Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3084128842', 'doi': 'https://doi.org/10.1101/2020.09.08.287466', 'title': 'Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity', 'display_name': 'Endothelial cell invasiveness is controlled by myosin IIA-dependent inhibition of Arp2/3 activity', 'publication_year': 2020, 'publication_date': '2020-09-08', 'ids': {'openalex': 'https://openalex.org/W3084128842', 'doi': 'https://doi.org/10.1101/2020.09.08.287466', 'mag': '3084128842'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.08.287466', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/09/08/2020.09.08.287466.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/09/08/2020.09.08.287466.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072848755', 'display_name': 'Ana M. Figueiredo', 'orcid': 'https://orcid.org/0000-0003-3499-9871'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Ana M. Figueiredo', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090524455', 'display_name': 'Pedro Barbacena', 'orcid': 'https://orcid.org/0000-0001-6905-040X'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Pedro Barbacena', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082996448', 'display_name': 'Ana Martins Russo', 'orcid': 'https://orcid.org/0000-0003-0302-2558'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Ana Russo', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009638138', 'display_name': 'Silvia Vaccaro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Vaccaro', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031670980', 'display_name': 'Daniela Ramalho', 'orcid': 'https://orcid.org/0000-0002-0904-2106'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Ramalho', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066715690', 'display_name': 'Andreia Pena', 'orcid': 'https://orcid.org/0000-0003-1668-0891'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Andreia Pena', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028245623', 'display_name': 'Aida P. Lima', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Aida P. Lima', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025930791', 'display_name': 'Rita R. Ferreira', 'orcid': 'https://orcid.org/0000-0001-7291-9495'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Rita R. Ferreira', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029159471', 'display_name': 'Fatima El-Marjou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2746051580', 'display_name': 'Université Paris Sciences et Lettres', 'ror': 'https://ror.org/013cjyk83', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2746051580']}, {'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Fatima El-Marjou', 'raw_affiliation_strings': ['Institut Curie, PSL Research University, CNRS UMR144, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Curie, PSL Research University, CNRS UMR144, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I2746051580', 'https://openalex.org/I80043', 'https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101926008', 'display_name': 'Yuliya Ponomareva', 'orcid': 'https://orcid.org/0000-0003-3733-1690'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Yulia Carvalho', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080645646', 'display_name': 'Francisca F. Vasconcelos', 'orcid': 'https://orcid.org/0000-0003-0601-5513'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Francisca F. Vasconcelos', 'raw_affiliation_strings': ['Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032736732', 'display_name': 'Ana-María Lennon-Duménil', 'orcid': 'https://orcid.org/0000-0002-8220-4482'}, 'institutions': [{'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Ana-Maria Lennon-Duménil', 'raw_affiliation_strings': ['INSERM U92, Institut Curie, ANR-10-IDEX-0001-02 PSL(∗) and ANR-11-LABX-004, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM U92, Institut Curie, ANR-10-IDEX-0001-02 PSL(∗) and ANR-11-LABX-004, Paris, France', 'institution_ids': ['https://openalex.org/I80043', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045339875', 'display_name': 'Danijela M. Vignevic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2746051580', 'display_name': 'Université Paris Sciences et Lettres', 'ror': 'https://ror.org/013cjyk83', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I2746051580']}, {'id': 'https://openalex.org/I80043', 'display_name': 'Institut Curie', 'ror': 'https://ror.org/04t0gwh46', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I80043']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Danijela M. Vignevic', 'raw_affiliation_strings': ['Institut Curie, PSL Research University, CNRS UMR144, F-75005 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Curie, PSL Research University, CNRS UMR144, F-75005 Paris, France', 'institution_ids': ['https://openalex.org/I2746051580', 'https://openalex.org/I80043', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020345179', 'display_name': 'Cláudio A. Franco', 'orcid': 'https://orcid.org/0000-0002-2861-3883'}, 'institutions': [{'id': 'https://openalex.org/I141596103', 'display_name': 'University of Lisbon', 'ror': 'https://ror.org/01c27hj86', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I141596103']}], 'countries': ['PT'], 'is_corresponding': True, 'raw_author_name': 'Claudio A. Franco', 'raw_affiliation_strings': ['Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.', 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal', 'institution_ids': ['https://openalex.org/I141596103']}, {'raw_affiliation_string': 'Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.', 'institution_ids': ['https://openalex.org/I141596103']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5020345179'], 'corresponding_institution_ids': ['https://openalex.org/I141596103'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.798112, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 70, 'max': 75}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/filopodia', 'display_name': 'Filopodia', 'score': 0.9467826}, {'id': 'https://openalex.org/keywords/sprouting-angiogenesis', 'display_name': 'Sprouting angiogenesis', 'score': 0.73213947}, {'id': 'https://openalex.org/keywords/lamellipodium', 'display_name': 'Lamellipodium', 'score': 0.5842705}, {'id': 'https://openalex.org/keywords/endothelial-cell-behavior', 'display_name': 'endothelial cell behavior', 'score': 0.566219}, {'id': 'https://openalex.org/keywords/endothelial-progenitor-cells', 'display_name': 'endothelial progenitor cells', 'score': 0.522779}, {'id': 'https://openalex.org/keywords/pseudopodia', 'display_name': 'Pseudopodia', 'score': 0.43813783}], 'concepts': [{'id': 'https://openalex.org/C90301020', 'wikidata': 'https://www.wikidata.org/wiki/Q14859810', 'display_name': 'Filopodia', 'level': 3, 'score': 0.9467826}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.7487176}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.734606}, {'id': 'https://openalex.org/C2910429298', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Sprouting angiogenesis', 'level': 4, 'score': 0.73213947}, {'id': 'https://openalex.org/C109185818', 'wikidata': 'https://www.wikidata.org/wiki/Q3092607', 'display_name': 'Lamellipodium', 'level': 4, 'score': 0.5842705}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.52660215}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4846054}, {'id': 'https://openalex.org/C6997183', 'wikidata': 'https://www.wikidata.org/wiki/Q271727', 'display_name': 'Myosin', 'level': 2, 'score': 0.45423976}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.45205846}, {'id': 'https://openalex.org/C2779717556', 'wikidata': 'https://www.wikidata.org/wiki/Q15325735', 'display_name': 'RAC1', 'level': 3, 'score': 0.43912458}, {'id': 'https://openalex.org/C199528912', 'wikidata': 'https://www.wikidata.org/wiki/Q165291', 'display_name': 'Pseudopodia', 'level': 3, 'score': 0.43813783}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.40362817}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.3826773}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.3009169}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.25157607}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.17069274}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.1675713}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.08.287466', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/09/08/2020.09.08.287466.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.09.08.287466', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2020/09/08/2020.09.08.287466.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.68}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1517374164', 'https://openalex.org/W1600721209', 'https://openalex.org/W1967720431', 'https://openalex.org/W1982409013', 'https://openalex.org/W1985907458', 'https://openalex.org/W1988194926', 'https://openalex.org/W2004351703', 'https://openalex.org/W2004641691', 'https://openalex.org/W2009022948', 'https://openalex.org/W2009234826', 'https://openalex.org/W2036123452', 'https://openalex.org/W2038634187', 'https://openalex.org/W2056986410', 'https://openalex.org/W2057414285', 'https://openalex.org/W2064026527', 'https://openalex.org/W2072722945', 'https://openalex.org/W2079548558', 'https://openalex.org/W2093351508', 'https://openalex.org/W2104010513', 'https://openalex.org/W2105094145', 'https://openalex.org/W2106369370', 'https://openalex.org/W2112251383', 'https://openalex.org/W2116299938', 'https://openalex.org/W2135459242', 'https://openalex.org/W2150102283', 'https://openalex.org/W2155382351', 'https://openalex.org/W2161443949', 'https://openalex.org/W2162310936', 'https://openalex.org/W2163455170', 'https://openalex.org/W2264665805', 'https://openalex.org/W2268496976', 'https://openalex.org/W2429042322', 'https://openalex.org/W2592302348', 'https://openalex.org/W2618307797', 'https://openalex.org/W2743742472', 'https://openalex.org/W2786318872', 'https://openalex.org/W2806161194', 'https://openalex.org/W2895470290', 'https://openalex.org/W2967212061', 'https://openalex.org/W2968035333', 'https://openalex.org/W2977346494', 'https://openalex.org/W2989943253', 'https://openalex.org/W3038933205', 'https://openalex.org/W51164494', 'https://openalex.org/W894880941'], 'related_works': ['https://openalex.org/W3022562655', 'https://openalex.org/W2803122114', 'https://openalex.org/W2538282264', 'https://openalex.org/W2160370078', 'https://openalex.org/W2157740045', 'https://openalex.org/W2094789107', 'https://openalex.org/W2084760353', 'https://openalex.org/W2048276106', 'https://openalex.org/W2018504997', 'https://openalex.org/W1559407638'], 'abstract_inverted_index': {'Abstract': [0], 'Sprouting': [1, 19], 'angiogenesis': [2, 20], 'is': [3, 32], 'fundamental': [4], 'for': [5, 65], 'development': [6, 110], 'and': [7, 16, 75, 83, 111, 151], 'contributes': [8], 'to': [9, 44, 113, 159], 'multiple': [10], 'diseases,': [11], 'including': [12], 'cancer,': [13], 'diabetic': [14], 'retinopathy': [15], 'cardiovascular': [17], 'diseases.': [18], 'depends': [21], 'on': [22, 36], 'the': [23, 37, 61, 129, 138, 154], 'invasive': [24, 161], 'properties': [25], 'of': [26, 92, 100, 106, 125, 132, 142], 'endothelial': [27, 40, 52, 103, 144], 'tip': [28, 41, 53, 145, 162], 'cells.': [29], 'However,': [30], 'there': [31], 'very': [33], 'limited': [34], 'knowledge': [35], 'mechanisms': [38], 'that': [39, 51, 73, 120], 'cells': [42, 54, 146, 163], 'use': [43, 55], 'invade': [45], 'into': [46, 67], 'tissues.': [47], 'Here,': [48], 'we': [49], 'prove': [50], 'long': [56], 'lamellipodia': [57], 'projections': [58], '(LLPs)': [59], 'as': [60], 'main': [62], 'cellular': [63], 'protrusion': [64], 'invasion': [66], 'non-vascular': [68], 'extracellular': [69], 'matrix.': [70], 'We': [71, 117], 'show': [72, 119], 'LLPs': [74, 96, 109], 'filopodia': [76, 115], 'protrusions': [77], 'are': [78], 'balanced': [79], 'by': [80, 127], 'myosin-IIA': [81], '(MIIA)': [82], 'actin-related': [84], 'protein': [85], '2/3': [86], '(Arp2/3)': [87], 'activity.': [88], 'Endothelial': [89], 'cell-autonomous': [90, 104], 'ablation': [91, 105], 'MIIA': [93, 121], 'promotes': [94], 'excessive': [95, 114], 'formation': [97], 'in': [98], 'detriment': [99], 'filopodia.': [101], 'Conversely,': [102], 'Arp2/3': [107], 'prevents': [108], 'leads': [112], 'formation.': [116], 'further': [118], 'inhibits': [122], 'Rac1-dependent': [123], 'activation': [124], 'Arp2/3,': [126], 'regulating': [128], 'maturation': [130], 'state': [131], 'focal': [133], 'adhesions.': [134], 'Our': [135], 'discoveries': [136], 'establish': [137], 'first': [139], 'comprehensive': [140], 'model': [141], 'how': [143], 'regulate': [147], 'its': [148], 'protrusive': [149], 'activity': [150], 'will': [152], 'pave': [153], 'way': [155], 'towards': [156], 'new': [157], 'strategies': [158], 'block': [160], 'during': [164], 'sprouting': [165], 'angiogenesis.': [166]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3084128842', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-08-29T18:20:55.052744', 'created_date': '2020-09-14'}