Title: Blood biomarkers of brain injury after cardiac arrest – A dynamic field
Abstract: Brain-derived blood biomarkers have gained increased interest during the recent years as a mean to quantify the extent of central nervous system injury in several neurological conditions. 1 Ashton N.J. Hye A. Rajkumar A.P. et al. An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nat Rev Neurol. 2020; 16: 265-284 Crossref PubMed Scopus (32) Google Scholar , 2 Novakova L. Axelsson M. Khademi M. et al. Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis. J Neurochem. 2017; 141: 296-304 Crossref PubMed Scopus (77) Google Scholar Technological development in this field is rapid and new candidate molecules emerge steadily. Several have been tested as prognostic tools after cardiac arrest. The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend using serum neuron-specific enolase (NSE) at 48–74 h as the only biomarker with sufficient clinical evidence to identify poor outcome in patients after cardiac arrest. 3 Nolan J.P. Soar J. Cariou A. et al. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015: Section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation. 2015; 95: 202-222 Abstract Full Text Full Text PDF PubMed Scopus (618) Google Scholar Most previous cardiac arrest studies, such as the large TTM-trial 4 Nielsen N. Wetterslev J. Cronberg T. et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. N Engl J Med. 2013; 369: 2197-2206 Crossref PubMed Scopus (1675) Google Scholar and others, 5 Streitberger K.J. Leithner C. Wattenberg M. et al. Neuron-specific enolase predicts poor outcome after cardiac arrest and targeted temperature management: a multicenter study on 1,053 patients. Crit Care Med. 2017; 45: 1145-1151 Crossref PubMed Scopus (45) Google Scholar examined prognostic accuracies at approximately 24–72 h post-arrest 6 Stammet P. Dankiewicz J. Nielsen N. et al. Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 degrees C and 36 degrees C. Crit Care. 2017; 21: 153 Crossref PubMed Scopus (46) Google Scholar , 7 Stammet P. Collignon O. Hassager C. et al. Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33 degrees C and 36 degrees C. J Am Coll Cardiol. 2015; 65: 2104-2114 Crossref PubMed Scopus (167) Google Scholar , 8 Mattsson N. Zetterberg H. Nielsen N. et al. Serum tau and neurological outcome in cardiac arrest. Ann Neurol. 2017; 82: 665-675 Crossref PubMed Scopus (49) Google Scholar , 9 Moseby-Knappe M. Mattsson N. Nielsen N. et al. Serum neurofilament light chain for prognosis of outcome after cardiac arrest. JAMA Neurol. 2019; 76: 64-71 Crossref PubMed Scopus (69) Google Scholar , 10 Ebner F. Moseby-Knappe M. Mattsson-Carlgren N. et al. Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients. Resuscitation. 2020; 154: 61-68 Abstract Full Text Full Text PDF PubMed Scopus (8) Google Scholar ; however, less is known on the performance of brain biomarkers within the first hours after cardiac arrest.
Publication Year: 2020
Publication Date: 2020-11-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 12
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