Publication Information

{'id': 'https://openalex.org/W3084956028', 'doi': 'https://doi.org/10.1101/2020.09.16.299800', 'title': 'Lopinavir-ritonavir is not an effective inhibitor of the main protease activity of SARS-CoV-2<i>in vitro</i>', 'display_name': 'Lopinavir-ritonavir is not an effective inhibitor of the main protease activity of SARS-CoV-2<i>in vitro</i>', 'publication_year': 2020, 'publication_date': '2020-09-16', 'ids': {'openalex': 'https://openalex.org/W3084956028', 'doi': 'https://doi.org/10.1101/2020.09.16.299800', 'mag': '3084956028'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.16.299800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1101/2020.09.16.299800', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070264413', 'display_name': 'Minsu Jang', 'orcid': 'https://orcid.org/0000-0003-4988-5930'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Minsu Jang', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056226234', 'display_name': 'Yea‐In Park', 'orcid': 'https://orcid.org/0000-0002-7851-8470'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yea-In Park', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080406945', 'display_name': 'Rackhyun Park', 'orcid': 'https://orcid.org/0000-0002-9499-459X'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Rackhyun Park', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089884936', 'display_name': 'Yeo-Eun Cha', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yeo-Eun Cha', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028715830', 'display_name': 'Sim Namkoong', 'orcid': 'https://orcid.org/0000-0003-1007-0371'}, 'institutions': [{'id': 'https://openalex.org/I165507594', 'display_name': 'Kangwon National University', 'ror': 'https://ror.org/01mh5ph17', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I165507594']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Sim Namkoong', 'raw_affiliation_strings': ['Department of Biochemistry, Kangwon National University, Chuncheon, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Kangwon National University, Chuncheon, South Korea', 'institution_ids': ['https://openalex.org/I165507594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014428204', 'display_name': 'Jin I. Lee', 'orcid': 'https://orcid.org/0000-0001-8074-5413'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jin I. Lee', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008795579', 'display_name': 'Junsoo Park', 'orcid': 'https://orcid.org/0000-0002-2355-6760'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Junsoo Park', 'raw_affiliation_strings': ['Division of Biological Science and Technology, Yonsei University, Wonju, South Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Science and Technology, Yonsei University, Wonju, South Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5008795579'], 'corresponding_institution_ids': ['https://openalex.org/I193775966'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.723894, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10041', 'display_name': 'COVID-19 Clinical Research Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11754', 'display_name': 'SARS-CoV-2 detection and testing', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lopinavir', 'display_name': 'Lopinavir', 'score': 0.9927132}, {'id': 'https://openalex.org/keywords/ritonavir', 'display_name': 'Ritonavir', 'score': 0.96373177}, {'id': 'https://openalex.org/keywords/lopinavir/ritonavir', 'display_name': 'Lopinavir/ritonavir', 'score': 0.8028022}, {'id': 'https://openalex.org/keywords/protease-inhibitor', 'display_name': 'Protease inhibitor (pharmacology)', 'score': 0.64570415}], 'concepts': [{'id': 'https://openalex.org/C2777182164', 'wikidata': 'https://www.wikidata.org/wiki/Q422585', 'display_name': 'Lopinavir', 'level': 5, 'score': 0.9927132}, {'id': 'https://openalex.org/C2779298103', 'wikidata': 'https://www.wikidata.org/wiki/Q422618', 'display_name': 'Ritonavir', 'level': 5, 'score': 0.96373177}, {'id': 'https://openalex.org/C2781392899', 'wikidata': 'https://www.wikidata.org/wiki/Q422618', 'display_name': 'Lopinavir/ritonavir', 'level': 5, 'score': 0.8028022}, {'id': 'https://openalex.org/C2781143361', 'wikidata': 'https://www.wikidata.org/wiki/Q55761529', 'display_name': 'Protease inhibitor (pharmacology)', 'level': 5, 'score': 0.64570415}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5868926}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.58546203}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5790206}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.57842934}, {'id': 'https://openalex.org/C3008058167', 'wikidata': 'https://www.wikidata.org/wiki/Q84263196', 'display_name': 'Coronavirus disease 2019 (COVID-19)', 'level': 4, 'score': 0.4391126}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.26453942}, {'id': 'https://openalex.org/C142462285', 'wikidata': 'https://www.wikidata.org/wiki/Q2528140', 'display_name': 'Viral load', 'level': 3, 'score': 0.22947234}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18073842}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1756967}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.13555726}, {'id': 'https://openalex.org/C2993143319', 'wikidata': 'https://www.wikidata.org/wiki/Q583050', 'display_name': 'Antiretroviral therapy', 'level': 4, 'score': 0.1187419}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.05912599}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.045338094}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.16.299800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.16.299800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1945961678', 'https://openalex.org/W1948326274', 'https://openalex.org/W2000932609', 'https://openalex.org/W2061256139', 'https://openalex.org/W2061777515', 'https://openalex.org/W2150120685', 'https://openalex.org/W2166189758', 'https://openalex.org/W2985346127', 'https://openalex.org/W3000413850', 'https://openalex.org/W3004896487', 'https://openalex.org/W3008131087', 'https://openalex.org/W3012379316', 'https://openalex.org/W3014850166', 'https://openalex.org/W3015372266', 'https://openalex.org/W3029177955', 'https://openalex.org/W3087242436'], 'related_works': ['https://openalex.org/W748358169', 'https://openalex.org/W3035595114', 'https://openalex.org/W2407014618', 'https://openalex.org/W2166306740', 'https://openalex.org/W2162955592', 'https://openalex.org/W2123402665', 'https://openalex.org/W2106855395', 'https://openalex.org/W2106522682', 'https://openalex.org/W2067601295', 'https://openalex.org/W2055153247'], 'abstract_inverted_index': {'ABSTRACT': [0], 'COVID-19': [1, 111], 'has': [2], 'caused': [3], 'over': [4], '900,000': [5], 'deaths': [6], 'worldwide': [7], 'as': [8, 21], 'of': [9, 24, 41, 68, 75, 82, 88], 'September': [10], '2020,': [11], 'and': [12, 28, 43, 70, 92, 109], 'effective': [13, 57], 'medicines': [14], 'are': [15], 'urgently': [16], 'needed.': [17], 'Lopinavir': [18], 'was': [19, 33, 55], 'identified': [20], 'an': [22, 56], 'inhibitor': [23], 'the': [25, 39, 66, 73, 76, 85, 103], 'HIV': [26], 'protease,': [27], 'a': [29], 'lopinavir-ritonavir': [30, 53], 'combination': [31], 'therapy': [32, 54], 'reported': [34], 'to': [35, 72], 'be': [36], 'beneficial': [37], 'for': [38, 59, 107], 'treatment': [40, 58], 'SARS': [42], 'MERS.': [44], 'However,': [45], 'recent': [46], 'clinical': [47, 112], 'tests': [48], 'could': [49], 'not': [50, 95], 'prove': [51], 'that': [52], 'COVID-19.': [60, 89], 'In': [61], 'this': [62], 'report,': [63], 'we': [64], 'examined': [65], 'effect': [67], 'lopinavir': [69, 91], 'ritonavir': [71, 93], 'activity': [74], 'purified': [77], 'main': [78], 'protease': [79], '(Mpro)': [80], 'protein': [81], 'SARS-': [83], 'CoV-2,': [84], 'causative': [86], 'virus': [87], 'Unexpectedly,': [90], 'did': [94], 'inhibit': [96], 'Mpro': [97], 'activity.': [98], 'These': [99], 'results': [100], 'will': [101], 'aid': [102], 'drug': [104], 'candidate': [105], 'selection': [106], 'ongoing': [108], 'future': [110], 'trials.': [113]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3084956028', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}], 'updated_date': '2024-12-17T06:36:16.529181', 'created_date': '2020-09-21'}