Title: EVALUATION OF CYSTATIN-C AS A BIOMARKER OF RENAL FUNCTION IN TYPE- 2 DIABETES MELLITUS
Abstract: Introduction: Diabetes has become the most common single cause of End Stage Renal Disease (ESRD) in most countries. About 20-30% of patients with diabetes develop evidence of nephropathy. Cystatin-C has been identified as a promising new biomarker for the detection of renal damage and is more sensitive than creatinine. Material and Method: In this study, 50 proven cases of Type-2 Diabetic patients and an equal number of age and sex matched healthy controls were included during the study period from November-2013 to August-2015. Result: The serum concentrations of FBG, Creatinine and Cystatin-C were increased and eGFR was decreased in Type-2 Diabetic patients as compared to healthy controls (p, < 0.001). We also found that there was a significant positive correlation of serum cystatin-C with FBG and Creatinine and negative correlation with eGFR in Type-2 Diabetes patients. Conclusion: This study concludes that cystatin-C is superior for renal glomerular function assessment in a well-defined patient group, its measurement may be recommended in the routine management of diabetic patients.
Publication Year: 2020
Publication Date: 2020-01-24
Language: en
Type: article
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