-00321-5