Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3083717020', 'doi': 'https://doi.org/10.1158/1538-7445.am2020-3340', 'title': 'Abstract 3340: Prostate cancer alters gut microbiota in mice', 'display_name': 'Abstract 3340: Prostate cancer alters gut microbiota in mice', 'publication_year': 2020, 'publication_date': '2020-08-15', 'ids': {'openalex': 'https://openalex.org/W3083717020', 'doi': 'https://doi.org/10.1158/1538-7445.am2020-3340', 'mag': '3083717020'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2020-3340', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051123041', 'display_name': 'Marco A. De Velasco', 'orcid': 'https://orcid.org/0000-0002-4011-6572'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Marco A. De Velasco', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015524135', 'display_name': 'Kazuko Sakai', 'orcid': 'https://orcid.org/0000-0003-1822-2720'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuko Sakai', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083740330', 'display_name': 'Yurie Kura', 'orcid': 'https://orcid.org/0009-0000-8785-3177'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yurie Kura', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054052615', 'display_name': 'Eri Banno', 'orcid': 'https://orcid.org/0000-0001-5108-4804'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Eri Banno', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047104997', 'display_name': 'Naomi Ando', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naomi Ando', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033730303', 'display_name': 'Noriko Sako', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriko Sako', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061277451', 'display_name': 'Kazuhiro Yoshikawa', 'orcid': 'https://orcid.org/0000-0002-8778-1174'}, 'institutions': [{'id': 'https://openalex.org/I16528096', 'display_name': 'Aichi Medical University', 'ror': 'https://ror.org/02h6cs343', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I16528096']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuhiro Yoshikawa', 'raw_affiliation_strings': ['2Aichi Medical University, Nagakute, Japan.'], 'affiliations': [{'raw_affiliation_string': '2Aichi Medical University, Nagakute, Japan.', 'institution_ids': ['https://openalex.org/I16528096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004282323', 'display_name': 'Kazuto Nishio', 'orcid': 'https://orcid.org/0000-0002-8275-0846'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuto Nishio', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058934672', 'display_name': 'Hirotsugu Uemura', 'orcid': 'https://orcid.org/0000-0002-3665-9523'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirotsugu Uemura', 'raw_affiliation_strings': ['1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;'], 'affiliations': [{'raw_affiliation_string': '1Kindai University Faculty of Medicine, Osaka-Sayama, Japan;', 'institution_ids': ['https://openalex.org/I916559398']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.079, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.333824, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 69}, 'biblio': {'volume': '80', 'issue': '16_Supplement', 'first_page': '3340', 'last_page': '3340'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10066', 'display_name': 'Gut microbiota and health', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10552', 'display_name': 'Colorectal Cancer Screening and Detection', 'score': 0.9225, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dysbiosis', 'display_name': 'Dysbiosis', 'score': 0.502028}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8056528}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.70846236}, {'id': 'https://openalex.org/C539455810', 'wikidata': 'https://www.wikidata.org/wiki/Q739734', 'display_name': 'Gut flora', 'level': 2, 'score': 0.547194}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.5078586}, {'id': 'https://openalex.org/C2777165150', 'wikidata': 'https://www.wikidata.org/wiki/Q269334', 'display_name': 'Dysbiosis', 'level': 3, 'score': 0.502028}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.49460217}, {'id': 'https://openalex.org/C143121216', 'wikidata': 'https://www.wikidata.org/wiki/Q1330402', 'display_name': 'Microbiome', 'level': 2, 'score': 0.4870153}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.44216177}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.44112724}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.43536156}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.27787048}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.26703304}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.07998255}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2020-3340', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Reduced inequalities', 'score': 0.5, 'id': 'https://metadata.un.org/sdg/10'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4381466049', 'https://openalex.org/W4311366456', 'https://openalex.org/W3214964065', 'https://openalex.org/W3198111711', 'https://openalex.org/W3135269674', 'https://openalex.org/W3093469531', 'https://openalex.org/W3067900727', 'https://openalex.org/W3007894746', 'https://openalex.org/W2801763052', 'https://openalex.org/W2783006976'], 'abstract_inverted_index': {'Abstract': [0], 'Commensal': [1], 'gut': [2, 62, 360], 'bacteria': [3, 157], 'are': [4, 35, 301], 'essential': [5], 'for': [6, 375], 'maintaining': [7], 'intestinal': [8], 'homeostasis,': [9], 'however,': [10, 230], 'aging,': [11], 'environmental': [12], 'factors': [13], 'and': [14, 34, 42, 115, 120, 145, 162, 214, 217, 248, 261, 272, 277, 297, 320, 332, 382], 'pathological': [15], 'conditions': [16], 'can': [17, 29], 'cause': [18], 'changes': [19, 60], 'in': [20, 24, 37, 61, 294, 313, 362], 'microbial': [21, 27], 'composition': [22, 102], 'resulting': [23], 'dysbiosis.': [25], 'Specific': [26], 'communities': [28], 'alter': [30], 'host': [31, 211, 215], 'immune': [32], 'functions': [33], 'implicated': [36], 'promoting': [38], 'carcinogenesis,': [39], 'tumor': [40], 'progression': [41, 331], 'therapeutic': [43], 'resistance.': [44], 'In': [45], 'this': [46], 'study': [47, 305], 'we': [48], 'use': [49], 'a': [50, 72], 'genetically': [51], 'engineered': [52], 'mouse': [53, 317], 'model': [54], 'of': [55, 75, 79, 94, 155, 188, 194, 223, 288, 310, 316, 367, 371], 'prostate': [56, 84, 169, 195, 224, 318], 'cancer': [57, 144, 170, 225, 253, 319, 333, 358], 'to': [58, 70, 126, 139, 151, 185, 205, 324], 'characterize': [59], 'microbiota.': [63], '16S': [64], 'marker': [65], 'sequencing': [66], 'data': [67], 'was': [68, 96, 105, 124, 137, 149, 183, 202], 'used': [69, 125, 138], 'perform': [71], 'comprehensive': [73], 'profile': [74], 'the': [76, 121, 160, 174, 192, 221, 237, 243, 314, 322, 327, 368, 372], 'fecal': [77, 156, 311], 'microbiomes': [78], 'conditional': [80], 'Pten-knockout': [81], 'mice': [82, 88, 255, 267, 363], 'harboring': [83], 'tumors': [85], 'versus': [86], 'wildtype': [87], 'with': [89, 143, 168, 173, 191, 210, 252, 265, 285, 329], 'normal': [90], 'prostate.': [91], 'Unsupervised': [92], 'clustering': [93], 'microbiota': [95, 361], 'performed': [97, 150, 184], 'by': [98, 107], 'hierarchical': [99], 'clustering.': [100], 'Community': [101], '(beta': [103], 'diversity)': [104], 'determine': [106, 127, 152], 'principal': [108, 111], 'components': [109], 'analysis,': [110], 'coordinates': [112], 'analysis': [113, 133, 181, 200], '(PCoA)': [114], 'Adonis': [116], '(permutational': [117], 'manova': [118], '(PERMANOVA))': [119], 'Shannon': [122], 'index': [123], 'alpha': [128], 'diversity.': [129], 'The': [130], 'linear': [131, 147], 'discriminant': [132], 'effect': [134], 'size': [135], 'method': [136], 'identify': [140, 186, 206], 'features': [141, 154], 'associated': [142, 167, 190, 209, 251, 264, 284], 'multiple': [146], 'regression': [148], 'relevant': [153], 'collected': [158], 'from': [159], 'proximal': [161], 'distal': [163], 'colon.': [164], 'Predictive': [165], 'biomarkers': [166, 283], 'were': [171, 234, 250, 263, 279, 292], 'identified': [172, 280, 293], 'Wilcoxon': [175], 'rank': [176], 'test.': [177], 'Weighted': [178], 'correlation': [179], 'network': [180], '(WGCNA)': [182], 'clusters': [187], 'taxa': [189, 291], 'presence': [193, 222], 'cancer.': [196, 286], 'Taxon': [197], 'set': [198], 'enrichment': [199], '(TSEA)': [201], 'carried': [203], 'out': [204], 'taxon': [207], 'sets': [208], 'genetic': [212], 'variations,': [213], 'intrinsic': [216], 'extrinsic': [218], 'factors.': [219], 'Overall,': [220, 303], 'did': [226], 'not': [227], 'affect': [228], 'diversity,': [229], 'significant': [231], 'compositional': [232], 'differences': [233], 'observed': [235], 'between': [236], 'cohorts': [238, 296], '(Bray-Curtis': [239], 'Adonis,': [240], 'P=0.003).': [241], 'At': [242], 'family': [244], 'level': [245], 'S24_7,': [246], 'Odoribacteraceae,': [247], 'Peptococcaceae': [249], 'bearing': [254], 'while': [256], 'Bifidobacteriaceae,': [257], 'Peptostreptococcaceae,': [258], 'Coriobacteriaceae,': [259], 'Ruminococcaceae': [260], 'Erysipelotrichaceae': [262], 'healthy': [266], '(P<0.05).': [268], 'Prevotella,': [269], 'Lactobacillus': [270], 'reuteri': [271], 'various': [273], 'unclassified': [274], 'Clostridiales,': [275], 'S24_7': [276], 'Rikenellaceae': [278], 'as': [281], 'predictive': [282], 'Clusters': [287], 'highly': [289], 'correlated': [290], 'both': [295], 'their': [298], 'functional': [299], 'influences': [300], 'summarized.': [302], 'our': [304], 'provides': [306, 321], 'an': [307], 'in-depth': [308], 'overview': [309], 'microbiome': [312], 'context': [315], 'foundation': [323], 'further': [325], 'investigate': [326], 'interactions': [328], 'disease': [330], 'therapy.': [334], 'Citation': [335], 'Format:': [336], 'Marco': [337], 'A.': [338], 'De': [339], 'Velasco,': [340], 'Kazuko': [341], 'Sakai,': [342], 'Yurie': [343], 'Kura,': [344], 'Eri': [345], 'Banno,': [346], 'Naomi': [347], 'Ando,': [348], 'Noriko': [349], 'Sako,': [350], 'Kazuhiro': [351], 'Yoshikawa,': [352], 'Kazuto': [353], 'Nishio,': [354], 'Hirotsugu': [355], 'Uemura.': [356], 'Prostate': [357], 'alters': [359], '[abstract].': [364], 'In:': [365], 'Proceedings': [366], 'Annual': [369], 'Meeting': [370], 'American': [373], 'Association': [374], 'Cancer': [376, 388], 'Research': [377], '2020;': [378], '2020': [379], 'Apr': [380], '27-28': [381], 'Jun': [383], '22-24.': [384], 'Philadelphia': [385], '(PA):': [386], 'AACR;': [387], 'Res': [389], '2020;80(16': [390], 'Suppl):Abstract': [391], 'nr': [392], '3340.': [393]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3083717020', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-25T05:21:15.979365', 'created_date': '2020-09-11'}