Long‐term outcomes of relapsed/refractory double‐hit lymphoma (r/r DHL) treated with CD19/22 CAR T‐cell cocktail therapy

Name: Work Video:
Duration: 3 min 30 s
Jia Wei; Zekai Mao; Na Wang; Lifang Huang; Yang Cao; Weimin Sun; Xiaolu Long; Jiaqi Tan; Chunrui Li; Yi Xiao; Chaojiang Gu; Shangkun Zhang; Yicheng Zhang; Tongcun Zhang; Jianfeng Zhou; Liang Huang
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[319, 425, 484], 'eight': [320], 'patients)': [321], 'B,': [333, 459, 662], 'six': [334], 'patients),': [335], 'including': [336, 377, 440, 473], 'switching': [339], 'Trial': [341, 424, 458, 483, 490, 507, 624, 661, 701, 883], 'A.': [342], 'The': [343, 358, 391, 574, 603, 644, 675, 1159, 1216, 1356, 1388], 'baseline': [344], 'characteristics': [345], 'across': [349, 414], 'well': [354], 'balanced': [355], 'S1).': [357], 'overall': [359, 586], '(ORR)': [363], 'month': [365, 434, 463, 810, 852], '3': [366, 435, 464, 811, 853], 'post': [367, 436, 465, 514, 812, 854], '83.3%': [372, 395, 669], '(10/12,': [373, 396], '95%': [374, 397], 'CI:': [375, 398, 610, 640, 651, 671, 688], '55.2-97.0%),': [376], 'three': [378], 'cases': [379, 385], 'CR': [381, 403, 505, 787, 805, 827, 874, 906], '(25%)': [382], 'partial': [387], '(PR)': [389], '(58.3%).': [390], 'best': [392, 402, 407], 'ORR': [393, 461], '55.2-97.0%)': [399], '33.3%': [406], 'PR': [408, 481, 821, 850, 864, 881, 978], 'rate.': [409], 'Comparable': [410], 'achieved': [413, 431, 504, 553, 808, 848, 862, 903], 'different': [415, 765], 'subtype-specific': [416], 'impact': [417], 'S2).': [419], 'Among': [420, 444, 477], '75.0%': [426, 608, 638], '(6/8,': [428], '95%CI:': [429], '40.9-95.6%)': [430], 'OR': [432], 'immunotherapy,': [439], 'CR.': [443, 476], 'five': [445, 479], 'PR,': [447], 'PD': [450, 510], '3.1': [452], '8.7': [454, 908], 'months,': [455, 911], 'respectively.': [456], '100%': [470], '(95%CI:': [471], '61-100%),': [472], 'those': [478], 'B': [491, 508, 625, 702], 'when': [492, 708, 816, 893], 'early': [493, 894, 987], 'recovery': [495, 896, 941, 989], 'detected.': [498, 899], 'Only': [499, 692], 'patient': [501, 694, 762, 1229], '5.9': [512], 'months': [513, 580, 628], 'eventually': [519], 'died': [520], '12.2': [522], 'months.': [523], 'Figure': [524, 673, 690], '1B': [525], 'presents': [526], 'duration': [527], 'all': [534, 613, 654, 683, 1070], 'patients.': [536, 615, 841, 1355], 'present': [539], 'study,': [540, 844], 'promising': [541, 1061], 'results': [542], 'treatet': [546], 'therapy': [550, 833], 'low-grade': [555], '(grade': [556], '≤2)': [557], 'cytokine': [558], 'release': [559], 'syndrome': [560, 566], '(CRS)': [561], 'T-cell-related': [564], 'encephalopathy': [565], '(CRES),': [567], 'respectively': [568], 'Table': [572, 747], 'S3).': [573], 'median': [575, 585, 618], 'follow-up': [576, 619, 951], '12.1': [579], '(range,': [581, 629], '1.3-37.0)': [582], 'both': [584], '(OS)': [588], 'progression-free': [590], '(PFS)': [592], 'cohort': [598], '1C': [600], 'D).': [602], '1-year': [604, 645, 677], 'OS': [605, 635, 794, 801], '(95%': [609, 639, 650, 670, 687], '40.8-91.2)': [611], '17.9': [627], '10.3-31.9)': [630], 'estimated': [633, 664, 676], '2-year': [634, 665], '12.8-96.1)': [641], '1C).': [643], 'PFS': [646, 666, 799], '63.6%': [649], '29.7-84.5)': [652], 'among': [653], 'patients;': [656], '27.3-97.5,': [672], '1D).': [674], 'incidence': [678], 'relapse': [680, 697], '36.4%': [686], '15.5-70.3,': [689], '1E).': [691], 'disease': [696], 'until': [703], 'cutoff': [705], 'date.': [706], 'Particularly,': [707], 'compared': [709, 817], 'received': [712, 885], 'CAR19/22': [713, 753, 887], 'cocktail': [715, 755, 889], 'alone,': [716], 'there': [717, 1163], 'trends': [719], 'toward': [720], 'numerical': [721], 'time,': [727], 'fewer': [728], 'relapses': [729], 'adverse': [731], 'effects,': [732], 'longer': [733], 'persistence': [734], 'CAR19': [736], 'CAR22': [738], 'transgenes,': [739], 'aplasia': [742], '(BCA)': [743], 'S1': [745], 'S4)': [748], 'undergone': [752], 'ASCT.': [757], 'Further': [758], 'testing': [759], 'larger': [761], 'cohorts': [763], 'ethnicity': [766], 'is': [767, 834, 952, 971, 1016, 1122, 1164, 1207, 1390], 'required.': [768], 'SCHOLAR-1,': [769], 'largest': [771, 1021], 'pooled': [772], 'retrospective': [773], 'on': [775], 'diffuse': [777], 'large': [778], '(DLBCL),10': [781], 'indicated': [782], 'that': [783, 1041, 1162, 1358], 'status': [788, 806], 'salvage': [790, 832], 'superior': [793], 'nonresponders.': [796], 'Remarkably': [797], 'extended': [798, 998], 'status.1': [822], 'Therefore,': [823], 'achieve': [825], 'second-': [829], 'late-line': [831], 'principal': [836], 'goal': [837], 'DLBCL': [840], 'our': [843], '66.7%': [845], 'infusion.': [858, 929, 949, 1037], 'could': [869, 921, 995], 'continue': [870], 'without': [875], 'additional': [876], 'treatment,': [877], 'A': [884], 'second-round': [886, 915, 965], 'Both': [900], 'thereafter': [902], 'an': [904], '9.6': [910], 'respectively,': [912], 'response-guided': [914, 964], 'reinforce': [922], 'efficiency': [924], 'first-round': [926], 'Hence,': [930], 'assessment': [932], 'kinetics': [934], 'screening': [935], 'transgenes': [938], 'are': [942, 1365, 1376], 'critical': [943], 'Regular': [950], 'proper': [953], 'detectable': [957], 'sustained': [961], 'BCA,': [962], 'but': [963, 979], 'reasonable': [973], 'strategy': [974, 994], 'fast': [981], 'reducing': [982], '1F).': [991], 'This': [992, 1120, 1169, 1205], 'proposed': [993], 'also': [996, 1104], 'B-NHL': [1004], 'should': [1006, 1412], 'investigated': [1008], 'future': [1010], 'trials.': [1012], 'conclusion,': [1014], 'dedicated': [1019], 'series': [1023], 'looking': [1024], 'Our': [1038], 'data': [1039, 1357, 1373], 'alone': [1046], 'outcome': [1054], 'It': [1058], 'provides': [1059], 'novel': [1062], 'therapeutically': [1063], 'option': [1064], 'We': [1068, 1103], 'thank': [1069], 'faculty': [1072], 'staff': [1074], 'Clinical': [1077], 'Laboratory': [1079], 'Unit': [1080], 'Department': [1083], 'Hematology,': [1085], 'Tongji': [1086, 1088, 1179, 1181], 'Hospital,': [1087, 1180], 'Medical': [1089, 1175, 1182], 'College,': [1090, 1183], 'Huazhong': [1091, 1184], 'University': [1092, 1185], 'Science': [1094, 1135, 1146, 1187, 1237, 1246], 'Technology': [1096, 1189], 'their': [1098, 1112, 1194], 'technical': [1101], 'supports.': [1102], 'appreciate': [1105], 'Wuhan': [1106], 'Bio-Raid': [1107], 'Biotechnology': [1108], 'Co.,': [1109], 'Ltd.': [1110], 'service': [1113], 'manufacturing': [1116], 'quality': [1118, 1288], 'control.': [1119], 'work': [1121], 'supported': [1123], 'funding': [1126], 'Key': [1129, 1231], 'Program': [1130, 1232], 'National': [1133, 1144, 1235, 1244], 'Natural': [1134, 1145, 1236, 1245], 'Foundation': [1136, 1147, 1238, 1247], 'China': [1138, 1149], '(81830008': [1139], 'JZ)': [1141], '(81670152,': [1150], 'LH;': [1152], '81873427,': [1153, 1253], 'JW;': [1155], '81600120,': [1156], 'NW).': [1158], 'authors': [1160, 1217], 'declare': [1161], 'conflict': [1166], 'interest.': [1168], 'study': [1170, 1206, 1364], 'approved': [1172], 'Ethics': [1176], 'Committee': [1177], '(TJ-IRB20160310).': [1190], 'All': [1191, 1371], 'gave': [1193], 'written': [1195], 'informed': [1196], 'consents': [1197], 'accordance': [1199], 'Declaration': [1202], 'Helsinki.': [1204], 'registered': [1208], 'www.chictr.org.cn': [1210], 'ChiCTR-OPN-16008526': [1212], 'ChiCTR-OPN-': [1214], '16009847.': [1215], 'consent': [1220], 'publish': [1222], 'participant': [1225], 'report': [1227], 'individual': [1228], 'data.': [1230], 'China;': [1240, 1249], 'Grant': [1241, 1250], 'Number:': [1242], '81830008;': [1243], 'Numbers:': [1251], '81670152,': [1252], '81600120).': [1255], 'Jianfeng': [1256, 1328], 'Zhou': [1257], 'Liang': [1259, 1311, 1330], 'Huang': [1260, 1302, 1312], 'designed': [1261], 'supervised': [1263, 1274], 'study;': [1266], 'Tongcun': [1267], 'Zhang,': [1268, 1339], 'Chaojiang': [1269], 'Gu,': [1270], 'Shangkun': [1272], 'Zhang': [1273], 'production;': [1278], 'Na': [1279, 1342], 'Wang': [1280], 'Yang': [1282, 1332], 'Cao': [1283], 'conducted': [1284], 'preclinical': [1285], 'validation': [1286], 'control;': [1289], 'Jia': [1290, 1306, 1320, 1340], 'Wei,': [1291, 1307, 1341], 'Zekai': [1292, 1308, 1323, 1344], 'Mao,': [1293, 1309, 1345], 'Weimin': [1294, 1347], 'Sun,': [1295], 'Xiaolu': [1296], 'Long,': [1297], 'Jiaqi': [1298], 'Tan,': [1299], 'Lifang': [1301], 'collected': [1303], 'data;': [1305], 'analyzed': [1313], 'wrote,': [1315], 'manuscript;': [1319], 'Wei': [1321], 'Mao': [1324], 'performed': [1325], 'statistical': [1326], 'analyses;': [1327], 'Zhou,': [1329], 'Huang,': [1331], 'Cao,': [1333], 'Chunrui': [1334], 'Li,': [1335], 'Yi': [1336], 'Xiao,': [1337], 'Yicheng': [1338], 'Wang,': [1343], 'Sun': [1348], 'took': [1351], 'care': [1352], 'support': [1359], 'findings': [1361], 'available': [1366, 1377], 'Supporting': [1369, 1384], 'Information.': [1370], 'published': [1372], 'material': [1375], 'upon': [1378], 'request': [1379], 'corresponding': [1382, 1417], 'authors.': [1383, 1405], 'Information': [1385], 'Please': [1386], 'note:': [1387], 'publisher': [1389], 'responsible': [1392], 'content': [1395], 'functionality': [1397], 'any': [1399], 'supporting': [1400], 'information': [1401], 'supplied': [1402], 'Any': [1406], 'queries': [1407], '(other': [1408], 'missing': [1410], 'content)': [1411], 'directed': [1414], 'author': [1418], 'article.': [1421]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3087504071', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-24T06:51:54.024476', 'created_date': '2020-09-25'}
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