Publication Information

{'id': 'https://openalex.org/W3087225691', 'doi': 'https://doi.org/10.3389/fimmu.2020.552925', 'title': 'Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status', 'display_name': 'Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status', 'publication_year': 2020, 'publication_date': '2020-09-18', 'ids': {'openalex': 'https://openalex.org/W3087225691', 'doi': 'https://doi.org/10.3389/fimmu.2020.552925', 'mag': '3087225691', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33072093', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7531039'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fimmu.2020.552925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fimmu.2020.552925/pdf', 'source': {'id': 'https://openalex.org/S2595292759', 'display_name': 'Frontiers in Immunology', 'issn_l': '1664-3224', 'issn': ['1664-3224'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fimmu.2020.552925/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041000253', 'display_name': 'Narasimha M. Beeraka', 'orcid': 'https://orcid.org/0000-0001-6879-7835'}, 'institutions': [{'id': 'https://openalex.org/I126824641', 'display_name': 'JSS Academy of Higher Education and Research', 'ror': 'https://ror.org/013x70191', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I126824641']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Narasimha M. Beeraka', 'raw_affiliation_strings': ['Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, India', 'institution_ids': ['https://openalex.org/I126824641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017771440', 'display_name': 'Surya Prabha Sadhu', 'orcid': 'https://orcid.org/0000-0002-9703-4340'}, 'institutions': [{'id': 'https://openalex.org/I100887729', 'display_name': 'Andhra University', 'ror': 'https://ror.org/049skhf47', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I100887729']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Surya P. Sadhu', 'raw_affiliation_strings': ['AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India'], 'affiliations': [{'raw_affiliation_string': 'AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India', 'institution_ids': ['https://openalex.org/I100887729']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007749446', 'display_name': 'SubbaRao V. Madhunapantula', 'orcid': 'https://orcid.org/0000-0001-9167-9271'}, 'institutions': [{'id': 'https://openalex.org/I126824641', 'display_name': 'JSS Academy of Higher Education and Research', 'ror': 'https://ror.org/013x70191', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I126824641']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'SubbaRao V. Madhunapantula', 'raw_affiliation_strings': ['Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, India', 'Special Interest Group in Cancer Biology and Cancer Stem Cells (SIG-CBCSC), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), JSS Academy of Higher Education & Research (JSS AHER), Mysore, India', 'institution_ids': ['https://openalex.org/I126824641']}, {'raw_affiliation_string': 'Special Interest Group in Cancer Biology and Cancer Stem Cells (SIG-CBCSC), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore, India', 'institution_ids': ['https://openalex.org/I126824641']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041971663', 'display_name': 'Rajeswara Rao Pragada', 'orcid': 'https://orcid.org/0000-0003-4581-7383'}, 'institutions': [{'id': 'https://openalex.org/I100887729', 'display_name': 'Andhra University', 'ror': 'https://ror.org/049skhf47', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I100887729']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Rajeswara Rao Pragada', 'raw_affiliation_strings': ['AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India'], 'affiliations': [{'raw_affiliation_string': 'AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India', 'institution_ids': ['https://openalex.org/I100887729']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010827733', 'display_name': 'Andrey Svistunov', 'orcid': 'https://orcid.org/0000-0003-1592-5703'}, 'institutions': [{'id': 'https://openalex.org/I17877952', 'display_name': 'Sechenov University', 'ror': 'https://ror.org/02yqqv993', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I17877952']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Andrey A. Svistunov', 'raw_affiliation_strings': ['I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia', 'institution_ids': ['https://openalex.org/I17877952']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060660729', 'display_name': 'Vladimir N. Nikolenko', 'orcid': 'https://orcid.org/0000-0001-9532-9957'}, 'institutions': [{'id': 'https://openalex.org/I19880235', 'display_name': 'Lomonosov Moscow State University', 'ror': 'https://ror.org/010pmpe69', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I19880235']}, {'id': 'https://openalex.org/I17877952', 'display_name': 'Sechenov University', 'ror': 'https://ror.org/02yqqv993', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I17877952']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Vladimir N. Nikolenko', 'raw_affiliation_strings': ['Department of Normal and Topographic Anatomy, M.V. Lomonosov Moscow State University, Moscow, Russia', 'I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Normal and Topographic Anatomy, M.V. Lomonosov Moscow State University, Moscow, Russia', 'institution_ids': ['https://openalex.org/I19880235']}, {'raw_affiliation_string': 'I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia', 'institution_ids': ['https://openalex.org/I17877952']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040838582', 'display_name': 'Л.М. Михалева', 'orcid': 'https://orcid.org/0000-0003-2052-914X'}, 'institutions': [{'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Liudmila M. Mikhaleva', 'raw_affiliation_strings': ['Research Institute of Human Morphology, Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Human Morphology, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072415195', 'display_name': 'Gjumrakch Aliev', 'orcid': 'https://orcid.org/0000-0001-7373-3182'}, 'institutions': [{'id': 'https://openalex.org/I17877952', 'display_name': 'Sechenov University', 'ror': 'https://ror.org/02yqqv993', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I17877952']}, {'id': 'https://openalex.org/I4210161309', 'display_name': 'International Biomedical (United States)', 'ror': 'https://ror.org/05x6z3731', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210161309']}, {'id': 'https://openalex.org/I4210162996', 'display_name': 'Institute of Physiologically Active Compounds', 'ror': 'https://ror.org/05xw3yj26', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210145551', 'https://openalex.org/I4210162996']}, {'id': 'https://openalex.org/I4210145101', 'display_name': 'Research Institute of Human Morphology', 'ror': 'https://ror.org/042k8ng80', 'country_code': 'RU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210145101']}], 'countries': ['RU', 'US'], 'is_corresponding': True, 'raw_author_name': 'Gjumrakch Aliev', 'raw_affiliation_strings': ['GALLY International Research Institute, San Antonio, TX, United States', 'Institute of Physiologically Active Compounds, Russian Academy of Sciences, Moscow, Russia', 'Research Institute of Human Morphology, Moscow, Russia', 'Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia'], 'affiliations': [{'raw_affiliation_string': 'Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia', 'institution_ids': ['https://openalex.org/I17877952']}, {'raw_affiliation_string': 'GALLY International Research Institute, San Antonio, TX, United States', 'institution_ids': ['https://openalex.org/I4210161309']}, {'raw_affiliation_string': 'Institute of Physiologically Active Compounds, Russian Academy of Sciences, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210162996']}, {'raw_affiliation_string': 'Research Institute of Human Morphology, Moscow, Russia', 'institution_ids': ['https://openalex.org/I4210145101']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5007749446', 'https://openalex.org/A5072415195'], 'corresponding_institution_ids': ['https://openalex.org/I126824641', 'https://openalex.org/I17877952', 'https://openalex.org/I4210161309', 'https://openalex.org/I4210162996', 'https://openalex.org/I4210145101'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 0.563, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.999516, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '11', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.978, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9776, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/coronavirus', 'display_name': 'Coronavirus', 'score': 0.5517268}, {'id': 'https://openalex.org/keywords/pandemic', 'display_name': 'Pandemic', 'score': 0.5175116}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6216517}, {'id': 'https://openalex.org/C2777648638', 'wikidata': 'https://www.wikidata.org/wiki/Q57751738', 'display_name': 'Coronavirus', 'level': 5, 'score': 0.5517268}, {'id': 'https://openalex.org/C3007834351', 'wikidata': 'https://www.wikidata.org/wiki/Q82069695', 'display_name': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)', 'level': 5, 'score': 0.5468086}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.54605293}, {'id': 'https://openalex.org/C89623803', 'wikidata': 'https://www.wikidata.org/wiki/Q12184', 'display_name': 'Pandemic', 'level': 5, 'score': 0.5175116}, {'id': 'https://openalex.org/C2777914695', 'wikidata': 'https://www.wikidata.org/wiki/Q12192', 'display_name': 'Pneumonia', 'level': 2, 'score': 0.50206304}, {'id': 'https://openalex.org/C2778859668', 'wikidata': 'https://www.wikidata.org/wiki/Q103177', 'display_name': 'Severe acute respiratory syndrome', 'level': 5, 'score': 0.437352}, {'id': 'https://openalex.org/C58475186', 'wikidata': 'https://www.wikidata.org/wiki/Q4118894', 'display_name': 'Viral entry', 'level': 4, 'score': 0.41772676}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.417643}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.3721513}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.37008333}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.28901315}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.1746037}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.13546702}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12642905}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000073640', 'descriptor_name': 'Betacoronavirus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018352', 'descriptor_name': 'Coronavirus Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016503', 'descriptor_name': 'Drug Delivery Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D058873', 'descriptor_name': 'Pandemics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011024', 'descriptor_name': 'Pneumonia, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053586', 'descriptor_name': 'Virus Internalization', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000085962', 'descriptor_name': 'Angiotensin-Converting Enzyme 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073640', 'descriptor_name': 'Betacoronavirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018352', 'descriptor_name': 'Coronavirus Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018352', 'descriptor_name': 'Coronavirus Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018352', 'descriptor_name': 'Coronavirus Infections', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007703', 'descriptor_name': 'Peptidyl-Dipeptidase A', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011024', 'descriptor_name': 'Pneumonia, Viral', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D011024', 'descriptor_name': 'Pneumonia, Viral', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011024', 'descriptor_name': 'Pneumonia, Viral', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D000086402', 'descriptor_name': 'SARS-CoV-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D064370', 'descriptor_name': 'Spike Glycoprotein, Coronavirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064370', 'descriptor_name': 'Spike Glycoprotein, Coronavirus', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D064370', 'descriptor_name': 'Spike Glycoprotein, Coronavirus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D053586', 'descriptor_name': 'Virus Internalization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fimmu.2020.552925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fimmu.2020.552925/pdf', 'source': {'id': 'https://openalex.org/S2595292759', 'display_name': 'Frontiers in Immunology', 'issn_l': '1664-3224', 'issn': ['1664-3224'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/6f6e5cb5eef946d9beaf6d92166bd469', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/33072093', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fimmu.2020.552925', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fimmu.2020.552925/pdf', 'source': {'id': 'https://openalex.org/S2595292759', 'display_name': 'Frontiers in Immunology', 'issn_l': '1664-3224', 'issn': ['1664-3224'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.57, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 222, 'referenced_works': ['https://openalex.org/W1515994079', 'https://openalex.org/W1547512866', 'https://openalex.org/W1597922646', 'https://openalex.org/W1597991178', 'https://openalex.org/W1721371055', 'https://openalex.org/W1859742880', 'https://openalex.org/W1872768675', 'https://openalex.org/W1881700820', 'https://openalex.org/W1956339943', 'https://openalex.org/W1964953975', 'https://openalex.org/W1965280032', 'https://openalex.org/W1965400930', 'https://openalex.org/W1965435260', 'https://openalex.org/W1965720352', 'https://openalex.org/W1966135195', 'https://openalex.org/W1966238900', 'https://openalex.org/W1966683713', 'https://openalex.org/W1967767097', 'https://openalex.org/W1967814129', 'https://openalex.org/W1970232220', 'https://openalex.org/W1972032770', 'https://openalex.org/W1975428045', 'https://openalex.org/W1976400886', 'https://openalex.org/W1976483167', 'https://openalex.org/W1977610810', 'https://openalex.org/W1977885214', 'https://openalex.org/W1978424248', 'https://openalex.org/W1978897742', 'https://openalex.org/W1981719274', 'https://openalex.org/W1981979160', 'https://openalex.org/W1983507144', 'https://openalex.org/W1983828703', 'https://openalex.org/W1984058914', 'https://openalex.org/W1985652369', 'https://openalex.org/W1989207797', 'https://openalex.org/W1992960225', 'https://openalex.org/W1993145638', 'https://openalex.org/W1993264878', 'https://openalex.org/W1993401362', 'https://openalex.org/W1997686688', 'https://openalex.org/W1998964868', 'https://openalex.org/W2000651798', 'https://openalex.org/W2000863740', 'https://openalex.org/W2001275070', 'https://openalex.org/W2001788362', 'https://openalex.org/W2002581355', 'https://openalex.org/W2005951184', 'https://openalex.org/W2006231275', 'https://openalex.org/W2009220832', 'https://openalex.org/W2009631807', 'https://openalex.org/W2010109835', 'https://openalex.org/W2012289331', 'https://openalex.org/W2014879168', 'https://openalex.org/W2015213940', 'https://openalex.org/W2018839292', 'https://openalex.org/W2019431237', 'https://openalex.org/W2022339063', 'https://openalex.org/W2024312910', 'https://openalex.org/W2027518730', 'https://openalex.org/W2028504310', 'https://openalex.org/W2028507800', 'https://openalex.org/W2029358388', 'https://openalex.org/W2031014666', 'https://openalex.org/W2031295191', 'https://openalex.org/W2031454744', 'https://openalex.org/W2032062610', 'https://openalex.org/W2033250723', 'https://openalex.org/W2035711908', 'https://openalex.org/W2039747951', 'https://openalex.org/W2040522635', 'https://openalex.org/W2041836794', 'https://openalex.org/W2042669556', 'https://openalex.org/W2044139515', 'https://openalex.org/W2047106864', 'https://openalex.org/W2047409850', 'https://openalex.org/W2047505752', 'https://openalex.org/W2048461516', 'https://openalex.org/W2049023031', 'https://openalex.org/W2049770171', 'https://openalex.org/W2052443867', 'https://openalex.org/W2055166695', 'https://openalex.org/W2056887495', 'https://openalex.org/W2057685193', 'https://openalex.org/W2058465738', 'https://openalex.org/W2059174340', 'https://openalex.org/W2062898287', 'https://openalex.org/W2064076043', 'https://openalex.org/W2064558921', 'https://openalex.org/W2068102085', 'https://openalex.org/W2069932188', 'https://openalex.org/W2072202424', 'https://openalex.org/W2073858684', 'https://openalex.org/W2075264981', 'https://openalex.org/W2076911722', 'https://openalex.org/W2078776138', 'https://openalex.org/W2079284334', 'https://openalex.org/W2084981497', 'https://openalex.org/W2085445235', 'https://openalex.org/W2086624515', 'https://openalex.org/W2086960330', 'https://openalex.org/W2088943364', 'https://openalex.org/W2091345827', 'https://openalex.org/W2091671824', 'https://openalex.org/W2095633747', 'https://openalex.org/W2098086455', 'https://openalex.org/W2098695079', 'https://openalex.org/W2099549544', 'https://openalex.org/W2100516702', 'https://openalex.org/W2100553420', 'https://openalex.org/W2101506295', 'https://openalex.org/W2101780807', 'https://openalex.org/W2102380386', 'https://openalex.org/W2103091783', 'https://openalex.org/W2103869681', 'https://openalex.org/W2110632746', 'https://openalex.org/W2110803674', 'https://openalex.org/W2111244140', 'https://openalex.org/W2111412754', 'https://openalex.org/W2112370026', 'https://openalex.org/W2114151399', 'https://openalex.org/W2114443908', 'https://openalex.org/W2115195851', 'https://openalex.org/W2115627436', 'https://openalex.org/W2118330057', 'https://openalex.org/W2118495604', 'https://openalex.org/W2119159050', 'https://openalex.org/W2119371081', 'https://openalex.org/W2119828399', 'https://openalex.org/W2120268813', 'https://openalex.org/W2120751457', 'https://openalex.org/W2121528674', 'https://openalex.org/W2122743894', 'https://openalex.org/W2124326929', 'https://openalex.org/W2126532419', 'https://openalex.org/W2127036378', 'https://openalex.org/W2127531900', 'https://openalex.org/W2129053556', 'https://openalex.org/W2129203060', 'https://openalex.org/W2131988685', 'https://openalex.org/W2133422078', 'https://openalex.org/W2134061616', 'https://openalex.org/W2134946424', 'https://openalex.org/W2137015441', 'https://openalex.org/W2137339316', 'https://openalex.org/W2140277400', 'https://openalex.org/W2140674451', 'https://openalex.org/W2141787825', 'https://openalex.org/W2142157385', 'https://openalex.org/W2142808320', 'https://openalex.org/W2143901293', 'https://openalex.org/W2145812375', 'https://openalex.org/W2146476111', 'https://openalex.org/W2148979869', 'https://openalex.org/W2149146712', 'https://openalex.org/W2149753575', 'https://openalex.org/W2151163583', 'https://openalex.org/W2158998622', 'https://openalex.org/W2162693092', 'https://openalex.org/W2162789710', 'https://openalex.org/W2163501419', 'https://openalex.org/W2165757151', 'https://openalex.org/W2166189758', 'https://openalex.org/W2166650533', 'https://openalex.org/W2168508973', 'https://openalex.org/W2169731328', 'https://openalex.org/W2171353131', 'https://openalex.org/W2179017989', 'https://openalex.org/W2245699751', 'https://openalex.org/W2337422248', 'https://openalex.org/W2337855427', 'https://openalex.org/W2337924133', 'https://openalex.org/W2415811952', 'https://openalex.org/W2433713077', 'https://openalex.org/W2466982071', 'https://openalex.org/W2468919751', 'https://openalex.org/W2470646526', 'https://openalex.org/W2496119966', 'https://openalex.org/W2509430738', 'https://openalex.org/W2610356532', 'https://openalex.org/W2617530769', 'https://openalex.org/W2682776814', 'https://openalex.org/W2734811226', 'https://openalex.org/W2766581718', 'https://openalex.org/W2769491968', 'https://openalex.org/W2769927008', 'https://openalex.org/W2775762540', 'https://openalex.org/W2788485001', 'https://openalex.org/W2888117441', 'https://openalex.org/W2899319752', 'https://openalex.org/W2903446452', 'https://openalex.org/W2909787042', 'https://openalex.org/W2963924055', 'https://openalex.org/W2970106832', 'https://openalex.org/W2994156659', 'https://openalex.org/W2999364275', 'https://openalex.org/W3001118548', 'https://openalex.org/W3001465255', 'https://openalex.org/W3003430844', 'https://openalex.org/W3003464757', 'https://openalex.org/W3003668884', 'https://openalex.org/W3004318991', 'https://openalex.org/W3004919484', 'https://openalex.org/W3005212621', 'https://openalex.org/W3005477624', 'https://openalex.org/W3007238890', 'https://openalex.org/W3007533211', 'https://openalex.org/W3008763357', 'https://openalex.org/W3008827533', 'https://openalex.org/W3009980084', 'https://openalex.org/W3010096538', 'https://openalex.org/W3010277308', 'https://openalex.org/W3010611713', 'https://openalex.org/W3011127849', 'https://openalex.org/W3011230580', 'https://openalex.org/W3012184818', 'https://openalex.org/W3012379316', 'https://openalex.org/W3013442544', 'https://openalex.org/W3033249816', 'https://openalex.org/W3125234664', 'https://openalex.org/W4206834558', 'https://openalex.org/W4297744082', 'https://openalex.org/W837231054'], 'related_works': ['https://openalex.org/W4377037192', 'https://openalex.org/W3090081136', 'https://openalex.org/W3047950519', 'https://openalex.org/W3046089062', 'https://openalex.org/W3045914288', 'https://openalex.org/W3023213585', 'https://openalex.org/W3002812395', 'https://openalex.org/W2893432007', 'https://openalex.org/W2151056719', 'https://openalex.org/W2067839860'], 'abstract_inverted_index': {'SARS-CoV-2-induced': [0], 'COVID-19': [1], 'cases': [2, 13], 'have': [3, 281], 'been': [4], 'increasing': [5], 'at': [6], 'an': [7], 'alarming': [8], 'rate': [9], '(~7.4': [10], 'million': [11], 'positive': [12], 'as': [14, 25, 222], 'on': [15, 26, 290], '11th': [16, 27], 'June': [17, 28], '2020),': [18], 'causing': [19], 'a': [20, 80, 84, 120, 175], 'high': [21], 'mortality': [22], '(~4,17,956': [23], 'deaths': [24], '2020)': [29, 39], 'and': [30, 55, 92, 110, 149, 184, 227, 250, 294], 'economic': [31], 'loss': [32], '(~3.2%': [33], 'shrink': [34], 'in': [35, 38, 232, 277], 'global': [36], 'economy': [37], 'across': [40], '212': [41], 'countries': [42], 'globally.': [43], 'The': [44], 'clinical': [45], 'manifestations': [46], 'of': [47, 74, 79, 130, 146, 166, 191, 194, 210, 243, 264, 285, 305], 'this': [48, 278], 'disease': [49], 'are': [50, 224], 'pneumonia,': [51], 'lung': [52], 'injury,': [53], 'inflammation,': [54], 'severe': [56, 228], 'acute': [57], 'respiratory': [58], 'syndrome': [59], '(SARS).': [60], 'Currently,': [61], 'there': [62, 223], 'is': [63, 83, 145, 150, 161, 198, 238, 258], 'no': [64], 'vaccine': [65, 82, 122], 'or': [66, 142], 'effective': [67], 'pharmacological': [68], 'agent(s)': [69], 'available': [70], 'for': [71, 302], 'the': [72, 101, 128, 151, 164, 208, 215, 235, 241, 262, 272, 303], 'prevention/treatment': [73], 'SARS-CoV2': [75], 'infections.': [76, 206], 'Moreover,': [77], 'development': [78, 123, 190, 242, 304], 'suitable': [81, 121], 'challenging': [85], 'task': [86], 'due': [87], 'to': [88, 114, 154, 171, 200, 203, 213, 253, 260, 270], 'antibody-dependent': [89], 'enhancement': [90], '(ADE)': [91], 'Th-2': [93], 'immunopathology,': [94], 'which': [95, 178, 245], 'aggravates': [96], 'infection': [97, 160], 'with': [98, 139, 287], 'SARS-CoV-2.': [99], 'Furthermore,': [100], 'emerging': [102], 'SARS': [103], 'CoV-2': [104], 'strain': [105], 'exhibits': [106], 'several': [107], 'distinct': [108], 'genomic': [109], 'structural': [111, 283], 'patterns': [112], 'compared': [113], 'other': [115], 'coronavirus': [116], 'strains,': [117], 'hence,': [118], 'making': [119], 'even': [124], 'more': [125], 'difficult.': [126], 'Therefore,': [127, 189, 276], 'identification': [129], 'novel': [131, 192], 'small': [132], 'molecules': [133], 'inhibitors': [134, 193, 212], '(NSMIs)': [135], 'that': [136, 298], 'can': [137, 299], 'interfere': [138], 'viral': [140, 143, 167, 217], 'entry': [141, 218], 'propagation': [144], 'special': [147, 288], 'interest': [148, 237], 'need-of-the': [152], 'hour': [153], 'manage': [155, 254], 'already': [156], 'infected': [157], 'cases.': [158], 'SARS-CoV-2': [159, 205, 216, 255, 286], 'mediated': [162], 'by': [163], 'binding': [165], 'Spike': [168], 'protein': [169], '(S-protein)': [170], 'human': [172], 'cells': [173], 'through': [174], '2-step': [176], 'process,': [177], 'involves': [179], 'Angiotensin': [180], 'Converting': [181], 'Enzyme-2': [182], '(ACE2)': [183], 'Transmembrane': [185], 'Serine': [186], 'Protease': [187], '(TMPRSS)-2.': [188], 'ACE2': [195], '/': [196], 'TMPRSS2': [197], 'likely': [199], 'be': [201, 300], 'beneficial': [202], 'combat': [204], 'However,': [207], 'usage': [209], 'ACE-2': [211], 'block': [214], 'requires': [219], 'additional': [220], 'studies': [221], 'conflicting': [225], 'findings': [226], 'health': [229], 'complications': [230], 'reported': [231], 'patients.': [233], 'Hence,': [234], 'current': [236], 'shifted': [239], 'towards': [240], 'NSMIs,': [244], 'includes': [246], 'natural': [247], 'antiviral': [248, 266], 'phytochemicals': [249], 'Nrf-2': [251, 268], 'activators': [252, 269], 'infection.': [256], 'It': [257], 'imperative': [259], 'investigate': [261], 'efficacy': [263], 'existing': [265], 'phytochemicals,': [267], 'mitigate': [271], 'SARS-CoV-2-mediated': [273], 'oxidative': [274], 'stress.': [275], 'review,': [279], 'we': [280], 'reviewed': [282], 'features': [284], 'emphasis': [289], 'key': [291], 'molecular': [292], 'targets': [293], 'their': [295], 'known': [296], 'modulators': [297], 'considered': [301], 'NSMIs.': [306]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3087225691', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2025-01-06T03:53:52.919835', 'created_date': '2020-09-25'}