Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3085536640', 'doi': 'https://doi.org/10.3390/microorganisms8091410', 'title': 'Regulating Oral Biofilm from Cariogenic State to Non-Cariogenic State via Novel Combination of Bioactive Therapeutic Composite and Gene-Knockout', 'display_name': 'Regulating Oral Biofilm from Cariogenic State to Non-Cariogenic State via Novel Combination of Bioactive Therapeutic Composite and Gene-Knockout', 'publication_year': 2020, 'publication_date': '2020-09-13', 'ids': {'openalex': 'https://openalex.org/W3085536640', 'doi': 'https://doi.org/10.3390/microorganisms8091410', 'mag': '3085536640', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32933157', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7564907'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms8091410', 'pdf_url': 'https://www.mdpi.com/2076-2607/8/9/1410/pdf?version=1599986875', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2076-2607/8/9/1410/pdf?version=1599986875', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100420429', 'display_name': 'Hong Chen', 'orcid': 'https://orcid.org/0000-0002-4152-624X'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Hong Chen', 'raw_affiliation_strings': ['Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'Department of Conservative Dentistry and Endodontics, College of Stomatological, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China', 'State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}, {'raw_affiliation_string': 'Department of Conservative Dentistry and Endodontics, College of Stomatological, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China', 'institution_ids': ['https://openalex.org/I87780372']}, {'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056959473', 'display_name': 'Yingming Yang', 'orcid': 'https://orcid.org/0000-0002-6514-6428'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingming Yang', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088320537', 'display_name': 'Michael D. Weir', 'orcid': 'https://orcid.org/0000-0002-7961-3787'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael D. Weir', 'raw_affiliation_strings': ['Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053803788', 'display_name': 'Quan Dai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I87445476', 'display_name': "Xi'an Jiaotong University", 'ror': 'https://ror.org/017zhmm22', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87445476']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Quan Dai', 'raw_affiliation_strings': ['Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research; College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China', "College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China", 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research Center of Shanxi Province for Dental and Maxillofacial Diseases, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research; College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China', 'institution_ids': ['https://openalex.org/I87445476']}, {'raw_affiliation_string': "College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China", 'institution_ids': ['https://openalex.org/I87445476']}, {'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100381336', 'display_name': 'Lei Lei', 'orcid': 'https://orcid.org/0000-0002-0125-0904'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Lei', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047710785', 'display_name': 'Negar Homayounfar', 'orcid': 'https://orcid.org/0000-0002-7616-7072'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Negar Homayounfar', 'raw_affiliation_strings': ['Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083258987', 'display_name': 'Thomas W. Oates', 'orcid': 'https://orcid.org/0000-0001-6435-1326'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas W. Oates', 'raw_affiliation_strings': ['Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000459340', 'display_name': 'Kai Yang', 'orcid': 'https://orcid.org/0000-0003-0118-9370'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kai Yang', 'raw_affiliation_strings': ['Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China', 'institution_ids': ['https://openalex.org/I183519381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100365688', 'display_name': 'Ke Zhang', 'orcid': 'https://orcid.org/0000-0001-7982-5758'}, 'institutions': [{'id': 'https://openalex.org/I183519381', 'display_name': 'Capital Medical University', 'ror': 'https://ror.org/013xs5b60', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I183519381']}, {'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['CN', 'US'], 'is_corresponding': True, 'raw_author_name': 'Ke Zhang', 'raw_affiliation_strings': ['Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China', 'institution_ids': ['https://openalex.org/I183519381']}, {'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053415156', 'display_name': 'Tao Hu', 'orcid': 'https://orcid.org/0000-0002-0418-1246'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Tao Hu', 'raw_affiliation_strings': ['State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006690496', 'display_name': 'Hockin H.K. Xu', 'orcid': 'https://orcid.org/0000-0001-5160-8866'}, 'institutions': [{'id': 'https://openalex.org/I126744593', 'display_name': 'University of Maryland, Baltimore', 'ror': 'https://ror.org/04rq5mt64', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I126744593']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Hockin H. K. Xu', 'raw_affiliation_strings': ['Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA', 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}, {'raw_affiliation_string': 'Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA', 'institution_ids': ['https://openalex.org/I126744593']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5100365688', 'https://openalex.org/A5053415156', 'https://openalex.org/A5006690496'], 'corresponding_institution_ids': ['https://openalex.org/I183519381', 'https://openalex.org/I126744593', 'https://openalex.org/I24185976', 'https://openalex.org/I126744593'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 0.595, 'has_fulltext': False, 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.603774, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 82}, 'biblio': {'volume': '8', 'issue': '9', 'first_page': '1410', 'last_page': '1410'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10257', 'display_name': 'Periodontal Diseases and Oral Microbiome', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3506', 'display_name': 'Periodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10257', 'display_name': 'Periodontal Diseases and Oral Microbiome', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3506', 'display_name': 'Periodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10113', 'display_name': 'Dental Restorative Materials', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/3505', 'display_name': 'Orthodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides in Host Defense and Therapy', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/streptococcus-sanguinis', 'display_name': 'Streptococcus sanguinis', 'score': 0.9203156}, {'id': 'https://openalex.org/keywords/streptococcus-gordonii', 'display_name': 'Streptococcus gordonii', 'score': 0.9089787}, {'id': 'https://openalex.org/keywords/dental-plaque', 'display_name': 'Dental plaque', 'score': 0.49229658}, {'id': 'https://openalex.org/keywords/oral-microbiome', 'display_name': 'Oral Microbiome', 'score': 0.445594}], 'concepts': [{'id': 'https://openalex.org/C2778430296', 'wikidata': 'https://www.wikidata.org/wiki/Q131452', 'display_name': 'Streptococcus mutans', 'level': 3, 'score': 0.94879025}, {'id': 'https://openalex.org/C58123911', 'wikidata': 'https://www.wikidata.org/wiki/Q467410', 'display_name': 'Biofilm', 'level': 3, 'score': 0.9270036}, {'id': 'https://openalex.org/C2777867728', 'wikidata': 'https://www.wikidata.org/wiki/Q2033849', 'display_name': 'Streptococcus sanguinis', 'level': 4, 'score': 0.9203156}, {'id': 'https://openalex.org/C2780368718', 'wikidata': 'https://www.wikidata.org/wiki/Q7623352', 'display_name': 'Streptococcus gordonii', 'level': 4, 'score': 0.9089787}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.66691935}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54613733}, {'id': 'https://openalex.org/C2779914569', 'wikidata': 'https://www.wikidata.org/wiki/Q143504', 'display_name': 'Dental plaque', 'level': 2, 'score': 0.49229658}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.273283}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25283635}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.072493196}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms8091410', 'pdf_url': 'https://www.mdpi.com/2076-2607/8/9/1410/pdf?version=1599986875', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/aa75b23eaa4c4687b25a825c1d4f6095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564907', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32933157', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/microorganisms8091410', 'pdf_url': 'https://www.mdpi.com/2076-2607/8/9/1410/pdf?version=1599986875', 'source': {'id': 'https://openalex.org/S4210222090', 'display_name': 'Microorganisms', 'issn_l': '2076-2607', 'issn': ['2076-2607'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81771068'}, {'funder': 'https://openalex.org/F4320333337', 'funder_display_name': 'Applied Basic Research Program of Sichuan Province', 'award_id': '2018JY0580'}], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W110975304', 'https://openalex.org/W138828180', 'https://openalex.org/W1487532921', 'https://openalex.org/W1601152448', 'https://openalex.org/W1963874687', 'https://openalex.org/W1967720051', 'https://openalex.org/W1985712894', 'https://openalex.org/W1987702644', 'https://openalex.org/W1989571679', 'https://openalex.org/W1989804346', 'https://openalex.org/W1994892071', 'https://openalex.org/W2022926706', 'https://openalex.org/W2029989802', 'https://openalex.org/W2034507629', 'https://openalex.org/W2042774380', 'https://openalex.org/W2043893006', 'https://openalex.org/W2059065076', 'https://openalex.org/W2068317501', 'https://openalex.org/W2077584582', 'https://openalex.org/W2098874088', 'https://openalex.org/W2106116364', 'https://openalex.org/W2110493055', 'https://openalex.org/W2110621364', 'https://openalex.org/W2116893589', 'https://openalex.org/W2122836009', 'https://openalex.org/W2127466890', 'https://openalex.org/W2128769815', 'https://openalex.org/W2139962100', 'https://openalex.org/W2141749643', 'https://openalex.org/W2146498624', 'https://openalex.org/W2150586609', 'https://openalex.org/W2156520524', 'https://openalex.org/W2157532610', 'https://openalex.org/W2161616012', 'https://openalex.org/W2163802229', 'https://openalex.org/W2166669634', 'https://openalex.org/W2332766354', 'https://openalex.org/W2345320332', 'https://openalex.org/W2349128164', 'https://openalex.org/W2398236992', 'https://openalex.org/W2550762460', 'https://openalex.org/W2576446872', 'https://openalex.org/W2592900587', 'https://openalex.org/W2604070293', 'https://openalex.org/W2758396470', 'https://openalex.org/W2762801383', 'https://openalex.org/W2765088376', 'https://openalex.org/W2777482520', 'https://openalex.org/W2780248041', 'https://openalex.org/W2790097242', 'https://openalex.org/W2795432770', 'https://openalex.org/W2801072950', 'https://openalex.org/W2804274900', 'https://openalex.org/W2895637293', 'https://openalex.org/W2910410915', 'https://openalex.org/W2941974751', 'https://openalex.org/W2946696053', 'https://openalex.org/W2972061700', 'https://openalex.org/W2973343568', 'https://openalex.org/W2995655942', 'https://openalex.org/W3000649027', 'https://openalex.org/W3009672935', 'https://openalex.org/W41930042', 'https://openalex.org/W4211107393'], 'related_works': ['https://openalex.org/W4385423290', 'https://openalex.org/W4317746054', 'https://openalex.org/W4307038682', 'https://openalex.org/W4232622758', 'https://openalex.org/W4225091005', 'https://openalex.org/W3112653543', 'https://openalex.org/W3040753656', 'https://openalex.org/W2315957845', 'https://openalex.org/W2143170784', 'https://openalex.org/W2004579744'], 'abstract_inverted_index': {'The': [0, 73], 'objectives': [1], 'were': [2, 57], 'to': [3, 64, 89, 141, 155, 191, 195], 'investigate': [4], 'a': [5, 21, 25, 122], 'novel': [6, 187], 'combination': [7, 123], 'of': [8, 68, 103, 124], 'gene-knockout': [9, 75], 'with': [10, 79, 121, 160], 'antimicrobial': [11], 'dimethylaminohexadecyl': [12], 'methacrylate': [13], '(DMAHDM)': [14], 'composite': [15, 81, 112, 165], 'in': [16, 71, 108, 137, 170, 177], 'regulating': [17], 'oral': [18], 'biofilm': [19, 30, 83, 138], 'from': [20], 'cariogenic': [22, 33, 133], 'state': [23], 'toward': [24], 'non-cariogenic': [26, 39, 146, 178], 'state.': [27], 'A': [28], 'tri-species': [29], 'model': [31], 'included': [32], 'Streptococcus': [34, 40, 45], 'mutans': [35, 78, 101, 126, 135], '(S.': [36, 42, 47], 'mutans),': [37], 'and': [38, 44, 54, 105, 113, 129, 162, 173, 198], 'sanguinis': [41, 148], 'sanguinis)': [43], 'gordonii': [46, 151], 'gordonii).': [48], 'Biofilm': [49], 'colony-forming-units': [50], '(CFUs),': [51], 'lactic': [52, 184], 'acid': [53], 'polysaccharide': [55], 'production': [56], 'measured.': [58], 'TaqMan': [59], 'real-time-polymerase-chain': [60], 'reaction': [61], 'was': [62, 139, 153], 'used': [63], 'determine': [65], 'the': [66, 132, 145, 167, 174, 182], 'percentage': [67, 102, 136, 152], 'each': [69], 'species': [70], 'biofilm.': [72], 'rnc': [74, 127], 'for': [76], 'S.': [77, 96, 100, 125, 134, 147, 150, 171], 'DMAHDM': [80, 115, 130], 'reduced': [82, 140], 'CFU': [84], 'by': [85], 'five': [86], 'logs,': [87], 'compared': [88], 'control': [90], '(p': [91], '<': [92], '0.05).': [93], 'Using': [94], 'parent': [95], 'mutans,': [97, 172], 'an': [98], 'overwhelming': [99], '68.99%': [104], '69.00%': [106], 'existed': [107], 'biofilms': [109, 197], 'on': [110], 'commercial': [111], '0%': [114], 'composite,': [116, 131], 'respectively.': [117], 'In': [118], 'sharp': [119], 'contrast,': [120], 'knockout': [128], 'only': [142], '6.33%.': [143], 'Meanwhile,': [144], '+': [149], 'increased': [154], '93.67%.': [156], 'Therefore,': [157], 'combining': [158], 'rnc-knockout': [159], 'bioactive': [161], 'therapeutic': [163], 'dental': [164, 200], 'achieved': [166], 'greatest': [168, 175], 'reduction': [169], 'increase': [176], 'species,': [179], 'thereby': [180], 'yielding': [181], 'least': [183], 'acid-production.': [185], 'This': [186], 'method': [188], 'is': [189], 'promising': [190], 'obtain': [192], 'wide': [193], 'applications': [194], 'regulate': [196], 'inhibit': [199], 'caries.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3085536640', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-12T02:00:36.253053', 'created_date': '2020-09-21'}